Comprehensive profiling of clinical JAK inhibitors in myeloproliferative neoplasms

Authors: Kong, Tim, Yu, LaYow, Laranjeira, Angelo B. A., Fisher, Daniel A. C., He, Fan, Cox, Maggie J., Oh, Stephen T.

Source: American journal of hematology. 98(7):1029-1042

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185218620.0x000001&indx=1&recIds=ETOCvdc_100185218620.0x000001

Carrimycin, a first in-class anti-cancer agent, targets selenoprotein H to induce nucleolar oxidative stress and inhibit ribosome biogenesis

Authors: Yu, LaYow C., Dang, Danielle D., Zhuang, Sophie, Chen, Shuran, Zhuang, Zhengping, Rosenblum, Jared S.

Source: In Cancer Pathogenesis and Therapy April 2023 1(2):111-115

RSK1 is an exploitable dependency in myeloproliferative neoplasms and secondary acute myeloid leukemia.

Authors: Kong, Tim, Laranjeira, Angelo B. A., Letson, Christopher T., Yu, LaYow, Lin, Shuyang, Fowles, Jared S., Fisher, Daniel A. C., Ng, Sherwin, Yang, Wei, He, Fan, Youn, Minyoung, Mark, Kailen, Jose, Ana San, Liu, Jingxian, Kim, Alexander B., Cox, Maggie J., Fulbright, Mary C., Jayanthan, Aarthi, Los, Gerrit, Rentschler, Stacey L.

Source: Nature Communications; 1/16/2025, Vol. 16 Issue 1, p1-20, 20p

Subject Terms: ACUTE myeloid leukemia, MYELOPROLIFERATIVE neoplasms, MEDICAL sciences, TUMOR necrosis factors, MOUSE leukemia

RSK1 dependency in FLT3-ITD acute myeloid leukemia.

Authors: Kong, Tim, Laranjeira, Angelo B. A., Letson, Christopher T., Yu, LaYow, He, Fan, Jayanthan, Aarthi, Los, Gerrit, Dunn, Sandra E., Challen, Grant A., Oh, Stephen T.

Source: Blood Cancer Journal; 11/26/2024, Vol. 14 Issue 1, p1-10, 10p

Subject Terms: ACUTE myeloid leukemia, PROTEIN-tyrosine kinases, RIBOSOMAL proteins, PROTEIN stability, OVERALL survival, PRELEUKEMIA

Transcriptional and Metabolic Profiling Reveals Alpha-Ketoglutarate As a Novel Mediator of Aberrant Platelet Activity and Inflammation in Myeloproliferative Neoplasms

Authors: He, Fan, Laranjeira, Angelo BA ^*, Kong, Tim, Bark, Katrina ^*, Liu, Alice ^*, Allen, Maggie J. ^*, Fisher, Daniel AC ^*, Fulbright, Mary ^*, Yu, LaYow ^*, Lasky, Nina M. ^*, Sykes, Stephen M., D'Alessandro, Angelo, Di Paola, Jorge, Oh, Stephen T

Source: In Blood 15 November 2022 140 Supplement 1:1095-1097

RSK1 Is an Exploitable Dependency in Myeloid Malignancies

Authors: Kong, Tim, Laranjeira, Angelo B. A., Yu, LaYow, Fowles, Jared Scott, Fisher, Daniel A.C., Ng, Sherwin, Yang, Wei, He, Fan, Cox, Maggie J, Fulbright, Mary C., Rentschler, Stacey L., Huynh, My-my, Los, Gerrit, Dunn, Sandra E., Challen, Grant A, Oh, Stephen T.

Source: In Blood 2 November 2023 142 Supplement 1:46-46

Targeting RSK1-Mediated Dependency and Inflammation in Myeloid Malignancies

Authors: Kong, Tim, Laranjeira, Angelo BA ^*, Yu, LaYow ^*, Fowles, Jared S., He, Fan, Allen, Maggie J. ^*, Oh, Stephen T

Source: In Blood 15 November 2022 140 Supplement 1:6724-6725

Comprehensive Profiling of Clinical JAK2 Inhibitors in Myeloproliferative Neoplasms

Authors: Kong, Tim, Yu, LaYow ^*, Laranjeira, Angelo BA ^*, He, Fan, Allen, Maggie J. ^*, Oh, Stephen T

Source: In Blood 15 November 2022 140 Supplement 1:3951-3952

DUSP6 Mediates Resistance to JAK2 Inhibition and Drives Myeloproliferative Neoplasm Disease Progression

Authors: Kong, Tim, Laranjeira, Angelo BA, Yang, Kangning, Fisher, Daniel AC, Yu, LaYow, Wang, Anthony Z, Ruzinova, Marianna B., Fowles, Jared S., Allen, Maggie J., Celik, Hamza, Challen, Grant A., Huang, Sidong, Oh, Stephen T.

Source: In Blood 23 November 2021 138 Supplement 1:55-55