Comprehensive Analysis of Hypermutation in Human Cancer

Authors: Campbell, Brittany B., Light, Nicholas, Fabrizio, David, Zatzman, Matthew, Fuligni, Fabio, de Borja, Richard, Davidson, Scott, Edwards, Melissa, Elvin, Julia A., Hodel, Karl P., Zahurancik, Walter J., Suo, Zucai, Lipman, Tatiana, Wimmer, Katharina, Kratz, Christian P., Bowers, Daniel C., Laetsch, Theodore W., Dunn, Gavin P., Johanns, Tanner M., Grimmer, Matthew R., Smirnov, Ivan V., Larouche, Valérie, Samuel, David, Bronsema, Annika, Osborn, Michael, Stearns, Duncan, Raman, Pichai, Cole, Kristina A., Storm, Phillip B., Yalon, Michal, Opocher, Enrico, Mason, Gary, Thomas, Gregory A., Sabel, Magnus, George, Ben, Ziegler, David S., Lindhorst, Scott, Issai, Vanan Magimairajan, Constantini, Shlomi, Toledano, Helen, Elhasid, Ronit, Farah, Roula, Dvir, Rina, Dirks, Peter, Huang, Annie, Galati, Melissa A., Chung, Jiil, Ramaswamy, Vijay, Irwin, Meredith S., Aronson, Melyssa, Durno, Carol, Taylor, Michael D., Rechavi, Gideon, Maris, John M., Bouffet, Eric, Hawkins, Cynthia, Costello, Joseph F., Meyn, M. Stephen, Pursell, Zachary F., Malkin, David, Tabori, Uri, Shlien, Adam

Source: In Cell 16 November 2017 171(5):1042-1056

Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis.

Authors: Light, Nicholas, Layeghifard, Mehdi, Attery, Ayush, Subasri, Vallijah, Zatzman, Matthew, Anderson, Nathaniel D., Hatkar, Rupal, Blay, Sasha, Chen, David, Novokmet, Ana, Fuligni, Fabio, Tran, James, de Borja, Richard, Agarwal, Himanshi, Waldman, Larissa, Abegglen, Lisa M., Albertson, Daniel, Finlay, Jonathan L., Hansford, Jordan R., Behjati, Sam

Source: Nature Communications; 1/5/2023, Vol. 14 Issue 1, p1-12, 12p

Subject Terms: SOMATIC mutation, TUMOR diagnosis, GERM cells, HEREDITARY cancer syndromes, PI3K/AKT pathway, DNA copy number variations, NUCLEOTIDE sequencing, HETEROZYGOSITY

Widespread hypertranscription in aggressive human cancers.

Authors: Zatzman, Matthew^1,2, Fuligni, Fabio², Ripsman, Ryan², Suwal, Tannu^1,3, Comitani, Federico², Edward, Lisa-Monique², Denroche, Rob⁴, Gun Ho Jang⁴, Notta, Faiyaz⁴, Gallinger, Steven^4,5,6,7, Selvanathan, Saravana P.⁸, Toretsky, Jeffrey A.⁸, Hellmann, Matthew D.^9,10, Tabori, Uri^2,3,11, Huang, Annie^1,3,12, Shlien, Adam^1,2,13 adam.shlien@sickkids.ca

Source: Science Advances. 11/25/2022, Vol. 8 Issue 47, p1-18. 18p.

Subject Terms: *GENE expression, *P53 antioncogene, *BREAST, *PROLIFERATING cell nuclear antigen

Resolving driver events in MLL-r negative high-risk infant ALL.

Authors: Seelisch, Jennifer, Zatzman, Matthew, Comitani, Federico, Fuligni, Fabio, Brunga, Ledia, Brown, Patrick A., Shlien, Adam, Gupta, Sumit

Source: Journal of clinical oncology. 39(15 suppl):10030-10030

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100173226441.0x000001&indx=1&recIds=ETOCvdc_100173226441.0x000001

Single-cell chromatin accessibility reveals malignant regulatory programs in primary human cancers.

