Disruption of cotranscriptional splicing suggests RBM39 is a therapeutic target in acute lymphoblastic leukemia

Authors: Jin, Qi, Harris, Ethan, Myers, Jacquelyn A., Mehmood, Rashid, Cotton, Anitria, Shirnekhi, Hazheen K., Baggett, David W., Wen, Jeremy Qiang, Schild, Andrew B., Bhansali, Rahul S., Klein, Jonathon, Narina, Shilpa, Pieters, Tim, Yoshimi, Akihide, Pruett-Miller, Shondra M., Kriwacki, Richard, Abdel-Wahab, Omar, Malinge, Sebastien, Ntziachristos, Panagiotis, Obeng, Esther A., Crispino, John D.

Source: In Blood 5 December 2024 144(23):2417-2431

SRSF2 plays an unexpected role as reader of m5C on mRNA, linking epitranscriptomics to cancer

Authors: Ma, Hai-Li, Bizet, Martin, Soares Da Costa, Christelle, Murisier, Frédéric, de Bony, Eric James, Wang, Meng-Ke, Yoshimi, Akihide, Lin, Kuan-Ting, Riching, Kristin M., Wang, Xing, Beckman, John I., Arya, Shailee, Droin, Nathalie, Calonne, Emilie, Hassabi, Bouchra, Zhang, Qing-Yang, Li, Ang, Putmans, Pascale, Malbec, Lionel, Hubert, Céline, Lan, Jie, Mies, Frédérique, Yang, Ying, Solary, Eric, Daniels, Danette L., Gupta, Yogesh K., Deplus, Rachel, Abdel-Wahab, Omar, Yang, Yun-Gui, Fuks, François

Source: In Molecular Cell 7 December 2023 83(23):4239-4254

Electrically Driven, Bioluminescent Compliant Devices for Soft Robotics.

Authors: Kusama, Kengo, Oishi, Atsuro, Ueno, Hitoshi, Yoshimi, Akihide, Nagase, Miki, Shintake, Jun

Source: ACS Applied Materials & Interfaces; 2/19/2025, Vol. 17 Issue 7, p11248-11258, 11p

Aberrant RNA splicing and therapeutic opportunities in cancers

Authors: Yamauchi, Hirofumi, Nishimura, Kazuki, Yoshimi, Akihide

Source: Cancer science. 113(2):373-381

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139983353.0x000001&indx=1&recIds=ETOCvdc_100139983353.0x000001

Efficient production of human neutrophils from iPSCs that prevent murine lethal infection with immune cell recruitment

Authors: Miyauchi, Masashi ^*, Ito, Yusuke ^*, Nakahara, Fumio, Hino, Toshiya, Nakamura, Fumi, Iwasaki, Yuki, Kawagoshi, Taiki, Koya, Junji, Yoshimi, Akihide, Arai, Shunya, Kagoya, Yuki, Kurokawa, Mineo ^*

Source: In Blood 16 December 2021 138(24):2555-2569

Physical interaction between BAALC and DBN1 induces chemoresistance in leukemia

Authors: Maki, Hiroaki, Yoshimi, Akihide, Shimada, Takashi, Arai, Shunya, Morita, Ken, Kamikubo, Yasuhiko, Ikegawa, Masaya, Kurokawa, Mineo

Source: In Experimental Hematology February 2021 94:31-36

Aberrant RNA splicing and development of hematological malignancies

Authors: Yoshimi, Akihide

Source: Rinshō ketsueki. 61(6):634-642

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624135890&indx=1&recIds=ETOCRN624135890

Nationwide epidemiological survey of familial myelodysplastic syndromes/acute myeloid leukemia in Japan: a multicenter retrospective study

Authors: Takaoka, Kensuke, Koya, Junji, Yoshimi, Akihide, Toya, Takashi, Kobayashi, Takashi, Nannya, Yasuhito, Nakazaki, Kumi, Arai, Shunya, Ueno, Hironori, Usuki, Kensuke, Yamashita, Takeshi, Imanishi, Daisuke, Sato, Shinya, Suzuki, Kenshi, Harada, Hironori, Manabe, Atsushi, Hayashi, Yasuhide, Miyazaki, Yasushi, Kurokawa, Mineo

Source: Leukemia & lymphoma. 61(7):1688-1694

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110727431.0x000001&indx=1&recIds=ETOCvdc_100110727431.0x000001

Mechanistic insights into lethal hyper progressive disease induced by PD-L1 inhibitor in metastatic urothelial carcinoma.

