Isotope-labeled click-free probes to identify protein targets of lysine-targeting covalent reversible molecules

Authors: Ma, Xingyu, Chen, Yi-Xin, Ye, Zi, Zhang, Chong-Jing ^⁎

Source: In Chinese Chemical Letters May 2025 36(5)

Pairs of thiol-substituted 1,2,4-triazole-based isomeric covalent inhibitors with tunable reactivity and selectivity

Authors: Xu, Shiqi, Ye, Zi, Shang, Shuang, Wang, Fengge, Zhang, Huan, Chen, Lianguo, Lin, Hao, Chen, Chen, Hua, Fang, Zhang, Chong-Jing

Source: In Chinese Chemical Letters July 2024 35(7)

Rhodojaponin VI indirectly targets Cav2.2 channels via N-ethylmaleimide-sensitive fusion protein to alleviate neuropathic pain

Authors: Chen, Keliang, Wang, Tao, Li, Yong, Wu, Jun, Zhao, Cheng-Xiao, Liu, Sheng, Sun, Fengrun, Fang, Yehong, Hu, Jiahuan, Hu, Jinping, Zhang, Chong-Jing, Yu, Haibo, Ma, Chao, Yu, Shi-Shan

Source: Acta pharmaceutica sinica B. 13(3):1326-1336

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Concentration-Dependent Enrichment Identifies Primary Protein Targets of Multitarget Bioactive Molecules

Authors: Xu, Manyi, Ma, Xingyu, Ye, Zi, Wang, Fengge, Xu, Shiqi, Zhang, Chong-Jing

Source: Journal of proteome research. 22(3):802-811

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Synthesis and structure-activity relationships of N - (3 - (1H-imidazol-2-yl) phenyl) - 3-phenylpropionamide derivatives as a novel class of covalent inhibitors of p97/VCP ATPase

Authors: Wang, Ke, Chen, Lianguo, Dai, Xinyan, Ye, Zi, Zhou, Chuan, Zhang, Chong-Jing, Feng, Zhiqiang

Source: In European Journal of Medicinal Chemistry 15 February 2023 248

A targeted covalent inhibitor of p97 with proteome-wide selectivity

Authors: Ye, Zi, Wang, Ke, Chen, Lianguo, Jin, Xiaofeng, Chen, Hao, Tang, Guanghui, Yao, Shao Q., Feng, Zhiqiang, Zhang, Chong-Jing

Source: Acta pharmaceutica sinica B. 12(2):982-989

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A fundamental study on the fluorescence-quenching effect of nitro groups in tetraphenylethene AIE dyes with electron-withdrawing groups

Authors: Zhao, Cheng-Xiao, Liu, Tian, Xu, Manyi, Lin, Hao, Zhang, Chong-Jing

Source: Chinese chemical letters. 32(6):1925-1928

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Strategic Design of Catalytic Lysine‐Targeting Reversible Covalent BCR‐ABL Inhibitors**

Authors: Quach, David, Tang, Guanghui, Anantharajan, Jothi, Baburajendran, Nithya, Poulsen, Anders, Wee, John L. K., Retna, Priya, Li, Rong, Liu, Boping, Tee, Doris H. Y., Kwek, Perlyn Z., Joy, Joma K., Yang, Wan‐Qi, Zhang, Chong‐Jing, Foo, Klement, Keller, Thomas H., Yao, Shao Q.

Source: Angewandte Chemie. 133(31):17268-17274

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Chemoproteomics-based target profiling of sinomenine reveals multiple protein regulators of inflammationElectronic supplementary information (ESI) available: Intermediates and methods, supplementary and extended figures. See DOI: 10.1039/d1cc01522b

Authors: Chen, Lianguo, Wang, Hong-jian, Ji, Teng-fei, Zhang, Chong-Jing

Source: Chemical communications. 57(48):5981-5984

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Discovery of Fluorescent Naturally‐Occurring Inhibitor of SARS‐CoV‐2 Main Protease by AIE Fluorescent Probe.

