Characterizing the genetic architecture of drug response using gene-context interaction methods

Authors: Sadowski, Michal, Thompson, Mike, Mefford, Joel, Haldar, Tanushree, Oni-Orisan, Akinyemi, Border, Richard, Pazokitoroudi, Ali, Cai, Na, Ayroles, Julien F., Sankararaman, Sriram, Dahl, Andy W., Zaitlen, Noah

Source: In Cell Genomics 11 December 2024 4(12)

Local genetic correlation via knockoffs reduces confounding due to cross-trait assortative mating

Authors: Ma, Shiyang, Wang, Fan, Border, Richard, Buxbaum, Joseph, Zaitlen, Noah, Ionita-Laza, Iuliana

Source: In The American Journal of Human Genetics 5 December 2024 111(12):2839-2848

Genetic liability estimated from large-scale family data improves genetic prediction, risk score profiling, and gene mapping for major depression

Authors: Dybdahl Krebs, Morten ^{1, 2, ∗}, Georgii Hellberg, Kajsa-Lotta ^{1, 2}, Lundberg, Mischa ^{1, 2}, Appadurai, Vivek ^{1, 2}, Ohlsson, Henrik ³, Pedersen, Emil ⁴, Steinbach, Jette ⁴, Matthews, Jamie ⁵, Border, Richard ⁵, LaBianca, Sonja ^{1, 2}, Calle, Xabier ^{1, 2}, Meijsen, Joeri J. ^{1, 2}, Ingason, Andrés ^{1, 2}, Buil, Alfonso ^{1, 2}, Vilhjálmsson, Bjarni J. ^{2, 4, 6}, Flint, Jonathan ⁷, Bacanu, Silviu-Alin ^{8, 9}, Cai, Na ¹⁰, Dahl, Andy ¹¹, Zaitlen, Noah ^{5, 12}, Werge, Thomas ^{1, 2}, Kendler, Kenneth S. ^{8, 9}, Schork, Andrew J. ^{1, 2, 13, ∗∗}

Source: In The American Journal of Human Genetics 7 November 2024 111(11):2494-2509

A scalable and robust variance components method reveals insights into the architecture of gene-environment interactions underlying complex traits

Authors: Pazokitoroudi, Ali, Liu, Zhengtong, Dahl, Andrew, Zaitlen, Noah, Rosset, Saharon, Sankararaman, Sriram

Source: In The American Journal of Human Genetics 11 July 2024 111(7):1462-1480

Cell-type deconvolution of bulk-blood RNA-seq reveals biological insights into neuropsychiatric disorders

Authors: Boltz, Toni, Schwarz, Tommer, Bot, Merel, Hou, Kangcheng, Caggiano, Christa, Lapinska, Sandra, Duan, Chenda, Boks, Marco P., Kahn, Rene S., Zaitlen, Noah, Pasaniuc, Bogdan, Ophoff, Roel

Source: In The American Journal of Human Genetics 1 February 2024 111(2):323-337

A comprehensive analysis of clinical and polygenic germline influences on somatic mutational burden

Authors: Taraszka, Kodi, Groha, Stefan, King, David, Tell, Robert, White, Kevin, Ziv, Elad, Zaitlen, Noah, Gusev, Alexander

Source: In The American Journal of Human Genetics 1 February 2024 111(2):242-258

Genotype error due to low-coverage sequencing induces uncertainty in polygenic scoring

Authors: Petter, Ella, Ding, Yi, Hou, Kangcheng, Bhattacharya, Arjun, Gusev, Alexander, Zaitlen, Noah, Pasaniuc, Bogdan

Source: In The American Journal of Human Genetics 3 August 2023 110(8):1319-1329

Multi-omic approach associates blood methylome with bronchodilator drug response in pediatric asthma

Authors: Perez-Garcia, Javier, Herrera-Luis, Esther, Li, Annie, Mak, Angel C.Y., Huntsman, Scott, Oh, Sam S., Elhawary, Jennifer R., Eng, Celeste, Beckman, Kenneth B., Hu, Donglei, Lorenzo-Diaz, Fabian, Lenoir, Michael A., Rodriguez-Santana, Jose, Zaitlen, Noah, Villar, Jesús, Borrell, Luisa N., Burchard, Esteban G., Pino-Yanes, Maria

Source: In The Journal of Allergy and Clinical Immunology June 2023 151(6):1503-1512

Ancestry-driven recalibration of tumor mutational burden and disparate clinical outcomes in response to immune checkpoint inhibitors

