Whole exome sequencing identified mutations of forkhead box I 1 (FOXI1), keratin 6 C (KRT6C) and gap junction protein delta 2 (GJD2) in a low-grade oncocytic tumor of the kidney: a case report

Authors: Akinari Kakumoto, Koichi Nishimura, Daisuke Toki, Rika Kasajima, Hajime Kuroda, Yoji Nagashima, Tsunenori Kondo, Yohei Miyagi, Atsuko Masunaga

Source: Diagnostic Pathology, Vol 20, Iss 1, Pp 1-7 (2025)

Subject Terms: Low-grade oncocytic tumor, Kidney, Whole-exome sequencing, FOXI1, Keratin 6c, GJD2, Pathology, RB1-214

File Description: electronic resource

Relation: https://doaj.org/toc/1746-1596

Access URL: https://doaj.org/article/dddf3334dd12416ba083d588d10492ae

A mouse model of deep vein thrombosis by inferior vena cava hypoperfusion using ameroid constrictors

Authors: Hiroko Tadokoro, Yukihide Ota, Mari Uomoto, Shiro Koizume, Shinya Sato, Yoshiyasu Nakamura, Mitsuyo Yoshihara, Yoko Endo-Takahashi, Yoichi Negishi, Etsuko Miyagi, Yohei Miyagi

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-14 (2025)

Subject Terms: Animal model, Nude mice, Blood flow, Cancer-associated thrombosis, Venous thrombosis, Ultrasound image, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/6e0b3951d8984bad92cb382b42d7c272

Protocol for generating a pancreatic cancer organoid associated with heterogeneous tumor microenvironment

Authors: Kenta Takeuchi, Shunsuke Tabe, Yuya Yamamoto, Kenta Takahashi, Megumi Matsuo, Yasuharu Ueno, Masayuki Ohtsuka, Soichiro Morinaga, Yohei Miyagi, Tomoyuki Yamaguchi, Naoki Tanimizu, Hideki Taniguchi

Source: STAR Protocols, Vol 6, Iss 1, Pp 103539- (2025)

Subject Terms: Cancer, Stem Cells, Organoids, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666166724007044; https://doaj.org/toc/2666-1667

Access URL: https://doaj.org/article/c48f85f8440a4bc2aa30bc78f63517d4

Chemokine Expression in Well‐Differentiated Liposarcoma May Be Involved in the Tumorigenesis of Lymphoplasmacytic Lymphoma: A Case Study

Authors: Kota Washimi, Rika Kasajima, Shinya Sato, Yutaka Nezu, Hiroyuki Takahashi, Rika Sakai, Naoya Nakamura, Masayuki Takagi, Chie Hasegawa, Emi Yoshioka, Yoichiro Okubo, Kotoe Katayama, Seiya Imoto, Tomoyuki Yokose, Yohei Miyagi

Source: Cancer Reports, Vol 8, Iss 2, Pp n/a-n/a (2025)

Subject Terms: chemokine, lymphoplasmacytic lymphoma, MDM2, well‐differentiated liposarcoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2573-8348

Access URL: https://doaj.org/article/3c90217652804f00b1b5f16cdd9af876

Triple immunostaining demonstrates the possible existence of segregated-nucleus-containing atypical monocytes in human primary myelofibrosis bone marrow: a case report

Authors: Shunsuke Homma, Toshie Ogasawara, Michie Suga, Yoshiyasu Nakamura, Katsuya Takenaka, Shoko Marshall, Kiyotaka Kawauchi, Naoki Mori, Hajime Kuroda, Naoya Nakamura, Yohei Miyagi, Atsuko Masunaga

Source: Journal of Medical Case Reports, Vol 18, Iss 1, Pp 1-7 (2024)

Subject Terms: Bone marrow, Immunohistochemistry, Monocyte, Primary myelofibrosis, Segregated-nucleus-containing atypical monocyte, Case report, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1752-1947

Access URL: https://doaj.org/article/0b19be3410124971a2457cc59a1cf9c1

Tissue factor pathway inhibitor 2 as a serum biomarker for endometrial cancer: a single-center retrospective study

Authors: Mari Uomoto, Yukihide Ota, Yukio Suzuki, Asuna Yumori, Hiroto Narimatsu, Shiro Koizume, Shinya Sato, Yoshiyasu Nakamura, Shohei Myoba, Norihisa Ohtake, Haruya Saji, Etsuko Miyagi, Yohei Miyagi

Source: BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)