Authors: Lin, Hao, Zhang, Chong‐Jing

Source: ChemMedChem; 11/4/2024, Vol. 19 Issue 21, p1-5, 5p

New electrophiles targeting thiols in a reversible covalent manner.

Authors: Ma, Xingyu, Xu, Manyi, Wang, Fengge, Hu, Tingting, Chen, Xinyuan, Zhang, Chong-Jing

Source: Chemical Communications; 11/4/2024, Vol. 60 Issue 85, p12437-12440, 4p

Subject Terms: PHARMACEUTICAL chemistry, CHEMICAL biology, ACRYLAMIDE, ELECTROPHILES, THIOLS

Stereochemistry and antimalarial activity of C-10 carba analogues of artemisinin

Authors: Wang, Fengge, Xu, Shiqi, Chen, Chen, Wei, Chunyan, Zhang, Chong-Jing

Source: Bioorganic & medicinal chemistry letters. 93

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Orthogonal Strategies for Profiling Potential Cellular Targets of Anandamide and Cannabidiol

Authors: Tang, Guanghui, Lim, Ying‐Jie, Wang, Wei, Ye, Zi, Zhang, Chong‐Jing, Yao, Shao Q.

Source: Chemistry. 29(43)

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A Late‐Stage Aryl C−H Olefination Strategy and Its Application Towards Global Proteome Profiling of Δ8‐Tetrahydrocannabinol

Authors: Lim, Ying‐Jie, Tang, Guanghui, Ye, Zi, Zhang, Chong‐Jing, Wu, Jie, Yao, Shao Q.

Source: Chemistry. 29(29)

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Small Molecule-Induced Post-Translational Acetylation of Catalytic Lysine of Kinases in Mammalian Cells.

Authors: Tang, Guanghui, Wang, Xuan, Huang, Huisi, Xu, Manyi, Ma, Xingyu, Miao, Fengfei, Lu, Xiaoyun, Zhang, Chong-Jing, Gao, Liqian, Zhang, Zhi-Min, Yao, Shao Q.

Source: Journal of the American Chemical Society; 8/28/2024, Vol. 146 Issue 34, p23978-23988, 11p

Study on the properties and applications of cis and trans-tetraphenylethene derivatives

Authors: Zhang, Hong, Lin, Hao, Wang, Hong-xiao, Yu, Ming-jie, Wu, Zhong-yu, Dou, Jin-di, Wang, Fu-wen, Zhang, Chong-jing

Source: Chinese journal of analysis laboratory. 38(5):590-595

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Identification of Potent Caspase‐8 Inhibitors from a Library of Fluorescent Natural Products Screened by an AIEgen‐Based Light‐Up Probe

Authors: Lin, Hao, Yang, Wan‐Qi, Ye, Zi, Zhang, Chong‐Jing

Source: Chembiochem. 20(10):1292-1296

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Cell‐Active, Reversible, and Irreversible Covalent Inhibitors That Selectively Target the Catalytic Lysine of BCR‐ABL Kinase

Authors: Chen, Peng, Sun, Jie, Zhu, Chengjun, Tang, Guanghui, Wang, Wei, Xu, Manyi, Xiang, Menghua, Zhang, Chong‐Jing, Zhang, Zhi‐Min, Gao, Liqian, Yao, Shao Q.

Source: Angewandte Chemie international edition. 61(26)

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A Radical-Generating Probe to Release Free Fluorophores and Identify Artemisinin-Sensitive Cancer Cells.

Authors: Chen, Chen, Chen, Yi-Xin, Zhang, Chong-Jing

Source: ACS Sensors; 5/24/2024, Vol. 9 Issue 5, p2310-2316, 7p

Aggregation-Induced Emission Probe for Specific Turn-On Quantification of Soluble Transferrin Receptor: An Important Disease Marker for Iron Deficiency Anemia and Kidney Diseases

Authors: Zhang, Ruoyu, Sung, Simon H. P., Feng, Guangxue, Zhang, Chong-Jing, Kenry, Tang, Ben Zhong, Liu, Bin

Source: Analytical chemistry. 90(2):1154-1160

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