Authors: Nassar, Amin H., Adib, Elio, Abou Alaiwi, Sarah, El Zarif, Talal, Groha, Stefan, Akl, Elie W., Nuzzo, Pier Vitale, Mouhieddine, Tarek H., Perea-Chamblee, Tomin, Taraszka, Kodi, El-Khoury, Habib, Labban, Muhieddine, Fong, Christopher, Arora, Kanika S., Labaki, Chris, Xu, Wenxin, Sonpavde, Guru, Haddad, Robert I., Mouw, Kent W., Giannakis, Marios, Hodi, F. Stephen, Zaitlen, Noah, Schoenfeld, Adam J., Schultz, Nikolaus, Berger, Michael F., MacConaill, Laura E., Ananda, Guruprasad, Kwiatkowski, David J., Choueiri, Toni K., Schrag, Deborah, Carrot-Zhang, Jian, Gusev, Alexander

Source: In Cancer Cell 10 October 2022 40(10):1161-1172

A model and test for coordinated polygenic epistasis in complex traits

Authors: Sheppard, Brooke, Rappoport, Nadav, Loh, Po-Ru, Sanders, Stephan J., Zaitlen, Noah, Dahl, Andy

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Apr . 118(15), 1-11.

Access URL: https://www.jstor.org/stable/27040130

An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients

Authors: Phatnani, Hemali, Kwan, Justin, Sareen, Dhruv, Broach, James R., Simmons, Zachary, Arcila-Londono, Ximena, Lee, Edward B., Van Deerlin, Vivianna M., Shneider, Neil A., Fraenkel, Ernest, Ostrow, Lyle W., Baas, Frank, Zaitlen, Noah, Berry, James D., Malaspina, Andrea, Fratta, Pietro, Cox, Gregory A., Thompson, Leslie M., Finkbeiner, Steve, Dardiotis, Efthimios, Miller, Timothy M., Chandran, Siddharthan, Pal, Suvankar, Hornstein, Eran, MacGowan, Daniel J., Heiman-Patterson, Terry, Hammell, Molly G., Patsopoulos, Nikolaos.A., Butovsky, Oleg, Dubnau, Joshua, Nath, Avindra, Bowser, Robert, Harms, Matt, Poss, Mary, Phillips-Cremins, Jennifer, Crary, John, Atassi, Nazem, Lange, Dale J., Adams, Darius J., Stefanis, Leonidas, Gotkine, Marc, Baloh, Robert H., Babu, Suma, Raj, Towfique, Paganoni, Sabrina, Shalem, Ophir, Smith, Colin, Zhang, Bin, Harris, Brent, Broce, Iris, Drory, Vivian, Ravits, John, McMillan, Corey, Menon, Vilas, Wu, Lani, Altschuler, Steven, Li, Jonathan, Lim, Ryan G., Kaye, Julia A., Dardov, Victoria, Coyne, Alyssa N., Wu, Jie, Milani, Pamela, Cheng, Andrew, Thompson, Terri G., Ornelas, Loren, Frank, Aaron, Adam, Miriam, Banuelos, Maria G., Casale, Malcolm, Cox, Veerle, Escalante-Chong, Renan, Daigle, J. Gavin, Gomez, Emilda, Hayes, Lindsey, Holewenski, Ronald, Lei, Susan, Lenail, Alex, Lima, Leandro, Mandefro, Berhan, Matlock, Andrea, Panther, Lindsay, Patel-Murray, Natasha Leanna, Pham, Jacqueline, Ramamoorthy, Divya, Sachs, Karen, Shelley, Brandon, Stocksdale, Jennifer, Trost, Hannah, Wilhelm, Mark, Venkatraman, Vidya, Wassie, Brook T., Wyman, Stacia, Yang, Stephanie, Van Eyk, Jennifer E., Lloyd, Thomas E., Finkbeiner, Steven, Rothstein, Jeffrey D., Svendsen, Clive N.

Source: In iScience 19 November 2021 24(11)

Toward a fine-scale population health monitoring system

Authors: Belbin, Gillian M., Cullina, Sinead, Wenric, Stephane, Soper, Emily R., Glicksberg, Benjamin S., Torre, Denis, Moscati, Arden, Wojcik, Genevieve L., Shemirani, Ruhollah, Beckmann, Noam D., Cohain, Ariella, Sorokin, Elena P., Park, Danny S., Ambite, Jose-Luis, Ellis, Steve, Auton, Adam, Bottinger, Erwin P., Cho, Judy H., Loos, Ruth J.F., Abul-Husn, Noura S., Zaitlen, Noah A., Gignoux, Christopher R., Kenny, Eimear E.

