Molecular basis of pigment structural diversity in echinoderms

Authors: Feng Li, Zhenjian Lin, Eric W. Schmidt

Source: iScience, Vol 27, Iss 9, Pp 110834- (2024)

Subject Terms: Natural sciences, Chemistry, Inorganic chemistry, Chemical reaction, Catalysis, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004224020595; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/db910d340f3046fba0eee822f02f98e2

The polyketide to fatty acid transition in the evolution of animal lipid metabolism

Authors: Zhenjian Lin, Feng Li, Patrick J. Krug, Eric W. Schmidt

Source: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/a1c8dbea0fb34a798fadcda3fcf72d7a

Resistance mechanisms for Gram-negative bacteria-specific lipopeptides, turnercyclamycins, differ from that of colistin

Authors: Albebson L. Lim, Bailey W. Miller, Zhenjian Lin, Mark A. Fisher, Louis R. Barrows, Margo G. Haygood, Eric W. Schmidt

Source: Microbiology Spectrum, Vol 11, Iss 6 (2023)

Subject Terms: lipopeptides, antibiotics, Gram-negative bacteria, Acinetobacter, colistin, drug resistance, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/54c4046ef672420ebbd5753d2a69f3bd

Translating Marine Symbioses toward Drug Development

Authors: Eric W. Schmidt, Zhenjian Lin

Source: mBio, Vol 13, Iss 6 (2022)

Subject Terms: drug development, marine microbiology, metagenomics, natural products, symbiosis, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/10fb51b0ec0f40ecb74e07aef9f5b58b

Animal biosynthesis of complex polyketides in a photosynthetic partnership

Authors: Joshua P. Torres, Zhenjian Lin, Jaclyn M. Winter, Patrick J. Krug, Eric W. Schmidt

Source: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/e4be631f0db64b18a746004d3fa1c1f3

Non-Peptidic Small Molecule Components from Cone Snail Venoms

Authors: Zhenjian Lin, Joshua P. Torres, Maren Watkins, Noemi Paguigan, Changshan Niu, Julita S. Imperial, Jortan Tun, Helena Safavi-Hemami, Rocio K. Finol-Urdaneta, Jorge L. B. Neves, Samuel Espino, Manju Karthikeyan, Baldomero M. Olivera, Eric W. Schmidt

Source: Frontiers in Pharmacology, Vol 12 (2021)

Subject Terms: secondary metabolites, conus, gastropod, prey capture, conopeptides, natural products, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2021.655981/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/d53cb04f1077429cb543b44418d5afd0

Correction for Altamia et al., 'Secondary Metabolism in the Gill Microbiota of Shipworms (Teredinidae) as Revealed by Comparison of Metagenomes and Nearly Complete Symbiont Genomes'

Authors: Marvin A. Altamia, Zhenjian Lin, Amaro E. Trindade-Silva, Iris Diana Uy, J. Reuben Shipway, Diego Veras Wilke, Gisela P. Concepcion, Daniel L. Distel, Eric W. Schmidt, Margo G. Haygood

Source: mSystems, Vol 6, Iss 2 (2021)

Subject Terms: Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2379-5077

Access URL: https://doaj.org/article/2d9888f6a1334417bb7f8e7e9bc0353e

Secondary Metabolism in the Gill Microbiota of Shipworms (Teredinidae) as Revealed by Comparison of Metagenomes and Nearly Complete Symbiont Genomes

Authors: Marvin A. Altamia, Zhenjian Lin, Amaro E. Trindade-Silva, Iris Diana Uy, J. Reuben Shipway, Diego Veras Wilke, Gisela P. Concepcion, Daniel L. Distel, Eric W. Schmidt, Margo G. Haygood

Source: mSystems, Vol 5, Iss 3 (2020)

Subject Terms: biosynthesis, metagenomics, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2379-5077

Access URL: https://doaj.org/article/eed8927a86ea4648baae9d7893d5c6cb

A symbiotic bacterium of shipworms produces a compound with broad spectrum anti-apicomplexan activity.

