Discovery of antibiotics that selectively kill metabolically dormant bacteria

Authors: Zheng, Erica J., Valeri, Jacqueline A., Andrews, Ian W., Krishnan, Aarti, Bandyopadhyay, Parijat, Anahtar, Melis N., Herneisen, Alice, Schulte, Fabian, Linnehan, Brooke, Wong, Felix, Stokes, Jonathan M., Renner, Lars D., Lourido, Sebastian, Collins, James J.

Source: In Cell Chemical Biology 18 April 2024 31(4):712-728

An online research immersion program to increase introductory science student confidence and science identity.

Authors: Zheng, Erica J.¹, Oakes, Elizabeth^1,2, Roden, Julie^2,3, jroden@wellesley.edu

Source: Biochemistry & Molecular Biology Education; Jan2024, Vol. 52 Issue 1, p45-57, 13p

Bacterial metabolic state more accurately predicts antibiotic lethality than growth rate

Authors: Lopatkin, Allison J., Stokes, Jonathan M., Zheng, Erica J., Yang, Jason H., Takahashi, Melissa K., You, Lingchong, Collins, James J.

Source: Nature microbiology. 4(12):2109-2117

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130017705.0x000001&indx=1&recIds=ETOCvdc_100130017705.0x000001

Benchmarking AlphaFold‐enabled molecular docking predictions for antibiotic discovery

Authors: Wong, Felix, Krishnan, Aarti, Zheng, Erica J, Stärk, Hannes, Manson, Abigail L, Earl, Ashlee M, Jaakkola, Tommi, Collins, James J

Source: Molecular systems biology. 18(9)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100166391877.0x000001&indx=1&recIds=ETOCvdc_100166391877.0x000001

Identification of inhibitors of the E. coli chaperone SurA using in silico and in vitro techniques

Authors: Bell, Eric W., Zheng, Erica J., Ryno, Lisa M.

Source: Bioorganic & medicinal chemistry letters. 28(22):3540-3548

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100070784566.0x000001&indx=1&recIds=ETOCvdc_100070784566.0x000001

Discovery of a structural class of antibiotics with explainable deep learning.

Authors: Wong, Felix, Zheng, Erica J., Valeri, Jacqueline A., Donghia, Nina M., Anahtar, Melis N., Omori, Satotaka, Li, Alicia, Cubillos-Ruiz, Andres, Krishnan, Aarti, Jin, Wengong, Manson, Abigail L., Friedrichs, Jens, Helbig, Ralf, Hajian, Behnoush, Fiejtek, Dawid K., Wagner, Florence F., Soutter, Holly H., Earl, Ashlee M., Stokes, Jonathan M., Renner, Lars D.

Source: Nature; Feb2024, Vol. 626 Issue 7997, p177-185, 9p

Eradicating Bacterial Persisters with Combinations of Strongly and Weakly Metabolism-Dependent Antibiotics

Authors: Zheng, Erica J., Stokes, Jonathan M., Collins, James J.

Source: Cell chemical biology. 27(12):1544-1552.e3

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100117034915.0x000001&indx=1&recIds=ETOCvdc_100117034915.0x000001

Modulating the evolutionary trajectory of tolerance using antibiotics with different metabolic dependencies.

Authors: Zheng, Erica J., Andrews, Ian W., Grote, Alexandra T., Manson, Abigail L., Alcantar, Miguel A., Earl, Ashlee M., Collins, James J.

Source: Nature Communications; 5/9/2022, Vol. 13 Issue 1, p1-11, 11p

Subject Terms: ANTIBIOTICS, BACTERIAL metabolism, ESCHERICHIA coli, DISEASE relapse, TREATMENT effectiveness

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