Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3

Authors: Ye, Ling ^{1, 6}, Shen, Shengqi ^{5, 6}, Mao, Qiankun ¹, Lu, Hui ¹, Liu, Haiying ¹, Zhang, Pinggen ¹, Jiang, Zetan ^{1, 2}, Ma, Wenhao ¹, Sun, Yuchen ¹, Chu, Yiyang ¹, Zhou, Zilong ¹, Liu, Rui ¹, Li, Jian ¹, Li, Shi-ting ⁵, Gao, Ping ^{5, ∗}, Zhang, Huafeng ^{1, 2, 3, 4, 7, ∗∗}

Source: In Cell Reports 25 February 2025 44(2)

Carbonic anhydrase 2 facilitates sorafenib resistance by counteracting MCT4-mediated intracellular pH dysregulation in HCC

Authors: Lu, Hui ^{1, 2, 4, 6}, Liu, Huiya ^{1, 6}, Yan, Ronghui ¹, Ma, Wenhao ¹, Liu, Haiying ¹, Liu, Rui ¹, Sun, Yuchen ¹, Ye, Ling ¹, Gao, Ping ⁵, Jia, Weidong ¹, Zhang, Pinggen ^{1, 2, 3, ∗}, Zhang, Huafeng ^{1, 2, 3, 7, ∗∗}

Source: In Cell Reports 24 December 2024 43(12)

OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB

Authors: Ma, Wenhao, Sun, Yuchen, Yan, Ronghui, Zhang, Pinggen, Shen, Shengqi, Lu, Hui, Zhou, Zilong, Jiang, Zetan, Ye, Ling, Mao, Qiankun, Xiong, Nanchi, Jia, Weidong, Sun, Linchong, Gao, Ping, Zhang, Huafeng

Source: In Molecular Cell 1 February 2024 84(3):538-551

Branched-chain amino acid catabolism breaks glutamine addiction to sustain hepatocellular carcinoma progression

Authors: Yang, Dongdong, Liu, Haiying, Cai, Yongping, Lu, Kangyang, Zhong, Xiuying, Xing, Songge, Song, Wei, Zhang, Yaping, Ye, Ling, Zhu, Xia, Wang, Ting, Zhang, Pinggen, Li, Shi-Ting, Feng, Jiaqian, Jia, Weidong, Zhang, Huafeng, Gao, Ping

Source: In Cell Reports 22 November 2022 41(8)

PDHX acetylation facilitates tumor progression by disrupting PDC assembly and activating lactylation-mediated gene expression.

Authors: Jiang, Zetan, Xiong, Nanchi, Yan, Ronghui, Li, Shi-ting, Liu, Haiying, Mao, Qiankun, Sun, Yuchen, Shen, Shengqi, Ye, Ling, Gao, Ping, Zhang, Pinggen, Jia, Weidong, Zhang, Huafeng

Source: Protein & Cell; Jan2025, Vol. 16 Issue 1, p49-63, 15p

Itaconate promotes hepatocellular carcinoma progression by epigenetic induction of CD8⁺ T-cell exhaustion.

Authors: Gu, Xuemei, Wei, Haoran, Suo, Caixia, Shen, Shengqi, Zhu, Chuxu, Chen, Liang, Yan, Kai, Li, Zhikun, Bian, Zhenhua, Zhang, Pinggen, Yuan, Mengqiu, Yu, Yingxuan, Du, Jinzhi, Zhang, Huafeng, Sun, Linchong, Gao, Ping

Source: Nature Communications; 12/9/2023, Vol. 14 Issue 1, p1-15, 15p

Subject Terms: T-cell exhaustion, HEPATOCELLULAR carcinoma, EPIGENETICS, T cells, HEPATITIS A virus cellular receptors, GENE knockout

Secreted protease PRSS35 suppresses hepatocellular carcinoma by disabling CXCL2-mediated neutrophil extracellular traps.

Authors: Wang, Ting, Zhou, Yingli, Zhou, Zilong, Zhang, Pinggen, Yan, Ronghui, Sun, Linchong, Ma, Wenhao, Zhang, Tong, Shen, Shengqi, Liu, Haiying, Lu, Hui, Ye, Ling, Feng, Junru, Chen, Zhaolin, Zhong, Xiuying, Wu, Gao, Cai, Yongping, Jia, Weidong, Gao, Ping, Zhang, Huafeng

Source: Nature Communications; 3/18/2023, Vol. 14 Issue 1, p1-16, 16p

Subject Terms: HEPATOCELLULAR carcinoma, NEUTROPHILS, PROPROTEIN convertases, MACROPHAGE inflammatory proteins, CELL communication, ELASTASES, PROTEOLYTIC enzymes