Identification of TAP2 as a novel immune target in human cancers: insights from integrated bioinformatics and experimental approaches

Authors: Lufei Yang, Jiawei Gui, Yilei Sheng, Junzhe Liu, Chong Wang, Zhansheng Fang, Le Huang, Zewei Tu, Xingen Zhu, Kai Huang

Source: European Journal of Medical Research, Vol 30, Iss 1, Pp 1-19 (2025)

Subject Terms: Immunotherapy response, Molecular docking, Pan-cancer, Prognostic biomarker, TAP2, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2047-783X

Access URL: https://doaj.org/article/dc1583078e5946e1b1e1d9b9733cd603

Mechanisms underlining R-loop biology and implications for human disease

Authors: Junzhe Liu, Fengze Li, Yulong Cao, Yonghui Lv, Kunjian Lei, Zewei Tu, Chuandong Gong, Haiyan Wang, Feng Liu, Kai Huang

Source: Frontiers in Cell and Developmental Biology, Vol 13 (2025)

Subject Terms: R-loop, replication-transcription collision, genomic instability, neurodegenerative disorders, gene regulation, cancer, Biology (General), QH301-705.5

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Relation: https://www.frontiersin.org/articles/10.3389/fcell.2025.1537731/full; https://doaj.org/toc/2296-634X

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Cathepsin B Nuclear Flux in a DNA-Guided 'Antinuclear Missile' Cancer Therapy

Authors: Fei Cao, Caroline Tang, Xiaoyong Chen, Zewei Tu, Ying Jin, Olivia M. Turk, Robert N. Nishimura, Allen Ebens, Valentina Dubljevic, James A. Campbell, Jiangbing Zhou, James E. Hansen

Source: ACS Central Science, Vol 10, Iss 8, Pp 1562-1572 (2024)

Subject Terms: Chemistry, QD1-999

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Relation: https://doaj.org/toc/2374-7951

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The peritumoral edema index and related mechanisms influence the prognosis of GBM patients

Authors: Zhansheng Fang, Ting Shu, Pengxiang Luo, Yiqing Shao, Li Lin, Zewei Tu, Xingen Zhu, Lei Wu

Source: Frontiers in Oncology, Vol 14 (2024)

Subject Terms: glioblastoma, peritumoral brain edema, MRI, bioinformatics glioblastoma, bioinformatics, image segmentation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: https://www.frontiersin.org/articles/10.3389/fonc.2024.1417208/full; https://doaj.org/toc/2234-943X

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Protein disulfide-isomerase A4 confers glioblastoma angiogenesis promotion capacity and resistance to anti-angiogenic therapy

Authors: Zewei Tu, Chong Wang, Qing Hu, Chuming Tao, Zhansheng Fang, Li Lin, Kunjian Lei, Min Luo, Yilei Sheng, Xiaoyan Long, Jingying Li, Lei Wu, Kai Huang, Xingen Zhu

Source: Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-19 (2023)

Subject Terms: Protein disulfide-isomerase A4 (PDIA4), Glioblastoma (GBM), Angiogenesis, Endoplasmic reticulum stress (ERS), X-box binding protein 1 (XBP1), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/e14bf50e1a3342008ce82826d018e82b

Pan-cancer analysis: predictive role of TAP1 in cancer prognosis and response to immunotherapy

Authors: Zewei Tu, Kuangxun Li, Qiankun Ji, Yuyang Huang, Shigang Lv, Jingying Li, Lei Wu, Kai Huang, Xingen Zhu

Source: BMC Cancer, Vol 23, Iss 1, Pp 1-17 (2023)

Subject Terms: Transporter associated with antigen processing 1 (TAP1), Pan-cancer, Prognostic biomarker, Cancer immunotherapy, Immune Check-point Inhibitor (ICI), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: https://doaj.org/toc/1471-2407

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Development and validation of a leukocyte‐associated immunoglobulin‐like receptor‐1 prognostic signature for lower‐grade gliomas

