IgA class switching enhances neutralizing potency against SARS-CoV-2 by increased antibody hinge flexibility

Authors: Xu, Mengxin ^{a, 1}, Zhang, Zhaoyong ^{b, 1}, Sun, Yuzhu ^a, Mai, Haoting ^a, Liu, Siqi ^c, Liu, Shuning ^a, Lv, Kexin ^a, Yu, Feiyang ^d, Wang, Yuanyuan ^a, Yue, Xinyu ^a, Zhang, Jiayi ^a, Cai, Xiaoyu ^a, Zhao, Ruixin ^a, Lu, Hongjie ^a, Liu, Lin ^a, Luo, Huanle ^a, Zhao, Haiyan ^d, Wang, Yanqun ^{b, e, f}, Gong, Peng ^g, Chen, Shoudeng ^{c, h, ⁎}, Jing, Xuping ^{g, ⁎⁎}, Zhao, Jincun ^{b, i, j, k, ⁎⁎⁎}, Chen, Yao-Qing ^{a, l, m, ⁎⁎⁎⁎}

Source: In Antiviral Research March 2025 235

Enhancing protective immunity against SARS-CoV-2 with a self-amplifying RNA lipid nanoparticle vaccine

Authors: Lin, Guibin ^{a, b, c, d, 1}, Tang, Yan-Lai ^{e, 1}, Fu, Zhengqiang ^{a, b, c, d, 1}, Chen, Runjun ^{a, b, c, d, 1}, Liu, Yan ^{a, b, c, d}, Liu, Zhanyan ^{a, b, c, d}, Kuang, Xueli ^{a, b, c, d}, Sun, Jing ^f, Zhao, Jincun ^{f, g}, Zhang, Yuan ^{a, b, c, d, ⁎}

Source: In Journal of Controlled Release 10 February 2025 378:250-265

Design, synthesis, and biological evaluation of novel 2′-deoxy-2′-spirooxetane-7-deazapurine nucleoside analogs as anti-SARS-CoV-2 agents

Authors: Gao, Minli ^{a, b, 1}, Zhang, Zhaoyong ^{c, 1}, Yao, Guoqiang ^a, Zhang, Lu ^d, Duan, Anna ^a, Zhang, Yuanyuan ^c, Wang, Yanqun ^{c, ⁎⁎}, Zhao, Jincun ^{c, ⁎⁎⁎}, Zhang, Jiancun ^{a, e, ⁎}

Source: In Antiviral Research February 2025 234

Single-cell analysis reveals T cell dysfunction driven by macrophages and differential expression of transposable elements in severe COVID-19 patients

Authors: Zhu, Airu ^{a, 1}, Zhou, Liang ^{b, 1}, Chen, Zhao ^a, Liu, Dongdong ^b, Feng, Huijian ^{c, d}, Cai, Baomei ^{c, d}, Chen, Xinwen ^e, Zhao, Jincun ^{a, e}, Zhao, Jingxian ^{a, e}, Chen, Jiekai ^{c, d}, Li, Manshu ^{b, ⁎⁎}, He, Jiangping ^{d, e, ⁎}

Source: In Heliyon 15 October 2024 10(19)

Biosafety and immunology: An interdisciplinary field for health priority

Authors: Liu, Jun, Wong, Gary, Li, Hui, Yang, Yan, Cao, Yuxi, Li, Yongfeng, Wu, Yan, Zhang, Zijie, Jin, Cong, Wang, Xi, Chen, Yongwen, Su, Bin, Wang, Zhongfang, Wang, Qihui, Cao, Yunlong, Chen, Guobing, Qian, Zhaohui, Zhao, Jincun, Wu, Guizhen

Source: In Biosafety and Health October 2024 6(5):310-318

An unconventional VH1-2 antibody tolerates escape mutations and shows an antigenic hotspot on SARS-CoV-2 spike

Authors: Liu, Banghui, Niu, Xuefeng, Deng, Yijun, Zhang, Zhaoyong, Wang, Yanqun, Gao, Xijie, Liang, Huan, Li, Zimu, Wang, Qian, Cheng, Yuanyi, Chen, Qiuluan, Huang, Shuangshuang, Pan, Yingxian, Su, Mengzhen, Lin, Xiancheng, Niu, Chuanying, Chen, Yinglin, Yang, Wenyi, Zhang, Yudi, Yan, Qihong, He, Jun, Zhao, Jincun, Chen, Ling, Xiong, Xiaoli

Source: In Cell Reports 25 June 2024 43(6)

Characterization of humoral immune responses against SARS-CoV-2 accessory proteins in infected patients and mouse model

