MHC-I upregulation safeguards neoplastic T cells in the skin against NK cell-mediated eradication in mycosis fungoides

Authors: Yun-Tsan Chang, Pacôme Prompsy, Susanne Kimeswenger, Yi-Chien Tsai, Desislava Ignatova, Olesya Pavlova, Christoph Iselin, Lars E. French, Mitchell P. Levesque, François Kuonen, Malgorzata Bobrowicz, Patrick M. Brunner, Steve Pascolo, Wolfram Hoetzenecker, Emmanuella Guenova

Source: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/1a3bf0a991644740869501ab71bb08ef

Th17-associated cytokines IL-17 and IL-23 in inflamed skin of Darier disease patients as potential therapeutic targets

Authors: Monika Ettinger, Teresa Burner, Anshu Sharma, Yun-Tsan Chang, Angelika Lackner, Pacôme Prompsy, Isabella M. Deli, Judith Traxler, Gerald Wahl, Sabine Altrichter, Rupert Langer, Yi-Chien Tsai, Suraj R. Varkhande, Leonie C. Schoeftner, Christoph Iselin, Iris K. Gratz, Susanne Kimeswenger, Emmanuella Guenova, Wolfram Hoetzenecker

Source: Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/8eec8722afcf4e4cb83878c6585c3720

Increased Chlormethine-Induced DNA Double-Stranded Breaks in Malignant T Cells from Mycosis Fungoides Skin Lesions

Authors: Yun-Tsan Chang, Desislava Ignatova, Wolfram Hoetzenecker, Steve Pascolo, Christina Fassnacht, Emmanuella Guenova

Source: JID Innovations, Vol 2, Iss 1, Pp 100069- (2022)

Subject Terms: Dermatology, RL1-803

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2667026721000709; https://doaj.org/toc/2667-0267

Access URL: https://doaj.org/article/ba6db92400c0419cb01a87244cd68145

Identification of Dermatophyte and Non-Dermatophyte Agents in Onychomycosis by PCR and DNA Sequencing—A Retrospective Comparison of Diagnostic Tools

Authors: Isabella Pospischil, Charlotte Reinhardt, Olympia Bontems, Karine Salamin, Marina Fratti, Gabriela Blanchard, Yun-Tsan Chang, Helga Wagner, Philipp Hermann, Michel Monod, Wolfram Hoetzenecker, Emmanuella Guenova

Source: Journal of Fungi, Vol 8, Iss 10, p 1019 (2022)

Subject Terms: dermatophyte, fungal culture, molecular mycology, NDM, onychomycosis, PCR, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2309-608X/8/10/1019; https://doaj.org/toc/2309-608X

Access URL: https://doaj.org/article/05ef85568bb84c8cb16292f71dea3df4

Enhancement of antibody-dependent cellular cytotoxicity is associated with treatment response to extracorporeal photopheresis in Sézary syndrome

Authors: Christoph Iselin, Yun-Tsan Chang, Tanja Schlaepfer, Christina Fassnacht, Florentia Dimitriou, Mirjam Nägeli, Steve Pascolo, Wolfram Hoetzenecker, Malgorzata Bobrowicz, Emmanuella Guenova

Source: OncoImmunology, Vol 10, Iss 1 (2021)

Subject Terms: cutaneous t cell lymphoma, sézary syndrome, mycosis fungoides, dermatology, extracorporeal photophoresis, cellular cytotoxicity, biomarker, treatment response, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/79be4c7424ec40aabeb2285e0800e27d

Aggressive Rare T-cell Lymphomas with Manifestation in the Skin: A Monocentric Cross-sectional Case Study

Authors: Marie-Charlotte Brüggen, Katrin Kerl, Eugenia Haralambieva, Urs Schanz, Yun-Tsan Chang, Desislava Ignatova, Reinhard Dummer, Antonio Cozzio, Wolfram Hoetzenecker, Lars E. French, Emmanuella Guenova

Source: Acta Dermato-Venereologica, Vol 98, Iss 9, Pp 835-841 (2018)

Subject Terms: lymphoma, manifestationintheskin, ENKTL, PC-AECTL, allogeneichematopoieticstemcelltransplantation, Dermatology, RL1-803

