Net benefit of ivacaftor during prolonged tezacaftor/elexacaftor exposure in vitro

Authors: Shaughnessy, Ciaran A., Zeitlin, Pamela L., Bratcher, Preston E.

Source: In Journal of Cystic Fibrosis July 2022 21(4):637-643

The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions

Authors: Billheimer, Dean, Bleecker, Eugene R., Branch, Emily, Conway, Michelle, Daines, Cori, Deaton, Isaac, Evans, Alexandria, Field, Paige, Francisco, Dave, Hastie, Annette T., Hmieleski, Bob, Krings, Jeffrey O., Liu, Yanqin, Merchen, Janell L., Meyers, Deborah A., Narendran, Nirushan, Peters, Stephen P., Pippins, Anna, Rank, Matthew A., Schunk, Ronald, Skeps, Raymond, Wright, Benjamin, Banzon, Tina M., Bartnikas, Lisa M., Baxi, Sachin N., Betapudi, Vishwanath, Brick, Isabelle, Brockway, Conor, Casale, Thomas B., Castillo-Ruano, Kathleen, Cinelli, Maria Angeles, Crestani, Elena, Cunningham, Amparito, Day-Lewis, Megan, Diaz-Cabrera, Natalie, DiMango, Angela, Esty, Brittany, Fandozzi, Eva, Fernandez, Jesse, Fitzpatrick, Elizabeth, Forth, Victoria E., Gentile, Katarina, Gubernick, David, Gueye-Ndiaye, Seyni, Gunnlaagsson, Sigfus, Hauptmann, Marissa, Hudey, Stephanie N., Imanirad, Donya S., Kaage, Tiffani, Kolinsky, Nicholas, LaBere, Brenna, Lai, Peggy Sue, Le, Meghan, Ledford, Dennis K., Lockey, Richard, Louisias, Margee, Macginnitie, Andrew J., Maciag, Michelle C., O’Neill, Allison, Pepper, Amber N., Permaul, Perdita, Pugh, Mya, Queheillalt, Dianna, Saroya, Tarnjot, Sheehan, William, Smith, Catherine, Socolovsky, Carmela, Treffeisen, Else, Trippa, Lorenzo, Tulchinsky, Abigail, Yee, Christina, Carter, Tina, Fu, Jun, Garcia, Vanessa, Hixon, Jenny, Jackson, Carly, Ji, Yuan, Kalhan, Ravi, Kaur, Opinderjit, Li, Grace, Makhija, Melanie M., Maleckar, Spring, Naureckas, Edward T., Peters, Anju T., Press, Valerie, Qureshi, Mehreen, Reyfman, Paul A., Rosenberg, Sharon R., Ryba, Dominika, Sheng, Jianrong, Xu, Ben, Alam, Rafeul, Anderson, Darci, Belimezova, Sonya, Bitzan, Jennifer, Chupp, Geoffrey, Clark, Brian J., Cohn, Lauren, Cruse, Margaret Hope, Estrom, Jean, Freid, Leah, Villalobos, Jose Gomez, Grant, Nicole, Guntur, Vamsi P., Holm, Carole, Kolakowski, Christena, Manka, Laurie A., Miyazawa, Naomi, Pak, Juno, Pruitt, Diana M., Sharma, Sunita, Stevens, Allen D., Thomas, Kisori, Tippin, Brooke, Valente, Karissa, Wainscoat, Cynthia L., White, Michael P., Winnica, Daniel, Ye, Shuyu, Zeitlin, Pamela L., Bach, Julia, Brownell, Joshua, Castro, Lauren, DeLisa, Julie, Fain, Sean B., Fichtinger, Paul S., Floerke, Heather, Gern, James E., Goswamy, Vinay, Grogan, Jenelle, Hasse, Wendy, Kelley, Rick L., Klaus, Danika, LaBedz, Stephanie, Lowell, Paige, Maddox, Andrew, Mathur, Sameer K., McIntyre, Amanda, Norwick, Lourdes M., Nyenhuis, Sharmilee M., O’Brien, Matthew J., Palas, Tina, Pappalardo, Andrea A., Potter, Mark, Ramratnam, Sima K., Rosenberg, Daniel L., Schauberger, Eric M., Schiebler, Mark L., Schraml, Angela, Sorkness, Ronald L., Taki, Mohamed, Tattersall, Matthew