Transcriptional activation of Jun and Fos members of the AP‐1 complex is a conserved signature of immune aging that contributes to inflammaging

Authors: Karakaslar, Emin Onur, Katiyar, Neerja, Hasham, Muneer, Youn, Ahrim, Sharma, Siddhartha, Chung, Cheng‐han, Marches, Radu, Korstanje, Ron, Banchereau, Jacques, Ucar, Duygu

Source: Aging cell. 22(4)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184958549.0x000001&indx=1&recIds=ETOCvdc_100184958549.0x000001

A case study: Assessing the efficacy of the revised dosage regimen via prediction model for recurrent event rate using biomarker data.

Authors: Youn, Ahrim¹ (AUTHOR) ahrim.youn@sanofi.com, Chi, Jiarui¹ (AUTHOR) Jiarui.Chi@sanofi.com, Cui, Yue² (AUTHOR), Quan, Hui¹ (AUTHOR)

Source: Pharmaceutical Statistics. Jul/Aug2024, Vol. 23 Issue 4, p570-584. 15p.

Subject Terms: *CLINICAL trials, *PREDICTION models, *BIOMARKERS, *TREATMENT effectiveness, *RARE diseases

The MiAge Calculator: a DNA methylation-based mitotic age calculator of human tissue types

Authors: Youn, Ahrim, Wang, Shuang

Source: Epigenetics. 13(2):192-206

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100079386428.0x000001&indx=1&recIds=ETOCvdc_100079386428.0x000001

A pan-cancer analysis of driver gene mutations, DNA methylation and gene expressions reveals that chromatin remodeling is a major mechanism inducing global changes in cancer epigenomes

Authors: Youn, Ahrim, Kim, Kyung In, Rabadan, Raul, Tycko, Benjamin, Shen, Yufeng, Wang, Shuang

Source: BMC medical genomics. 11(1):1-16

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185396360.0x000001&indx=1&recIds=ETOCvdc_100185396360.0x000001

Alpha TC1 and Beta-TC-6 genomic profiling uncovers both shared and distinct transcriptional regulatory features with their primary islet counterparts

Authors: Lawlor, Nathan, Youn, Ahrim, Kursawe, Romy, Ucar, Duygu, Stitzel, Michael

Source: Scientific reports. 7(1):1-14

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182752581.0x000001&indx=1&recIds=ETOCvdc_100182752581.0x000001

Phase 1/2 Study Investigating CC-90011, a Potent, Selective, and Reversible Oral Inhibitor of Lysine-Specific Demethylase 1 (LSD1), Plus Concurrent Venetoclax (VEN) and Azacitidine (AZA) in Patients with Acute Myeloid Leukemia (AML)

Authors: DiNardo, Courtney D., Borthakur, Gautam, Ball, Brian, Erba, Harry P., Mawad, Raya, Kremyanskaya, Marina, Blachly, James S., Carraway, Hetty E., Youn, Ahrim, Garzon, Jessica, Lopes de Menezes, Daniel, Martin-Regueira, Patricia, Beach, C.L., Watts, Justin

Source: In Blood 23 November 2021 138 Supplement 1:4430-4430

Using passenger mutations to estimate the timing of driver mutations and identify mutator alterations.

Authors: Youn, Ahrim¹ youna2@mail.nih.gov, Simon, Richard¹ rsimon@mail.nih.gov

Source: BMC Bioinformatics. 2013, Vol. 14 Issue 1, p1-20. 20p. 3 Diagrams, 2 Charts, 1 Graph.

Subject Terms: *SOMATIC cells, *TUMORS, *NEOPLASTIC cell transformation, *TUMOR growth, *NUCLEOTIDE sequence, *PROBABILISTIC generative models

Identifying cancer driver genes in tumor genome sequencing studies.

Authors: Youn, Ahrim, Simon, Richard

Source: Bioinformatics; January 15 2011, Vol. 27 Issue 2, p175-181, 7p

Learning transcriptional networks from the integration of ChIP-chip and expression data in a non-parametric model.

Authors: Youn, Ahrim, Reiss, David J., Stuetzle, Werner

Source: Bioinformatics; August 1 2010, Vol. 26 Issue 15, p1879-1886, 8p

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BiFET: sequencing Bi as-free transcription factor F ootprint E nrichment T est.

Authors: Youn, Ahrim, Marquez, Eladio J, Lawlor, Nathan, Stitzel, Michael L, Ucar, Duygu

Source: Nucleic Acids Research; 1/25/2019, Vol. 47 Issue 2, pe11-e11, 1p