A shark-derived broadly neutralizing nanobody targeting a highly conserved epitope on the S2 domain of sarbecoviruses

Authors: Bo Feng, Cuiyun Li, Zhaoyong Zhang, Yongming Huang, Banghui Liu, Zhengyuan Zhang, Jia Luo, Qian Wang, Li Yin, Si Chen, Ping He, Xiaoli Xiong, Jincun Zhao, Xuefeng Niu, Zhilong Chen, Ling Chen

Source: Journal of Nanobiotechnology, Vol 23, Iss 1, Pp 1-14 (2025)

Subject Terms: Shark nanobody, SARS-CoV-2, Sarbecovirus, Broad spectrum neutralization, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5

File Description: electronic resource

Relation: https://doaj.org/toc/1477-3155

Access URL: https://doaj.org/article/3ff7f8d4d7f24cf691d8086b37aa8a1b

A nucleoside-modified mRNA vaccine prevents enterovirus A71 infection in mouse model

Authors: Fengyu Chi, Xu Zhang, Dong Zhang, Airu Zhu, Zhen Zhuang, Zhaoyong Zhang, Zhenjie Zhang, Chuansong Quan, Kaixiao Nie, Juan Li, Chunhong Yin, Jie Tong, Yuming Li

Source: Frontiers in Immunology, Vol 16 (2025)

Subject Terms: human enterovirus A71, non-enveloped virus, VP1, mRNA vaccine, immune response, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1535758/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/36a40dc30b234eac9815272c9d0556d4

Defining the features and structure of neutralizing antibody targeting the silent face of the SARS‐CoV‐2 spike N‐terminal domain

Authors: Zhaoyong Zhang, Yuanyuan Zhang, Yuting Zhang, Linling Cheng, Lu Zhang, Qihong Yan, Xuesong Liu, Jiantao Chen, Jun Dai, Yingying Guo, Peilan Wei, Xinyi Xiong, Juxue Xiao, Airu Zhu, Jianfen Zhuo, Ruoxi Cai, Jingjun Zhang, Haiyue Rao, Bin Qu, Shengnan Zhang, Jiaxin Feng, Jinling Cheng, Jingyi Su, Canjie Chen, Shu Li, Lei Chen, Yingkang Jin, Yonghao Xu, Xiaoqing Liu, Yimin Li, Jingxian Zhao, Yanqun Wang, Qiang Zhou, Jincun Zhao

Source: MedComm, Vol 5, Iss 12, Pp n/a-n/a (2024)

Subject Terms: glycan shield, neutralizing antibody, N‐terminal domain, SARS‐CoV‐2, silent face, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2688-2663

Access URL: https://doaj.org/article/3552ad81f3c14299b6bd002e4faa2278

Impact of volume indices in bioelectrical impedance measurement on the assessment of cardiac function indices by echocardiography in hemodialysis patients

Authors: Yudan Wang, Yang Wang, Shun Wu, Na Xu, Zhaoyong Zhang, Zhenmin Ruan, Rui Wang, Xin Geng, Chuanzhen Zhang, Zhiyong Luan, Guofang Chen, Hongqi Ren

Source: Renal Failure, Vol 46, Iss 2 (2024)

Subject Terms: Hemodialysis, volume indices, bioelectrical impedance, cardiac function, echocardiography, Diseases of the genitourinary system. Urology, RC870-923

File Description: electronic resource

Relation: https://doaj.org/toc/0886-022X; https://doaj.org/toc/1525-6049

Access URL: https://doaj.org/article/58b8c0c8c7e14e9c9f1b120d9128c2d1

A bispecific antibody exhibits broad neutralization against SARS-CoV-2 Omicron variants XBB.1.16, BQ.1.1 and sarbecoviruses

Authors: Yingdan Wang, Aihua Hao, Ping Ji, Yunping Ma, Zhaoyong Zhang, Jiali Chen, Qiyu Mao, Xinyi Xiong, Palizhati Rehati, Yajie Wang, Yanqun Wang, Yumei Wen, Lu Lu, Zhenguo Chen, Jincun Zhao, Fan Wu, Jinghe Huang, Lei Sun

Source: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/1baaece47e9e413588ae2c3a07909406

