Genomic landscape and chronological reconstruction of driver events in multiple myeloma

Authors: Francesco Maura, Niccoló Bolli, Nicos Angelopoulos, Kevin J. Dawson, Daniel Leongamornlert, Inigo Martincorena, Thomas J. Mitchell, Anthony Fullam, Santiago Gonzalez, Raphael Szalat, Federico Abascal, Bernardo Rodriguez-Martin, Mehmet Kemal Samur, Dominik Glodzik, Marco Roncador, Mariateresa Fulciniti, Yu Tzu Tai, Stephane Minvielle, Florence Magrangeas, Philippe Moreau, Paolo Corradini, Kenneth C. Anderson, Jose M. C. Tubio, David C. Wedge, Moritz Gerstung, Hervé Avet-Loiseau, Nikhil Munshi, Peter J. Campbell

Source: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/a38608a486ef471e8da57b4ab94d19b3

Genomic patterns of progression in smoldering multiple myeloma

Authors: Niccolò Bolli, Francesco Maura, Stephane Minvielle, Dominik Gloznik, Raphael Szalat, Anthony Fullam, Inigo Martincorena, Kevin J. Dawson, Mehmet Kemal Samur, Jorge Zamora, Patrick Tarpey, Helen Davies, Mariateresa Fulciniti, Masood A. Shammas, Yu Tzu Tai, Florence Magrangeas, Philippe Moreau, Paolo Corradini, Kenneth Anderson, Ludmil Alexandrov, David C. Wedge, Herve Avet-Loiseau, Peter Campbell, Nikhil Munshi

Source: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/7915841302254896b2f39285aed1718f

Epigenetic regulation of CD38/CD48 by KDM6A mediates NK cell response in multiple myeloma

Authors: Jiye Liu, Lijie Xing, Jiang Li, Kenneth Wen, Ning Liu, Yuntong Liu, Gongwei Wu, Su Wang, Daisuke Ogiya, Tian-Yu Song, Keiji Kurata, Johany Penailillo, Eugenio Morelli, Tingjian Wang, Xiaoning Hong, Annamaria Gulla, Yu-Tzu Tai, Nikhil Munshi, Paul Richardson, Ruben Carrasco, Teru Hideshima, Kenneth C. Anderson

Source: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/7f2fe4cc076c4f8aab09d7ab7cfd3475

Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma

Authors: Andrea Schmidts, Maria Ormhøj, Bryan D. Choi, Allison O. Taylor, Amanda A. Bouffard, Irene Scarfò, Rebecca C. Larson, Matthew J. Frigault, Kathleen Gallagher, Ana P. Castano, Lauren S. Riley, Maria L. Cabral, Angela C. Boroughs, Rubí M.-H. Velasco Cárdenas, Wolfgang Schamel, Jing Zhou, Sean Mackay, Yu-Tzu Tai, Kenneth C. Anderson, Marcela V. Maus

Source: Blood Advances, Vol 3, Iss 21, Pp 3248-3260 (2019)

Subject Terms: Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2473952920317869; https://doaj.org/toc/2473-9529

Access URL: https://doaj.org/article/744190eefb7f4eac95dde4520a55224b

The impact of response kinetics for multiple myeloma in the era of novel agents

Authors: Yuting Yan, Xuehan Mao, Jiahui Liu, Huishou Fan, Chenxing Du, Zengjun Li, Shuhua Yi, Yan Xu, Rui Lv, Wei Liu, Shuhui Deng, Weiwei Sui, Qi Wang, Dehui Zou, Jianxiang Wang, Tao Cheng, Fenghuang Zhan, Yu-Tzu Tai, Chenglu Yuan, Xin Du, Lugui Qiu, Kenneth C. Anderson, Gang An

Source: Blood Advances, Vol 3, Iss 19, Pp 2895-2904 (2019)

Subject Terms: Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2473952920318528; https://doaj.org/toc/2473-9529

Access URL: https://doaj.org/article/ba9e6e03412b466aa552482a4a129eb8

Bispecific antibodies in multiple myeloma treatment: A journey in progress.

