Immune inactivation of anti-simian immunodeficiency virus chimeric antigen receptor T cells in rhesus macaques

Authors: Françoise Haeseleer, Yoshinori Fukazawa, Haesun Park, Benjamin Varco-Merth, Blake J. Rust, Jeremy V. Smedley, Karsten Eichholz, Christopher W. Peterson, Rosemarie Mason, Hans-Peter Kiem, Mario Roederer, Louis J. Picker, Afam A. Okoye, Lawrence Corey

Source: Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 304-319 (2021)

Subject Terms: CAR T cells, HIV, SIV, infectious diseases, humoral immune response, autologous cell therapy, Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050121001108; https://doaj.org/toc/2329-0501

Access URL: https://doaj.org/article/2e4204042ab849e8adedcd5d6bbb820e

Rapamycin limits CD4+ T cell proliferation in simian immunodeficiency virus–infected rhesus macaques on antiretroviral therapy

Authors: Benjamin D. Varco-Merth, William Brantley, Alejandra Marenco, Derick D. Duell, Devin N. Fachko, Brian Richardson, Kathleen Busman-Sahay, Danica Shao, Walter Flores, Kathleen Engelman, Yoshinori Fukazawa, Scott W. Wong, Rebecca L. Skalsky, Jeremy Smedley, Michael K. Axthelm, Jeffrey D. Lifson, Jacob D. Estes, Paul T. Edlefsen, Louis J. Picker, Cheryl M.A. Cameron, Timothy J. Henrich, Afam A. Okoye

Source: The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)

Subject Terms: AIDS/HIV, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/0626fdc3092c4cc489640700d2cf76b5

The ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription.

Authors: Afam A Okoye, Rémi Fromentin, Hiroshi Takata, Jessica H Brehm, Yoshinori Fukazawa, Bryan Randall, Marion Pardons, Vincent Tai, Jun Tang, Jeremy Smedley, Michael Axthelm, Jeffrey D Lifson, Louis J Picker, David Favre, Lydie Trautmann, Nicolas Chomont

Source: PLoS Pathogens, Vol 18, Iss 1, p e1010245 (2022)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/010dc74613b6426081cb5b18f4918266

Interleukin-15 response signature predicts RhCMV/SIV vaccine efficacy.

Authors: Fredrik Barrenäs, Scott G Hansen, Lynn Law, Connor Driscoll, Richard R Green, Elise Smith, Jean Chang, Inah Golez, Taryn Urion, Xinxia Peng, Leanne Whitmore, Daniel Newhouse, Colette M Hughes, David Morrow, Kurt T Randall, Andrea N Selseth, Julia C Ford, Roxanne M Gilbride, Bryan E Randall, Emily Ainslie, Kelli Oswald, Rebecca Shoemaker, Randy Fast, William J Bosche, Michael K Axthelm, Yoshinori Fukazawa, George N Pavlakis, Barbara K Felber, Slim Fourati, Rafick-Pierre Sekaly, Jeffrey D Lifson, Jan Komorowski, Ewelina Kosmider, Danica Shao, Wenjun Song, Paul T Edlefsen, Louis J Picker, Michael Gale

Source: PLoS Pathogens, Vol 17, Iss 7, p e1009278 (2021)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/cd57c9263ff449bb8bd672c756c1208a

Anti-PD-1 chimeric antigen receptor T cells efficiently target SIV-infected CD4⁺ T cells in germinal centers.

Authors: Eichholz, Karsten¹, Yoshinori Fukazawa², Peterson, Christopher W.³, Francoise, Francoise^1,4,5, Medina, Manuel², Hoffmeister, Shelby², Duel, Derick M.^1,2, Varco-Merth, Benjamin D.², Dross, Sandra^6,7, Haesun Park², Labriola, Caralyn S.², Axthelm, Michael K.², Murnane, Robert D.⁶, Smedley, Jeremy V.², Lei Jin¹, Jiaxin Gong¹, Rust, Blake J.³, Fuller, Deborah H.^6,7, Kiem, Hans-Peter^1,3,5, Picker, Louis J.²

Source: Journal of Clinical Investigation. 4/1/2024, Vol. 134 Issue 7, p1-14. 14p.

Subject Terms: *CHIMERIC antigen receptors, *T cells, *GERMINAL centers, *IMMUNOLOGIC memory, *IMMUNE checkpoint proteins

Rapamycin limits CD4+ T cell proliferation in simian immunodeficiency virus-infected rhesus macaques on antiretroviral therapy.

Authors: Varco-Merth, Benjamin D., Brantley, William, Marenco, Alejandra, Duell, Derick D., Fachko, Devin N., Richardson, Brian, Busman-Sahay, Kathleen, Shao, Danica, Flores, Walter, Engelman, Kathleen, Yoshinori Fukazawa, Wong, Scott W., Skalsky, Rebecca L., Smedley, Jeremy, Axthelm, Michael K., Lifson, Jeffrey D., Estes, Jacob D., Edlefsen, Paul T., Picker, Louis J., Cameron, Cheryl M. A.

Source: Journal of Clinical Investigation. 5/16/2022, Vol. 132 Issue 10, p1-15. 15p.