Resazurin dye is an in vivo sensor of kidney tubular function

Authors: Martinez, Shirely Acosta ^{1, 19}, Karel, Isaac Z. ^{1, 19}, Silvaroli, Josie A. ^{1, 19}, Ahmed, Eman ¹, Kim, Ji Young ¹, Stayton, Amanda ², Patel, Prisha S. ², Afjal, Mohammad Amir ², Horton, Thomas ², Bohmer, Margaret ¹, Vanichapol, Thitinee ³, Sander, Veronika ³, Andrade, Gabriel Mayoral ⁴, Allison, Corynne Vermillion ¹, Mondal, Milon ¹, Thorson, Victoria C. ¹, Partey, Alexandra ¹, Nimkar, Kartik ¹, Williams, Victoria ⁵, Quimby, Jessica ⁶, Ganesan, Latha ⁷, Madhavan, Sethu M. ⁷, Davidson, Alan J. ³, Peterson, Blake R. ⁸, Adebiyi, Adebowale ⁹, Rao, Reena ^{10, 11}, Sweet, Douglas H. ¹², Singh, Prabhleen ¹³, Bennett, Kevin M. ¹⁴, Zepeda-Orozco, Diana ⁴, Mallipattu, Sandeep K. ^{15, 16}, Eisenmann, Eric D. ¹, Sparreboom, Alex ¹, Rovin, Brad H. ⁷, Bajwa, Amandeep ^{2, 17, 18, ∗}, Pabla, Navjot S. ^{1, ∗}

Source: In Kidney International March 2025 107(3):508-520

The antioxidant and anti-inflammatory activities of avasopasem manganese in age-associated, cisplatin-induced renal injury

Authors: Mapuskar, Kranti A., Pulliam, Casey F., Tomanek-Chalkley, Ann, Rastogi, Prerna, Wen, Hsiang, Dayal, Sanjana, Griffin, Benjamin R., Zepeda-Orozco, Diana, Sindler, Amy L., Anderson, Carryn M., Beardsley, Robert, Kennedy, Eugene P., Spitz, Douglas R., Allen, Bryan G.

Source: In Redox Biology April 2024 70

Neutrophil NADPH oxidase promotes bacterial eradication and regulates NF-κB-Mediated inflammation via NRF2 signaling during urinary tract infections

Authors: Cotzomi-Ortega, Israel ^a, Rosowski, Emily E. ^{c, d}, Wang, Xin ^a, Sanchez-Zamora, Yuriko I. ^a, Lopez-Torres, Jeimy M. ^a, Sanchez-Orellana, Gamaliel ^a, Han, Rachel ^e, Vásquez-Martínez, Gabriela ^a, Andrade, Gabriel Mayoral ^{a, f}, Ballash, Gregory ^g, Cortado, Hanna ^a, Li, Birong ^a, Ali, Yusuf ^a, Rascon, Raul ^h, Robledo-Avila, Frank ^h, Partida-Sanchez, Santiago ^h, Pérez-Campos, Eduardo ⁱ, Olofsson-Sahl, Peter ^{j, k}, Zepeda-Orozco, Diana ^{a, b}, Spencer, John David ^{a, b}, Becknell, Brian ^{a, b, ⁎}, Ruiz-Rosado, Juan de Dios ^{a, b, ⁎}

Source: In Mucosal Immunology December 2024

Tubular mitochondrial pyruvate carrier disruption elicits redox adaptations that protect from acute kidney injury

Authors: Rauckhorst, Adam J., Vasquez Martinez, Gabriela, Mayoral Andrade, Gabriel, Wen, Hsiang, Kim, Ji Young, Simoni, Aaron, Robles-Planells, Claudia, Mapuskar, Kranti A., Rastogi, Prerna, Steinbach, Emily J., McCormick, Michael L., Allen, Bryan G., Pabla, Navjot S., Jackson, Ashley R., Coleman, Mitchell C., Spitz, Douglas R., Taylor, Eric B., Zepeda-Orozco, Diana

Source: In Molecular Metabolism January 2024 79

Zinc finger protein 24-dependent transcription factor SOX9 up-regulation protects tubular epithelial cells during acute kidney injury

Authors: Kim, Ji Young, Silvaroli, Josie A., Martinez, Gabriela Vasquez, Bisunke, Bijay, Luna Ramirez, Alanys V., Jayne, Laura A., Feng, Mei Ji He Ho, Girotra, Bhavya, Acosta Martinez, Shirely M., Vermillion, Corynne R., Karel, Isaac Z., Ferrell, Nicholas, Weisleder, Noah, Chung, Sangwoon, Christman, John W., Brooks, Craig R., Madhavan, Sethu M., Hoyt, Kari R., Cianciolo, Rachel E., Satoskar, Anjali A., Zepeda-Orozco, Diana, Sullivan, Jennifer C., Davidson, Alan J., Bajwa, Amandeep, Pabla, Navjot Singh

Source: Kidney international. 103(6):1093-1104

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190350519.0x000001&indx=1&recIds=ETOCvdc_100190350519.0x000001

