Discovery of Small Molecules that Bind to Son of Sevenless 2 (SOS2).

Authors: Zak, Krzysztof M., Waterson, Alex G., Geist, Leonhard, Braun, Nina, Hauer, Katja, Rumpel, Klaus, Ramharter, Juergen, Stadtmueller, Heinz, Wolkerstorfer, Bernhard, Schoenbauer, David, Cui, Jianwen, Phan, Jason, Abbott, Jason R., Sarkar, Dhruba, Hodges, Timothy R., Arnold, Allison, Sensintaffar, John L., Fesik, Stephen W., Kessler, Dirk

Source: Journal of Medicinal Chemistry; 2/13/2025, Vol. 68 Issue 3, p2680-2693, 14p

NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems

Authors: Biebl, Maximilian M., Delhommel, Florent, Faust, Ofrah, Zak, Krzysztof M., Agam, Ganesh, Guo, Xiaoyan, Mühlhofer, Moritz, Dahiya, Vinay, Hillebrand, Daniela, Popowicz, Grzegorz M., Kampmann, Martin, Lamb, Don C., Rosenzweig, Rina, Sattler, Michael, Buchner, Johannes

Source: In Molecular Cell 3 February 2022 82(3):555-569

Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia

Authors: Zak, Krzysztof M., Bostock, Mark J., Waligorska, Irena, Thøgersen, Ida B., Enghild, Jan J., Popowicz, Grzegorz M., Grudnik, Przemyslaw, Potempa, Jan, Ksiazek, Miroslaw

Source: Journal of enzyme inhibition and medicinal chemistry. 36(1):1267-1281

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138859611.0x000001&indx=1&recIds=ETOCvdc_100138859611.0x000001

Structure and characterization of Aspergillus fumigatus lipase B with a unique, oversized regulatory subdomain

Authors: Huang, Weiqian, Lan, Dongming, Popowicz, Grzegorz M., Zak, Krzysztof M., Zhao, Zexin, Yuan, Hong, Yang, Bo, Wang, Yonghua

Source: FEBS journal. 286(12):2366-2380

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100084043993.0x000001&indx=1&recIds=ETOCvdc_100084043993.0x000001

Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2

Authors: Zak, Krzysztof M., Grudnik, Przemyslaw, Magiera, Katarzyna, Dömling, Alexander, Dubin, Grzegorz, Holak, Tad A.

Source: In Structure 1 August 2017 25(8):1163-1174

A ligand discovery toolbox for the WWE domain family of human E3 ligases.

Authors: Münzker, Lena, Kimani, Serah W., Fowkes, Milan M., Dong, Aiping, Zheng, Hong, Li, Yanjun, Dasovich, Morgan, Zak, Krzysztof M., Leung, Anthony K. L., Elkins, Jonathan M., Kessler, Dirk, Arrowsmith, Cheryl H., Halabelian, Levon, Böttcher, Jark

Source: Communications Biology; 7/24/2024, Vol. 7 Issue 1, p1-15, 15p

Subject Terms: UBIQUITIN ligases, LIGASES, BINDING site assay, SMALL molecules

Chasing Red Herrings: Palladium Metal Salt Impurities Feigning KRAS Activity in Biochemical Assays.

Authors: Gerstberger, Thomas, Berger, Helmut, Büttner, Frank H., Gmachl, Michael, Kessler, Dirk, Koegl, Manfred, Lucas, Simon, Martin, Laetitia J., Mayer, Moriz, McConnell, Darryl B., Mitzner, Sophie, Scholz, Guido, Treu, Matthias, Wolkerstorfer, Bernhard, Zahn, Stephan, Zak, Krzysztof M., Jaeger, Philipp A., Ettmayer, Peter

Source: Journal of Medicinal Chemistry; 7/25/2024, Vol. 67 Issue 14, p11701-11711, 11p

Ligandability assessment of the C‐terminal Rel‐homology domain of NFAT1.

Authors: Böttcher, Jark, Fuchs, Julian E., Mayer, Moriz, Kahmann, Jan, Zak, Krzysztof M., Wunberg, Tobias, Woehrle, Simon, Kessler, Dirk

Source: Archiv der Pharmazie; Jun2024, Vol. 357 Issue 6, p1-7, 7p

Modulation of peroxisomal import by the PEX13 SH3 domain and a proximal FxxxF binding motif.

Authors: Gaussmann, Stefan, Peschel, Rebecca, Ott, Julia, Zak, Krzysztof M., Sastre, Judit, Delhommel, Florent, Popowicz, Grzegorz M., Boekhoven, Job, Schliebs, Wolfgang, Erdmann, Ralf, Sattler, Michael

Source: Nature Communications; 4/18/2024, Vol. 15 Issue 1, p1-17, 17p

Subject Terms: PEPTIDES, PEROXISOMES, CRYSTAL structure

Bioactive Macrocyclic Inhibitors of the PD‐1/PD‐L1 Immune Checkpoint

Authors: Magiera‐Mularz, Katarzyna, Skalniak, Lukasz, Zak, Krzysztof M., Musielak, Bogdan, Rudzinska‐Szostak, Ewa, Berlicki, Łukasz, Kocik, Justyna, Grudnik, Przemyslaw, Sala, Dominik, Zarganes‐Tzitzikas, Tryfon, Shaabani, Shabnam, Dömling, Alexander, Dubin, Grzegorz, Holak, Tad A.