C., Torres, Jissell, Wollet, Lori, Abi-Saleh, Simon, Bendy, Lisa, Borish, Larry, Chmiel, James F., Dix, Aska, France, Lisa, Gammell, Rebecca, Gluvna, Adam, Hirth, Brittany, Hu, Bo, Hyser, Elise, Kloepfer, Kirsten M., Koo, Michelle, Krupp, Nadia L., Labadia, Monica, Lawrence, Joy, Logan, Laurie, Marko, Angela, Matuska, Brittany, Murphy, Deborah, Owensby, Rachel, Roesch, Erica A., Sanders, Don B., Sharp, Jackie, Teague, W. Gerald, Veri, Laura, Shifflett, Kristin Wavell, Camiolo, Matt, Collins, Sarah, Demas, Jessa, Elvin, Courtney, Gauthier, Marc C., Ilnicki, Melissa, Ingram, Jenn, Lane, Lisa, Nouraie, Seyed Mehdi, Trudeau, John B., Zhang, Michael, Barry, Jeffrey, Brickner, Howard, Celso, Janelle, Cernelc-Kohan, Matejka, Diaz, Damaris, Du, Ashley, Jain, Sonia, Liu, Neiman, Nazir, Yusife, Ryu, Julie, Vijayanand, Pandurangan, Almario, Rogelio, Baum, Ariana, Brown, Kellen, Chan, Marilynn H., Gale, Barbara, Haczku, Angela, Harper, Richart W., Heromin, Raymond, Kivler, Celeste, Kuhn, Brooks T., Ly, Ngoc P., McCourt, Paula, Orain, Xavier, Plough, Audrey, Ramirez, Karla, Roberts, Ellese, Schivo, Michael, Singapuri, Amisha, Tham, Tina, Tompkins, Daniel, Twitmyer, Patricia Michelle, Vi, Jade, Atha, Jarron, Bedard, Jennifer, Boomer, Jonathan S., Chung, Andrew, Curtis, Vanessa, Hall, Chase S., Hart, Emily, Jackson, Fatima, Kemp, Pamela, Maxwell, Sharli, Messplay, Maggie, Ramirez, Crystal, Thompson, Brynne, Britt, Ashley, Bryan, Hope, Gotman, Nathan M., Jiang, Yue, Kosorok, Michael R., Mauger, David T., Meekins, Kelsey, Mollenhauer, Jeanette K., Moody, Sarah, Ritz, Cheyanne, Schwartz, Stefanie, Thomlinson, Chalmer, Wilson, Nicole, Georas, Steve N., Wright, Rosalind J., Ivanova, Anastasia, Israel, Elliot, LaVange, Lisa M., Akuthota, Praveen, Carr, Tara F., Denlinger, Loren C., Fajt, Merritt L., Kumar, Rajesh, O’Neal, Wanda K., Phipatanakul, Wanda, Szefler, Stanley J., Aronica, Mark A., Bacharier, Leonard B., Burbank, Allison J., Castro, Mario, Crotty Alexander, Laura, Bamdad, Julie, Cardet, Juan Carlos, Comhair, Suzy A.A., Covar, Ronina A., DiMango, Emily A., Erwin, Kim, Erzurum, Serpil C., Fahy, John V., Gaffin, Jonathan M., Gaston, Benjamin, Gerald, Lynn B., Hoffman, Eric A., Holguin, Fernando, Jackson, Daniel J., James, John, Jarjour, Nizar N., Kenyon, Nicholas J., Khatri, Sumita, Kirwan, John P., Kraft, Monica, Krishnan, Jerry A., Liu, Andrew H., Liu, Mark C., Marquis, M. Alison, Martinez, Fernando, Mey, Jacob, Moore, Wendy C., Moy, James N., Ortega, Victor E., Peden, David B., Pennington, Emily, Peters, Michael C., Ross, Kristie, Sanchez, Maria, Smith, Lewis J., Wechsler, Michael E., Wenzel, Sally E., White, Steven R., Zein, Joe, Zeki, Amir A., Noel, Patricia

Source: In The Journal of Allergy and Clinical Immunology February 2022 149(2):488-516

Impact of sleep opportunity on asthma outcomes in adolescents

Authors: Meltzer, Lisa J., Beebe, Dean W., Jump, Stephanie, Flewelling, Kassie, Sundström, D., White, Michael, Zeitlin, Pamela L., Strand, Matthew J.

