Mitochondrial DNA copy number variation in asthma risk, severity, and exacerbations

Authors: Xu, Weiling ^a, Hong, Yun Soo ^b, Hu, Bo ^c, Comhair, Suzy A.A. ^a, Janocha, Allison J. ^a, Zein, Joe G. ^d, Chen, Ruoying ^c, Meyers, Deborah A. ^d, Mauger, David T. ^e, Ortega, Victor E. ^d, Bleecker, Eugene R. ^d, Castro, Mario ^f, Denlinger, Loren C. ^g, Fahy, John V. ^h, Israel, Elliot ⁱ, Levy, Bruce D. ⁱ, Jarjour, Nizar N. ^j, Moore, Wendy C. ^k, Wenzel, Sally E. ^l, Gaston, Benjamin ^m, Liu, Chunyu ⁿ, Arking, Dan E. ^b, Erzurum, Serpil C. ^{a, o, ∗}

Source: In The Journal of Allergy and Clinical Immunology April 2025 155(4):1224-1235

Asthma Exacerbation Risk in Pregnancy and Postpartum: Assessing the Impact of Gestational Diabetes Mellitus and Other Key Factors

Authors: Zhang, Peng ^{a, ∗}, Lappen, Justin R. ^b, Attaway, Amy ^a, Erzurum, Serpil ^{a, c}, Love, Thomas E. ^{d, e, f}, Zein, Joe ^{g, ∗}, Tsuang, Wayne ^{a, ∗}

Source: In The Journal of Allergy and Clinical Immunology: In Practice March 2025 13(3):576-582

α1-Antitrypsin Gene Variation Associates With Asthma Exacerbations and Related Health Care Utilization

Authors: Ortega, Victor E. ^{a, ∗}, Tejwani, Vickram ^{b, c}, Shrivastav, Abhishek Kumar ^a, Pasha, Sara ^d, Zein, Joe G. ^a, Boorgula, Meher ^e, Castro, Mario ^f, Denlinger, Loren ^g, Erzurum, Serpil C. ^h, Fahy, John V. ⁱ, Israel, Elliot ^j, Jarjour, Nizar N. ^g, Levy, Bruce ^j, Mauger, David ^k, Moore, Wendy C. ^l, Wenzel, Sally E. ^m, Woodruff, Prescott ⁿ, Hawkins, Gregory A. ^o, Bleecker, Eugene R. ^a, Meyers, Deborah A. ^a

Source: In The Journal of Allergy and Clinical Immunology: In Practice January 2025

Development of an asthma health-care burden score as a measure of severity and predictor of remission in SARP III and U-BIOPRED: results from two major longitudinal asthma cohorts

Authors: Zein, Joe G ^{a, *}, Zounemat-Kermani, Nazanin ^b, Adcock, Ian M ^b, Hu, Bo ^c, Attaway, Amy ^{c, d}, Castro, Mario ^e, Dahlén, Sven-Erik ^f, Denlinger, Loren C ^g, Erzurum, Serpil C ^{c, d}, Fahy, John V ^h, Gaston, Benjamin ⁱ, Hastie, Annette T ^j, Israel, Elliot ^k, Jarjour, Nizar N ^g, Levy, Bruce D ^k, Mauger, David T ^l, Moore, Wendy ^j, Peters, Michael C ^h, Sumino, Kaharu ^m, Townsend, Elizabeth ^g, Woodruff, Prescott ^h, Ortega, Victor E ^a, Wenzel, Sally E ⁿ, Meyers, Deborah A ^a, Chung, Kian Fan ^b, Bleecker, Eugene R ^a

Source: In The Lancet Respiratory Medicine January 2025 13(1):35-46

COVID-19 and Its Impact on Common Diseases in the Allergy Clinics

Authors: Kocatürk, Emek, Abrams, Elissa M., Maurer, Marcus, Mitri, Jad, Oppenheimer, John, Vestergaard, Christian, Zein, Joe

Source: In The Journal of Allergy and Clinical Immunology: In Practice November 2023 11(11):3289-3303

Distinct single-cell transcriptional profile in CD4+ T-lymphocytes among obese children with asthma.

Authors: Tejwani, Vickram, Wang, Rulin, Villabona-Rueda, Andres, Suresh, Karthik, Wu, Tianshi David, Adcock, Ian M., Kermani, Nazanin Z., Zein, Joe, Hansel, Nadia N., Yegnasubramanian, Srinivasan, McCormack, Meredith C., D'Alessio, Franco R.