Source: In Cell 15 April 2021 184(8):2068-2083

Disentangling selection on genetically correlated polygenic traits via whole-genome genealogies

Authors: Stern, Aaron J., Speidel, Leo, Zaitlen, Noah A., Nielsen, Rasmus

Source: In The American Journal of Human Genetics 4 February 2021 108(2):219-239

Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis

Authors: Adeleye, Adelani, Alba, Camille, Bacikova, Dagmar, Hupalo, Daniel N., Martinez, Elisa McGrath, Pollard, Harvey B., Sukumar, Gauthaman, Soltis, Anthony R., Tuck, Meila, Zhang, Xijun, Wilkerson, Matthew D., Smith, Bradley N., Ticozzi, Nicola, Fallini, Claudia, Gkazi, Athina Soragia, Topp, Simon D., Kost, Jason, Scotter, Emma L., Kenna, Kevin P., Miller, Jack W., Tiloca, Cinzia, Vance, Caroline, Danielson, Eric W., Troakes, Claire, Colombrita, Claudia, Al-Sarraj, Safa, Lewis, Elizabeth A., King, Andrew, Calini, Daniela, Pensato, Viviana, Castellotti, Barbara, de Belleroche, Jacqueline, Baas, Frank, ten Asbroek, Anneloor L.M.A., Sapp, Peter C., McKenna-Yasek, Diane, McLaughlin, Russell L., Polak, Meraida, Asress, Seneshaw, Esteban-Pérez, Jesús, Muñoz-Blanco, José Luis, Stevic, Zorica, D’Alfonso, Sandra, Mazzini, Letizia, Comi, Giacomo P., Del Bo, Roberto, Ceroni, Mauro, Gagliardi, Stella, Querin, Giorgia, Bertolin, Cinzia, van Rheenen, Wouter, Diekstra, Frank P., Rademakers, Rosa, van Blitterswijk, Marka, Boylan, Kevin B., Lauria, Giuseppe, Duga, Stefano, Corti, Stefania, Cereda, Cristina, Corrado, Lucia, Sorarù, Gianni, Williams, Kelly L., Nicholson, Garth A., Blair, Ian P., Leblond-Manry, Claire, Rouleau, Guy A., Hardiman, Orla, Morrison, Karen E., Veldink, Jan H., van den Berg, Leonard H., Al-Chalabi, Ammar, Pall, Hardev, Shaw, Pamela J., Turner, Martin R., Talbot, Kevin, Taroni, Franco, García-Redondo, Alberto, Wu, Zheyang, Gellera, Cinzia, Ratti, Antonia, Brown, Robert H., Jr., Shaw, Christopher E., Ambrose, John C., Arumugam, Prabhu, Baple, Emma L., Bleda, Marta, Boardman-Pretty, Freya, Boissiere, Jeanne M., Boustred, Christopher R., Brittain, H., Caulfield, Mark J., Chan, Georgia C., Craig, Clare E.H., Daugherty, Louise C., de Burca, Anna, Devereau, Andrew, Elgar, Greg, Foulger, Rebecca E., Fowler, Tom, Furió-Tarí, Pedro, Hackett, Joanne M., Halai, Dina, Hamblin, Angela, Henderson, Shirley, Holman, James E., Hubbard, Tim J.P., Jackson, Rob, Jones, Louise J., Kasperaviciute, Dalia, Kayikci, Melis, Lahnstein, Lea, Lawson, Kay, Leigh, Sarah E.A., Leong, Ivonne U.S., Lopez, Javier F., Maleady-Crowe, Fiona, Mason, Joanne, McDonagh, Ellen M., Moutsianas, Loukas, Mueller, Michael, Murugaesu, Nirupa, Need, Anna C., Odhams, Chris A., Patch, Christine, Perez-Gil, Daniel, Polychronopoulos, Dimitris, Pullinger, John, Rahim, Tahrima, Rendon, Augusto, Riesgo-Ferreiro, Pablo, Rogers, Tim, Savage, Kevin, Sawant, Kushmita, Scott, Richard