Complement factor H targeting antibody GT103 in refractory non-small cell lung cancer: a phase 1b dose escalation trial

Authors: Jeffrey M. Clarke, George R. Simon, Hirva Mamdani, Lin Gu, James E. Herndon, Thomas E. Stinchcombe, Neal Ready, Jeffrey Crawford, Guru Sonpavde, Stephen Balevic, Andrew B. Nixon, Michael Campa, Elizabeth B. Gottlin, Huihua Li, Ruchi Saxena, You Wen He, Scott Antonia, Edward F. Patz

Source: Nature Communications, Vol 16, Iss 1, Pp 1-10 (2025)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/d6c5fe0d4de14eb8a7276b6c8c2bf723

Targeting regulated cell death pathways in cancers for effective treatment: a comprehensive review

Authors: Ruchi Saxena, Craig M. Welsh, You-Wen He

Source: Frontiers in Cell and Developmental Biology, Vol 12 (2024)

Subject Terms: regulated cell death pathway, cancer therapy, apoptosis, autophagy, necroptosis, ferroptosis, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2024.1462339/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/38f1cddc3b9a4f37a6d9829366b1433e

Clinical efficacy of CDK4/6 inhibitor plus endocrine therapy in HR-positive/HER2-0 and HER2-low-positive metastatic breast cancer: a secondary analysis of PALOMA-2 and PALOMA-3 trialsResearch in context

Authors: Huiyue Li, Yun Wu, Haotian Zou, Salil Koner, Jennifer K. Plichta, Sara M. Tolaney, Jian Zhang, You-Wen He, Qingyi Wei, Li Tang, Hui Zhang, Baoshan Zhang, Yuanyuan Guo, Xin Chen, Kan Li, Liyou Lian, Fei Ma, Sheng Luo

Source: EBioMedicine, Vol 105, Iss , Pp 105186- (2024)

Subject Terms: HER2-low-positive, HER2-0, CDK4/6 inhibitor, Endocrine therapy, First-line treatment, Metastatic breast cancer, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396424002214; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/a88a4058f89f47909933524af7e014a0

Complement factor H: a novel innate immune checkpoint in cancer immunotherapy

Authors: Ruchi Saxena, Elizabeth B. Gottlin, Michael J. Campa, Ryan T. Bushey, Jian Guo, Edward F. Patz, You-Wen He

Source: Frontiers in Cell and Developmental Biology, Vol 12 (2024)

Subject Terms: complement, complement factor H, immunosuppression, tumor micro-environment, immune checkpoint, immunotherapy, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2024.1302490/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/85eb01f6674348539cfa2ed07c7dc695

Combination immunotherapy of glioblastoma with dendritic cell cancer vaccines, anti-PD-1 and poly I:C

Authors: Ping Zhu, Shi-You Li, Jin Ding, Zhou Fei, Sheng-Nan Sun, Zhao-Hui Zheng, Ding Wei, Jun Jiang, Jin-Lin Miao, San-Zhong Li, Xing Luo, Kui Zhang, Bin Wang, Kun Zhang, Su Pu, Qian-Ting Wang, Xin-Yue Zhang, Gao-Liu Wen, Jun O. Liu, John Thomas August, Huijie Bian, Zhi-Nan Chen, You-Wen He

Source: Journal of Pharmaceutical Analysis, Vol 13, Iss 6, Pp 616-624 (2023)

Subject Terms: Glioblastoma multiforme, DC vaccine, Tumor-associated antigens, Neoantigens, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2095177923000734; https://doaj.org/toc/2095-1779

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Clinically approved combination immunotherapy: Current status, limitations, and future perspective

Authors: Ligong Lu, Meixiao Zhan, Xian-Yang Li, Hui Zhang, Danielle J. Dauphars, Jun Jiang, Hua Yin, Shi-You Li, Sheng Luo, Yong Li, You-Wen He

Source: Current Research in Immunology, Vol 3, Iss , Pp 118-127 (2022)