Authors: Nishimura, Kazuki, Takahara, Kiyoshi, Komura, Kazumasa, Ishida, Mitsuaki, Hirosuna, Kensuke, Maenosono, Ryoichi, Ajiro, Masahiko, Sakamoto, Moritoshi, Iwatsuki, Kengo, Nakajima, Yuki, Tsujino, Takuya, Taniguchi, Kohei, Tanaka, Tomohito, Inamoto, Teruo, Hirose, Yoshinobu, Ono, Fumihito, Kondo, Yoichi, Yoshimi, Akihide, Azuma, Haruhito

Source: NPJ Precision Oncology; 9/17/2024, Vol. 8 Issue 1, p1-8, 8p

Subject Terms: DISEASE progression, IMMUNE checkpoint inhibitors, METASTASIS, TUMOR growth, TRANSITIONAL cell carcinoma

Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene U2af1

Authors: Fei, Dennis Liang, Zhen, Tao, Durham, Benjamin, Ferrarone, John, Zhang, Tuo, Garrett, Lisa, Yoshimi, Akihide, Abdel-Wahab, Omar, Bradley, Robert K., Liu, Paul, Varmus, Harold

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 Oct . 115(44), E10437-E10446.

Access URL: https://www.jstor.org/stable/26532469

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations

Authors: Lee, Stanley Chun-Wei, North, Khrystyna, Kim, Eunhee, Jang, Eunjung, Obeng, Esther, Lu, Sydney X., Liu, Bo, Inoue, Daichi, Yoshimi, Akihide, Ki, Michelle, Yeo, Mirae, Zhang, Xiao Jing, Kim, Min Kyung, Cho, Hana, Chung, Young Rock, Taylor, Justin, Durham, Benjamin H., Kim, Young Joon, Pastore, Alessandro, Monette, Sebastien, Palacino, James, Seiler, Michael, Buonamici, Silvia, Smith, Peter G., Ebert, Benjamin L., Bradley, Robert K., Abdel-Wahab, Omar

Source: In Cancer Cell 13 August 2018 34(2):225-241

ADAM8 Is an Antigen of Tyrosine Kinase Inhibitor-Resistant Chronic Myeloid Leukemia Cells Identified by Patient-Derived Induced Pluripotent Stem Cells

Authors: Miyauchi, Masashi, Koya, Junji, Arai, Shunya, Yamazaki, Sho, Honda, Akira, Kataoka, Keisuke, Yoshimi, Akihide, Taoka, Kazuki, Kumano, Keiki, Kurokawa, Mineo

Source: In Stem Cell Reports 13 March 2018 10(3):1115-1130

Targeting mRNA Decapping in AML

Authors: Yoshimi, Akihide, Abdel-Wahab, Omar

Source: In Cancer Cell 12 March 2018 33(3):339-341

Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms

Authors: Durham, Benjamin H., Lopez Rodrigo, Estibaliz, Picarsic, Jennifer, Abramson, David, Rotemberg, Veronica, De Munck, Steven, Pannecoucke, Erwin, Lu, Sydney X., Pastore, Alessandro, Yoshimi, Akihide, Mandelker, Diana, Ceyhan-Birsoy, Ozge, Ulaner, Gary A., Walsh, Michael, Yabe, Mariko, Petrova-Drus, Kseniya, Arcila, Maria E., Ladanyi, Marc, Solit, David B., Berger, Michael F., Hyman, David M., Lacouture, Mario E., Erickson, Caroline, Saganty, Ruth, Ki, Michelle, Dunkel, Ira J., Santa-María López, Vicente, Mora, Jaume, Haroche, Julien, Emile, Jean-Francois, Decaux, Olivier, Geissmann, Frederic, Savvides, Savvas N., Drilon, Alexander, Diamond, Eli L., Abdel-Wahab, Omar

Source: Nature medicine. 25(12):1839-1842

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193246864.0x000001&indx=1&recIds=ETOCvdc_100193246864.0x000001

