NRICM101 in combatting COVID-19 induced brain fog: Neuroprotective effects and neurovascular integrity preservation in hACE2 mice

Authors: Cher-Chia Chang, Yea-Hwey Wang, Jiin-Cherng Yen, Chia-Ching Liaw, Keng-Chang Tsai, Wen-Chi Wei, Wen-Fei Chiou, Chun-Tang Chiou, Kuo-Tong Liou, Yuh-Chiang Shen, Yi-Chang Su

Source: Journal of Traditional and Complementary Medicine, Vol 15, Iss 1, Pp 36-50 (2025)

Subject Terms: COVID-19, NRICM101, Traditional Chinese medicine, Brain fog, Neurovasculature disruption, Complement &NET activation, Medicine

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Relation: http://www.sciencedirect.com/science/article/pii/S2225411024000841; https://doaj.org/toc/2225-4110

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NRICM101 ameliorates SARS-CoV-2–S1-induced pulmonary injury in K18-hACE2 mice model

Authors: Wen-Chi Wei, Keng-Chang Tsai, Chia-Ching Liaw, Chun-Tang Chiou, Yu-Hwei Tseng, Geng-You Liao, Yu-Chi Lin, Wen-Fei Chiou, Kuo-Tong Liou, I-Shing Yu, Yuh-Chiang Shen, Yi-Chang Su

Source: Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: COVID-19, NRICM101, traditional Chinese medicine, lung injury, pattern recognition receptors, Therapeutics. Pharmacology, RM1-950

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Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1125414/full; https://doaj.org/toc/1663-9812

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Anti-inflammatory effect of euphane- and tirucallane-type triterpenes isolated from the traditional herb Euphorbia neriifolia L

Authors: Stephen S. Chang, Hung-Tse Huang, Wen-Chi Wei, I-Wen Lo, Yu-Chi Lin, Chih-Hua Chao, Geng-You Liao, Yuh-Chiang Shen, Jih-Jung Chen, Tsung-Lin Li, Liang-Tzung Lin, Chen-Jei Tai, Yao-Haur Kuo, Chia-Ching Liaw

Source: Frontiers in Chemistry, Vol 11 (2023)

Subject Terms: Euphorbia neriifolia L., Euphorbiaceae, neritriterpenols, euphane, tirucallane, anti-inflammatory activity, Chemistry, QD1-999

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Relation: https://www.frontiersin.org/articles/10.3389/fchem.2023.1223335/full; https://doaj.org/toc/2296-2646

Access URL: https://doaj.org/article/940b49ebe74243b2b2c83ac233fee367

Anti-inflammatory sesquiterpene and triterpene acids from Mesona procumbens Hemsley

Authors: Hung-Tse Huang, I-Wen Lo, Geng-You Liao, Yu-Chi Lin, Yuh-Chiang Shen, Hui-Chi Huang, Tsung-Lin Li, Kung-Ta Lee, Yao-Haur Kuo, Chia-Ching Liaw

Source: Frontiers in Chemistry, Vol 10 (2022)

Subject Terms: Mesona procumbens Hemsley, triterpene acid, mesonaic acid, sesquiterpene, mesoeudesmol, anti-inflammatory, Chemistry, QD1-999

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Relation: https://www.frontiersin.org/articles/10.3389/fchem.2022.1003356/full; https://doaj.org/toc/2296-2646

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Dietary supplementation of rutin and rutin-rich buckwheat elevates endogenous glucagon-like peptide 1 levels to facilitate glycemic control in type 2 diabetic mice

Authors: Lin-Chien Lee, Yu-Chang Hou, Ying-Ying Hsieh, Yu-Hsin Chen, Yuh-Chiang Shen, I-Jung Lee, Meng-Chun Monica Shih, Wen-Chi Hou, Hui-Kang Liu

Source: Journal of Functional Foods, Vol 85, Iss , Pp 104653- (2021)

Subject Terms: Glucagon-like peptide 1, Rutin, Tartary buckwheat, Type 2 diabetes, Dipeptidyl peptidase-4, GLP-1-receptor-knockout mice, Nutrition. Foods and food supply, TX341-641

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Relation: http://www.sciencedirect.com/science/article/pii/S1756464621003029; https://doaj.org/toc/1756-4646

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Disclosure of suboptimal health status through traditional Chinese medicine-based body constitution and pulse patterns

Authors: Yen-Ying Kung, Terry B.J. Kuo, Chun-Ting Lai, Yuh-Chiang Shen, Yi-Chang Su, Cheryl C.H. Yang

Source: Complementary Therapies in Medicine, Vol 56, Iss , Pp 102607- (2021)

Subject Terms: Suboptimal health status, Body constitution, Radial pulse analysis, Other systems of medicine, RZ201-999

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Relation: http://www.sciencedirect.com/science/article/pii/S0965229920318744; https://doaj.org/toc/0965-2299

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Combined proteomic and metabolomic analyses of cerebrospinal fluid from mice with ischemic stroke reveals the effects of a Buyang Huanwu decoction in neurodegenerative disease.