Source: American Journal of Physiology: Lung Cellular & Molecular Physiology; Mar2025, Vol. 328 Issue 3, pL372-L378, 7p

Subject Terms: OBESITY, ASTHMA, T helper cells, RNA sequencing, DRUG target, CORTICOSTEROIDS, GENE expression, IMMUNE response

Eosinophilia Is Associated with Improved COVID-19 Outcomes in Inhaled Corticosteroid-Treated Patients

Authors: Zein, Joe G., Strauss, Ronald, Attaway, Amy H., Hu, Bo, Milinovich, Alex, Jawhari, Nesreen, Chamat, Soulaima S., Ortega, Victor E.

Source: In The Journal of Allergy and Clinical Immunology: In Practice March 2022 10(3):742-750

The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions

Authors: Billheimer, Dean, Bleecker, Eugene R., Branch, Emily, Conway, Michelle, Daines, Cori, Deaton, Isaac, Evans, Alexandria, Field, Paige, Francisco, Dave, Hastie, Annette T., Hmieleski, Bob, Krings, Jeffrey O., Liu, Yanqin, Merchen, Janell L., Meyers, Deborah A., Narendran, Nirushan, Peters, Stephen P., Pippins, Anna, Rank, Matthew A., Schunk, Ronald, Skeps, Raymond, Wright, Benjamin, Banzon, Tina M., Bartnikas, Lisa M., Baxi, Sachin N., Betapudi, Vishwanath, Brick, Isabelle, Brockway, Conor, Casale, Thomas B., Castillo-Ruano, Kathleen, Cinelli, Maria Angeles, Crestani, Elena, Cunningham, Amparito, Day-Lewis, Megan, Diaz-Cabrera, Natalie, DiMango, Angela, Esty, Brittany, Fandozzi, Eva, Fernandez, Jesse, Fitzpatrick, Elizabeth, Forth, Victoria E., Gentile, Katarina, Gubernick, David, Gueye-Ndiaye, Seyni, Gunnlaagsson, Sigfus, Hauptmann, Marissa, Hudey, Stephanie N., Imanirad, Donya S., Kaage, Tiffani, Kolinsky, Nicholas, LaBere, Brenna, Lai, Peggy Sue, Le, Meghan, Ledford, Dennis K., Lockey, Richard, Louisias, Margee, Macginnitie, Andrew J., Maciag, Michelle C., O’Neill, Allison, Pepper, Amber N., Permaul, Perdita, Pugh, Mya, Queheillalt, Dianna, Saroya, Tarnjot, Sheehan, William, Smith, Catherine, Socolovsky, Carmela, Treffeisen, Else, Trippa, Lorenzo, Tulchinsky, Abigail, Yee, Christina, Carter, Tina, Fu, Jun, Garcia, Vanessa, Hixon, Jenny, Jackson, Carly, Ji, Yuan, Kalhan, Ravi, Kaur, Opinderjit, Li, Grace, Makhija, Melanie M., Maleckar, Spring, Naureckas, Edward T., Peters, Anju T., Press, Valerie, Qureshi, Mehreen, Reyfman, Paul A., Rosenberg, Sharon R., Ryba, Dominika, Sheng, Jianrong, Xu, Ben, Alam, Rafeul, Anderson, Darci, Belimezova, Sonya, Bitzan, Jennifer, Chupp, Geoffrey, Clark, Brian J., Cohn, Lauren, Cruse, Margaret Hope, Estrom, Jean, Freid, Leah, Villalobos, Jose Gomez, Grant, Nicole, Guntur, Vamsi P., Holm, Carole, Kolakowski, Christena, Manka, Laurie A., Miyazawa, Naomi, Pak, Juno, Pruitt, Diana M., Sharma, Sunita, Stevens, Allen D., Thomas, Kisori, Tippin, Brooke, Valente, Karissa, Wainscoat, Cynthia L., White, Michael P., Winnica, Daniel, Ye, Shuyu, Zeitlin, Pamela L., Bach, Julia, Brownell, Joshua, Castro, Lauren, DeLisa, Julie, Fain, Sean B., Fichtinger, Paul S., Floerke, Heather, Gern, James E., Goswamy, Vinay, Grogan, Jenelle, Hasse, Wendy, Kelley, Rick L., Klaus, Danika, LaBedz, Stephanie, Lowell, Paige, Maddox, Andrew, Mathur, Sameer