H., Siddiq, Afshan, Sieghart, Alexander, Smedley, Damian, Smith, Katherine R., Sosinsky, Alona, Spooner, William, Stevens, Helen E., Stuckey, Alexander, Sultana, Razvan, Thomas, Ellen R.A., Thompson, Simon R., Tregidgo, Carolyn, Walsh, Emma, Watters, Sarah A., Welland, Matthew J., Williams, Eleanor, Witkowska, Katarzyna, Wood, Suzanne M., Zarowiecki, Magdalena, Arepalli, Sampath, Auluck, Pavan, Baloh, Robert H., Bowser, Robert, Brice, Alexis, Broach, James, Camu, William, Chiò, Adriano, Cooper-Knock, John, Corcia, Philippe, Drepper, Carsten, Drory, Vivian E., Dunckley, Travis L., Faghri, Faraz, Farren, Jennifer, Feldman, Eva, Floeter, Mary Kay, Fratta, Pietro, Gerhard, Glenn, Gibson, Summer B., Goutman, Stephen A., Heiman-Patterson, Terry D., Hernandez, Dena G., Hoover, Ben, Jansson, Lilja, Kamel, Freya, Kirby, Janine, Kowall, Neil W., Laaksovirta, Hannu, Landi, Francesco, Le Ber, Isabelle, Lumbroso, Serge, MacGowan, Daniel JL., Maragakis, Nicholas J., Mora, Gabriele, Mouzat, Kevin, Myllykangas, Liisa, Nalls, Mike A., Orrell, Richard W., Ostrow, Lyle W., Pamphlett, Roger, Pioro, Erik, Pulst, Stefan M., Ravits, John M., Renton, Alan E., Robberecht, Wim, Robey, Ian, Rogaeva, Ekaterina, Rothstein, Jeffrey D., Sendtner, Michael, Sidle, Katie C., Simmons, Zachary, Stone, David J., Tienari, Pentti J., Trojanowski, John Q., Troncoso, Juan C., Valori, Miko, Van Damme, Philip, Van Den Bosch, Ludo, Zinman, Lorne, Albani, Diego, Borroni, Barbara, Padovani, Alessandro, Bruni, Amalia, Clarimon, Jordi, Dols-Icardo, Oriol, Illán-Gala, Ignacio, Lleó, Alberto, Danek, Adrian, Galimberti, Daniela, Scarpini, Elio, Serpente, Maria, Graff, Caroline, Chiang, Huei-Hsin, Khoshnood, Behzad, Öijerstedt, Linn, Morris, Christopher M., Nacmias, Benedetta, Sorbi, Sandro, Nielsen, Jorgen E., Hjermind, Lynne E., Novelli, Valeria, Puca, Annibale A., Pastor, Pau, Alvarez, Ignacio, Diez-Fairen, Monica, Aguilar, Miquel, Perneczky, Robert, Diehl-Schimd, Janine, Rossi, Mina, Ruiz, Agustin, Boada, Mercè, Hernández, Isabel, Moreno-Grau, Sonia, Schlachetzki, Johannes C., Aarsland, Dag, Albert, Marilyn S., Attems, Johannes, Barrett, Matthew J., Beach, Thomas G., Bekris, Lynn M., Bennett, David A., Besser, Lilah M., Bigio, Eileen H., Black, Sandra E., Boeve, Bradley F., Bohannan, Ryan C., Brett, Francesca, Brunetti, Maura, Caraway, Chad A., Palma, Jose-Alberto, Calvo, Andrea, Canosa, Antonio, Dickson, Dennis, Duyckaerts, Charles, Faber, Kelley, Ferman, Tanis, Flanagan, Margaret E., Floris, Gianluca, Foroud, Tatiana M., Fortea, Juan, Gan-Or, Ziv, Gentleman, Steve, Ghetti, Bernardino, Gibbs, Jesse Raphael, Goate, Alison, Goldstein, David, González-Aramburu, Isabel, Graff-Radford, Neill R., Hodges, Angela K., Hu, Heng-Chen, Hupalo, Daniel, Infante, Jon, Iranzo, Alex, Kaiser, Scott M., Kaufmann, Horacio, Keith, Julia, Kim, Ronald