Authors: Wei-Hsiang Hsu, Yuh-Chiang Shen, Young-Ji Shiao, Ching-Hua Kuo, Chung-Kuang Lu, Tai-Yuan Lin, Wei-Chi Ku, Yun-Lian Lin

Source: PLoS ONE, Vol 14, Iss 1, p e0209184 (2019)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/8f371b00a0974025af0d46a5d1ee288c

Unique Mechanisms of Sheng Yu Decoction (聖愈湯 Shèng Yù Tang) on Ischemic Stroke Mice Revealed by an Integrated Neurofunctional and Transcriptome Analysis

Authors: Yu-Chang Hou, Chung-Kuang Lu, Yea-Hwey Wang, Chang-Ming Chern, Kuo-Tong Liou, Hsei-Wei Wang, Yuh-Chiang Shen

Source: Journal of Traditional and Complementary Medicine, Vol 3, Iss 4, Pp 240-249 (2013)

Subject Terms: Genome-wide transcriptome analysis, Ischemic stroke, Microarray, Positron emission tomography, Sheng Yu Decoction, Medicine

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Relation: http://www.sciencedirect.com/science/article/pii/S2225411016301997; https://doaj.org/toc/2225-4110

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Multiplex Brain Proteomic Analysis Revealed the Molecular Therapeutic Effects of Buyang Huanwu Decoction on Cerebral Ischemic Stroke Mice.

Authors: Hong-Jhang Chen, Yuh-Chiang Shen, Young-Ji Shiao, Kuo-Tong Liou, Wei-Hsiang Hsu, Pei-Hsuan Hsieh, Chi-Ying Lee, Yet-Ran Chen, Yun-Lian Lin

Source: PLoS ONE, Vol 10, Iss 10, p e0140823 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4619651?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/2ddab912273a4d55b9eb5862450122c4

A new drug design targeting the adenosinergic system for Huntington's disease.

Authors: Nai-Kuei Huang, Jung-Hsin Lin, Jiun-Tsai Lin, Chia-I Lin, Eric Minwei Liu, Chun-Jung Lin, Wan-Ping Chen, Yuh-Chiang Shen, Hui-Mei Chen, Jhih-Bin Chen, Hsing-Lin Lai, Chieh-Wen Yang, Ming-Chang Chiang, Yu-Shuo Wu, Chen Chang, Jiang-Fan Chen, Jim-Min Fang, Yun-Lian Lin, Yijuang Chern

Source: PLoS ONE, Vol 6, Iss 6, p e20934 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3119665?pdf=render; https://doaj.org/toc/1932-6203

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Ethanol-Soluble Extract of Terminalia chebula Attenuates Paraquat-Induced Apoptosis in PC12 Cells.

Authors: Hua-Sin Chen¹, Yuh-Chiang Shen^2,3,4, Chi-Cheng Lin⁵, Chi-Wen Juan^5,6, Chia-Lin Chang^7,8 clchang@sunrise.hk.edu.tw, Shu-Yang Liang⁸

Source: Current Topics in Nutraceutical Research. Feb2023, Vol. 21 Issue 1, p25-30. 6p.

Subject Terms: *DRUG therapy for Parkinson's disease, *BIOLOGICAL models, *STATISTICS, *MEDICINAL plants, *WESTERN immunoblotting, *ONE-way analysis of variance, *MICROSCOPY, *APOPTOSIS, *NEUROPROTECTIVE agents, *RESEARCH funding, *DESCRIPTIVE statistics, *PLANT extracts, *CELL lines, *REACTIVE oxygen species, *CALCIUM, *DATA analysis software, *DATA analysis, *CASPASES, *PHARMACODYNAMICS

Protective Effects of Crataegus pinnatifida Extracts and Crataegolic Acid Against Neurotoxicity of Paraquat in PC12 Cells.

Authors: Chi-Sen Chang^1,2, Yuh-Chiang Shen^3,4,5, Chi-Wen Juan^6,7, Chia-Lin Chang⁸ clchang@sunrise.hk.edu.tw, Po-Kai Lin⁸

Source: Current Topics in Nutraceutical Research. 2022, Vol. 20 Issue 1, p76-83. 8p.

Subject Terms: *MEDICINAL plants, *ANIMAL experimentation, *APOPTOSIS, *CELLULAR signal transduction, *NEUROPROTECTIVE agents, *PLANT extracts, *CELL lines, *CELL surface antigens, *REACTIVE oxygen species, *MICE, *IMMUNODIAGNOSIS, *CASPASES

Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its anti-inflammatory effect.

