A molecular video-derived foundation model for scientific drug discovery

Authors: Hongxin Xiang, Li Zeng, Linlin Hou, Kenli Li, Zhimin Fu, Yunguang Qiu, Ruth Nussinov, Jianying Hu, Michal Rosen-Zvi, Xiangxiang Zeng, Feixiong Cheng

Source: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/d86f383c80f347838207afa1e693fe5c

MBOAT7-driven lysophosphatidylinositol acylation in adipocytes contributes to systemic glucose homeostasis

Authors: William J. Massey, Venkateshwari Varadharajan, Rakhee Banerjee, Amanda L. Brown, Anthony J. Horak, Rachel C. Hohe, Bryan M. Jung, Yunguang Qiu, E. Ricky Chan, Calvin Pan, Renliang Zhang, Daniela S. Allende, Belinda Willard, Feixiong Cheng, Aldons J. Lusis, J. Mark Brown

Source: Journal of Lipid Research, Vol 64, Iss 4, Pp 100349- (2023)

Subject Terms: non-alcoholic fatty liver disease, obesity, metabolism, diabetes, hyperinsulinemia, systemic insulin resistance, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227523000226; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/4c86927b018244dab52502931112ad14

Direct Cardiac Actions of the Sodium Glucose Co‐Transporter 2 Inhibitor Empagliflozin Improve Myocardial Oxidative Phosphorylation and Attenuate Pressure‐Overload Heart Failure

Authors: Xuan Li, Qingguo Lu, Yunguang Qiu, Jussara M. do Carmo, Zhen Wang, Alexandre A. da Silva, Alan Mouton, Ana C. M. Omoto, Michael E. Hall, Ji Li, John E. Hall

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 6 (2021)

Subject Terms: cardiac hypertrophy, cardiac metabolism, cardiomyocytes, sodium glucose cotransporter 2, transverse aortic constriction, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/06d54fe46ce34956bd6c16e9fee86fdf

The Mechanism by Which Luteolin Disrupts the Cytoplasmic Membrane of Methicillin-Resistant Staphylococcus aureus.

Authors: Tao Zhang¹, Yunguang Qiu^2,3, Qichao Luo^2,3, Lifen Zhao², Xin Yan^2,4, Qiaoce Ding², Hualiang Jiang^1,2,3 hljiang@simm.ac.cn, Huaiyu Yang^2,3 hyyang@simm.ac.cn

Source: Journal of Physical Chemistry B. 2/1/2018, Vol. 122 Issue 4, p1427-1438. 12p.

Subject Terms: *LUTEOLIN, *CELL membranes, *METHICILLIN-resistant staphylococcus aureus, *MOLECULAR dynamics, *LECITHIN, *THERMODYNAMICS

Extra Sugar on Vancomycin: New Analogues for Combating Multidrug-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci.

Authors: Dongliang Guan, Feifei Chen, Lun Xiong, Feng Tang, Faridoon, Yunguang Qiu, Naixia Zhang, Likun Gong, Jian Li, Lefu Lan, Wei Huang

Source: Journal of Medicinal Chemistry; 1/11/2018, Vol. 61 Issue 1, p286-304, 19p