K., McIntyre, Amanda, Norwick, Lourdes M., Nyenhuis, Sharmilee M., O’Brien, Matthew J., Palas, Tina, Pappalardo, Andrea A., Potter, Mark, Ramratnam, Sima K., Rosenberg, Daniel L., Schauberger, Eric M., Schiebler, Mark L., Schraml, Angela, Sorkness, Ronald L., Taki, Mohamed, Tattersall, Matthew C., Torres, Jissell, Wollet, Lori, Abi-Saleh, Simon, Bendy, Lisa, Borish, Larry, Chmiel, James F., Dix, Aska, France, Lisa, Gammell, Rebecca, Gluvna, Adam, Hirth, Brittany, Hu, Bo, Hyser, Elise, Kloepfer, Kirsten M., Koo, Michelle, Krupp, Nadia L., Labadia, Monica, Lawrence, Joy, Logan, Laurie, Marko, Angela, Matuska, Brittany, Murphy, Deborah, Owensby, Rachel, Roesch, Erica A., Sanders, Don B., Sharp, Jackie, Teague, W. Gerald, Veri, Laura, Shifflett, Kristin Wavell, Camiolo, Matt, Collins, Sarah, Demas, Jessa, Elvin, Courtney, Gauthier, Marc C., Ilnicki, Melissa, Ingram, Jenn, Lane, Lisa, Nouraie, Seyed Mehdi, Trudeau, John B., Zhang, Michael, Barry, Jeffrey, Brickner, Howard, Celso, Janelle, Cernelc-Kohan, Matejka, Diaz, Damaris, Du, Ashley, Jain, Sonia, Liu, Neiman, Nazir, Yusife, Ryu, Julie, Vijayanand, Pandurangan, Almario, Rogelio, Baum, Ariana, Brown, Kellen, Chan, Marilynn H., Gale, Barbara, Haczku, Angela, Harper, Richart W., Heromin, Raymond, Kivler, Celeste, Kuhn, Brooks T., Ly, Ngoc P., McCourt, Paula, Orain, Xavier, Plough, Audrey, Ramirez, Karla, Roberts, Ellese, Schivo, Michael, Singapuri, Amisha, Tham, Tina, Tompkins, Daniel, Twitmyer, Patricia Michelle, Vi, Jade, Atha, Jarron, Bedard, Jennifer, Boomer, Jonathan S., Chung, Andrew, Curtis, Vanessa, Hall, Chase S., Hart, Emily, Jackson, Fatima, Kemp, Pamela, Maxwell, Sharli, Messplay, Maggie, Ramirez, Crystal, Thompson, Brynne, Britt, Ashley, Bryan, Hope, Gotman, Nathan M., Jiang, Yue, Kosorok, Michael R., Mauger, David T., Meekins, Kelsey, Mollenhauer, Jeanette K., Moody, Sarah, Ritz, Cheyanne, Schwartz, Stefanie, Thomlinson, Chalmer, Wilson, Nicole, Georas, Steve N., Wright, Rosalind J., Ivanova, Anastasia, Israel, Elliot, LaVange, Lisa M., Akuthota, Praveen, Carr, Tara F., Denlinger, Loren C., Fajt, Merritt L., Kumar, Rajesh, O’Neal, Wanda K., Phipatanakul, Wanda, Szefler, Stanley J., Aronica, Mark A., Bacharier, Leonard B., Burbank, Allison J., Castro, Mario, Crotty Alexander, Laura, Bamdad, Julie, Cardet, Juan Carlos, Comhair, Suzy A.A., Covar, Ronina A., DiMango, Emily A., Erwin, Kim, Erzurum, Serpil C., Fahy, John V., Gaffin, Jonathan M., Gaston, Benjamin, Gerald, Lynn B., Hoffman, Eric A., Holguin, Fernando, Jackson, Daniel J., James, John, Jarjour, Nizar N., Kenyon, Nicholas J., Khatri, Sumita, Kirwan, John P., Kraft, Monica, Krishnan, Jerry A., Liu, Andrew H., Liu, Mark C., Marquis, M. Alison, Martinez, Fernando, Mey, Jacob, Moore, Wendy C., Moy, James N., Ortega, Victor E., Peden, David B., Pennington, Emily, Peters, Michael C., Ross, Kristie, Sanchez, Maria, Smith, Lewis J., Wechsler, Michael E., Wenzel, Sally E., White, Steven R., Zein, Joe, Zeki, Amir A., Noel, Patricia

