Design, synthesis, and biological evaluation of novel 2′-deoxy-2′-spirooxetane-7-deazapurine nucleoside analogs as anti-SARS-CoV-2 agents

Authors: Gao, Minli ^{a, b, 1}, Zhang, Zhaoyong ^{c, 1}, Yao, Guoqiang ^a, Zhang, Lu ^d, Duan, Anna ^a, Zhang, Yuanyuan ^c, Wang, Yanqun ^{c, ⁎⁎}, Zhao, Jincun ^{c, ⁎⁎⁎}, Zhang, Jiancun ^{a, e, ⁎}

Source: In Antiviral Research February 2025 234

Polyvalent mpox mRNA vaccines elicit robust immune responses and confer potent protection against vaccinia virus

Authors: Ye, Tianxi, Zhou, Jinge, Guo, Chen, Zhang, Kaiyue, Wang, Yuping, Liu, Yanhui, Zhou, Junhui, Xie, Yalin, Li, Entao, Gong, Rui, Zhang, Jiancun, Chuai, Xia, Chiu, Sandra

Source: In Cell Reports 25 June 2024 43(6)

Enhancing nicotinamide N-methyltransferase bisubstrate inhibitor activity through 7-deazaadenosine and linker modifications

Authors: Li, Pengyu, Xia, Cuicui, Kong, Xiangqian, Zhang, Jiancun

Source: In Bioorganic Chemistry February 2024 143

Design, synthesis, and biological evaluation of novel 2′-methyl-2′-fluoro-6-methyl-7-alkynyl-7-deazapurine nucleoside analogs as anti-Zika virus agents

Authors: Yao, Guoqiang, Yu, Jianchen, Lin, Cai, Zhu, Yujia, Duan, Anna, Li, Mengfeng, Yuan, Jie, Zhang, Jiancun

Source: In European Journal of Medicinal Chemistry 15 April 2022 234

The development of HEC-866 and its analogues for the treatment of idiopathic pulmonary fibrosisElectronic supplementary information (ESI) available. See DOI: 10.1039/d1md00023c

Authors: Lin, Runfeng, Zhang, Zheng, Cao, Shengtian, Yang, Wen, Zuo, Yinglin, Yang, Xinye, Zhang, Jiancun, Xu, Juan, Li, Jing, Wang, Xiaojun

Source: RSC medicinal chemistry. 12(7):1222-1231

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123600403.0x000001&indx=1&recIds=ETOCvdc_100123600403.0x000001

An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode.

Authors: Jia, Xiaoying, Jing, Xuping, Li, Ming, Gao, Minli, Zhong, Yao, Li, Entao, Liu, Yang, Li, Rui, Yao, Guoqiang, Liu, Qiaojie, Zhou, Minmin, Hou, Yuxia, An, Linfeng, Hong, Yibao, Li, Shanshan, Zhang, Jiancun, Wang, Wei, Zhang, Kaiming, Gong, Peng, Chiu, Sandra

Source: Nature Communications; 12/30/2024, Vol. 15 Issue 1, p1-16, 16p

Subject Terms: RNA replicase, RNA synthesis, CORONAVIRUSES, RIBOSE, DRUG development

Synthesis and computational studies of highly selective inhibitors of human recombinant tissue non-specific alkaline phosphatase (h-TNAP): A therapeutic target against vascular calcification

Authors: Andleeb, Hina, Hussain, Muzammal, Abida Ejaz, Syeda, Sevigny, Jean, Farman, Muhammad, Yasinzai, Masoom, Zhang, Jiancun, Iqbal, Jamshed, Hameed, Shahid

Source: In Bioorganic Chemistry August 2020 101

CXCL13/CXCR5 signaling axis in cancer

Authors: Hussain, Muzammal, Adah, Dickson, Tariq, Muqddas, Lu, Yongzhi, Zhang, Jiancun, Liu, Jinsong

Source: In Life Sciences 15 June 2019 227:175-186

Ligand binding and heterodimerization with retinoid X receptor α (RXRα) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding

Authors: Wang, Na, Zou, Qingan, Xu, Jinxin, Zhang, Jiancun, Liu, Jinsong

Source: In Journal of Biological Chemistry 23 November 2018 293(47):18180-18191

Design, synthesis, and biological evaluation of novel 7-deazapurine nucleoside derivatives as potential anti-dengue virus agents

Authors: Lin, Cai, Yu, Jianchen, Hussain, Muzammal, Zhou, Yiqian, Duan, Anna, Pan, Weiqi, Yuan, Jie, Zhang, Jiancun