Identification of a highly conserved neutralizing epitope within the RBD region of diverse SARS-CoV-2 variants

Authors: Yanqun Wang, An Yan, Deyong Song, Maoqin Duan, Chuangchuang Dong, Jiantao Chen, Zihe Jiang, Yuanzhu Gao, Muding Rao, Jianxia Feng, Zhaoyong Zhang, Ruxi Qi, Xiaomin Ma, Hong Liu, Beibei Yu, Qiaoping Wang, Mengqi Zong, Jie Jiao, Pingping Xing, Rongrong Pan, Dan Li, Juxue Xiao, Junbo Sun, Ying Li, Linfeng Zhang, Zhenduo Shen, Baiping Sun, Yanyan Zhao, Lu Zhang, Jun Dai, Jingxian Zhao, Lan Wang, Changlin Dou, Zheng Liu, Jincun Zhao

Source: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c33908424c5646a8b6688faee41eaca1

An unconventional VH1-2 antibody tolerates escape mutations and shows an antigenic hotspot on SARS-CoV-2 spike

Authors: Banghui Liu, Xuefeng Niu, Yijun Deng, Zhaoyong Zhang, Yanqun Wang, Xijie Gao, Huan Liang, Zimu Li, Qian Wang, Yuanyi Cheng, Qiuluan Chen, Shuangshuang Huang, Yingxian Pan, Mengzhen Su, Xiancheng Lin, Chuanying Niu, Yinglin Chen, Wenyi Yang, Yudi Zhang, Qihong Yan, Jun He, Jincun Zhao, Ling Chen, Xiaoli Xiong

Source: Cell Reports, Vol 43, Iss 6, Pp 114265- (2024)

Subject Terms: CP: Immunology, CP: Microbiology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S221112472400593X; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/7cad8a13089e4ac2a602d4984949494b

Mosaic RBD Nanoparticles Elicit Protective Immunity Against Multiple Human Coronaviruses in Animal Models

Authors: Yanjun Zhang, Jing Sun, Jian Zheng, Suxiang Li, Haiyue Rao, Jun Dai, Zhaoyong Zhang, Yanqun Wang, Donglan Liu, Zhao Chen, Wei Ran, Airu Zhu, Fang Li, Qihong Yan, Yiliang Wang, Kuai Yu, Shengnan Zhang, Dong Wang, Yanhong Tang, Banghui Liu, Linling Cheng, Jiandong Huo, Stanley Perlman, Jingxian Zhao, Jincun Zhao

Source: Advanced Science, Vol 11, Iss 9, Pp n/a-n/a (2024)

Subject Terms: mosaic RBD nanoparticle vaccine coronavirus, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/6fa82e832d8449bf945f6a6e96549e8b

Identification of a broad sarbecovirus neutralizing antibody targeting a conserved epitope on the receptor-binding domain

Authors: Yanqun Wang, Zhaoyong Zhang, Minnan Yang, Xinyi Xiong, Qihong Yan, Lei Cao, Peilan Wei, Yuting Zhang, Lu Zhang, Kexin Lv, Jiantao Chen, Xuesong Liu, Xiaochu Zhao, Juxue Xiao, Shengnan Zhang, Airu Zhu, Mian Gan, Jingjun Zhang, Ruoxi Cai, Jianfen Zhuo, Yanjun Zhang, Haiyue Rao, Bin Qu, Yuanyuan Zhang, Lei Chen, Jun Dai, Linling Cheng, Qingtao Hu, Yaoqing Chen, Huibin Lv, Ray T.Y. So, Malik Peiris, Jingxian Zhao, Xiaoqing Liu, Chris Ka Pun Mok, Xiangxi Wang, Jincun Zhao

Source: Cell Reports, Vol 43, Iss 1, Pp 113653- (2024)

Subject Terms: CP: Immunology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723016649; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/08a7908f7f674401bcbdd5e3709922fc

The impact of the Belt and Road Initiative on green innovation and innovation modes: empirical evidence from Chinese listed enterprises

Authors: Bowen Li, Zijing Zhang, Zhaoyong Zhang

Source: Frontiers in Environmental Science, Vol 11 (2024)