File Description: electronic resource

Relation: https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2950; https://doaj.org/toc/0001-5555; https://doaj.org/toc/1651-2057

Access URL: https://doaj.org/article/70fbda1f6fe84108b577265160ad9f1c

Uniparental Disomy of Chromosome 2 Unmasks New ITGA6 Recessive Mutation and Results in a Lethal Junctional Epidermolysis Bullosa in a Newborn

Authors: Rebecca Higgins, Annika N. Jensen, Julian Wachstein, Leena Bruckner-Tuderman, Roland Spiegel, Hubert Traber, Josef Achermann, Martin Schaller, Birgit Fehrenbacher, Martin Röcken, Desislava Ignatova, Yun-Tsan Chang, Tina Fischer, Agnes E. Schwieger-Briel, Lars E. French, Wolfram Hoetzenecker, René Hornung, Andreas Malzacher, Antonio Cozzio, Alexander Navarini, Cristina Has, Emmanuella Guenova

Source: Acta Dermato-Venereologica, Vol 100, Iss 1, p adv00041 (2020)

Subject Terms: Dermatology, RL1-803

File Description: electronic resource

Relation: https://www.medicaljournals.se/jadv/content/html/10.2340/00015555-3313; https://doaj.org/toc/0001-5555; https://doaj.org/toc/1651-2057

Access URL: https://doaj.org/article/f8616c3fa96d47a2b8962e6e4d6e4fed

Blockade of programmed cell death protein 1 (PD-1) in Sézary syndrome reduces Th2 phenotype of non-tumoral T lymphocytes but may enhance tumor proliferation

Authors: Ieva Saulite, Desislava Ignatova, Yun-Tsan Chang, Christina Fassnacht, Florentia Dimitriou, Eleni Varypataki, Florian Anzengruber, Mirjam Nägeli, Antonio Cozzio, Reinhard Dummer, Julia Scarisbrick, Steve Pascolo, Wolfram Hoetzenecker, Malgorzata Bobrowicz, Emmanuella Guenova

Source: OncoImmunology, Vol 9, Iss 1 (2020)

Subject Terms: monoclonal antibody, immunotherapy, pd-1, pd-l1, pd-l2, leukemic cutaneous t-cell lymphoma, sézary syndrome, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/39901325e57947a4b3306900403a79ac

mRNA-Based Anti-TCR CDR3 Tumour Vaccine for T-Cell Lymphoma

Authors: Marina Tusup, Severin Läuchli, Natalia Teresa Jarzebska, Lars E. French, Yun-Tsan Chang, Maya Vonow-Eisenring, Andreas Su, Thomas M. Kündig, Emmanuella Guenova, Steve Pascolo

Source: Pharmaceutics, Vol 13, Iss 7, p 1040 (2021)

Subject Terms: in vitro transcribed mRNA, ivt mRNA, vaccine, T-cell lymphoma, CTCL, TCR, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/13/7/1040; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/740ac46bbfb44586b93eb42bb91c79c1

PD-L1 expression is an independent predictor of favorable outcome in patients with localized esophageal adenocarcinoma

Authors: Dagmar Kollmann, Desislava Ignatova, Julia Jedamzik, Yun-Tsan Chang, Gerd Jomrich, Andreas Baierl, Dmitry Kazakov, Michal Michal, Lars E. French, Wolfram Hoetzenecker, Tobias Schatton, Reza Asari, Matthias Preusser, Michael Gnant, Emmanuella Guenova, Sebastian F. Schoppmann

Source: OncoImmunology, Vol 7, Iss 6 (2018)

Subject Terms: pd-1, pd-l1, pd-l2, esophageal adenocarcinoma, esophageal carcinoma, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/68247f40b804489683c749b0f2a3c84a

PD1-positive tumor-infiltrating lymphocytes are associated with poor clinical outcome after pulmonary metastasectomy for colorectal cancer

Authors: Dagmar Kollmann, Thomas Schweiger, Stefan Schwarz, Desislava Ignatova, Yun-Tsan Chang, Gerrit Lewik, Sebastian F. Schoppmann, Wolfram Hoetzenecker, Walter Klepetko, Emmanuella Guenova, Konrad Hoetzenecker

Source: OncoImmunology, Vol 6, Iss 9 (2017)

Subject Terms: colorectal cancer, lung metastasis, outcome, pd-1, pd-l1, prognosis, pulmonary metastasectomy, selection criteria, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/77b3934642ed403186d0691cea86e86e

Correction: The New Face of the Old Molecules: Crustin Pm4 and Transglutaminase Type I Serving as RNPs Down-Regulate Astakine-Mediated Hematopoiesis.