Spliceosomal disruption of the non-canonical BAF complex in cancer

Authors: Inoue, Daichi, Chew, Guo-Liang, Liu, Bo, Michel, Brittany, Pangallo, Joseph, D'Avino, Andrew, Hitchman, Tyler, North, Khrystyna, Lee, Stanley, Bitner, Lillian, Block, Ariele, Moore, Amanda, Yoshimi, Akihide, Escobar-Hoyos, Luisa, Cho, Hana, Penson, Alex, Lu, Sydney, Taylor, Justin, Chen, Yu, Kadoch, Cigall, Abdel-Wahab, Omar, Bradley, Robert

Source: Nature. 574(7778):432-436

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190853460.0x000001&indx=1&recIds=ETOCvdc_100190853460.0x000001

Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis

Authors: Yoshimi, Akihide, Lin, Kuan-Ting, Wiseman, Daniel, Rahman, Mohammad, Pastore, Alessandro, Wang, Bo, Lee, Stanley, Micol, Jean-Baptiste, Zhang, Xiao, de Botton, Stephane, Penard-Lacronique, Virginie, Stein, Eytan, Cho, Hana, Miles, Rachel, Inoue, Daichi, Albrecht, Todd, Somervaille, Tim, Batta, Kiran, Amaral, Fabio, Simeoni, Fabrizio, Wilks, Deepti, Cargo, Catherine, Intlekofer, Andrew, Levine, Ross, Dvinge, Heidi, Bradley, Robert, Wagner, Eric, Krainer, Adrian, Abdel-Wahab, Omar

Source: Nature. 574(7777):273-277

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190844431.0x000001&indx=1&recIds=ETOCvdc_100190844431.0x000001

A germline HLTF mutation in familial MDS induces DNA damage accumulation through impaired PCNA polyubiquitination

Authors: Takaoka, Kensuke, Kawazu, Masahito, Koya, Junji, Yoshimi, Akihide, Masamoto, Yosuke, Maki, Hiroaki, Toya, Takashi, Kobayashi, Takashi, Nannya, Yasuhito, Arai, Shunya, Ueno, Toshihide, Ueno, Hironori, Suzuki, Kenshi, Harada, Hironori, Manabe, Atsushi, Hayashi, Yasuhide, Mano, Hiroyuki, Kurokawa, Mineo

Source: Leukemia. 33(7):1773-1782

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184151889.0x000001&indx=1&recIds=ETOCvdc_100184151889.0x000001

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

Authors: Cimmino, Luisa, Dolgalev, Igor, Wang, Yubao, Yoshimi, Akihide, Martin, Gaëlle H., Wang, Jingjing, Ng, Victor, Xia, Bo, Witkowski, Matthew T., Mitchell-Flack, Marisa, Grillo, Isabella, Bakogianni, Sofia, Ndiaye-Lobry, Delphine, Martín, Miguel Torres, Guillamot, Maria, Banh, Robert S., Xu, Mingjiang, Figueroa, Maria E., Dickins, Ross A., Abdel-Wahab, Omar, Park, Christopher Y., Tsirigos, Aristotelis, Neel, Benjamin G., Aifantis, Iannis

Source: In Cell 7 September 2017 170(6):1079-1095

Robust patient-derived xenografts of MDS/MPN overlap syndromes capture the unique characteristics of CMML and JMML

Authors: Yoshimi, Akihide ^*, Balasis, Maria E. ^*, Vedder, Alexis, Feldman, Kira, Ma, Yan, Zhang, Hailing, Lee, Stanley Chun-Wei, Letson, Christopher, Niyongere, Sandrine, Lu, Sydney X., Ball, Markus, Taylor, Justin, Zhang, Qing, Zhao, Yulong, Youssef, Salma, Chung, Young Rock, Zhang, Xiao Jing, Durham, Benjamin H., Yang, Wendy, List, Alan F., Loh, Mignon L., Klimek, Virginia, Berger, Michael F., Stieglitz, Elliot, Padron, Eric, Abdel-Wahab, Omar

Source: In Blood 27 July 2017 130(4):397-407

ProteomeGenerator: A Framework for Comprehensive Proteomics Based on de Novo Transcriptome Assembly and High-Accuracy Peptide Mass Spectral Matching

Authors: Cifani, Paolo, Dhabaria, Avantika, Chen, Zining, Yoshimi, Akihide, Kawaler, Emily, Abdel-Wahab, Omar, Poirier, John T., Kentsis, Alex

Source: Journal of proteome research. 17(11):3681-3692

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN617986587&indx=1&recIds=ETOCRN617986587