Targeted amplicon deep sequencing of ama1 and mdr1 to track within-host P. falciparum diversity throughout treatment in a clinical drug trial [version 4; peer review: 2 approved, 2 approved with reservations]

Authors: Mainga Hamaluba, Juliana Wambua, Arjen M. Dondorp, Jennifer Musyoki, Caroline Ngetsa, Oksana Kharabora, Leonard Ndwiga, Zaydah de Laurent, Kevin Wamae, Kelvin Kimenyi, Gabriel Mwambingu, Peter Kalume, Philip Bejon, Jeffrey Bailey, Rob van der Pluijm, Lynette Ochola-Oyier, Jonathan Juliano, Victor Osoti

Source: Wellcome Open Research, Vol 7 (2024)

Subject Terms: Artemisinin-based combination therapy, pfama1, Pfmdr1, artemisinin resistance, antimalarial resistance, targeted deep sequencing, eng, Medicine, Science

File Description: electronic resource

Relation: https://wellcomeopenresearch.org/articles/7-95/v4; https://doaj.org/toc/2398-502X

Access URL: https://doaj.org/article/54f1bc978ccb46b1ae6ec30ff6a0a2bd

Targeted amplicon deep sequencing of ama1 and mdr1 to track within-host P. falciparum diversity throughout treatment in a clinical drug trial [version 3; peer review: 2 approved, 2 approved with reservations]

Authors: Mainga Hamaluba, Juliana Wambua, Arjen M. Dondorp, Jennifer Musyoki, Caroline Ngetsa, Oksana Kharabora, Leonard Ndwiga, Zaydah de Laurent, Kevin Wamae, Kelvin Kimenyi, Gabriel Mwambingu, Peter Kalume, Philip Bejon, Jeffrey Bailey, Rob van der Pluijm, Lynette Ochola-Oyier, Jonathan Juliano, Victor Osoti

Source: Wellcome Open Research, Vol 7 (2023)

Subject Terms: Artemisinin-based combination therapy, pfama1, Pfmdr1, artemisinin resistance, antimalarial resistance, targeted deep sequencing, eng, Medicine, Science

File Description: electronic resource

Relation: https://wellcomeopenresearch.org/articles/7-95/v3; https://doaj.org/toc/2398-502X

Access URL: https://doaj.org/article/7c572512032142968047eeeffce301e6

Targeted amplicon deep sequencing of ama1 and mdr1 to track within-host P. falciparum diversity throughout treatment in a clinical drug trial [version 2; peer review: 2 approved, 1 approved with reservations]

Authors: Mainga Hamaluba, Juliana Wambua, Arjen M. Dondorp, Jennifer Musyoki, Caroline Ngetsa, Oksana Kharabora, Leonard Ndwiga, Zaydah de Laurent, Kevin Wamae, Kelvin Kimenyi, Gabriel Mwambingu, Peter Kalume, Philip Bejon, Jeffrey Bailey, Rob van der Pluijm, Lynette Ochola-Oyier, Jonathan Juliano, Victor Osoti

Source: Wellcome Open Research, Vol 7 (2022)

Subject Terms: Artemisinin-based combination therapy, pfama1, Pfmdr1, artemisinin resistance, antimalarial resistance, targeted deep sequencing, eng, Medicine, Science

File Description: electronic resource

Relation: https://wellcomeopenresearch.org/articles/7-95/v2; https://doaj.org/toc/2398-502X

Access URL: https://doaj.org/article/6bd7502636b44e8791a08344545ed43c

Breadth of Antibodies to Plasmodium falciparum Variant Surface Antigens Is Associated With Immunity in a Controlled Human Malaria Infection Study

Authors: Hannah W. Kimingi, Ann W. Kinyua, Nicole A. Achieng, Kennedy M. Wambui, Shaban Mwangi, Roselyne Nguti, Cheryl A. Kivisi, Anja T. R. Jensen, Philip Bejon, Melisa C. Kapulu, Abdirahman I. Abdi, Samson M. Kinyanjui, CHMI-SIKA Study Team, Abdirahman I Abdi, Yonas Abebe, Agnes Audi, Peter Billingsley, Peter C Bull, Primus Che, Zaydah de Laurent, Susanne H Hodgson, Stephen Hoffman, Eric James, Irene Jao, Dorcas Kamuya, Gathoni Kamuyu, Silvia Kariuki, Nelson Kibinge, Sam Kinyanjui, Cheryl Kivisi, Nelly Koskei, Mallika Imwong, Brett Lowe, Johnstone Makale, Kevin Marsh, Vicki Marsh, Khadija Said Mohammed, Moses Mosobo, Sean C Murphy, Jennifer Musyoki, Michelle Muthui, Jedidah Mwacharo, Daniel Mwanga, Joyce Mwongeli, Francis Ndungu, Maureen Njue, George Nyangweso, Domitila Kimani, Joyce M. Ngoi, Janet Musembi, Omar Ngoto, Edward Otieno, Bernhards Ogutu, Fredrick Olewe, James Oloo, Donwilliams Omuoyo, John Ongecha, Martin O Ongas, Michael Ooko, Jimmy Shangala, Betty Kim Lee Sim, Joel Tarning, Juliana Wambua, Thomas N Williams, Markus Winterberg

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: malaria, Plasmodium falciparum, CHMI, variant surface antigens, anti-VSA antibodies, antibody breadth, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.894770/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/330b0f288975431b9dc0453fdfdfcfe9

Enrichment approach for unbiased sequencing of respiratory syncytial virus directly from clinical samples [version 1; peer review: 2 approved]

Authors: Everlyn Kamau, Martin Mutunga, Zaydah de Laurent, Johnson Kinyua, George Githinji, Caleb Kibet, Charles Sande, D. James Nokes, Elijah Gicheru, Khadija Said Mohammed, Jacqueline Wahura Waweru

Source: Wellcome Open Research, Vol 6 (2021)

Subject Terms: metagenomics, sequencing, SISPA, RSV, centrifugal processing, Endoh primers, eng, Medicine, Science

File Description: electronic resource

Relation: https://wellcomeopenresearch.org/articles/6-99/v1; https://doaj.org/toc/2398-502X

Access URL: https://doaj.org/article/70d9efc3f19f41d3afd9e8d301075257