Source: In Sleep Medicine January 2020 65:134-141

Pharmacokinetics and safety of cavosonstat (N91115) in healthy and cystic fibrosis adults homozygous for F508DEL-CFTR

Authors: Donaldson, Scott H., Solomon, George M., Zeitlin, Pamela L., Flume, Patrick A., Casey, Alicia, McCoy, Karen, Zemanick, Edith T., Mandagere, Arun, Troha, Janice M., Shoemaker, Steven A., Chmiel, James F., Taylor-Cousar, Jennifer L.

Source: In Journal of Cystic Fibrosis May 2017 16(3):371-379

Analysis of ClC-2 Channels as an Alternative Pathway for Chloride Conduction in Cystic Fibrosis Airway Cells

Authors: Schwiebert, Erik M., Cid-Soto, Luis P., Stafford, Diane, Carter, Mark, Blaisdell, Carol J., Zeitlin, Pamela L., Guggino, William B., Cutting, Garry R.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1998 Mar . 95(7), 3879-3884.

Access URL: https://www.jstor.org/stable/44578

Clinical Phenotypes and Genotypic Spectrum of Cystic Fibrosis in Chinese Children

Authors: Shen, Yuelin, Liu, Jinrong, Zhong, Lili, Mogayzel, Peter J., Jr., Zeitlin, Pamela L., Sosnay, Patrick R., Zhao, Shunying

Source: In The Journal of Pediatrics April 2016 171:269-276

38 - Genetics and Pathophysiology of Cystic Fibrosis

Authors: Cutting, Garry R., Engelhardt, John F., Zeitlin, Pamela L.

Source: In Kendig and Wilmott’s Disorders of the Respiratory Tract in Children Edition: Tenth Edition. 2024:604-615

Measurements of spontaneous CFTR-mediated ion transport without acute channel activation in airway epithelial cultures after modulator exposure.

Authors: Nick, Heidi J.^1,2 (AUTHOR), Zeitlin, Pamela L.^1,2 (AUTHOR), Yadav, Sangya¹ (AUTHOR), Bratcher, Preston E.^1,2 (AUTHOR) BratcherP@NJHealth.org

Source: Scientific Reports. 11/19/2021, Vol. 11 Issue 1, p1-9. 9p.

Subject Terms: *ION transport (Biology), *CYSTIC fibrosis transmembrane conductance regulator, *SUPERIOR colliculus, *EPITHELIUM, *FUNCTIONAL status, *FORSKOLIN

Elexacaftor is a CFTR potentiator and acts synergistically with ivacaftor during acute and chronic treatment.

Authors: Shaughnessy, Ciaran A.¹ (AUTHOR) ShaughnessyC@NJHealth.org, Zeitlin, Pamela L.^1,2 (AUTHOR), Bratcher, Preston E.^1,2 (AUTHOR)

Source: Scientific Reports. 10/25/2021, Vol. 11 Issue 1, p1-11. 11p.

Subject Terms: *CHLORIDE channels, *CYSTIC fibrosis transmembrane conductance regulator, *DISEASE progression, *PROTEIN folding

Ataluren for the treatment of nonsense-mutation cystic fibrosis: a randomised, double-blind, placebo-controlled phase 3 trial

Authors: Kerem, Eitan, Konstan, Michael W, De Boeck, Kris, Accurso, Frank J, Sermet-Gaudelus, Isabelle, Wilschanski, Michael, Elborn, J Stuart, Melotti, Paola, Bronsveld, Inez, Fajac, Isabelle, Malfroot, Anne, Rosenbluth, Daniel B, Walker, Patricia A, McColley, Susanna A, Knoop, Christiane, Quattrucci, Serena, Rietschel, Ernst, Zeitlin, Pamela L, Barth, Jay, Elfring, Gary L, Welch, Ellen M, Branstrom, Arthur, Spiegel, Robert J, Peltz, Stuart W, Ajayi, Temitayo, Rowe, Steven M

Source: In The Lancet Respiratory Medicine July 2014 2(7):539-547

Asthma inflammatory subtypes and new biologic therapies.