Subject Terms: Combination immunotherapy, First-line therapy, Atezolizumab, Bevacizumab, HCC, Dose, Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2590255522000087; https://doaj.org/toc/2590-2555

Access URL: https://doaj.org/article/d4659b11267649d0a3c5cf3b7e2265ff

Editorial: Editor’s Pick 2021: Highlights in Cell Death and Survival

Authors: You-Wen He, Craig M. Walsh

Source: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Subject Terms: cell death, autophagy, survival, T lymphocyte, antitumor immunity, immunotherapy, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.887688/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/abead5df8cdf4456b485e6ca6114508f

Preventing Mortality in COVID-19 Patients: Which Cytokine to Target in a Raging Storm?

Authors: Ligong Lu, Hui Zhang, Meixiao Zhan, Jun Jiang, Hua Yin, Danielle J. Dauphars, Shi-You Li, Yong Li, You-Wen He

Source: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Subject Terms: COVID-19, mortality, cytokine storm, chemokine, inflammation, immunopathology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fcell.2020.00677/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/2e9d3be21f154ad6b8bfe7d506af4488

Modulation of NKG2D, KIR2DL and Cytokine Production by Pleurotus ostreatus Glucan Enhances Natural Killer Cell Cytotoxicity Toward Cancer Cells

Authors: Nehal M. EL-Deeb, Hala I. EL-Adawi, Abeer E. Abd EL-wahab, Ahmed M. Haddad, Hesham A. EL Enshasy, You-Wen He, Keith R. Davis

Source: Frontiers in Cell and Developmental Biology, Vol 7 (2019)

Subject Terms: NK cells, mushroom, Pleurotus ostreatus, breast cancer, lung cancer, polysaccharides, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fcell.2019.00165/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/3d51bd2cd41f47f8a2ffa79d29f86854

The Complement Receptors C3aR and C5aR Are a New Class of Immune Checkpoint Receptor in Cancer Immunotherapy

Authors: Yu Wang, Hui Zhang, You-Wen He

Source: Frontiers in Immunology, Vol 10 (2019)

Subject Terms: complement, cancer immuno therapy, complement receptor C3aR, complement receptor C5aR, IL-10 (interleukin-10), PD-1 - PDL-1 axis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.01574/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/5e3841fd4ca14ab9b6c5865cbec9a157

Complement factor H: a novel innate immune checkpoint in cancer immunotherapy.

Authors: Saxena, Ruchi, Gottlin, Elizabeth B., Campa, Michael J., Bushey, Ryan T., Jian Guo, Patz Jr., Edward F., You-Wen He

Source: Frontiers in Cell & Developmental Biology; 2024, p1-9, 9p

Subject Terms: COMPLEMENT factor H, IMMUNE checkpoint proteins, COMPLEMENT activation, IMMUNOTHERAPY, IMMUNE system

cFLIP Regulates Skin Homeostasis and Protects against TNF-Induced Keratinocyte Apoptosis

Authors: Diana Panayotova-Dimitrova, Maria Feoktistova, Michaela Ploesser, Beate Kellert, Mike Hupe, Sebastian Horn, Roman Makarov, Federico Jensen, Stefan Porubsky, Astrid Schmieder, Ana Claudia Zenclussen, Alexander Marx, Andreas Kerstan, Peter Geserick, You-Wen He, Martin Leverkus

Source: Cell Reports, Vol 5, Iss 2, Pp 397-408 (2013)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124713005585; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/3b195d1a55874f92aca59476358621bd

A novel antibody humanization method based on epitopes scanning and molecular dynamics simulation.

Authors: Ding Zhang, Cai-Feng Chen, Bin-Bin Zhao, Lu-Lu Gong, Wen-Jing Jin, Jing-Jun Liu, Jing-Fei Wang, Tian-Tian Wang, Xiao-Hui Yuan, You-Wen He

Source: PLoS ONE, Vol 8, Iss 11, p e80636 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3836750?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/75f002ea374f4f868fdd436f07d4c699

T lymphocytes from chronic HCV-infected patients are primed for activation-induced apoptosis and express unique pro-apoptotic gene signature.