Source: In Antiviral Research January 2018 149:95-105

Development of an Efficient and Scalable Asymmetric Synthesis of Eliglustat via Ruthenium(II)-Catalyzed Asymmetric Transfer Hydrogenation

Authors: Sun, Guodong, Jian, Weilin, Luo, Zhonghua, Sun, Tengfei, Li, Chao, Zhang, Jiancun, Wang, Zhongqing

Source: Organic process research & development. 23(6):1204-1212

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN620673879&indx=1&recIds=ETOCRN620673879

BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules

Authors: Huang, Yuejia, Lin, Lin, Liu, Xing, Ye, Sheng, Yao, Phil, Wang, Wenwen, Yang, Fengrui, Gao, Xinjiao, Li, Junying, Zhang, Yin, Zhang, Jiancun, Yang, Zhihong, Liu, Xu, Yang, Zhenye, Zang, Jianye, Teng, Maikun, Wang, Zhiyong, Ruan, Ke, Ding, Xia, Li, Lin, Cleveland, Don, Zhang, Rongguang, Yao, Xuebiao

Source: Cell research. 29(7):562-578

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183844473.0x000001&indx=1&recIds=ETOCvdc_100183844473.0x000001

Discovery of hepatitis B virus capsid assembly inhibitors leading to a heteroaryldihydropyrimidine based clinical candidate (GLS4)

Authors: Ren, Qingyun, Liu, Xinchang, Luo, Zhonghua, Li, Jing, Wang, Chaolei, Goldmann, Siegfried, Zhang, Jiancun, Zhang, Yingjun

Source: In Bioorganic & Medicinal Chemistry 1 February 2017 25(3):1042-1056

ATAD2 in cancer: a pharmacologically challenging but tractable target

Authors: Hussain, Muzammal, Zhou, Yang, Song, Yu, Hameed, H.M. Adnan, Jiang, Hao, Tu, Yaoquan, Zhang, Jiancun

Source: Expert opinion on therapeutic targets. 22(1):85-96

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100063154513.0x000001&indx=1&recIds=ETOCvdc_100063154513.0x000001

Skp1: Implications in cancer and SCF-oriented anti-cancer drug discovery

Authors: Hussain, Muzammal, Lu, Yongzhi, Liu, Yong-Qiang, Su, Kai, Zhang, Jiancun, Liu, Jinsong, Zhou, Guang-Biao

Source: In Pharmacological Research September 2016 111:34-42

Implications of MDSCs-targeting in lung cancer chemo-immunotherapeutics

Authors: Adah, Dickson, Hussain, Muzammal, Qin, Limei, Qin, Li, Zhang, Jiancun, Chen, Xiaoping

Source: In Pharmacological Research August 2016 110:25-34

Design, synthesis, and in vitro biological evaluation of novel 6-methyl-7-substituted-7-deaza purine nucleoside analogs as anti-influenza A agents

Authors: Lin, Cai, Sun, Chenghai, Liu, Xiao, Zhou, Yiqian, Hussain, Muzammal, Wan, Junting, Li, Minke, Li, Xue, Jin, Ruiliang, Tu, Zhengchao, Zhang, Jiancun

Source: In Antiviral Research May 2016 129:13-20

Targeting tumor-associated immune suppression with selective protein kinase A type I (PKAI) inhibitors may enhance cancer immunotherapy

Authors: Hussain, Muzammal, Shah, Zahir, Abbas, Nasir, Javeed, Aqeel, Mukhtar, Muhammad Mahmood, Zhang, Jiancun

Source: In Medical Hypotheses January 2016 86:56-59

Dichotomous role of protein kinase A type I (PKAI) in the tumor microenvironment: A potential target for ‘two-in-one’ cancer chemoimmunotherapeutics

Authors: Hussain, Muzammal, Tang, Fei, Liu, Jinsong, Zhang, Jiancun ^*, Javeed, Aqeel

Source: In Cancer Letters 1 December 2015 369(1):9-19

Chromatin Protein HP1α Interacts with the Mitotic Regulator Borealin Protein and Specifies the Centromere Localization of the Chromosomal Passenger Complex

Authors: Liu, Xing, Song, Zhenwei, Huo, Yuda, Zhang, Jiahai, Zhu, Tongge, Wang, Jianyu, Zhao, Xuannv, Aikhionbare, Felix, Zhang, Jiancun, Duan, Hequan, Wu, Jihui, Dou, Zhen, Shi, Yunyu, Yao, Xuebiao

Source: In Journal of Biological Chemistry 25 July 2014 289(30):20638-20649