The intestinal fungus Aspergillus tubingensis promotes polycystic ovary syndrome through a secondary metabolite

Authors: Wu, Jiayu ^{1, 2, 3, 13}, Wang, Kai ^{1, 2, 3, 13}, Qi, Xinyu ^{1, 4, 5, 13}, Zhou, Shuang ^{1, 2, 3, 13}, Zhao, Shuyun ^{6, 13}, Lu, Meisong ^{7, 13}, Nie, Qixing ¹, Li, Meng ⁸, Han, Mengwei ⁹, Luo, Xi ⁸, Yun, Chuyu ^{1, 4, 5}, Wang, Pengcheng ¹⁰, Li, Rong ^{1, 4, 5}, Zhong, Chao ², Yu, Xiaofei ¹¹, Yin, Wen-bing ¹², Jiang, Changtao ^{1, 2}, Qiao, Jie ^{1, 4, 5, ∗}, Pang, Yanli ^{1, 4, 5, 14, ∗∗}

Source: In Cell Host & Microbe 8 January 2025 33(1):119-136

Candida albicans accelerates atherosclerosis by activating intestinal hypoxia-inducible factor2α signaling

Authors: Wang, Xuemei, Zhou, Shuang, Hu, Xiaomin, Ye, Chuan, Nie, Qixing, Wang, Kai, Yan, Sen, Lin, Jun, Xu, Feng, Li, Meng, Wu, Qing, Sun, Lulu, Liu, Bo, Zhang, Yi, Yun, Chuyu, Wang, Xian, Liu, Huiying, Yin, Wen-Bing, Zhao, Dongyu, Hang, Jing, Zhang, Shuyang, Jiang, Changtao, Pang, Yanli

Source: In Cell Host & Microbe 12 June 2024 32(6):964-979

Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance

Authors: Li, Xiaopeng, Zhang, Xiujuan, Xia, Jialin, Zhang, Linqi, Chen, Bo, Lian, Guan, Yun, Chuyu, Yang, Juan, Yan, Yu, Wang, Pengcheng, Wang, Xuemei, Liu, Bo, Liu, Huiying, Liang, Hui, Pang, Yanli, Wang, Xian, Jiang, Changtao

Source: In Cell Reports 24 August 2021 36(8)

Bile acids in follicular fluid: potential new therapeutic targets and predictive markers for women with diminished ovarian reserve.

Authors: Ding, Shu, Li, Wenyan, Xiong, Xianglei, Si, Manfei, Yun, Chuyu, Wang, Yuqian, Huang, Lixuan, Yan, Sen, Zhen, Xiumei, Qiao, Jie, Qi, Xinyu

Source: Journal of Ovarian Research; 12/19/2024, Vol. 17 Issue 1, p1-12, 12p

Subject Terms: OVARIAN reserve, RANDOM forest algorithms, CHOLIC acid, GRANULOSA cells, CHENODEOXYCHOLIC acid

Interleukin-22 improves ovulation in polycystic ovary syndrome via STAT3 signaling.

Authors: Liao, Baoying, Chen, Weixuan, Qi, Xinyu, Yun, Chuyu, Pang, Yanli

Source: Molecular Human Reproduction; Oct2024, Vol. 30 Issue 10, p1-12, 12p

Liraglutide improves follicle development in polycystic ovary syndrome by inhibiting CXCL10 secretion.

Authors: Zhao, Min, Liao, Baoying, Yun, Chuyu, Qi, Xinyu, Pang, Yanli

Source: Reproductive Biology & Endocrinology; 8/6/2024, Vol. 22 Issue 1, p1-14, 14p

Subject Terms: GRANULOSA cells, OVARIAN follicle, GTPASE-activating protein, POLYCYSTIC ovary syndrome, CONNEXIN 43

Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome

Authors: Qi, Xinyu, Yun, Chuyu, Sun, Lulu, Xia, Jialin, Wu, Qing, Wang, Ying, Wang, Lina, Zhang, Yangming, Liang, Xianyi, Wang, Liying, Gonzalez, Frank, Patterson, Andrew, Liu, Huiying, Mu, Liangshan, Zhou, Zehong, Zhao, Yue, Li, Rong, Liu, Ping, Zhong, Chao, Pang, Yanli, Jiang, Changtao, Qiao, Jie

Source: Nature medicine. 25(8):1225-1233

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189364083.0x000001&indx=1&recIds=ETOCvdc_100189364083.0x000001

Sphingosine d18:1 promotes nonalcoholic steatohepatitis by inhibiting macrophage HIF-2α.