Subject Terms: Belt and Road Initiative, green innovation, Chinese listed enterprises, difference-in-difference model, collaborative vs. independent innovation modes, Environmental sciences, GE1-350

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fenvs.2023.1323888/full; https://doaj.org/toc/2296-665X

Access URL: https://doaj.org/article/aab3961188814911b3dccc5994388396

Inactivated vaccine-elicited potent antibodies can broadly neutralize SARS-CoV-2 circulating variants

Authors: Yubin Liu, Ziyi Wang, Xinyu Zhuang, Shengnan Zhang, Zhicheng Chen, Yan Zou, Jie Sheng, Tianpeng Li, Wanbo Tai, Jinfang Yu, Yanqun Wang, Zhaoyong Zhang, Yunfeng Chen, Liangqin Tong, Xi Yu, Linjuan Wu, Dong Chen, Renli Zhang, Ningyi Jin, Weijun Shen, Jincun Zhao, Mingyao Tian, Xinquan Wang, Gong Cheng

Source: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c7bb4ce8f3e74d5bad738ec40b3dfe16

A potent and broad‐spectrum neutralizing nanobody for SARS‐CoV‐2 viruses, including all major Omicron strains

Authors: Hebang Yao, Hongyang Wang, Zhaoyong Zhang, Yuchi Lu, Zhiying Zhang, Yu Zhang, Xinyi Xiong, Yanqun Wang, Zhizhi Wang, Haitao Yang, Jincun Zhao, Wenqing Xu

Source: MedComm, Vol 4, Iss 6, Pp n/a-n/a (2023)

Subject Terms: broad spectrum, nanobody, neutralize, Omicrons, SARS‐CoV‐2, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2688-2663

Access URL: https://doaj.org/article/cee4373ccde44db09dc56b7a4d5183bb

Two novel human coronavirus OC43 genotypes circulating in hospitalized children with pneumonia in China

Authors: Zhaoyong Zhang, Wenkuan Liu, Shengnan Zhang, Peilan Wei, Lu Zhang, Dehui Chen, Shuyan Qiu, Xiaobo Li, Jingxian Zhao, Yongxia Shi, Rong Zhou, Yanqun Wang, Jincun Zhao

Source: Emerging Microbes and Infections, Vol 11, Iss 1, Pp 168-171 (2022)

Subject Terms: hcov-oc43, hospitalized children, pneumonia, novel genotype, recombinant, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/2821e7f87dd04788ba475e66ce5fdc23

Broadly Effective ACE2 Decoy Proteins Protect Mice from Lethal SARS-CoV-2 Infection

Authors: Mengjia Lu, Weitong Yao, Yujun Li, Danting Ma, Zhaoyong Zhang, Haimin Wang, Xiaojuan Tang, Yanqun Wang, Chao Li, Dechun Cheng, Hua Lin, Yandong Yin, Jincun Zhao, Guocai Zhong

Source: Microbiology Spectrum, Vol 11, Iss 4 (2023)

Subject Terms: SARS-CoV-2, variant of concern, Omicron, ACE2, receptor decoy, ACE2-Ig, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/b1f25c8e9c044f1d8c631dd1a440d1be

Genetic and pathogenicity diversity of dengue virus type 2 strains circulating in Guangdong, China

Authors: Lu Zhang, Lingzhai Zhao, Zhaoyong Zhang, Wenxin Hong, Jian Wang, Shuang Qiu, Huiqin Yang, Mian Gan, Jing Sun, Jingxian Zhao, Yanqun Wang, Jincun Zhao, Fuchun Zhang

Source: Biosafety and Health, Vol 3, Iss 6, Pp 333-342 (2021)

Subject Terms: DENV-2, Genetic, Pathogenicity, Diversity, Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2590053621000732; https://doaj.org/toc/2590-0536

Access URL: https://doaj.org/article/e44a032bed7c4ed69d7a9d5ee45d07de

Potent prophylactic and therapeutic efficacy of recombinant human ACE2-Fc against SARS-CoV-2 infection in vivo