Authors: Li, Yuming, Tang, Yanhong, Wang, Xiaoqian, Zhu, Airu, Liu, Dongdong, He, Yiyun, Guo, Hu, Zheng, Jie, Liu, Xinzhuo, Chi, Fengyu, Wang, Yanqun, Zhuang, Zhen, Zhang, Zhaoyong, Liu, Donglan, Chen, Zhao, Li, Fang, Ran, Wei, Yu, Kuai, Wang, Dong, Wen, Liyan, Zhuo, Jianfen, Zhang, Yanjun, Xi, Yin, Zhao, Jingxian, Zhao, Jincun, Sun, Jing

Source: In Virologica Sinica June 2024 39(3):414-421

Discovery of natural catechol derivatives as covalent SARS-CoV-2 3CLpro inhibitors

Authors: Wang, Feng, Liu, Donglan, Gao, Dingding, Yuan, Jinwei, Zhao, Jingxian, Yuan, Shuai, Cen, Yixin, Lin, Guo-Qiang, Zhao, Jincun, Tian, Ping

Source: In International Journal of Biological Macromolecules April 2024 264 Part 1

Identification of a broad sarbecovirus neutralizing antibody targeting a conserved epitope on the receptor-binding domain

Authors: Wang, Yanqun, Zhang, Zhaoyong, Yang, Minnan, Xiong, Xinyi, Yan, Qihong, Cao, Lei, Wei, Peilan, Zhang, Yuting, Zhang, Lu, Lv, Kexin, Chen, Jiantao, Liu, Xuesong, Zhao, Xiaochu, Xiao, Juxue, Zhang, Shengnan, Zhu, Airu, Gan, Mian, Zhang, Jingjun, Cai, Ruoxi, Zhuo, Jianfen, Zhang, Yanjun, Rao, Haiyue, Qu, Bin, Zhang, Yuanyuan, Chen, Lei, Dai, Jun, Cheng, Linling, Hu, Qingtao, Chen, Yaoqing, Lv, Huibin, So, Ray T.Y., Peiris, Malik, Zhao, Jingxian, Liu, Xiaoqing, Mok, Chris Ka Pun, Wang, Xiangxi, Zhao, Jincun

Source: In Cell Reports 23 January 2024 43(1)

Dynamic immune landscape in vaccinated-BA.5-XBB.1.9.1 reinfections revealed a 5-month protection-duration against XBB infection and a shift in immune imprinting

Authors: Cui, Tingting ^{a, b, d}, Su, Xiaoling ^{a, b, d}, Sun, Jing ^{a, b, d}, Liu, Siyi ^{a, b}, Huang, Mingzhu ^{a, b}, Li, Weidong ^{a, b}, Luo, Chengna ^c, Cheng, Li ^{a, b}, Wei, Rui ^{a, b}, Song, Tao ^{a, b}, Sun, Xi ^{a, b}, Luo, Qi ^{a, b}, Li, Juan ^{a, b}, Su, Jie ^{a, b}, Deng, Shidong ^{a, b}, Zhao, Jincun ^{a, b, ∗∗∗∗}, Zhao, Zhuxiang ^{c, ∗∗∗}, Zhong, Nanshan ^{a, b, ∗∗}, Wang, Zhongfang ^{a, b, ∗}

Source: In eBioMedicine January 2024 99

A potent neutralizing nanobody targeting a unique epitope on the receptor-binding domain of SARS-CoV-2 spike protein

Authors: Zhang, Yuting ^{a, 1}, Wang, Dan ^{b, 1}, Xiang, Qi ^{c, 1}, Hu, Xiaohui ^a, Wu, Lijie ^e, Zhang, Zhaoyong ^f, Wang, Yanqun ^f, Zhao, Jincun ^{f, g, h, i}, McCormick, Peter J. ^j, Fu, Jinheng ^{k, ∗∗}, Fu, Yang ^{c, ∗∗∗}, Zhang, Jin ^{a, ∗∗∗∗}, Jiang, Haihai ^{a, ∗}, Li, Jian ^{l, ∗∗∗∗∗}

Source: In Virology January 2024 589

Self-replicating RNA nanoparticle vaccine elicits protective immune responses against SARS-CoV-2

Authors: Lin, Guibin, Yan, Huan, Sun, Jing, Zhao, Jincun, Zhang, Yuan

Source: Molecular therapy.Nucleic acids. 32:650-666

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100192234713.0x000001&indx=1&recIds=ETOCvdc_100192234713.0x000001