C., Klein, Gregory, Krüger, Rejko, Kukull, Walter, Kuzma, Amanda, Lage, Carmen, Lesage, Suzanne, Leverenz, James B., Logroscino, Giancarlo, Lopez, Grisel, Love, Seth, Mao, Qinwen, Marti, Maria Jose, Martinez-McGrath, Elisa, Masellis, Mario, Masliah, Eliezer, May, Patrick, McKeith, Ian, Mesulam, Marek-Marsel, Monuki, Edwin S., Newell, Kathy L., Norcliffe-Kaufmann, Lucy, Palmer, Laura, Perkins, Matthew, Pletnikova, Olga, Molina-Porcel, Laura, Reynolds, Regina H., Rodríguez-Rodríguez, Eloy, Rohrer, Jonathan D., Sanchez-Juan, Pascual, Scherzer, Clemens R., Serrano, Geidy E., Shakkottai, Vikram, Sidransky, Ellen, Tayebi, Nahid, Thomas, Alan J., Tilley, Bension S., Walton, Ronald L., Woltjer, Randy, Wszolek, Zbigniew K., Xiromerisiou, Georgia, Zecca, Chiara, Phatnani, Hemali, Kwan, Justin, Sareen, Dhruv, Broach, James R., Arcila-Londono, Ximena, Lee, Edward B., Shneider, Neil A., Fraenkel, Ernest, Zaitlen, Noah, Berry, James D., Malaspina, Andrea, Cox, Gregory A., Thompson, Leslie M., Finkbeiner, Steve, Dardiotis, Efthimios, Miller, Timothy M., Chandran, Siddharthan, Pal, Suvankar, Hornstein, Eran, MacGowan, Daniel J., Heiman-Patterson, Terry, Hammell, Molly G., Patsopoulos, Nikolaos.A., Butovsky, Oleg, Dubnau, Joshua, Nath, Avindra, Harms, Matt, Aronica, Eleonora, Poss, Mary, Phillips-Cremins, Jennifer, Crary, John, Atassi, Nazem, Lange, Dale J., Adams, Darius J., Stefanis, Leonidas, Gotkine, Marc, Babu, Suma, Raj, Towfique, Paganoni, Sabrina, Shalem, Ophir, Smith, Colin, Zhang, Bin, Harris, Brent, Broce, Iris, Drory, Vivian, Ravits, John, McMillan, Corey, Menon, Vilas, Wu, Lani, Altschuler, Steven, Amar, Khaled, Archibald, Neil, Bandmann, Oliver, Capps, Erica, Church, Alistair, Coebergh, Jan, Costantini, Alyssa, Critchley, Peter, Ghosh, Boyd CP., Hu, Michele T.M., Kobylecki, Christopher, Leigh, P. Nigel, Mann, Carl, Massey, Luke A., Morris, Huw R., Nath, Uma, Pavese, Nicola, Paviour, Dominic, Sharma, Jagdish, Vaughan, Jenny, Dewan, Ramita, Chia, Ruth, Ding, Jinhui, Hickman, Richard A., Stein, Thor D., Abramzon, Yevgeniya, Ahmed, Sarah, Sabir, Marya S., Portley, Makayla K., Tucci, Arianna, Ibáñez, Kristina, Shankaracharya, F.N.U., Keagle, Pamela, Rossi, Giacomina, Caroppo, Paola, Tagliavini, Fabrizio, Waldo, Maria L., Johansson, Per M., Nilsson, Christer F., Rowe, James B., Benussi, Luisa, Binetti, Giuliano, Ghidoni, Roberta, Jabbari, Edwin, Viollet, Coralie, Glass, Jonathan D., Singleton, Andrew B., Silani, Vincenzo, Ross, Owen A., Ryten, Mina, Torkamani, Ali, Tanaka, Toshiko, Ferrucci, Luigi, Resnick, Susan M., Pickering-Brown, Stuart, Brady, Christopher B., Kowal, Neil, Hardy, John A., Van Deerlin, Vivianna, Vonsattel, Jean Paul, Harms, Matthew B., Ferrari, Raffaele, Landers, John E., Gibbs, J. Raphael, Dalgard, Clifton L., Scholz, Sonja W., Traynor, Bryan J.