Authors: Yuh-Chiang Shen, Chieh-Fu Chen, Wen-Fei Chiou

Source: British Journal of Pharmacology. Jan2002, Vol. 135 Issue 2, p399. 8p.

Subject Terms: *DITERPENES, *LACTONES, *NEUTROPHILS

Króppel-like factor 4 is involved in cell scattering induced by hepatocyte growth factor.

Authors: Jun-Kai Lai, Han-Chung Wu, Yuh-Chiang Shen, Hsin-Ying Hsieh, Shu-Yi Yang, Chia-Che Chang

Source: Journal of Cell Science; 10/15/2012, Vol. 125 Issue 20, p4853-4864, 12p

Subject Terms: KRUPPEL-like factors, CELLS, HEPATOCYTE growth factor, CADHERINS, CHROMATIN

An Efficient Total Synthesis of a Potent Anti-Inflammatory Agent, Benzocamphorin F, and Its Anti-Inflammatory Activity.

Authors: Yu-Ren Liao, Ping-Chung Kuo, Jun-Weil Liang, Yuh-Chiang Shen, Tian-Shung Wu

Source: International Journal of Molecular Sciences; Aug2012, Vol. 13 Issue 8, p10432-10440, 9p, 4 Diagrams, 2 Charts

Subject Terms: BIOSYNTHESIS, ANTI-inflammatory agents, DRUG synergism, EDIBLE fungi, BIOACTIVE compounds, POLYPORACEAE, SPECTRUM analysis

Anti-inflammatory and anti-infectious effects of Evodia rutaecarpa (Wuzhuyu) and its major bioactive components.

Authors: Jyh-Fei Liao, Wen-Fei Chiou, Yuh-Chiang Shen, Guei-Jane Wang, Chieh-Fu Chen

Source: Chinese Medicine; 2011, Vol. 6 Issue 1, p1-8, 8p

Subject Terms: HERBAL medicine, INFECTION prevention, INFLAMMATION prevention, REACTIVE oxygen species, ALZHEIMER'S disease, ANTIEMETICS, ANTIOXIDANTS, BODY temperature regulation, DIABETES, GROWTH factors, HEPATITIS B, HYPERTENSION, CHINESE medicine, OBESITY

Dimemorfan protects rats against ischemic stroke through activation of sigma-1 receptor-mediated mechanisms by decreasing glutamate accumulation.

Authors: Yuh-Chiang Shen¹ yuhcs@nricm.edu.tw, Yea-Hwey Wang², Yueh-Ching Chou^2,3, Kuo-Tong Liou⁴, Jiin-Cherng Yen³, Wen-Yen Wang⁵, Jyh-Fei Liao³ jfliao@ym.edu.tw

Source: Journal of Neurochemistry. Jan2008, Vol. 104 Issue 2, p558-572. 15p. 5 Diagrams, 4 Charts, 2 Graphs.

Subject Terms: *CEREBRAL ischemia, *GLUTAMIC acid, *INFLAMMATION, *NEUROPROTECTIVE agents, *OXIDATIVE stress, *ISCHEMIA

Taxifolin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-oxidative effect and modulation of NF-kappa B activation.

Authors: Yea-Hwey Wang, Wen-Yen Wang, Chia-Che Chang, Kuo-Tong Liou, Yen-Jen Sung, Jyh-Fei Liao, Chieh-Fu Chen, Shiou Chang, Yu-Chang Hou, Yueh-Ching Chou, Yuh-Chiang Shen

Source: Journal of Biomedical Science; Jan2006, Vol. 13 Issue 1, p127-141, 15p, 4 Charts, 5 Graphs

Subject Terms: BRAIN injuries, LEUKOCYTES, BLOOD circulation disorders, NECROSIS, ARTERIAL occlusions, MALONDIALDEHYDE, CEREBRAL ischemia, PROTEINS, NITRIC oxide

The inhibitory effect of phenylpropanoid glycosides and iridoid glucosides on free radical production and β2 integrin expression in human leucocytes.

Authors: Lie-Chwen Lin, Yea-Hwey Wang, Yu-Chang Hou, Shiou Chang, Kuo-Tong Liou, Yueh-Ching Chou, Wen-Yen Wang, Yuh-Chiang Shen

Source: Journal of Pharmacy & Pharmacology; Jan2006, Vol. 58 Issue 1, p129-135, 7p

Evaluation of the anti-inflammatory and cytotoxic effects of anthraquinones and anthracenes derivatives in human leucocytes.

Authors: Rong-Fu Chen, Yuh-Chiang Shen, Hsu-Shan Huang, Jyh-Fei Liao, Li-Kang Ho, Yueh-Ching Chou, Wen-Yen Wang, Chieh-Fu Chen

Source: Journal of Pharmacy & Pharmacology; Jul2004, Vol. 56 Issue 7, p915-919, 5p