Metabolic profiling of patient-derived organoids reveals nucleotide synthesis as a metabolic vulnerability in malignant rhabdoid tumors

Authors: Kes, Marjolein M.G. ^{1, 2, 3, 6}, Morales-Rodriguez, Francisco ^{1, 2, 6}, Zaal, Esther A. ^{3, 6}, de Souza, Terezinha ^{1, 2}, Proost, Natalie ⁴, van de Ven, Marieke ⁴, van den Heuvel-Eibrink, Marry M. ^{1, 5}, Jansen, Jeroen W.A. ³, Berkers, Celia R. ^{3, ∗}, Drost, Jarno ^{1, 2, 7, ∗∗}

Source: In Cell Reports Medicine 21 January 2025 6(1)

Oral β-RA induces metabolic rewiring leading to the rescue of diet-induced obesity

Authors: Díaz-Casado, María Elena ^{a, b, c}, González-García, Pilar ^{a, b, c}, López-Herrador, Sergio ^{a, b}, Hidalgo-Gutiérrez, Agustín ^{a, b, d}, Jiménez-Sánchez, Laura ^c, Barriocanal-Casado, Eliana ^{d, e}, Bakkali, Mohammed ^f, van de Lest, Chris H.A. ^g, Corral-Sarasa, Julia ^c, Zaal, Esther A. ^g, Berkers, Celia R. ^g, López, Luis C. ^{a, b, c, h, ⁎}

Source: In BBA - Molecular Basis of Disease October 2024 1870(7)

Immune suppression by human thymus-derived effector Tregs relies on glucose/lactate-fueled fatty acid synthesis

Authors: de Kivit, Sander, Mensink, Mark, Kostidis, Sarantos, Derks, Rico J.E., Zaal, Esther A., Heijink, Marieke, Verleng, Lotte J., de Vries, Evert, Schrama, Ellen, Blomberg, Niek, Berkers, Celia R., Giera, Martin, Borst, Jannie

Source: In Cell Reports 24 September 2024 43(9)

Arginine deprivation enriches lung cancer proteomes with cysteine by inducing arginine-to-cysteine substitutants

Authors: Yang, Chao, Pataskar, Abhijeet, Feng, Xiaodong, Montenegro Navarro, Jasmine, Paniagua, Inés, Jacobs, Jacqueline J.L., Zaal, Esther A., Berkers, Celia R., Bleijerveld, Onno B., Agami, Reuven

Source: In Molecular Cell 16 May 2024 84(10):1904-1916

Specific labeling of newly synthesized lipopolysaccharide via metabolic incorporation of azido-galactose

Authors: Xu, Yang, Wang, Xiaoqi, Zaal, Esther A., Berkers, Celia R., Lorent, Joseph H., Heise, Torben, Cox, Ruud, Pieters, Roland J., Breukink, Eefjan

Source: In BBA - Molecular and Cell Biology of Lipids May 2024 1869(4)

Retinyl Ester Analysis by Orbitrap Mass Spectrometry

Authors: Jansen, Jeroen W. A., Haaker, Maya W., Zaal, Esther A., Helms, J. Bernd

Source: Methods in molecular biology. 2669:67-78

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN633334272&indx=1&recIds=ETOCRN633334272

Targeting coenzyme Q10 synthesis overcomes bortezomib resistance in multiple myelomaElectronic supplementary information (ESI) available. See DOI: 10.1039/d1mo00106j

Authors: Zaal, Esther A., de Grooth, Harm-Jan, Oudaert, Inge, Langerhorst, Pieter, Levantovsky, Sophie, van Slobbe, Gijs J. J., Jansen, Jeroen W. A., Menu, Eline, Wu, Wei, Berkers, Celia R.