Source: In The Journal of Allergy and Clinical Immunology February 2022 149(2):488-516

Intranasal Corticosteroids Are Associated with Better Outcomes in Coronavirus Disease 2019

Authors: Strauss, Ronald, Jawhari, Nesreen, Attaway, Amy H., Hu, Bo, Jehi, Lara, Milinovich, Alex, Ortega, Victor E., Zein, Joe G.

Source: In The Journal of Allergy and Clinical Immunology: In Practice November 2021 9(11):3934-3940

Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program

Authors: Mikhaylova, Anna V., McHugh, Caitlin P., Polfus, Linda M., Raffield, Laura M., Boorgula, Meher Preethi, Blackwell, Thomas W., Brody, Jennifer A., Broome, Jai, Chami, Nathalie, Chen, Ming-Huei, Conomos, Matthew P., Cox, Corey, Curran, Joanne E., Daya, Michelle, Ekunwe, Lynette, Glahn, David C., Heard-Costa, Nancy, Highland, Heather M., Hobbs, Brian D., Ilboudo, Yann, Jain, Deepti, Lange, Leslie A., Miller-Fleming, Tyne W., Min, Nancy, Moon, Jee-Young, Preuss, Michael H., Rosen, Jonathon, Ryan, Kathleen, Smith, Albert V., Sun, Quan, Surendran, Praveen, de Vries, Paul S., Walter, Klaudia, Wang, Zhe, Wheeler, Marsha, Yanek, Lisa R., Zhong, Xue, Abecasis, Goncalo R., Almasy, Laura, Barnes, Kathleen C., Beaty, Terri H., Becker, Lewis C., Blangero, John, Boerwinkle, Eric, Butterworth, Adam S., Chavan, Sameer, Cho, Michael H., Choquet, Hélène, Correa, Adolfo, Cox, Nancy, DeMeo, Dawn L., Faraday, Nauder, Fornage, Myriam, Gerszten, Robert E., Hou, Lifang, Johnson, Andrew D., Jorgenson, Eric, Kaplan, Robert, Kooperberg, Charles, Kundu, Kousik, Laurie, Cecelia A., Lettre, Guillaume, Lewis, Joshua P., Li, Bingshan, Li, Yun, Lloyd-Jones, Donald M., Loos, Ruth J.F., Manichaikul, Ani, Meyers, Deborah A., Mitchell, Braxton D., Morrison, Alanna C., Ngo, Debby, Nickerson, Deborah A., Nongmaithem, Suraj, North, Kari E., O’Connell, Jeffrey R., Ortega, Victor E., Pankratz, Nathan, Perry, James A., Psaty, Bruce M., Rich, Stephen S., Soranzo, Nicole, Rotter, Jerome I., Silverman, Edwin K., Smith, Nicholas L., Tang, Hua, Tracy, Russell P., Thornton, Timothy A., Vasan, Ramachandran S., Zein, Joe, Mathias, Rasika A., Reiner, Alexander P., Auer, Paul L.

Source: In The American Journal of Human Genetics 7 October 2021 108(10):1836-1851

Comparison of whole genome sequencing and targeted sequencing for mitochondrial DNA

Authors: Chen, Ruoying, Aldred, Micheala A, Xu, Weiling, Zein, Joe, Bazeley, Peter, Comhair, Suzy A.A, Meyers, Deborah A., Bleecker, Eugene R., Liu, Chunyu, Erzurum, Serpil C., Hu, Bo

Source: In Mitochondrion May 2021 58:303-310

Novel Machine Learning Can Predict Acute Asthma Exacerbation

Authors: Zein, Joe G., Wu, Chao-Ping, Attaway, Amy H., Zhang, Peng, Nazha, Aziz

Source: In Chest May 2021 159(5):1747-1757

Diabetes Mellitus Is Associated with Worse Outcome in Patients Hospitalized for Asthma

Authors: Zhang, Peng, Lopez, Rocio, Attaway, Amy H., Georas, Steve N., Khatri, Sumita B., Abi-Saleh, Simon, Zein, Joe G.