Source: In Neuron 3 February 2021 109(3):448-460

Evaluation of a biomarker for amyotrophic lateral sclerosis derived from a hypomethylated DNA signature of human motor neurons.

Authors: Harvey, Calum, Nowak, Alicja, Zhang, Sai, Moll, Tobias, Weimer, Annika K, Barcons, Aina Mogas, Souza, Cleide Dos Santos, Ferraiuolo, Laura, Kenna, Kevin, Zaitlen, Noah, Caggiano, Christa, Shaw, Pamela J, Snyder, Michael P, Mill, Jonathan, Hannon, Eilis, Cooper-Knock, Johnathan

Source: BMC Medical Genomics; 1/14/2025, Vol. 18 Issue 1, p1-14, 14p

Subject Terms: AMYOTROPHIC lateral sclerosis, CELL-free DNA, WHOLE genome sequencing, LIFE sciences, MOTOR neurons

Whole-Genome and RNA Sequencing Reveal Variation and Transcriptomic Coordination in the Developing Human Prefrontal Cortex

Authors: Werling, Donna M., Pochareddy, Sirisha, Choi, Jinmyung, An, Joon-Yong, Sheppard, Brooke, Peng, Minshi, Li, Zhen, Dastmalchi, Claudia, Santpere, Gabriel, Sousa, André M.M., Tebbenkamp, Andrew T.N., Kaur, Navjot, Gulden, Forrest O., Breen, Michael S., Liang, Lindsay, Gilson, Michael C., Zhao, Xuefang, Dong, Shan, Klei, Lambertus, Cicek, A. Ercument, Buxbaum, Joseph D., Adle-Biassette, Homa, Thomas, Jean-Leon, Aldinger, Kimberly A., O’Day, Diana R., Glass, Ian A., Zaitlen, Noah A., Talkowski, Michael E., Roeder, Kathryn, State, Matthew W., Devlin, Bernie, Sanders, Stephan J., Sestan, Nenad

Source: In Cell Reports 7 April 2020 31(1)

A Robust Method Uncovers Significant Context-Specific Heritability in Diverse Complex Traits

Authors: Dahl, Andy, Nguyen, Khiem, Cai, Na, Gandal, Michael J., Flint, Jonathan, Zaitlen, Noah

Source: In The American Journal of Human Genetics 2 January 2020 106(1):71-91

Fast and accurate imputation of summary statistics enhances evidence of functional enrichment

Authors: Pasaniuc, Bogdan, Zaitlen, Noah, Shi, Huwenbo, Bhatia, Gaurav, Gusev, Alexander, Pickrell, Joseph, Hirschhorn, Joel, Strachan, David P, Patterson, Nick, Price, Alkes L.

Subject Terms: Quantitative Biology - Quantitative Methods, Quantitative Biology - Genomics, Quantitative Biology - Populations and Evolution, Statistics - Applications

Access URL: http://arxiv.org/abs/1309.3258

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

Authors: Phatnani, Hemali, Kwan, Justin, Sareen, Dhruv, Broach, James R., Simmons, Zachary, Arcila-Londono, Ximena, Lee, Edward B., Van Deerlin, Vivianna M., Shneider, Neil A., Fraenkel, Ernest, Ostrow, Lyle W., Baas, Frank, Zaitlen, Noah, Berry, James D., Malaspina, Andrea, Fratta, Pietro, Cox, Gregory A., Thompson, Leslie M., Finkbeiner, Steve, Dardiotis, Efthimios, Miller, Timothy M., Chandran, Siddharthan, Pal, Suvankar, Hornstein, Eran, MacGowan, Daniel J., Heiman-Patterson, Terry, Hammell, Molly G., Patsopoulos, Nikolaos.A., Butovsky, Oleg, Dubnau, Joshua, Nath, Avindra, Bowser, Robert, Harms, Matt, Aronica, Eleonora, Poss, Mary, Phillips-Cremins, Jennifer, Crary, John, Atassi, Nazem, Lange, Dale J., Adams, Darius J., Stefanis, Leonidas, Gotkine, Marc, Baloh, Robert, Babu, Suma, Raj, Towfique, Paganoni, Sabrina, Shalem, Ophir, Smith, Colin, Zhang, Bin, Harris, Brent T., Tam, Oliver H., Rozhkov, Nikolay V., Shaw, Regina, Kim, Duyang, Hubbard, Isabel, Fennessey, Samantha, Propp, Nadia, Fagegaltier, Delphine, Ravits, John, Dubnau, Josh, Gale Hammell, Molly

Source: In Cell Reports 29 October 2019 29(5):1164-1177

Leveraging pleiotropy for joint analysis of genome-wide association studies with per trait interpretations.

Authors: Taraszka, Kodi¹ (AUTHOR), Zaitlen, Noah^2,3 (AUTHOR), Eskin, Eleazar^1,3,4 (AUTHOR) eeskin@cs.ucla.edu

Source: PLoS Genetics. 11/7/2022, Vol. 18 Issue 11, p1-24. 24p.

Subject Terms: *GENOME-wide association studies, *GENETIC variation, *GENETIC models, *LIKELIHOOD ratio tests, *DECOMPOSITION method, *FALSE positive error, *MULTITRAIT multimethod techniques

Geographic Terms: UNITED Kingdom