Engineered Extracellular Vesicles Derived from Dermal Fibroblasts Attenuate Inflammation in a Murine Model of Acute Lung Injury

Authors: Salazar‐Puerta, Ana I., Rincon‐Benavides, María A., Cuellar‐Gaviria, Tatiana Z., Aldana, Julian, Vasquez Martinez, Gabriela, Ortega‐Pineda, Lilibeth, Das, Devleena, Dodd, Daniel, Spencer, Charles A., Deng, Binbin, McComb, David W., Englert, Joshua A., Ghadiali, Samir, Zepeda‐Orozco, Diana, Wold, Loren E., Gallego‐Perez, Daniel, Higuita‐Castro, Natalia

Source: Advanced materials. 35(28)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187341555.0x000001&indx=1&recIds=ETOCvdc_100187341555.0x000001

Uric Acid Lowering and Biomarkers of Kidney Damage in CKD Stage 3: A Post Hoc Analysis of a Randomized Clinical Trial

Authors: Perrenoud, Loni, Kruse, Nicholas T., Andrews, Emily, You, Zhiying, Chonchol, Michel, Wu, Chaorong, Ten Eyck, Patrick, Zepeda-Orozco, Diana, Jalal, Diana

Source: In Kidney Medicine March-April 2020 2(2):155-161

Murine Ribonuclease 6 Limits Bacterial Dissemination during Experimental Urinary Tract Infection

Authors: Cortado, Hanna, Kercsmar, Macie, Li, Birong, Vasquez-Martinez, Gabriela, Gupta, Sudipti, Ching, Christina, Ballash, Gregory, Cotzomi-Ortega, Israel, Sanchez-Zamora, Yuriko I., Boix, Ester, Zepeda-Orozco, Diana, Jackson, Ashley R., Spencer, John David, Ruiz-Rosado, Juan de Dios, Becknell, Brian

Source: Journal of Innate Immunity; November 2024, Vol. 16 Issue: 1 p283-294, 12p

Role of the CDKL1-SOX11 signaling axis in acute kidney injury.

Authors: Silvaroli, Josie A., Martinez, Gabriela V., Vanichapol, Thitinee, Davidson, Alan J., Zepeda-Orozco, Diana, Pabla, Navjot S., Kim, Ji Young

Source: American Journal of Physiology: Renal Physiology; Sep2024, Vol. 327 Issue 3, pF426-F434, 9p

Subject Terms: GLYCOGEN synthase kinase-3, MITOGEN-activated protein kinases, ACUTE kidney failure, CELL cycle regulation, DRUG discovery, PROTEIN kinases

Insulin receptor orchestrates kidney antibacterial defenses.

Authors: Schwartz, Laura, Simoni, Aaron, Yan, Pearlly, Salamon, Kristin, Turkoglu, Altan, Martinez, Gabriela Vasquez, Zepeda-Orozco, Diana, Eichler, Tad, Xin Wang, Spencer, John David

Source: Proceedings of the National Academy of Sciences of the United States of America; 7/16/2024, Vol. 121 Issue 29, p1-29, 40p

Subject Terms: ANTIMICROBIAL peptides, KNOCKOUT mice, INSULIN receptors, URINARY tract infections, CELL receptors, PEOPLE with diabetes

Persistent increase in mitochondrial superoxide mediates cisplatin-induced chronic kidney disease

Authors: Mapuskar, Kranti A., Wen, Hsiang, Holanda, Danniele G., Rastogi, Prerna, Steinbach, Emily, Han, Rachel, Coleman, Mitchell C., Attanasio, Massimo, Riley, Dennis P., Spitz, Douglas R., Allen, Bryan G., Zepeda-Orozco, Diana

Source: In Redox Biology January 2019 20:98-106

Pre-clinical evaluation of biomarkers for the early detection of nephrotoxicity following alpha-particle radioligand therapy.

Authors: Li, Mengshi, Robles-Planells, Claudia, Liu, Dijie, Graves, Stephen A., Vasquez-Martinez, Gabriela, Mayoral-Andrade, Gabriel, Lee, Dongyoul, Rastogi, Prerna, Marks, Brenna M., Sagastume, Edwin A., Weiss, Robert M., Linn-Peirano, Sarah C., Johnson, Frances L., Schultz, Michael K., Zepeda-Orozco, Diana

Source: European Journal of Nuclear Medicine & Molecular Imaging; Apr2024, Vol. 51 Issue 5, p1395-1408, 14p

Subject Terms: ALPHA rays, NEPHROTOXICOLOGY, LIPOCALIN-2, URINATION, ACUTE kidney failure, CHRONIC kidney failure

Genome-Wide CRISPR Screen Identifies Phospholipid Scramblase 3 as the Biological Target of Mitoprotective Drug SS-31

Authors: Silvaroli, Josie A., Bisunke, Bijay, Kim, Ji Young, Stayton, Amanda, Jayne, Laura A., Martinez, Shirely A., Nguyen, Christopher, Patel, Prisha S., Vanichapol, Thitinee, Verma, Vivek, Akhter, Juheb, Bolisetty, Subhashini, Madhavan, Sethu M., Kuscu, Cem, Coss, Christopher C., Zepeda-Orozco, Diana, Parikh, Samir V., Satoskar, Anjali A., Davidson, Alan J., Eason, James D., Szeto, Hazel H., Pabla, Navjot S., Bajwa, Amandeep

Source: Journal of the American Society of Nephrology; June 2024, Vol. 35 Issue: 6 p681-695, 15p

Urinary biomarkers associated with acute kidney injury in pediatric mechanical circulatory support patients.