Authors: Zeitlin, Pamela L.¹

Source: Revista Mexicana de Anestesiología. Jul-Sep2019, Vol. 42 Issue S1, pS287-S293. 7p. 6 Charts.

Subject Terms: *ASTHMA treatment, *INFLAMMATION, *BIOLOGICALS, *ASTHMA in children, *COMORBIDITY, *DEGLUTITION disorders, *SINUSITIS

N-acetylcysteine Enhances Cystic Fibrosis Sputum Penetration and Airway Gene Transfer by Highly Compacted DNA Nanoparticles

Authors: Suk, Jung Soo, Boylan, Nicholas J, Trehan, Kanika, Tang, Benjamin C, Schneider, Craig S, Lin, Jung-Ming G, Boyle, Michael P, Zeitlin, Pamela L, Lai, Samuel K, Cooper, Mark J, Hanes, Justin

Source: In Molecular Therapy November 2011 19(11):1981-1989

Ubiquitin C-terminal Hydrolase-L1 Protects Cystic Fibrosis Transmembrane Conductance Regulator from Early Stages of Proteasomal Degradation

Authors: Henderson, Mark J., Vij, Neeraj, Zeitlin, Pamela L.

Source: In Journal of Biological Chemistry 9 April 2010 285(15):11314-11325

Transient effectiveness of vitamin D 2 therapy in pediatric cystic fibrosis patients

Authors: Green, Deanna M., Leonard, Amanda R., Paranjape, Shruti M., Rosenstein, Beryl J., Zeitlin, Pamela L., Mogayzel, Peter J., Jr.

Source: In Journal of Cystic Fibrosis 2010 9(2):143-149

The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles

Authors: Suk, Jung Soo, Lai, Samuel K., Wang, Ying-Ying, Ensign, Laura M., Zeitlin, Pamela L., Boyle, Michael P., Hanes, Justin

Source: In Biomaterials 2009 30(13):2591-2597

Cell Surface Distribution and Intracellular Fate of Asialoglycoproteins: A Morphological and Biochemical Study of Isolated Rat Hepatocytes and Monolayer Cultures

Authors: Zeitlin, Pamela L., Hubbard, Ann L.

Source: The Journal of Cell Biology, 1982 Mar 01. 92(3), 634-647.

Access URL: https://www.jstor.org/stable/1609756

Stable in vivo Expression of the Cystic Fibrosis Transmembrane Conductance Regulator with an Adeno-Associated Virus Vector

Authors: Flotte, Terence R., Afione, Sandra A., Conrad, Carol, McGarth, Sharon A., Solow, Rikki, Oka, Hidemi, Zeitlin, Pamela L., Guggino, William B., Carter, Barrie J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1993 Nov . 90(22), 10613-10617.

Access URL: https://www.jstor.org/stable/2363277

Steroid Hormones: Modulators of Na+ Absorption and Cl- Secretion in Cultured Tracheal Epithelia

Authors: Zeitlin, Pamela L., Wagner, Mary, Markakis, Diane, Loughlin, Gerald M., Guggino, William B.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1989 Apr 01. 86(7), 2502-2505.

Access URL: https://www.jstor.org/stable/33507

Immunocytochemical Localization of the Cystic Fibrosis Gene Product CFTR

Authors: Crawford, Isabelle, Maloney, Peter C., Zeitlin, Pamela L., Guggino, William B., Hyde, Stephen C., Turley, Helen, Gatter, Kevin C., Harris, Ann, Higgins, Christopher F.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1991 Oct . 88(20), 9262-9266.

Access URL: https://www.jstor.org/stable/2358127

CFTR Protein Expression in Primary and Cultured Epithelia

Authors: Zeitlin, Pamela L., Crawford, Isabelle, Lu, Luo, Woel, Sybille, Cohen, Michael E., Donowitz, Mark, Montrose, Marshall H., Hamosh, Ada, Cutting, Garry R., Gruenert, Dieter, Huganir, Richard, Maloney, Peter, Guggino, William B.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1992 Jan 01. 89(1), 344-347.

Access URL: https://www.jstor.org/stable/2358533