Authors: Roberta M O'Connor, Felix J Nepveux V, Jaypee Abenoja, Gregory Bowden, Patricia Reis, Josiah Beaushaw, Rachel M Bone Relat, Iwona Driskell, Fernanda Gimenez, Michael W Riggs, Deborah A Schaefer, Eric W Schmidt, Zhenjian Lin, Daniel L Distel, Jon Clardy, Timothy R Ramadhar, David R Allred, Heather M Fritz, Pradipsinh Rathod, Laura Chery, John White

Source: PLoS Pathogens, Vol 16, Iss 5, p e1008600 (2020)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/f409fe1b5c164785aed21bd8fb436bc8

Short macrocyclic peptides in sponge genomes.

Authors: Zhenjian Lin¹, Agarwal, Vinayak^2,3 vagarwal@gatech.edu, Ying Cong¹, Pomponi, Shirley A.⁴, Schmidt, Eric W.¹ ews1@utah.edu

Source: Proceedings of the National Academy of Sciences of the United States of America. 3/12/2024, Vol. 121 Issue 11, p1-8. 32p.

Subject Terms: *CYCLIC peptides, *PEPTIDES, *SIGNAL peptides, *AMINO acid sequence, *POST-translational modification

Salvianolic acid B attenuated cisplatin-induced cardiac injury and oxidative stress via modulating Nrf2 signal pathway.

Authors: Zhenjian Lin¹, Yuyan Bao¹, Bing Hong¹, Yangyang Wang¹, Xiaomin Zhang¹ smyyyjk@126.com, Yaping Wu¹ WYP2824@163.com

Source: Journal of Toxicological Sciences. 2021, Vol. 46 Issue 5, p199-207. 9p.

Subject Terms: *CISPLATIN, *HEART injuries, *OXIDATIVE stress, *CANCER chemotherapy, *CARDIOLOGICAL manifestations of general diseases, *TREATMENT effectiveness, *NUCLEAR factor E2 related factor

Animal FAS-like polyketide synthases produce diverse polypropionates.

Authors: Feng Li¹, Zhenjian Lin¹, Krug, Patrick J.², Catrow, J. Leon³, Cox, James E.^3,4, Schmidt, Eric W.¹ ews1@utah.edu

Source: Proceedings of the National Academy of Sciences of the United States of America. 9/19/2023, Vol. 120 Issue 38, p1-59. 69p.

Subject Terms: *POLYKETIDE synthases, *FATTY acid synthases, *LIPID synthesis, *POLYKETIDES

An Obligate Peptidyl Brominase Underlies the Discovery of Highly Distributed Biosynthetic Gene Clusters in Marine Sponge Microbiomes.

Authors: Nguyen, Nguyet A., Zhenjian Lin, Mohanty, Ipsita, Garg, Neha, Schmidt, Eric W., Agarwal, Vinayak

Source: Journal of the American Chemical Society; 7/14/2021, Vol. 143 Issue 27, p10221-10231, 11p

Small-molecule mimicry hunting strategy in the imperial cone snail, Conus imperialis.

Authors: Torres, Joshua P.¹, Zhenjian Lin¹ z.j.lin@utah.edu, Watkins, Maren², Salcedo, Paula Flórez³, Baskin, Robert P.², Elhabian, Shireen⁴, Safavi-Hemami, Helena^2,5,6, Taylor, Dylan², Tun, Jortan², Concepcion, Gisela P.⁷, Saguil, Noel¹, Yanagihara, Angel A.⁸, Yixin Fang¹, McArthur, Jeffrey R.⁹, Han-Shen Tae⁹, Finol-Urdaneta, Rocio K.⁹, Özpolat, B. Duygu¹⁰, Olivera, Baldomero M.², Schmidt, Eric W.^1,2 ews1@utah.edu

Source: Science Advances. 3/10/2021, Vol. 7 Issue 11, p1-12. 12p.