Authors: Yun-Tsan Chang, Cheng-Yung Lin, Che-Yiang Tsai, Vinu S Siva, Chia-Ying Chu, Huai-Jen Tsai, Yen-Ling Song

Source: PLoS ONE, Vol 12, Iss 7, p e0182405 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5531430?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/4d366329f1ed4536aa88d02d7b883022

The new face of the old molecules: crustin Pm4 and transglutaminase type I serving as rnps down-regulate astakine-mediated hematopoiesis.

Authors: Yun-Tsan Chang, Cheng-Yung Lin, Che-Yiang Tsai, Vinu S Siva, Chia-Ying Chu, Huai-Jen Tsai, Yen-Ling Song

Source: PLoS ONE, Vol 8, Iss 8, p e72793 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3754954?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/421921a405ea48b48113e8f872ea6d76

Enhancement of antibody-dependent cellular cytotoxicity is associated with treatment response to extracorporeal photopheresis in Sézary syndrome.

Authors: Iselin, Christoph, Yun-Tsan Chang, Schlaepfer, Tanja, Fassnacht, Christina, Dimitriou, Florentia, Nägeli, Mirjam, Pascolo, Steve, Hoetzenecker, Wolfram, Bobrowicz, Malgorzata, Guenova, Emmanuella

Source: OncoImmunology; 2021, Vol. 10 Issue 1, p1-7, 7p

Subject Terms: ANTIBODY-dependent cell cytotoxicity, SEZARY syndrome, CUTANEOUS T-cell lymphoma, CD30 antigen, KILLER cells, HEMATOMA, ANTINEOPLASTIC agents

Aggressive Rare T-cell Lymphomas with Manifestation in the Skin: A Monocentric Cross-sectional Case Study.

Authors: BRÜGGEN, Marie-Charlotte, KERL, Katrin, Yun-Tsan CHANG, IGNATOVA, Desislava, DUMMER, Reinhard, FRENCH, Lars E., GUENOVA, Emmanuella, HOETZENECKER, Wolfram, HARALAMBIEVA, Eugenia, SCHANZ, Urs, COZZIO, Antonio

Source: Acta Dermato-Venereologica; Oct2018, Vol. 98 Issue 9, p835-841, 7p

Subject Terms: T-cell lymphoma, HEMATOPOIETIC stem cell transplantation, EPSTEIN-Barr virus diseases, CANCER treatment, EARLY diagnosis, CUTANEOUS T-cell lymphoma

A novel proangiogenic B cell subset is increased in cancer and chronic inflammation.

Authors: van de Veen, Willem^1,2, Globinska, Anna¹, Jansen, Kirstin^1,2, Straumann, Alex³, Terufumi Kubo⁴, Verschoor, Daniëlle¹, Wirz, Oliver F.¹, Castro-Giner, Francesc^1,5, Ge Tan^1,5, Rückert, Beate¹, Ochsner, Urs¹, Herrmann, Marietta^3,6, Stanić, Barbara¹, van Splunter, Marloes¹, Huntjens, Daan¹, Wallimann, Alexandra^1,7, Guevara, Rodney J. Fonseca¹, Spits, Hergen^8,9, Ignatova, Desislava¹⁰, Yun-Tsan Chang¹⁰

Source: Science Advances. 5/15/2020, Vol. 6 Issue 20, p1-11. 11p.

Subject Terms: *B cells, *VASCULAR endothelial growth factors, *IMMUNOGLOBULIN E, *INTERLEUKIN-21, *TUMOR necrosis factor receptors