Authors: Bin-Bin Zhao, Su-Jun Zheng, Lu-Lu Gong, Yu Wang, Cai-Feng Chen, Wen-Jing Jin, Ding Zhang, Xiao-Hui Yuan, Jian Guo, Zhong-Ping Duan, You-Wen He

Source: PLoS ONE, Vol 8, Iss 10, p e77008 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3794995?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/c0bbce4cd38f4166bc70f4454e976342

Structure-based high-throughput epitope analysis of hexon proteins in B and C species human adenoviruses (HAdVs).

Authors: Xiao-Hui Yuan, Ying-Chen Wang, Wen-Jing Jin, Bin-Bin Zhao, Cai-Feng Chen, Jian Yang, Jing-Fei Wang, Ying-Ying Guo, Jing-Jun Liu, Ding Zhang, Lu-Lu Gong, You-Wen He

Source: PLoS ONE, Vol 7, Iss 3, p e32938 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3302796?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/b214f821531e49b99e8332426c70b23f

Downregulation of the AU-rich RNA-binding protein ZFP36 in chronic HBV patients: implications for anti-inflammatory therapy.

Authors: Wen-Jing Jin, Cai-Feng Chen, Hui-Yu Liao, Lu-Lu Gong, Xiao-Hui Yuan, Bin-Bin Zhao, Ding Zhang, Xia Feng, Jing-Jun Liu, Yu Wang, Guo-Feng Chen, Hui-Ping Yan, You-Wen He

Source: PLoS ONE, Vol 7, Iss 3, p e33356 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3302862?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/e4602ccaadf54dffa2eb6873d05dc40d

The Role of the Extracellular Matrix Protein Mindin in Airway Response to Environmental Airways Injury.

Authors: Frush, Sarah (AUTHOR), Zhuowei Li (AUTHOR), Potts, Erin N. (AUTHOR), Wanglei Du (AUTHOR), Eu, Jerry P. (AUTHOR), Garantziotis, Stavros (AUTHOR), You-Wen He (AUTHOR), Foster, W. Michael (AUTHOR), Hollingsworth, John W. (AUTHOR)

Source: Environmental Health Perspectives. Oct2011, Vol. 119 Issue 10, p1403-1408. 6p.

URL: 66654198

The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens.

Authors: You-Wen He, Dan R.¹ he000004@mc.duke.edu, Hong Li¹, Jun Zhang¹, Chia-Lin Hsu, Dan R.¹, Emily Lin, Dan R.¹, Nu Zhang, Dan R.¹, Jian Guo, Dan R.¹, Forbush, Katherine A.², Bevan, Michael J.² mbevan@u.washington.edu

Source: Nature Immunology. Jan2004, Vol. 5 Issue 1, p88-97. 10p.

Subject Terms: *PATHOGENIC microorganisms, *EXTRACELLULAR matrix, *BACTERIAL diseases, *PHAGOCYTOSIS, *MACROPHAGES, *IMMUNE response

Myeloid-Specific Deletion of Mcl-1 Yields Severely Neutropenic Mice That Survive and Breed in Homozygous Form.

Authors: Mócsai, Attila, Csepregi, Janka Zsófia, Orosz, Anita, Kása, Orsolya, Németh, Tamás, Simon, Edina, Zajta, Erik, Csonka, Katalin, Gácser, Attila, Fodor, Szabina, Barátki, Balázs L., Kövesdi, Dorottya, You-Wen He

Source: Journal of Immunology; 12/15/2018, Vol. 201 Issue 12, p3793-3803, 11p

Lung inflammation stalls Th17-cell migration en route to the central nervous system during the development of experimental autoimmune encephalomyelitis.

Authors: Masashi Kanayama, Keiko Danzaki, You-Wen He, Shinohara, Mari L.

Source: International Immunology; Sep2016, Vol. 28 Issue 9, p463-469, 7p

Subject Terms: CENTRAL nervous system, IMMUNOLOGY of inflammation, MULTIPLE sclerosis, DEMYELINATION, ENCEPHALOMYELITIS