Source: Molecular omics. 18(1):19-30

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140035035.0x000001&indx=1&recIds=ETOCvdc_100140035035.0x000001

The Q-junction and the inflammatory response are critical pathological and therapeutic factors in CoQ deficiency

Authors: González-García, Pilar, Díaz-Casado, María Elena, Hidalgo-Gutiérrez, Agustín, Jiménez-Sánchez, Laura, Bakkali, Mohammed, Barriocanal-Casado, Eliana, Escames, Germaine, Chiozzi, Riccardo Zenezini, Völlmy, Franziska, Zaal, Esther A., Berkers, Celia R., Heck, Albert J.R., López, Luis C.

Source: In Redox Biology September 2022 55

Ascorbate kills breast cancer cells by rewiring metabolism via redox imbalance and energy crisis

Authors: Ghanem, Ali, Melzer, Anna Maria, Zaal, Esther, Neises, Laura, Baltissen, Danny, Matar, Omar, Glennemeier-Marke, Hannah, Almouhanna, Fadi, Theobald, Jannick, Abu el Maaty, Mohamed A., Berkers, Celia, Wölfl, Stefan

Source: In Free Radical Biology and Medicine 1 February 2021 163:196-209

AMPK activation induces RALDH⁺ tolerogenic dendritic cells by rewiring glucose and lipid metabolism.

Authors: Brombacher, Eline C.¹, Patente, Thiago A.¹, van der Ham, Alwin J.¹, Moll, Tijmen J. A.¹, Otto, Frank¹, Verheijen, Fenne W. M.², Zaal, Esther A.², de Ru, Arnoud H.³, Tjokrodirijo, Rayman T. N.³, Berkers, Celia R.², van Veelen, Peter A.³, Guigas, Bruno¹, Everts, Bart¹, b.everts@lumc.nl

Source: Journal of Cell Biology; 10/7/2024, Vol. 223 Issue 10, p1-18, 23p

Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion

Authors: Jansen, Jitske, Jansen, Katja, Neven, Ellen, Poesen, Ruben, Othman, Amr, van Mil, Alain, Sluijter, Joost, Torano, Javier Sastre, Zaal, Esther A., Berkers, Celia R., Esser, Diederik, Wichers, Harry J., van Ede, Karin, van Duursen, Majorie, Burtey, Stéphane, Verhaar, Marianne C., Meijers, Björn, Masereeuw, Rosalinde

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 Aug 01. 116(32), 16105-16110.

Access URL: https://www.jstor.org/stable/26848470

Modulation of nucleotide metabolism by picornaviruses.

Authors: Nouwen, Lonneke V.¹, Breeuwsma, Martijn¹, Zaal, Esther A.², van de Lest, Chris H. A.², Buitendijk, Inge¹, Zwaagstra, Marleen¹, Balić, Pascal³, Filippov, Dmitri V.³, Berkers, Celia R.², C.R.Berkers@uu.nl, van Kuppeveld, Frank J. M.¹, C.R.Berkers@uu.nl

Source: PLoS Pathogens; 3/8/2024, Vol. 20 Issue 3, p1-23, 23p

P53-dependent hypusination of eIF5A affects mitochondrial translation and senescence immune surveillance.

Authors: Jiang, Xiangli, Baig, Ali Hyder, Palazzo, Giuliana, Del Pizzo, Rossella, Bortecen, Toman, Groessl, Sven, Zaal, Esther A., Amaya Ramirez, Cinthia Claudia, Kowar, Alexander, Aviles-Huerta, Daniela, Berkers, Celia R., Palm, Wilhelm, Tschaharganeh, Darjus, Krijgsveld, Jeroen, Loayza-Puch, Fabricio

Source: Nature Communications; 8/28/2024, Vol. 15 Issue 1, p1-16, 16p

Subject Terms: PROTEIN synthesis, MITOCHONDRIAL proteins, RIBOSOMAL proteins, IMMUNE response, METABOLISM, CELLULAR aging, P53 protein

Deciphering metabolic crosstalk in context: lessons from inflammatory diseases.

