The Role of vIL-6 in KSHV-Mediated Immune Evasion and Tumorigenesis

Authors: Somayeh Komaki, Tomoki Inagaki, Ashish Kumar, Yoshihiro Izumiya

Source: Viruses, Vol 16, Iss 12, p 1900 (2024)

Subject Terms: vIL-6, KSHV, transcription, immune response, oncogenesis, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/16/12/1900; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/a9dd9901bd8c4355a8d694df6ced9bde

KSHV vIL-6 enhances inflammatory responses by epigenetic reprogramming.

Authors: Tomoki Inagaki, Kang-Hsin Wang, Ashish Kumar, Chie Izumiya, Hiroki Miura, Somayeh Komaki, Ryan R Davis, Clifford G Tepper, Harutaka Katano, Michiko Shimoda, Yoshihiro Izumiya

Source: PLoS Pathogens, Vol 19, Iss 11, p e1011771 (2023)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011771&type=printable; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/db0380c7828a4eac8537464fb3507f31

Virally encoded interleukin-6 facilitates KSHV replication in monocytes and induction of dysfunctional macrophages

Authors: Michiko Shimoda, Tomoki Inagaki, Ryan R. Davis, Alexander Merleev, Clifford G. Tepper, Emanual Maverakis, Yoshihiro Izumiya

Source: PLoS Pathogens, Vol 19, Iss 10 (2023)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602306/?tool=EBI; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/9d9ee14f21d240688925f793a178a701

KSHV transactivator-derived small peptide traps coactivators to attenuate MYC and inhibits leukemia and lymphoma cell growth

Authors: Michiko Shimoda, Yuanzhi Lyu, Kang-Hsin Wang, Ashish Kumar, Hiroki Miura, Joshua F. Meckler, Ryan R. Davis, Chanikarn Chantarasrivong, Chie Izumiya, Clifford G. Tepper, Ken-ichi Nakajima, Joseph Tuscano, Gustavo Barisone, Yoshihiro Izumiya

Source: Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/eaec3f23d40d4e7a83a5c5ddca22da0a

Proprotein convertase subtilisin/kexin type 9 is a psoriasis-susceptibility locus that is negatively related to IL36G

Authors: Alexander Merleev, Antonio Ji-Xu, Atrin Toussi, Lam C. Tsoi, Stephanie T. Le, Guillaume Luxardi, Xianying Xing, Rachael Wasikowski, William Liakos, Marie-Charlotte Brüggen, James T. Elder, Iannis E. Adamopoulos, Yoshihiro Izumiya, Annie R. Leal, Qinyuan Li, Nikolay Y. Kuzminykh, Amanda Kirane, Alina I. Marusina, Johann E. Gudjonsson, Emanual Maverakis

Source: JCI Insight, Vol 7, Iss 16 (2022)

Subject Terms: Autoimmunity, Dermatology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/0af5f0392e5144bb91cb11d1e06f87ed

Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes

Authors: Alexander A. Merleev, Stephanie T. Le, Claire Alexanian, Atrin Toussi, Yixuan Xie, Alina I. Marusina, Steven M. Watkins, Forum Patel, Allison C. Billi, Julie Wiedemann, Yoshihiro Izumiya, Ashish Kumar, Ranjitha Uppala, J. Michelle Kahlenberg, Fu-Tong Liu, Iannis E. Adamopoulos, Elizabeth A. Wang, Chelsea Ma, Michelle Y. Cheng, Halani Xiong, Amanda Kirane, Guillaume Luxardi, Bogi Andersen, Lam C. Tsoi, Carlito B. Lebrilla, Johann E. Gudjonsson, Emanual Maverakis

Source: JCI Insight, Vol 7, Iss 16 (2022)

Subject Terms: Dermatology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/29f7b5c3c7314462ae63385c896e06c5

Marek’s disease virus Meq oncoprotein interacts with chicken HDAC 1 and 2 and mediates their degradation via proteasome dependent pathway

Authors: Yifei Liao, Blanca Lupiani, Yoshihiro Izumiya, Sanjay M. Reddy

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/39a72ddce0ef46dd9580dad908e6e118

PAN RNA: transcriptional exhaust from a viral engine

Authors: Mel Campbell, Yoshihiro Izumiya

Source: Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-10 (2020)

Subject Terms: Non-coding RNA, Herpesvirus, eRNAs, Chromatin looping, RNA pol II recruitment, Medicine

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12929-020-00637-y; https://doaj.org/toc/1423-0127

Access URL: https://doaj.org/article/06d66b9a766349b6b0c2784c72b80cc9

HIV-1 Tat enhances purinergic P2Y4 receptor signaling to mediate inflammatory cytokine production and neuronal damage via PI3K/Akt and ERK MAPK pathways

Authors: Feng Zhou, Xiaomei Liu, Lin Gao, Xinxin Zhou, Qianwen Cao, Liping Niu, Jing Wang, Dongjiao Zuo, Xiangyang Li, Ying Yang, Minmin Hu, Yinghua Yu, Renxian Tang, Bong Ho Lee, Byoung Wook Choi, Yugang Wang, Yoshihiro Izumiya, Min Xue, Kuiyang Zheng, Dianshuai Gao

Source: Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-13 (2019)

Subject Terms: HIV-associated neurocognitive disorders, Astrocytes, Inflammatory cytokines, Purinergic P2Y4 receptor, Tat, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12974-019-1466-8; https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/ac247a78099d4705b8a93bc9b98faed4

HIV-1 Nef-induced lncRNA AK006025 regulates CXCL9/10/11 cluster gene expression in astrocytes through interaction with CBP/P300

