Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel

Authors: Zhang, Si Min ^{1, ∗}, Paulin, Cynthia B.J. ^{1, 4}, Shu, Huazhang ¹, Yagüe-Capilla, Miriam ¹, Michel, Maurice ¹, Marttila, Petra ¹, Ortis, Florian ¹, Bwanika, Henri Colyn ¹, Dirks, Christopher ¹, Venkatram, Rajagopal Papagudi ^{1, 5}, Wiita, Elisée ¹, Jemth, Ann-Sofie ¹, Almlöf, Ingrid ¹, Loseva, Olga ¹, Hormann, Femke M. ¹, Koolmeister, Tobias ¹, Linde, Erika ^{1, 6}, Lee, Sun ^{1, 7}, Llona-Minguez, Sabin ^{1, 8}, Haraldsson, Martin ², Axelsson, Hanna ², Strömberg, Kia ^{1, 9}, Homan, Evert J. ¹, Scobie, Martin ¹, Lundbäck, Thomas ^{2, 10}, Helleday, Thomas ^{1, 3}, Rudd, Sean G. ^{1, 11, ∗∗}

Source: In iScience 16 February 2024 27(2)

NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir

Authors: Zhang, Si Min, Rehling, Daniel, Jemth, Ann-Sofie, Throup, Adam, Landázuri, Natalia, Almlöf, Ingrid, Göttmann, Mona, Valerie, Nicholas C.K., Borhade, Sanjay R., Wakchaure, Prasad, Page, Brent D.G., Desroses, Matthieu, Homan, Evert J., Scobie, Martin, Rudd, Sean G., Berglund, Ulrika Warpman, Söderberg-Nauclér, Cecilia, Stenmark, Pål, Helleday, Thomas

Source: In Cell Chemical Biology 16 December 2021 28(12):1693-1702

Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity

Authors: Rehling, Daniel, Zhang, Si Min, Jemth, Ann-Sofie, Koolmeister, Tobias, Throup, Adam, Wallner, Olov, Scaletti, Emma, Moriyama, Takaya, Nishii, Rina, Davies, Jonathan, Desroses, Matthieu, Rudd, Sean G., Scobie, Martin, Homan, Evert, Berglund, Ulrika Warpman, Yang, Jun J., Helleday, Thomas, Stenmark, Pål

Source: In Journal of Biological Chemistry January-June 2021 296

Accuracy of artificial intelligence‐assisted detection of esophageal cancer and neoplasms on endoscopic images: A systematic review and meta‐analysis

Authors: Zhang, Si Min, Wang, Yong Jun, Zhang, Shu Tian

Source: Journal of digestive diseases. 22(6):318-328

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100122581282.0x000001&indx=1&recIds=ETOCvdc_100122581282.0x000001

The N-terminal SAM domain of the dNTPase SAMHD1 is not required for inhibition by small molecule TH6342.

Authors: Dirks, Christopher, Bwanika, Henri Colyn, Jemth, Ann-Sofie, Zhang, Si Min, Rudd, Sean G.

Source: Nucleosides, Nucleotides & Nucleic Acids; 2024, Vol. 43 Issue 8, p831-836, 6p

Subject Terms: CANCER chemotherapy, SMALL molecules, BINDING sites, CANCER cells, METABOLITES

Identification and application of self-binding zipper-like sequences in SARS-CoV spike protein

Authors: Zhang, Si Min, Liao, Ying, Neo, Tuan Ling, Lu, Yanning, Liu, Ding Xiang, Vahlne, Anders, Tam, James P.