Authors: Xia, Jialin, Chen, Hong, Wang, Xiaoxiao, Chen, Weixuan, Lin, Jun, Xu, Feng, Nie, Qixing, Ye, Chuan, Zhong, Bitao, Zhao, Min, Yun, Chuyu, Zeng, Guangyi, Mao, Yuejian, Wen, Yongping, Zhang, Xuguang, Yan, Sen, Wang, Xuemei, Sun, Lulu, Liu, Feng, Zhong, Chao

Source: Nature Communications; 6/4/2024, Vol. 15 Issue 1, p1-16, 16p

Subject Terms: NON-alcoholic fatty liver disease, HEPATIC fibrosis, MACROPHAGES, HEPATITIS, SPHINGOSINE

Interlukin-22 improves ovarian function in polycystic ovary syndrome independent of metabolic regulation: a mouse-based experimental study.

Authors: Chen, Weixuan, Liao, Baoying, Yun, Chuyu, Zhao, Min, Pang, Yanli

Source: Journal of Ovarian Research; 5/11/2024, Vol. 17 Issue 1, p1-11, 11p

Subject Terms: OVARIAN follicle, POLYCYSTIC ovary syndrome, METABOLIC regulation, TYPE 2 diabetes, GRANULOSA cells, ESTRUS

Lithocholic acid phenocopies anti-ageing effects of calorie restriction

Authors: Qu, Qi, Chen, Yan, Wang, Yu, Long, Shating, Wang, Weiche, Yang, Heng-Ye, Li, Mengqi, Tian, Xiao, Wei, Xiaoyan, Liu, Yan-Hui, Xu, Shengrong, Zhang, Cixiong, Zhu, Mingxia, Lam, Sin Man, Wu, Jianfeng, Yun, Chuyu, Chen, Junjie, Xue, Shengye, Zhang, Baoding, Zheng, Zhong-Zheng, Piao, Hai-Long, Jiang, Changtao, Guo, Hao, Shui, Guanghou, Deng, Xianming, Zhang, Chen-Song, Lin, Sheng-Cai

Source: Nature; 20240101, Issue: Preprints p1-9, 9p

Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism.

Authors: Yan, Ying, Niu, Zhoumin, Sun, Chao, Li, Peng, Shen, Siyi, Liu, Shengnan, Wu, Yuting, Yun, Chuyu, Jiao, Tingying, Jia, Sheng, Li, Yuying, Fang, Zhong-Ze, Zhao, Lin, Wang, Jiqiu, Xie, Cen, Jiang, Changtao, Li, Yan, Feng, Xiaoyun, Hu, Cheng, Jiang, Jingjing

Source: Nature Communications; 10/27/2022, Vol. 13 Issue 1, p1-16, 16p

Subject Terms: THYROID hormone regulation, THYROID hormone receptors, THYROID hormones, FARNESOID X receptor, TRIIODOTHYRONINE, GLUCOSE, HOMEOSTASIS, GLUCOSE metabolism

Effects of Androgen Excess-Related Metabolic Disturbances on Granulosa Cell Function and Follicular Development.

Authors: Liao, Baoying, Qi, Xinyu, Yun, Chuyu, Qiao, Jie, Pang, Yanli

Source: Frontiers in Endocrinology; 2/14/2022, Vol. 13, p1-14, 14p

Subject Terms: ANDROGEN receptors, GRANULOSA cells, METABOLIC disorders, CELL physiology, HORMONE synthesis, POLYCYSTIC ovary syndrome

The impact of the gut microbiota on the reproductive and metabolic endocrine system.

Authors: Qi, Xinyu, Yun, Chuyu, Pang, Yanli, Qiao, Jie

Source: Gut Microbes; 2021, Vol. 13 Issue 1, p1-30, 30p

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Publisher Correction: Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome

Authors: Qi, Xinyu, Yun, Chuyu, Sun, Lulu, Xia, Jialin, Wu, Qing, Wang, Ying, Wang, Lina, Zhang, Yangming, Liang, Xianyi, Wang, Liying, Gonzalez, Frank, Patterson, Andrew, Liu, Huiying, Mu, Liangshan, Zhou, Zehong, Zhao, Yue, Li, Rong, Liu, Ping, Zhong, Chao, Pang, Yanli, Jiang, Changtao, Qiao, Jie

Source: Nature Medicine; September 2019, Vol. 25 Issue: 9 p1459-1459, 1p