Authors: Verheijen, Fenne W. M., Tran, Thi N. M., Chang, Jung‐Chin, Broere, Femke, Zaal, Esther A., Berkers, Celia R.

Source: Molecular Oncology; Jul2024, Vol. 18 Issue 7, p1759-1776, 18p

Extracellular vesicles from seminal plasma interact with T cells in vitro and drive their differentiation into regulatory T‐cells.

Authors: Zhang, Xiaogang, Greve, Patrick F., Minh, Thi Tran Ngoc, Wubbolts, Richard, Demir, Ayşe Y., Zaal, Esther A., Berkers, Celia R., Boes, Marianne, Stoorvogel, Willem

Source: Journal of Extracellular Vesicles; Jul2024, Vol. 13 Issue 7, p1-22, 22p

Subject Terms: REGULATORY T cells, T cells, MONONUCLEAR leukocytes, EXTRACELLULAR vesicles, SEMINAL vesicles, T cell differentiation

CTGF/VEGFA-activated Fibroblasts Promote Tumor Migration Through Micro-environmental Modulation

Authors: Wu, Wei ^{‡, §}, Zaal, Esther A. ^‡, Berkers, Celia R. ^‡, Lemeer, Simone ^{‡, §}, Heck, Albert J.R. ^{‡, §, ¶}

Source: In Molecular & Cellular Proteomics August 2018 17(8):1502-1514

A fragment-like approach to PYCR1 inhibition

Authors: Milne, Kirsty, Sun, Jianhui, Zaal, Esther A., Mowat, Jenna, Celie, Patrick H.N., Fish, Alexander, Berkers, Celia R., Forlani, Giuseppe, Loayza-Puch, Fabricio, Jamieson, Craig, Agami, Reuven

Source: Bioorganic & medicinal chemistry letters. 29(18):2626-2631

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110613313.0x000001&indx=1&recIds=ETOCvdc_100110613313.0x000001

New Insight into the Catalytic Mechanism of Bacterial MraY from Enzyme Kinetics and Docking Studies

Authors: Liu, Yao, 刘, 垚, Rodrigues, João P.G.L.M., Bonvin, Alexandre M.J.J., Zaal, Esther A., Berkers, Celia R., Heger, Michal, Gawarecka, Katarzyna ^**, Swiezewska, Ewa ^**, Breukink, Eefjan, Egmond, Maarten R.

Source: In Journal of Biological Chemistry 15 July 2016 291(29):15057-15068

Cysteamine–bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis

Authors: Jamalpoor, Amer, Gelder, Charlotte AGH, Yousef Yengej, Fjodor A, Zaal, Esther A, Berlingerio, Sante P, Veys, Koenraad R, Pou Casellas, Carla, Voskuil, Koen, Essa, Khaled, Ammerlaan, Carola ME, Rega, Laura Rita, Welle, Reini EN, Lilien, Marc R, Rookmaaker, Maarten B, Clevers, Hans, Klumperman, Judith, Levtchenko, Elena, Berkers, Celia R, Verhaar, Marianne C, Altelaar, Maarten, Masereeuw, Rosalinde, Janssen, Manoe J

Source: EMBO molecular medicine. 13(7)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125408064.0x000001&indx=1&recIds=ETOCvdc_100125408064.0x000001

Oncogene-dependent sloppiness in mRNA translation

Authors: Champagne, Julien, Pataskar, Abhijeet, Blommaert, Naomi, Nagel, Remco, Wernaart, Demi, Ramalho, Sofia, Kenski, Juliana, Bleijerveld, Onno B., Zaal, Esther A., Berkers, Celia R., Altelaar, Maarten, Peeper, Daniel S., Faller, William J., Agami, Reuven

Source: Molecular cell. 81(22):4709-4721.e9

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100166786512.0x000001&indx=1&recIds=ETOCvdc_100166786512.0x000001