Discovery of highly potent covalent SARS-CoV-2 3CLpro inhibitors bearing 2-sulfoxyl-1,3,4-oxadiazole scaffold for combating COVID-19

Authors: Zhang, Fu-Mao, Huang, Ting, Wang, Feng, Zhang, Gui-Shan, Liu, Donglan, Dai, Jun, Zhang, Jian-Wei, Li, Qing-Hua, Lin, Guo-Qiang, Gao, Dingding, Zhao, Jincun, Tian, Ping

Source: In European Journal of Medicinal Chemistry 15 November 2023 260

Organo-Se BTSAs-enabled performance: From racemic and asymmetric synthesis to click chemistry application

Authors: Zhou, Zhi, Gu, Yuang, Wu, Liexin, Wang, Yan, Xu, Huiying, Ma, Lei, Zhang, Zhaoyong, Zhao, Jincun, Zhang, Wei, Peng, Wei, Yang, Guang, Yu, Xiyong, Xu, Hongtao, Yi, Wei

Source: In Chem 9 November 2023 9(11):3335-3346

SARS-CoV-2 induces cardiomyocyte apoptosis and inflammation but can be ameliorated by ACE inhibitor Captopril

Authors: Huang, Xiaohan, Fan, Wenxia, Sun, Jing, Yang, Jiaqing, Zhang, Yanjun, Wang, Qian, Li, Pingchao, Zhang, Yudi, Zhang, Shengnan, Li, Heying, Wang, Jianhua, Feng, Liqiang, Zhao, Jincun, Chen, Ling, Qu, Linbing

Source: In Antiviral Research July 2023 215

GPI-anchored ligand-BioID2-tagging system identifies Galectin-1 mediating Zika virus entry

Authors: Gao, Shan-Shan, Shi, Run, Sun, Jing, Tang, Yanhong, Zheng, Zhenhua, Li, Jing-Feng, Li, Huan, Zhang, Jie, Leng, Qibin, Xu, Jiang, Chen, Xinwen, Zhao, Jincun, Sy, Man-Sun, Feng, Liqiang, Li, Chaoyang

Source: In iScience 22 December 2022 25(12)

MRNA based vaccines provide broad protection against different SARS-CoV-2 variants of concern

Authors: Wang, Haomeng, Chen, Zhao, Wang, Zhenghua, Li, Jin, Yan, Zhihong, Yuan, Jinbo, Zhu, Airu, Chen, Lan, Liu, Ye, Hu, Chenlong, Zhu, Ali, Li, Guowei, Li, Yuehu, Deng, Jie, Ma, Liqiao, Sui, Xiuwen, Miao, Wei, Li, Junqiang, Zheng, Xiuyu, Piao, Jinhua, Yao, Yanfeng, Rao, Juhong, Shan, Chao, Yuan, Zhiming, Zhao, Jincun, Zhu, Tao

Source: Emerging microbes & infections. 11(1):1550-1553

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194681082.0x000001&indx=1&recIds=ETOCvdc_100194681082.0x000001

Shared IGHV1-69-encoded neutralizing antibodies contribute to the emergence of L452R substitution in SARS-CoV-2 variants

Authors: Yan, Qihong, Hou, Ruitian, Huang, Xiaohan, Zhang, Yanjun, He, Ping, Zhang, Yudi, Liu, Banghui, Wang, Qian, Rao, Haiyue, Chen, Xianying, Zhao, Xinwei, Niu, Xuefeng, Zhao, Jincun, Xiong, Xiaoli, Chen, Ling

Source: Emerging microbes & infections. 11(1):2749-2761

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194692384.0x000001&indx=1&recIds=ETOCvdc_100194692384.0x000001

Two novel human coronavirus OC43 genotypes circulating in hospitalized children with pneumonia in China

Authors: Zhang, Zhaoyong, Liu, Wenkuan, Zhang, Shengnan, Wei, Peilan, Zhang, Lu, Chen, Dehui, Qiu, Shuyan, Li, Xiaobo, Zhao, Jingxian, Shi, Yongxia, Zhou, Rong, Wang, Yanqun, Zhao, Jincun

Source: Emerging microbes & infections. 11(1):168-171

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194665812.0x000001&indx=1&recIds=ETOCvdc_100194665812.0x000001

Immune responses to human respiratory coronaviruses infection in mouse models

Authors: Zhuang, Zhen, Liu, Donglan, Sun, Jing, Li, Fang, Zhao, Jincun

Source: Current opinion in virology. 52:102-111

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100155373286.0x000001&indx=1&recIds=ETOCvdc_100155373286.0x000001