Authors: Shih-Feng Cho, Tsung-Jang Yeh, Anderson, Kenneth C., Yu-Tzu Tai

Source: Frontiers in Oncology; 10/18/2022, Vol. 12, p1-15, 15p

Subject Terms: BISPECIFIC antibodies, MULTIPLE myeloma, CYTOKINE release syndrome, OVERALL survival, SURVIVAL analysis (Biometry)

Monoclonal Antibody: A New Treatment Strategy against Multiple Myeloma.

Authors: Shih-Feng Cho^1,2,3, shih-feng_cho@dfci.harvard.edu, Liang Lin³, liang_lin@dfci.harvard.edu, Lijie Xing^3,4, lijie_xing@dfci.harvard.edu, Tengteng Yu³, tengteng_yu@dfci.harvard.edu, KennethWen³, kenneth_wen@dfci.harvard.edu, Anderson, Kenneth C.³, Kenneth_anderson@dfci.harvard.edu, Yu-Tzu Tai³, yu-tzu_tai@dfci.harvard.edu

Source: Antibodies (2073-4468); Dec2017, Vol. 6 Issue 4, p18, 22p

Antibody-Based Therapies inMultipleMyeloma.

Authors: Yu-Tzu Tai¹ yu-tzutai@dfci.harvard.edu, Anderson, Kenneth C.¹

Source: Bone Marrow Research. 2011, p1-14. 14p. 1 Diagram, 1 Chart.

Subject Terms: *MULTIPLE myeloma, *MONOCLONAL antibodies, *CANCER cells, *IMMUNE response, *CLINICAL trials, PURE Food & Drug Act of 1906

Geographic Terms: UNITED States

Genomic patterns of progression in smoldering multiple myeloma.

Authors: Bolli, Niccolò, Maura, Francesco, Minvielle, Stephane, Gloznik, Dominik, Szalat, Raphael, Fullam, Anthony, Martincorena, Inigo, Dawson, Kevin J., Samur, Mehmet Kemal, Zamora, Jorge, Tarpey, Patrick, Davies, Helen, Fulciniti, Mariateresa, Shammas, Masood A., Yu Tzu Tai, Magrangeas, Florence, Moreau, Philippe, Corradini, Paolo, Anderson, Kenneth, Alexandrov, Ludmil

Source: Nature Communications; 8/22/2018, Vol. 9, p1-10, 10p

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Cell of the month: Neural progenitor cells expressing tyrosine hydrolase.

Authors: Yu-Tzu Tai¹ ytt21@cam.ac.uk

Source: Nature Cell Biology. Sep2003, Vol. 5 Issue 9, p779-781. 3p.

Subject Terms: *TYROSINE, *HYDROLASES, *CELLS

Widespread intronic polyadenylation diversifies immune cell transcriptomes.

Authors: Singh, Irtisha, Shih-Han Lee, Sperling, Adam S., Samur, Mehmet K., Yu-Tzu Tai, Fulciniti, Mariateresa, Munshi, Nikhil C., Mayr, Christine, Leslie, Christina S.

Source: Nature Communications; 4/30/2018, Vol. 9 Issue 1, p1-16, 16p, 6 Graphs

Interferon-alpha-based immunotherapies in the treatment of B cell-derived hematologic neoplasms in today's treat-to-target era.

Authors: Li Zhang^1,2, Yu-Tzu Tai¹ yu-tzu_tai@dfci.harvard.edu, Zhi Guang Ho, Matthew^1,3,4, Lugui Qiu⁵, Anderson, Kenneth C.¹ kenneth_anderson@dfci.harvard.edu

Source: Experimental Hematology & Oncology. 7/14/2017, Vol. 6, p1-9. 9p.

Subject Terms: *B cells, *IMMUNOTHERAPY, *LYMPHOMA treatment, *PHYSIOLOGY

Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma.

Authors: Teru Hideshima, Jun Qi, Paranal, Ronald M., Greenberg, Edward, West, Nathan, Colling, Meaghan E., Perry, Jennifer A., Hiroto Ohguchi, Cottini, Francesca, Naoya Mimura, Görgün, Güllü, Yu-Tzu Tai, Richardson, Paul G., Carrasco, Ruben D., Anderson, Kenneth C., Bradner, James E., Weiping Tang, Schreiber, Stuart L., Mazitschek, Ralph, Estiu, Guillermina

Source: Proceedings of the National Academy of Sciences of the United States of America; 11/15/2016, Vol. 113 Issue 46, p13162-13167, 6p

Subject Terms: MULTIPLE myeloma, HISTONE deacetylase inhibitors, BORTEZOMIB, PROTEASOME inhibitors, CANCER research

APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment.