Source: Angewandte Chemie. 129(44):13920-13923

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191684291.0x000001&indx=1&recIds=ETOCvdc_100191684291.0x000001

A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction

Authors: Surmiak, Ewa, Twarda-Clapa, Aleksandra, Zak, Krzysztof M., Musielak, Bogdan, Tomala, Marcin D., Kubica, Katarzyna, Grudnik, Przemyslaw, Madej, Mariusz, Jablonski, Mateusz, Potempa, Jan

Source: ACS chemical biology. 11(12):3310-3318

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN609312310&indx=1&recIds=ETOCRN609312310

2, 3′-Bis(1′H-indole) heterocycles: New p53/MDM2/MDMX antagonists

Authors: Neochoritis, Constantinos G., Wang, Kan, Estrada-Ortiz, Natalia, Herdtweck, Eberhardt, Kubica, Katarzyna, Twarda, Aleksandra, Zak, Krzysztof M., Holak, Tad A., Dömling, Alexander

Source: Bioorganic & medicinal chemistry letters. 25(24):5661-5666

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100141519908.0x000001&indx=1&recIds=ETOCvdc_100141519908.0x000001

Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1

Authors: Zak, Krzysztof M., Kitel, Radoslaw, Przetocka, Sara, Golik, Przemyslaw, Guzik, Katarzyna, Musielak, Bogdan, Dömling, Alexander, Dubin, Grzegorz, Holak, Tad A.

Source: STRUCTURE -CAMBRIDGE MASSACHUSETTS. 23(12):2341-2348

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100064173289.0x000001&indx=1&recIds=ETOCvdc_100064173289.0x000001

Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders.

Authors: Wątor, Elżbieta, Wilk, Piotr, Biela, Artur, Rawski, Michał, Zak, Krzysztof M., Steinchen, Wieland, Bange, Gert, Glatt, Sebastian, Grudnik, Przemysław

Source: Nature Communications; 3/27/2023, Vol. 14 Issue 1, p1-14, 14p

Subject Terms: NEURODEGENERATION, POST-translational modification, POLYPROLINE, CRYSTAL structure, MOLECULAR spectroscopy, HUMAN beings, X-ray crystallography

Bis-choline tetrathiomolybdate prevents copper-induced blood-brain barrier damage.

Authors: Borchard, Sabine, Raschke, Stefanie, Zak, Krzysztof M., Eberhagen, Carola, Einer, Claudia, Weber, Elisabeth, Müller, Sandra M., Michalke, Bernhard, Lichtmannegger, Josef, Wieser, Albrecht, Rieder, Tamara, Popowicz, Grzegorz M., Adamski, Jerzy, Klingenspor, Martin, Coles, Andrew H., Viana, Ruth, Vendelbo, Mikkel H., Sandahl, Thomas D., Schwerdtle, Tanja, Plitz, Thomas

Source: Life Science Alliance; Mar2022, Vol. 5 Issue 3, p1-16, 16p

2,3′-Bis(1′H-indole) heterocycles: New p53/MDM2/MDMX antagonists

Authors: Neochoritis, Constantinos G., Wang, Kan, Estrada-Ortiz, Natalia, Herdtweck, Eberhardt, Kubica, Katarzyna, Twarda, Aleksandra, Zak, Krzysztof M., Holak, Tad A., Dömling, Alexander

Source: In Bioorganic & Medicinal Chemistry Letters 15 December 2015 25(24):5661-5666

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Crystal Structure of Kluyveromyces lactis Glucokinase (KlGlk1).

Authors: Zak, Krzysztof M.^1,2 (AUTHOR) guta@friend.pl, Kalińska, Magdalena² (AUTHOR) elkon.wator@gmail.com, Wątor, Elżbieta² (AUTHOR) kuska.kk@gmail.com, Kuśka, Katarzyna^2,3 (AUTHOR) rostyslav.krutyholova@gmail.com, Krutyhołowa, Rościsław^2,3 (AUTHOR) grzegorz.dubin@uj.edu.pl, Dubin, Grzegorz^2,3 (AUTHOR), Popowicz, Grzegorz M.^1,4 (AUTHOR) grzegorz.popowicz@helmholtz-muenchen.de, Grudnik, Przemysław² (AUTHOR) przemyslaw.grudnik@uj.edu.pl

Source: International Journal of Molecular Sciences. Oct2019, Vol. 20 Issue 19, p4821. 1p.

Subject Terms: *KLUYVEROMYCES marxianus, *GLUCOKINASE, *ENZYME specificity, *CRYSTAL structure, *ADENOSINE diphosphate, *ENZYME kinetics