Authors: Sundaram, Laksshman, lakss@stanford.edu, Kumar, Arvind, Zatzman, Matthew, Salcedo, Adriana, Ravindra, Neal, Shams, Shadi, Louie, Brian H., Bagdatli, S. Tansu, Myers, Matthew A., Sarmashghi, Shahab, Hyo Young Choi, Won-Young Choi, Yost, Kathryn E., Yanding Zhao, Granja, Jeffrey M., Hinoue, Toshinori, Hayes, D. Neil, Cherniack, Andrew, Felau, Ina, Choudhry, Hani

Source: Science; 9/6/2024, Vol. 385 Issue 6713, p1060-1060, 1p, 1 Diagram

Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival.

Authors: Anderson, Nathaniel D., Babichev, Yael, Fuligni, Fabio, Comitani, Federico, Layeghifard, Mehdi, Venier, Rosemarie E., Dentro, Stefan C., Maheshwari, Anant, Guram, Sheena, Wunker, Claire, Thompson, J. Drew, Yuki, Kyoko E., Hou, Huayun, Zatzman, Matthew, Light, Nicholas, Bernardini, Marcus Q., Wunder, Jay S., Andrulis, Irene L., Ferguson, Peter, Razak, Albiruni R. Abdul

Source: Nature Communications; 7/23/2021, Vol. 12 Issue 1, p1-14, 14p

Subject Terms: DIAGNOSIS, LEIOMYOSARCOMA, THERAPEUTICS, SMOOTH muscle, DNA damage, MOLECULAR cloning

Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency

Authors: Das, Anirban, Sudhaman, Sumedha, Morgenstern, Daniel, Coblentz, Ailish, Chung, Jiil, Stone, Simone C., Alsafwani, Noor, Liu, Zhihui Amy, Karsaneh, Ola Abu Al, Soleimani, Shirin, Ladany, Hagay, Chen, David, Zatzman, Matthew, Cabric, Vanja, Nobre, Liana, Bianchi, Vanessa, Edwards, Melissa, C, Lauren, Nahum, Sambira, Ercan, Ayse B., Nabbi, Arash, Constantini, Shlomi, Dvir, Rina, Yalon-Oren, Michal, Campino, Gadi Abebe, Caspi, Shani, Larouche, Valerie, Reddy, Alyssa, Osborn, Michael, Mason, Gary, Lindhorst, Scott, Bronsema, Annika, Magimairajan, Vanan, Opocher, Enrico, De Mola, Rebecca Loret, Sabel, Magnus, Frojd, Charlotta, Sumerauer, David, Samuel, David, Cole, Kristina, Chiaravalli, Stefano, Massimino, Maura, Tomboc, Patrick, Ziegler, David S., George, Ben, Van Damme, An, Hijiya, Nobuko, Gass, David, McGee, Rose B., Mordechai, Oz, Bowers, Daniel C., Laetsch, Theodore W., Lossos, Alexander, Blumenthal, Deborah T., Sarosiek, Tomasz, Yen, Lee Yi, Knipstein, Jeffrey, Bendel, Anne, Hoffman, Lindsey M., Luna-Fineman, Sandra, Zimmermann, Stefanie, Scheers, Isabelle, Nichols, Kim E., Zapotocky, Michal, Hansford, Jordan R., Maris, John M., Dirks, Peter, Taylor, Michael D., Kulkarni, Abhaya V., Shroff, Manohar, Tsang, Derek S., Villani, Anita, Xu, Wei, Aronson, Melyssa, Durno, Carol, Shlien, Adam, Malkin, David, Getz, Gad, Maruvka, Yosef E., Ohashi, Pamela S., Hawkins, Cynthia, Pugh, Trevor J., Bouffet, Eric, Tabori, Uri

Source: Nature Medicine; 20220101, Issue: Preprints p1-11, 11p