Source: In The Journal of Allergy and Clinical Immunology: In Practice April 2021 9(4):1562-1569

Asthma innovations from the second International Collaborative Asthma Network (ICAN) forum.

Authors: Jarjour, Nizar N., Winders, Tonya, Hansen, Ann M., Akuthota, Praveen, Chung, Kian Fan, Durrington, Hannah, Fowler, Stephen J., Gaston, Benjamin, Mendonca, Eneida A., Siddiqui, Salman, Walker, Samantha, Zein, Joe, Djukanovic, Ratko

Source: Journal of Asthma; Feb2025, Vol. 62 Issue 2, p185-188, 4p

Subject Terms: ASTHMATICS, CIRCADIAN rhythms, ASTHMA, MEETING planning, RESEARCH methodology

Skeletal muscle loss phenotype in cirrhosis: A nationwide analysis of hospitalized patients

Authors: Vural, Adil, Attaway, Amy, Welch, Nicole, Zein, Joe, Dasarathy, Srinivasan

Source: In Clinical Nutrition December 2020 39(12):3711-3720

SARS-CoV-2 infection in the COPD population is associated with increased healthcare utilization: An analysis of Cleveland clinic's COVID-19 registry

Authors: Attaway, Amy A, Zein, Joe, Hatipoğlu, Umur S

Source: In EClinicalMedicine September 2020 26

HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma

Authors: Zein, Joe, Gaston, Benjamin, Bazeley, Peter, DeBoer, Mark D., Igo, Robert P., Bleecker, Eugene R., Meyers, Deborah, Comhair, Suzy, Marozkina, Nadzeya V., Cotton, Calvin, Patel, Mona, Alyamani, Mohammad, Xu, Weiling, Busse, William W., Calhoun, William J., Ortega, Victor, Hawkins, Gregory A., Castro, Mario, Chung, Kian Fan, Fahy, John V., Fitzpatrick, Anne M., Israel, Elliot, Jarjour, Nizar N., Levy, Bruce, Mauger, David T., Moore, Wendy C., Noel, Patricia, Peters, Stephen P., Teague, W. Gerald, Wenzel, Sally E., Erzurum, Serpil C., Sharifi, Nima

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Jan . 117(4), 2187-2193.

Access URL: https://www.jstor.org/stable/26897818

Association between orchiectomy and asthma: Insights from 2 population-based cohorts

Authors: Fakhry, Battoul ^a, Chedraoui, Celine ^a, Sleiman, Joelle ^a, Attaway, Amy ^a, Kim, Hyun Jo ^b, Zein, Joe G. ^{c, ∗}

Source: In Journal of Allergy and Clinical Immunology: Global May 2025 4(2)

Development and initial validation of the Asthma Severity Scoring System (ASSESS)

Authors: Fitzpatrick, Anne M., Szefler, Stanley J., Mauger, David T., Phillips, Brenda R., Denlinger, Loren C., Moore, Wendy C., Sorkness, Ronald L., Wenzel, Sally E., Gergen, Peter J., Bleecker, Eugene R., Castro, Mario, Erzurum, Serpil C., Fahy, John V., Gaston, Benjamin M., Israel, Elliot, Levy, Bruce D., Meyers, Deborah A., Teague, W.Gerald, Bacharier, Leonard B., Ly, Ngoc P., Phipatanakul, Wanda, Ross, Kristie R., Zein, Joe, Jarjour, Nizar N.

Source: In The Journal of Allergy and Clinical Immunology January 2020 145(1):127-139

Severe asthma during childhood and adolescence: A longitudinal study

Authors: Ross, Kristie R., Gupta, Ritika, DeBoer, Mark D., Zein, Joe, Phillips, Brenda R., Mauger, David T., Li, Chun, Myers, Ross E., Phipatanakul, Wanda, Fitzpatrick, Anne M., Ly, Ngoc P., Bacharier, Leonard B., Jackson, Daniel J., Celedón, Juan C., Larkin, Allyson, Israel, Elliot, Levy, Bruce, Fahy, John V., Castro, Mario, Bleecker, Eugene R., Meyers, Deborah, Moore, Wendy C., Wenzel, Sally E., Jarjour, Nizar N., Erzurum, Serpil C., Teague, W.Gerald, Gaston, Benjamin

Source: In The Journal of Allergy and Clinical Immunology January 2020 145(1):140-146