Authors: Zhansheng Fang, Li Lin, Zewei Tu, Xingen Zhu, Jingying Li, Pengxiang Luo, Kai Huang, Lei Wu

Source: Cancer Medicine, Vol 12, Iss 1, Pp 712-732 (2023)

Subject Terms: immune checkpoints, leukocyte‐associated immunoglobulin‐like receptor‐1, overall survival, tumor immune microenvironment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: https://doaj.org/toc/2045-7634

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Intrinsic immune evasion patterns predict temozolomide sensitivity and immunotherapy response in lower-grade gliomas

Authors: Zewei Tu, Qiankun Ji, Qing Han, Xiaoyan Long, Jingying Li, Lei Wu, Kai Huang, Xingen Zhu

Source: BMC Cancer, Vol 22, Iss 1, Pp 1-17 (2022)

Subject Terms: Lower-grade glioma (LGG), Prognosis, Cancer immune evasion, Immunotherapy response, Temozolomide (TMZ) sensitivity, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: https://doaj.org/toc/1471-2407

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Comprehensive analysis of the prognostic implications and functional exploration of PAK gene family in human cancer

Authors: Kunjian Lei, Min Luo, Zewei Tu, Shigang Lv, Junzhe Liu, Chuandong Gong, Minhua Ye, Miaojing Wu, Yilei Sheng, Xiaoyan Long, Jingying Li, Xingen Zhu, Kai Huang

Source: Cancer Cell International, Vol 22, Iss 1, Pp 1-21 (2022)

Subject Terms: p21-activated kinase (PAK), Pan-cancer, Biomarker, Tumor immunity, Therapeutic targets, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

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Relation: https://doaj.org/toc/1475-2867

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Comprehensive analysis of the prognostic and role in immune cell infiltration of MSR1 expression in lower‐grade gliomas

Authors: Qiankun Ji, Kai Huang, Yuan Jiang, Kunjian Lei, Zewei Tu, Haitao Luo, Xingen Zhu

Source: Cancer Medicine, Vol 11, Iss 9, Pp 2020-2035 (2022)

Subject Terms: lower‐grade gliomas, macrophage scavenger receptor 1, tumor microenvironment, tumor‐infiltrating immune cells, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: https://doaj.org/toc/2045-7634

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The role of lysosomal peptidases in glioma immune escape: underlying mechanisms and therapeutic strategies

Authors: Hao Liu, Jie Peng, Linzhen Huang, Dong Ruan, Yuguang Li, Fan Yuan, Zewei Tu, Kai Huang, Xingen Zhu

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: lysosomal peptidases, glioma, immune escape, autophagy, cell signal pathways, cathepsin, Immunologic diseases. Allergy, RC581-607

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Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1154146/full; https://doaj.org/toc/1664-3224

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Sperm Autoantigenic Protein 17 Predicts the Prognosis and the Immunotherapy Response of Cancers: A Pan-Cancer Analysis

Authors: Zewei Tu, Jie Peng, Xiaoyan Long, Jingying Li, Lei Wu, Kai Huang, Xingen Zhu

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: sperm autoantigenic protein 17 (SPA17), pan-cancer, prognostic biomarker, immunotherapy response, CMap, Immunologic diseases. Allergy, RC581-607

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Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.844736/full; https://doaj.org/toc/1664-3224

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Protein Disulfide-Isomerase A3 Is a Robust Prognostic Biomarker for Cancers and Predicts the Immunotherapy Response Effectively

Authors: Zewei Tu, Qin Ouyang, Xiaoyan Long, Lei Wu, Jingying Li, Xingen Zhu, Kai Huang

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: protein disulfide-isomerase A3 (PDIA3), pan-cancer, prognostic biomarker, immunotherapy response, CMap., Immunologic diseases. Allergy, RC581-607

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Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.837512/full; https://doaj.org/toc/1664-3224

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CLCF1 Is a Novel Potential Immune-Related Target With Predictive Value for Prognosis and Immunotherapy Response in Glioma