Source: In International Journal of Biochemistry and Cell Biology August 2018 101:103-112

Expression of Serum HMGB1 and CD14^+ mononuclear Toll-like Receptors in Children with Hemophagocytic Syndrome and Their Effect on Prognosis

Authors: Zhang, Si-Min, Wang, Min, Chen, Zhi, Cai, Xiao-Fang

Source: Zhongguo shi yan xue ye xue za zhi. 27(5):1664-1671

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN622956833&indx=1&recIds=ETOCRN622956833

Dynamic changes of cyclophosphamide-induced liver injury in mice

Authors: Huang, Can, He, Fa-jing, Yang, Xiao, Guan, Li-huan, Zhang, Si-min, Zhou, Yan-ying, Fan, Shi-cheng, Yao, Xin-peng, Huang, Min, Bi, Hui-chang

Source: Yaoxue xuebao. 54(6):1062-1068

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN621242269&indx=1&recIds=ETOCRN621242269

TRIM44 activates the AKT/mTOR signal pathway to induce melanoma progression by stabilizing TLR4

Authors: Wei, Chuan-Yuan, Wang, Lu, Zhu, Meng-Xuan, Deng, Xin-Yi, Wang, Dao-He, Zhang, Si-Min, Ying, Jiang-Hui, Yuan, Xin, Wang, Qiang, Xuan, Tian-Fan, He, An-Qi, Qi, Fa-Zhi, Gu, Jian-Ying

Source: Journal of experimental & clinical cancer research. 38(1):1-13

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Drug synergy scoring using minimal dose response matrices

Authors: Mäkelä, Petri, Zhang, Si Min, Rudd, Sean G.

Source: BMC research notes. 14(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193137712.0x000001&indx=1&recIds=ETOCvdc_100193137712.0x000001

Absorption and Reflection Characteristics of Black Water Blooms in the Eutrophic Water

Authors: Zhang, Si-min, Li, Yun-mei, Wang, Qiao

Source: Huan jing ke xue. 37(9):3402-3412

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN608466251&indx=1&recIds=ETOCRN608466251

Ribonucleotide reductase inhibitors suppress SAMHD1 ara‐CTPase activity enhancing cytarabine efficacy

Authors: Rudd, Sean G, Tsesmetzis, Nikolaos, Sanjiv, Kumar, Paulin, Cynthia BJ, Sandhow, Lakshmi, Kutzner, Juliane, Hed Myrberg, Ida, Bunten, Sarah S, Axelsson, Hanna, Zhang, Si Min, Rasti, Azita, Mäkelä, Petri, Coggins, Si'Ana A, Tao, Sijia, Suman, Sharda, Branca, Rui M, Mermelekas, Georgios, Wiita, Elisée, Lee, Sun, Walfridsson, Julian, Schinazi, Raymond F, Kim, Baek, Lehtiö, Janne, Rassidakis, Georgios Z, Pokrovskaja Tamm, Katja, Warpman‐Berglund, Ulrika, Heyman, Mats, Grandér, Dan, Lehmann, Sören, Lundbäck, Thomas, Qian, Hong, Henter, Jan‐Inge, Schaller, Torsten, Helleday, Thomas, Herold, Nikolas

Source: EMBO molecular medicine. 12(3)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103212656.0x000001&indx=1&recIds=ETOCvdc_100103212656.0x000001

A Screening Approach for Mitochondrial tRNALeu(UUR) A3243G Mutation in a Hospital-Based Population with Diabetes

Authors: Tian, Li-Hua, Han, Xue-Yao, Huang, Xiu-Ting, Zhang, Si-Min, Gong, Si-Qian, Ma, Yu-Min, Cai, Xiao-Ling, Zhou, Ling-Li, Luo, Ying-Ying, Li, Meng, Liu, Wei, Zhang, Xiu-Ying, Ren, Qian, Zhu, Yu, Zhou, Xiang-Hai, Zhang, Rui, Chen, Ling, Gao, Xue-Ying, Liu, Yan, Zhang, Fang, Ji, Li-Nong

Source: Chinese medical journal. 131(9):1117-1119

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100089199767.0x000001&indx=1&recIds=ETOCvdc_100089199767.0x000001