Authors: Zhaoyong Zhang, Eric Zeng, Lu Zhang, Weiming Wang, Yingkang Jin, Jiye Sun, Shuxiang Huang, Wenguang Yin, Jun Dai, Zhen Zhuang, Zhao Chen, Jing Sun, Airu Zhu, Fang Li, Weitao Cao, Xiaobo Li, Yongxia Shi, Mian Gan, Shengnan Zhang, Peilan Wei, Jicheng Huang, Nanshan Zhong, Guocai Zhong, Jingxian Zhao, Yanqun Wang, Weihui Shao, Jincun Zhao

Source: Cell Discovery, Vol 7, Iss 1, Pp 1-15 (2021)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2056-5968

Access URL: https://doaj.org/article/9b704b1c51eb428aae1ea4a9d75ae69c

Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis, prognosis and drug target discovery

Authors: Yuming Li, Guixue Hou, Haibo Zhou, Yanqun Wang, Hein Min Tun, Airu Zhu, Jingxian Zhao, Fei Xiao, Shanwen Lin, Dongdong Liu, Dunrong Zhou, Lang Mai, Lu Zhang, Zhaoyong Zhang, Lijun Kuang, Jiao Guan, Qiushi Chen, Liyan Wen, Yanjun Zhang, Jianfen Zhuo, Fang Li, Zhen Zhuang, Zhao Chen, Ling Luo, Donglan Liu, Chunke Chen, Mian Gan, Nanshan Zhong, Jincun Zhao, Yan Ren, Yonghao Xu

Source: Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-11 (2021)

Subject Terms: Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2059-3635

Access URL: https://doaj.org/article/0bb9c81df58b4db7ae229257d20afc55

Characterization of respiratory microbial dysbiosis in hospitalized COVID-19 patients

Authors: Huanzi Zhong, Yanqun Wang, Zhun Shi, Lu Zhang, Huahui Ren, Weiqun He, Zhaoyong Zhang, Airu Zhu, Jingxian Zhao, Fei Xiao, Fangming Yang, Tianzhu Liang, Feng Ye, Bei Zhong, Shicong Ruan, Mian Gan, Jiahui Zhu, Fang Li, Fuqiang Li, Daxi Wang, Jiandong Li, Peidi Ren, Shida Zhu, Huanming Yang, Jian Wang, Karsten Kristiansen, Hein Min Tun, Weijun Chen, Nanshan Zhong, Xun Xu, Yi-min Li, Junhua Li, Jincun Zhao

Source: Cell Discovery, Vol 7, Iss 1, Pp 1-14 (2021)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2056-5968

Access URL: https://doaj.org/article/d42e299fa0c44086ae5e82cc148cd7cc

Intra-host variation and evolutionary dynamics of SARS-CoV-2 populations in COVID-19 patients

Authors: Yanqun Wang, Daxi Wang, Lu Zhang, Wanying Sun, Zhaoyong Zhang, Weijun Chen, Airu Zhu, Yongbo Huang, Fei Xiao, Jinxiu Yao, Mian Gan, Fang Li, Ling Luo, Xiaofang Huang, Yanjun Zhang, Sook-san Wong, Xinyi Cheng, Jingkai Ji, Zhihua Ou, Minfeng Xiao, Min Li, Jiandong Li, Peidi Ren, Ziqing Deng, Huanzi Zhong, Xun Xu, Tie Song, Chris Ka Pun Mok, Malik Peiris, Nanshan Zhong, Jingxian Zhao, Yimin Li, Junhua Li, Jincun Zhao

Source: Genome Medicine, Vol 13, Iss 1, Pp 1-13 (2021)

Subject Terms: SARS-CoV-2, COVID-19, Intra-host, Variation, Dynamics, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/c037fd5f63eb4d69b8a47eb4779767d9

Intranasal Lentiviral Vector-Mediated Antibody Delivery Confers Reduction of SARS-CoV-2 Infection in Elderly and Immunocompromised Mice

Authors: Yue Du, Shengnan Zhang, Zhaoyong Zhang, Kamran M. Miah, Peilan Wei, Lu Zhang, Yuhui Zhu, Zhengtu Li, Feng Ye, Deborah R. Gill, Stephen C. Hyde, Yanqun Wang, Jincun Zhao

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: monoclonal neutralizing antibody, SIV.F/HN vectored immunoprophylaxis, COVID-19, old and immunodeficient mice, passive immunoprophylaxis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.819058/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/882b0663b0c74c2d88e868f70d05fc7a