Authors: Yuan Jiang, Qiankun Ji, Xiaoyan Long, Peng Wang, Zewei Tu, Xian Zhang, Xingen Zhu, Kai Huang, Jingying Li

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: CLCF1, glioma, prognosis, tumor microenvironment, immunotherapy, Immunologic diseases. Allergy, RC581-607

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Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.810832/full; https://doaj.org/toc/1664-3224

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Integrin Alpha-2 as a Potential Prognostic and Predictive Biomarker for Patients With Lower-Grade Glioma

Authors: Li Lin, Kai Huang, Zewei Tu, Xingen Zhu, Jingying Li, Kunjian Lei, Min Luo, Peng Wang, Chuandong Gong, Xiaoyan Long, Lei Wu

Source: Frontiers in Oncology, Vol 11 (2021)

Subject Terms: immune infiltration, prognostic signature, overall survival (OS), lower grade gliomas, integrin alpha-2 (ITGA2), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.738651/full; https://doaj.org/toc/2234-943X

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Prognostic and Predictive Value of Immune-Related Gene Pair Signature in Primary Lower-Grade Glioma Patients

Authors: Kunjian Lei, Jingying Li, Zewei Tu, Feng Liu, Minhua Ye, Miaojing Wu, Yue Zhu, Min Luo, Li Lin, Chuming Tao, Kai Huang, Xingen Zhu

Source: Frontiers in Oncology, Vol 11 (2021)

Subject Terms: lower-grade glioma, immune-related gene pairs (IRGPs), overall survival (OS), prognostic signature, ssGSEA, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.665870/full; https://doaj.org/toc/2234-943X

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Systematic and Multi-Omics Prognostic Analysis of Lysine Acetylation Regulators in Glioma

Authors: Zewei Tu, Lei Wu, Haitao Luo, Jingying Li, Shigang Lv, Minhua Ye, Feng Liu, Chuming Tao, Xingen Zhu, Kai Huang

Source: Frontiers in Molecular Biosciences, Vol 8 (2021)

Subject Terms: glioma, lysine acetylation regulator, epigenetic, prognostic signature, biomarker, Biology (General), QH301-705.5

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Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2021.587516/full; https://doaj.org/toc/2296-889X

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A Novel Signature Constructed by RNA-Binding Protein Coding Genes to Improve Overall Survival Prediction of Glioma Patients

Authors: Zewei Tu, Lei Shu, Jingying Li, Lei Wu, Chuming Tao, Minhua Ye, Xingen Zhu, Kai Huang

Source: Frontiers in Cell and Developmental Biology, Vol 8 (2021)

Subject Terms: glioma, RNA binding protein, overall survival, prognostic signature, biomarker, Biology (General), QH301-705.5

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Relation: https://www.frontiersin.org/articles/10.3389/fcell.2020.588368/full; https://doaj.org/toc/2296-634X

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Identification of RNA: 5-Methylcytosine Methyltransferases-Related Signature for Predicting Prognosis in Glioma

Authors: Peng Wang, Miaojing Wu, Zewei Tu, Chuming Tao, Qing Hu, Kuangxun Li, Xingen Zhu, Kai Huang

Source: Frontiers in Oncology, Vol 10 (2020)

Subject Terms: glioma, 5-methylcytosine methyltransferases, RNA modification, gene expression profile, prognostic signature, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: https://www.frontiersin.org/article/10.3389/fonc.2020.01119/full; https://doaj.org/toc/2234-943X

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N6-Methylandenosine-Related lncRNAs Are Potential Biomarkers for Predicting the Overall Survival of Lower-Grade Glioma Patients

Authors: Zewei Tu, Lei Wu, Peng Wang, Qing Hu, Chuming Tao, Kuangxun Li, Kai Huang, Xingen Zhu

Source: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Subject Terms: lower-grade glioma, N6-methylandenosine, long non-coding RNA, prognostic signature, ceRNA network, Biology (General), QH301-705.5

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Relation: https://www.frontiersin.org/article/10.3389/fcell.2020.00642/full; https://doaj.org/toc/2296-634X

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