IL-1B rs1143623 and EEF1A1P11-RPL7P9 rs10783050 polymorphisms affect the glucose-lowing efficacy of metformin in Chinese overweight or obese Type 2 diabetes mellitus patients

Authors: Xiao, Di, Zhang, Si-Min, Li, Xi, Yin, Ji-Ye, Gong, Wei-Jing, Zheng, Yi, Xu, Xiao-Jing, Lin, Xu, Ji, Li-Nong, Liu, Rang-Ru, Tang, Qiang, Zhang, Wei, Zhou, Hong-Hao, Han, Xue-Yao, Liu, Zhao-Qian

Source: Pharmacogenomics. 16(14):1621-1629

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127431609.0x000001&indx=1&recIds=ETOCvdc_100127431609.0x000001

Tryptophan-Dependent Membrane Interaction and Heteromerization with the Internal Fusion Peptide by the Membrane Proximal External Region of SARS-CoV Spike Protein

Authors: Liao, Ying, Zhang, Si Min, Neo, Tuan Ling, Tam, James P.

Source: Biochemistry. 54(9):1819-1830

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN600071942&indx=1&recIds=ETOCRN600071942

A new benzaldehyde from residue left over rectification of star anise oil

Authors: Lin, Kui, Xie, Ji-zhao, Zhang, Si-min, Xu, Hui, Huang, Dao-ping, Wei, Ying-liang

Source: Zhong cao yao. 46(10):1423-1425

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN602422548&indx=1&recIds=ETOCRN602422548

Membrane-Active Sequences within gp41 Membrane Proximal External Region (MPER) Modulate MPER-Containing Peptidyl Fusion Inhibitor Activity and the Biosynthesis of HIV-1 Structural Proteins.

Authors: Zhang, Si Min^1,2, Jejcic, Alenka³, Tam, James P.², Vahlne, Anders¹ anders.vahlne@ki.se

Source: PLoS ONE. 7/31/2015, Vol. 10 Issue 7, p1-22. 22p.

Subject Terms: *NUCLEOTIDE sequence, *ENZYME inhibitors, *CYTOSKELETAL proteins, *BIOSYNTHESIS, *HIV infections, *VIRAL proteins

Interdiscipline between optoelectronic materials and mechanical sensors: Recent advances of organic triboluminescent compounds and their applications in sensing.

Alternate Title: 光电材料与应力传感的交叉学科: 有机摩擦发光化合物及其传感应用的最新进展 (Chinese)

Authors: Sun, Hao-dong, Du, Bei-bei, Wu, Ya-zhang, Wang, Hai-lan, Zhang, Xia-yu, Wang, Juan, Zhang, Si-min, Wei, Shan-shan, Yu, Tao

Source: Journal of Central South University; Dec2021, Vol. 28 Issue 12, p3907-3934, 28p

Genetics and Clinical Characteristics of PPARγ Variant-Induced Diabetes in a Chinese Han Population.

Authors: Gong, Siqian, Han, Xueyao, Li, Meng, Cai, Xiaoling, Liu, Wei, Luo, Yingying, Zhang, Si-min, Zhou, Lingli, Ma, Yumin, Huang, Xiuting, Li, Yufeng, Zhou, Xianghai, Zhu, Yu, Wang, Qiuping, Chen, Ling, Ren, Qian, Zhang, Ping, Ji, Linong

Source: Frontiers in Endocrinology; 10/26/2021, Vol. 12, p1-13, 13p

Subject Terms: CHINESE people, TYPE 2 diabetes, MEDICAL genetics, DIABETIC nephropathies, INSULIN resistance

M2-polarized macrophages mediate wound healing by regulating connective tissue growth factor via AKT, ERK1/2, and STAT3 signaling pathways.

Authors: Zhang, Si-Min, Wei, Chuan-Yuan, Wang, Qiang, Wang, Lu, Lu, Lu, Qi, Fa-Zhi

Source: Molecular Biology Reports; Sep2021, Vol. 48 Issue 9, p6443-6456, 14p