Authors: Feng Zhou, Xiaomei Liu, Dongjiao Zuo, Min Xue, Lin Gao, Ying Yang, Jing Wang, Liping Niu, Qianwen Cao, Xiangyang Li, Hui Hua, Bo Zhang, Minmin Hu, Dianshuai Gao, Kuiyang Zheng, Yoshihiro Izumiya, Renxian Tang

Source: Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-14 (2018)

Subject Terms: HIV-associated neurocognitive disorder, HIV-1, lncRNAs, Astrocytes, Nef, CBP/P300, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12974-018-1343-x; https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/689dc8834ce64ebc8cff47e1f2748b5f

KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation

Authors: Mel Campbell, Tadashi Watanabe, Kazushi Nakano, Ryan R. Davis, Yuanzhi Lyu, Clifford G. Tepper, Blythe Durbin-Johnson, Masahiro Fujimuro, Yoshihiro Izumiya

Source: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/dda9944922624a1d8b1fe07d7ee176f6

KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch between Mitochondrial Oxidation and Glycolysis

Authors: Ling-Yu Wang, Chiu-Lien Hung, Yun-Ru Chen, Joy C. Yang, Junjian Wang, Mel Campbell, Yoshihiro Izumiya, Hong-Wu Chen, Wen-Ching Wang, David K. Ann, Hsing-Jien Kung

Source: Cell Reports, Vol 16, Iss 11, Pp 3016-3027 (2016)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124716310646; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/d8929b5dd7de42458a3bca31f0b46884

Long Non-Coding RNA and Epigenetic Gene Regulation of KSHV

Authors: Mel Campbell, Hsing-Jien Kung, Yoshihiro Izumiya

Source: Viruses, Vol 6, Iss 11, Pp 4165-4177 (2014)

Subject Terms: viruses, long non-coding RNA, epigenetics, viral latency, viral reactivation, Microbiology, QR1-502

File Description: electronic resource

Relation: http://www.mdpi.com/1999-4915/6/11/4165; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/e5f5ac83c5c248b0a19542fb5c38b44b

An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses.

Authors: Claire A Schreiber, Toshie Sakuma, Yoshihiro Izumiya, Sara J Holditch, Raymond D Hickey, Robert K Bressin, Upamanyu Basu, Kazunori Koide, Aravind Asokan, Yasuhiro Ikeda

Source: PLoS Pathogens, Vol 11, Iss 8, p e1005082 (2015)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4526370?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/5782021d39314041814496d41ad5a7ef

The binding of monomeric C-reactive protein (mCRP) to Integrins αvβ3 and α4β1 is related to its pro-inflammatory action.

Authors: Masaaki Fujita, Yoko K Takada, Yoshihiro Izumiya, Yoshikazu Takada

Source: PLoS ONE, Vol 9, Iss 4, p e93738 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093738&type=printable; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/bfcabcb48a6c4f91baa3484528c9af87

Biphasic euchromatin-to-heterochromatin transition on the KSHV genome following de novo infection.

Authors: Zsolt Toth, Kevin Brulois, Hye-Ra Lee, Yoshihiro Izumiya, Clifford Tepper, Hsing-Jien Kung, Jae U Jung

Source: PLoS Pathogens, Vol 9, Iss 12, p e1003813 (2013)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3868514?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/134acbe8080a4a55b01bdebda672d838

Kaposi's sarcoma-associated herpesvirus K-Rta exhibits SUMO-targeting ubiquitin ligase (STUbL) like activity and is essential for viral reactivation.

Authors: Yoshihiro Izumiya, Keisuke Kobayashi, Kevin Y Kim, Mamata Pochampalli, Chie Izumiya, Bogdan Shevchenko, Don-Hong Wang, Steve B Huerta, Anthony Martinez, Mel Campbell, Hsing-Jien Kung

Source: PLoS Pathogens, Vol 9, Iss 8, p e1003506 (2013)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3749962?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/f2099a97d1774c93a822916574ce05dc

Functional Imaging of Viral Transcription Factories Using 3D Fluorescence Microscopy

Authors: Christopher P. Chen, author¹, Frank Chuang, author², Yoshihiro Izumiya, author¹

Source: Journal of Visualized Experiments. (131)

Availability: http://www.jove.com/video/56832

Kaposi’s sarcoma-associated herpesvirus terminal repeat regulates inducible lytic gene promoters.

Authors: Yoshihiro Izumiya^1,2 yizumiya@ucdavis.edu, Algalil, Adhraa^1,3, Espera, Jonna M.¹, Hiroki Miura¹, Chie Izumiya¹, Tomoki Inagaki¹, Kumar, Ashish¹

Source: Journal of Virology. Feb2024, Vol. 98 Issue 2, p1-22. 22p.

Subject Terms: *KAPOSI'S sarcoma-associated herpesvirus, *THYROID hormone receptors, *GENE enhancers, *GENE expression, *BINDING sites, *REGULATOR genes, *VIRAL genes

KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation.

Authors: Campbell, Mel, Tadashi Watanabe, Kazushi Nakano, Davis, Ryan R., Yuanzhi Lyu, Tepper, Clifford G., Durbin-Johnson, Blythe, Masahiro Fujimuro, Yoshihiro Izumiya

Source: Nature Communications; 1/4/2018, Vol. 9 Issue 1, p1-14, 14p

Subject Terms: GENETIC regulation, KAPOSI'S sarcoma-associated herpesvirus, EPISOMES, RNA polymerase II, GENE regulatory networks