Subject Terms: *CONOTOXINS, *CONUS, *SEXUAL cycle, *LIFE sciences, *BIOLOGICAL systems, *MEDICAL sciences

Post-Translational Tyrosine Geranylation in Cyanobactin Biosynthesis.

Authors: Morita, Maho¹, Yue Hao², Jokela, Jouni K.³, Sardar, Debosmita¹, Zhenjian Lin¹, Sivonen, Kaarina³, Nair, Satish K.², s-nair@life.illinois.edu, Schmidt, Eric W.¹, ews1@utah.edu

Source: Journal of the American Chemical Society; 5/16/2018, Vol. 140 Issue 19, p6044-6048, 5p

Cysteine-Free Intramolecular Ligation of N-Sulfanylethylanilide Peptide Using 4-Mercaptobenzylphosphonic Acid: Synthesis of Cyclic Peptide Trichamide.

Authors: Keisuke Aihara, Tsubasa Inokuma, Takahisa Jichu, Zhenjian Lin, Feixue Fu, Kosuke Yamaoka, Akira Shigenaga, Hutchins, David A., Schmidt, Eric W., Akira Otaka

Source: Synlett; 2017, Vol. 28 Issue 15, p1944-1949, 6p

Subject Terms: CYSTEINE, LIGATION reactions, PHOSPHONIC acids

Discovery of chemoautotrophic symbiosis in the giant shipworm Kuphus polythalamia (Bivalvia: Teredinidae) extends wooden-steps theory.

Authors: Distel, Daniel L., Shipway, J. Reuben, Altamia, Marvin A., Forteza, Imelda, Antemano, Rowena, Peñaflor Limbaco, Ma. Gwen J., Concepcion, Gisela P., Zhenjian Lin, Schmidt, Eric W., Haygood, Margo G., Han, Andrew, Tebo, Alison G., Dechavez, Rande, Albano, Julie, Rosenberg, Gary

Source: Proceedings of the National Academy of Sciences of the United States of America; 5/2/2017, Vol. 114 Issue 18, pE3652-E3658, 7p

Subject Terms: CHEMOAUTOTROPHIC bacteria, SYMBIOSIS, SHIPWORMS, CHROMATIACEAE, FLUORESCENCE in situ hybridization

Enzymatic N- and C-Protection in Cyanobactin RiPP Natural Products.

Authors: Sardar, Debosmita¹, Yue Hao², Zhenjian Lin¹, Maho Morita¹, Nair, Satish K.², s-nair@life.illinois.edu, Schmidt, Eric W.¹, ews1@utah.edu

Source: Journal of the American Chemical Society; 3/1/2017, Vol. 139 Issue 8, p2884-2887, 4p

Origin of Chemical Diversity in Prochloron-Tunicate Symbiosis.

Authors: Zhenjian Lin¹, Torres, Joshua P.¹, Tianero, M. Diarey¹, Kwan, Jason C.¹, Schmidt, Eric W.¹ ews1@utah.edu

Source: Applied & Environmental Microbiology. Jun2016, Vol. 82 Issue 12, p3450-3460. 11p.

Subject Terms: *TUNICATA, *PROCHLORON, *ANIMAL-bacterial symbiosis, *PHYLOGENY, *METABOLITE synthesis, *COMBINATORIAL chemistry

Combinatorialization of Fungal Polyketide Synthase--Peptide Synthetase Hybrid Proteins.

Authors: Kakule, Thomas B.¹, Zhenjian Lin¹, Schmidt, Eric W.¹ ews1@utah.edu

Source: Journal of the American Chemical Society. 12/24/2014, Vol. 136 Issue 51, p17882-17890. 9p.

Subject Terms: *POLYKETIDE synthases, *NONRIBOSOMAL peptide synthetases, *AMINO acids, *GENE fusion, *ACYL carrier protein, *CONDENSATION, *BIOCHEMICAL substrates, *DIELS-Alder reaction