Authors: Yu-Tzu Tai^1,2 yu-tzu_tai@dfci.harvard.edu, Acharya, Chirag¹, Gang An¹, Moschetta, Michele¹, Zhong, Mike Y.¹, Xiaoyan Feng¹, Cea, Michele¹, Cagnetta, Antonia¹, Wen, Kenneth¹, van Eenennaam, Hans³, van Elsas, Andrea³, Lugui Qiu⁴, Richardson, Paul^1,2, Munshi, Nikhil^1,2, Anderson, Kenneth C.^1,2

Source: Blood. 6/23/2016, Vol. 127 Issue 25, p3225-3236. 12p.

Subject Terms: *B cell lymphoma, *LIGANDS (Biochemistry), *GROWTH factors, *GENETIC overexpression, *GENE expression, *NEOVASCULARIZATION, *BORTEZOMIB

Genetically Modified Cells as a Source for Grafting in Parkinson's Disease.

Authors: Brundin, Patrik¹, Olanow, C. Warren², Hyun-Jung Kim³, Paul, Gesine⁴, Yu-Tzu Tai⁵, Svendsen, Clive N.⁶

Source: Restorative Therapies in Parkinson's Disease. 2006, p285-296. 12p.

P-089: Identification of novel targets in multiple myeloma for "undruggable" RAS/CDK signaling cascade.

Authors: Adamia, Sophia, Chyra, Zuzana, OKeefe, Morgan, Bhatt, Shruti, Wen, Kenneth, Fell, Geoffrey G., Yu-Tzu Tai, Abiatari, Ivane, Letai, Anthony, Dorfman, David M., Teru Hideshima, Anderson, Kenneth

Source: Clinical Lymphoma, Myeloma & Leukemia; 2021 Supplement 2, Vol. 21, pS87-S88, 2p

OAB-021: BCMA-specific ADC MEDI2228 and Daratumumab induce synergistic myeloma cytotoxicity via enhanced IFN-driven innate immune responses and expression of CD38 and NKG2D ligands.

Authors: Lijie Xing, Su Wang, Jiye Liu, Tengteng Yu, Hailin Chen, Wen, Kenneth, Hsieh, Phillip, Shih-Feng Cho, Gang An, Lugui Qiu, Munshi, Nikhil C., Anderson, Kenneth, Yu-Tzu Tai

Source: Clinical Lymphoma, Myeloma & Leukemia; 2021 Supplement 2, Vol. 21, pS13-S14, 2p

OAB-009: Genome-wide CRISPR interference screen identifies RNA Regulator of Lipogenesis (RROL) as a leading LncRNA dependency in Multiple Myeloma.

Authors: Morelli, Eugenio, Fulciniti, Mariateresa, Samur, Mehmet K., Ribeiro, Caroline, Wert-Lamas, Leon, Henninger, Jon, Gulla, Annamaria, Aktas-Samur, Anil, Todoerti, Katia, Talluri, Srikanth, Park, Woojun D., Amodio, Nicola, Bianchi, Giada, Lin, Charles, Yu-Tzu Tai, Neri, Antonino, Chauhan, Dharminder, Teru Hideshima, Shammas, Masood, Tassone, Pierfrancesco

Source: Clinical Lymphoma, Myeloma & Leukemia; 2021 Supplement 2, Vol. 21, pS6-S7, 2p

Elevated Nuclease Activity Correlates With Clinical Spectrum Of Plasma Cell Dyscrasias

Authors: Patel, Jaymin M. ^*, Vahia, Ankit V ^*, Nanjappa, Puru ^*, Bajwa, Ashun ^*, Shah, Sima ^*, Yu-Tzu, Tai ^*, Anderson, Kenneth C., Shammas, Masood, Munshi, Nikhil C. ^*

Source: In Blood 15 November 2013 122(21):4885-4885