Authors: Harris, Rachel E., Yates, Andrew R., Nandi, Deipanjan, Krawczeski, Catherine D., Klamer, Brett, Martinez, Gabriela Vasquez, Andrade, Gabriel Mayoral, Beckman, Brian F., Bi, Jianli, Zepeda-Orozco, Diana

Source: Pediatric Nephrology; Feb2024, Vol. 39 Issue 2, p569-577, 9p

Subject Terms: ARTIFICIAL blood circulation, BIOMARKERS, RESEARCH, ALBUMINS, CONFIDENCE intervals, EPIDERMAL growth factor, PEDIATRICS, RETROSPECTIVE studies, ACQUISITION of data, EXTRACORPOREAL membrane oxygenation, HEART assist devices, COMPARATIVE studies, MEDICAL records, DESCRIPTIVE statistics, RESEARCH funding, ACUTE kidney failure in children, ODDS ratio, LONGITUDINAL method, CREATININE

Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis

Authors: Gray, Lawrence R., Sultana, Mst Rasheda, Rauckhorst, Adam J., Oonthonpan, Lalita, Tompkins, Sean C., Sharma, Arpit, Fu, Xiaorong, Miao, Ren, Pewa, Alvin D., Brown, Kathryn S., Lane, Erin E., Dohlman, Ashley, Zepeda-Orozco, Diana, Xie, Jianxin, Rutter, Jared, Norris, Andrew W., Cox, James E., Burgess, Shawn C., Potthoff, Matthew J., Taylor, Eric B.

Source: In Cell Metabolism 6 October 2015 22(4):669-681

Redox Regulation of Nrf2 in Cisplatin-Induced Kidney Injury.

Authors: Mapuskar, Kranti A., Pulliam, Casey F., Zepeda-Orozco, Diana, Griffin, Benjamin R., Furqan, Muhammad, Spitz, Douglas R., Allen, Bryan G.

Source: Antioxidants; Sep2023, Vol. 12 Issue 9, p1728, 17p

Subject Terms: CISPLATIN, KIDNEY injuries, NUCLEAR factor E2 related factor, OXIDATION-reduction reaction, POST-translational modification, OXIDATIVE stress

Engineered Extracellular Vesicle-Based Therapies for Valvular Heart Disease.

Authors: Salazar-Puerta, Ana I.¹, Kordowski, Mia², Cuellar-Gaviria, Tatiana Z.¹, Rincon-Benavides, Maria A.², Hussein, Jad¹, Flemister, Dorma¹, Mayoral-Andrade, Gabriel³, Barringer, Grant¹, Guilfoyle, Elizabeth¹, Blackstone, Britani N.⁴, Deng, Binbin⁵, Zepeda-Orozco, Diana^3,6,7, McComb, David W.^4,5, Powell, Heather^1,4,8, Dasi, Lakshmi P.⁹, Gallego-Perez, Daniel^1,2,10,11, Higuita-Castro, Natalia^1,2,11,12, higuitacastro.1@osu.edu

Source: Cellular & Molecular Bioengineering; Aug2023, Vol. 16 Issue 4, p309-324, 16p

Mitochondrial Oxidative Metabolism: An Emerging Therapeutic Target to Improve CKD Outcomes.

Authors: Mapuskar, Kranti A., Vasquez-Martinez, Gabriela, Mayoral-Andrade, Gabriel, Tomanek-Chalkley, Ann, Zepeda-Orozco, Diana, Allen, Bryan G.

Source: Biomedicines; Jun2023, Vol. 11 Issue 6, p1573, 18p

Subject Terms: MITOCHONDRIAL pathology, CHRONIC kidney failure, CLINICAL trials, MITOCHONDRIA, REACTIVE oxygen species, METABOLISM

ELEVATED URINE NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) PREDICTS DEVELOPMENT OF ACUTE KIDNEY INJURY FOLLOWING INITIATION OF MECHANICAL CIRCULATORY SUPPORT

Authors: Harris, Rachel, Yates, Andrew, Nandi, Deipanjan, Klamer, Brett, Krawczeski, Catherine D., Zepeda-Orozco, Diana

Source: Journal of the American College of Cardiology. 79(S):1368-1368

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100158525865.0x000001&indx=1&recIds=ETOCvdc_100158525865.0x000001

Autophagy Is a Component of Epithelial Cell Fate in Obstructive Uropathy

Authors: Li, Ling, Zepeda-Orozco, Diana, Black, Rachel, Lin, Fangming

Source: In The American Journal of Pathology 2010 176(4):1767-1778