Subject Terms: TFPI2, Endometrial cancer, Serum biomarker, Prognostic factor, Immunohistochemistry, Discrepancy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/0b972ce8dada4faabcf3ff7c7faa693b

Efficacy of Combined Encorafenib and Binimetinib Treatment for Erdheim–Chester Disease Harboring Concurrent BRAFV600E and KRASG12R Mutations: A Case Report

Authors: Yuto Hibino, Rika Sakai, Hiroyuki Takahashi, Takaaki Takeda, Natsuki Hirose, Mayumi Tokunaga, Kota Washimi, Tomoyuki Yokose, Rika Kasajima, Yukihiko Hiroshima, Yohei Miyagi, Hideaki Nakajima

Source: Cancer Reports, Vol 7, Iss 12, Pp n/a-n/a (2024)

Subject Terms: BRAF inhibitor, Erdheim–Chester disease, genomic profiling, histiocytosis, MEK inhibitor, molecular‐targeted therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2573-8348

Access URL: https://doaj.org/article/3743ff2ee06048b5aa563e627ec9f4c9

Multi-omics analysis-based clinical and functional significance of a novel prognostic and immunotherapeutic gene signature derived from amino acid metabolism pathways in lung adenocarcinoma

Authors: Huihui Xiang, Rika Kasajima, Koichi Azuma, Tomoyuki Tagami, Asami Hagiwara, Yoshiro Nakahara, Haruhiro Saito, Yuka Igarashi, Feifei Wei, Tatsuma Ban, Mitsuyo Yoshihara, Yoshiyasu Nakamura, Shinya Sato, Shiro Koizume, Tomohiko Tamura, Tetsuro Sasada, Yohei Miyagi

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: prognostic gene signature, amino acid metabolism pathway, lung adenocarcinoma, multi-omics analysis, TP53 mutation, plasma-free α-aminobutyric acid, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1361992/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/d732c09627bd42d4a3c49f52310aabb2

Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses

Authors: Kouya Shiraishi, Atsushi Takahashi, Yukihide Momozawa, Yataro Daigo, Syuzo Kaneko, Takahisa Kawaguchi, Hideo Kunitoh, Shingo Matsumoto, Hidehito Horinouchi, Akiteru Goto, Takayuki Honda, Kimihiro Shimizu, Masahiro Torasawa, Daisuke Takayanagi, Motonobu Saito, Akira Saito, Yuichiro Ohe, Shun‐ichi Watanabe, Koichi Goto, Masahiro Tsuboi, Katsuya Tsuchihara, Sadaaki Takata, Tomomi Aoi, Atsushi Takano, Masashi Kobayashi, Yohei Miyagi, Kazumi Tanaka, Hiroyuki Suzuki, Daichi Maeda, Takumi Yamaura, Maiko Matsuda, Yoko Shimada, Takaaki Mizuno, Hiromi Sakamoto, Teruhiko Yoshida, Yasushi Goto, Tatsuya Yoshida, Taiki Yamaji, Makoto Sonobe, Shinichi Toyooka, Kazue Yoneda, Katsuhiro Masago, Fumihiro Tanaka, Megumi Hara, Nobuo Fuse, Satoshi S. Nishizuka, Noriko Motoi, Norie Sawada, Yuichiro Nishida, Kazuki Kumada, Kenji Takeuchi, Kozo Tanno, Yasushi Yatabe, Kuniko Sunami, Tomoyuki Hishida, Yasunari Miyazaki, Hidemi Ito, Mitsuhiro Amemiya, Hirohiko Totsuka, Haruhiko Nakayama, Tomoyuki Yokose, Kazuyoshi Ishigaki, Toshiteru Nagashima, Yoichi Ohtaki, Kazuhiro Imai, Ken Takasawa, Yoshihiro Minamiya, Kazuma Kobayashi, Kenichi Okubo, Kenji Wakai, Atsushi Shimizu, Masayuki Yamamoto, Motoki Iwasaki, Koichi Matsuda, Johji Inazawa, Yuichi Shiraishi, Hiroyoshi Nishikawa, Yoshinori Murakami, Michiaki Kubo, Fumihiko Matsuda, Yoichiro Kamatani, Ryuji Hamamoto, Keitaro Matsuo, Takashi Kohno

Source: Cancer Communications, Vol 44, Iss 2, Pp 287-293 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2523-3548

Access URL: https://doaj.org/article/a4b8ea6db19942899046a4b6375483b8

Lipid droplets: a candidate new research field for epithelial ovarian cancer

Authors: Shiro Koizume, Tomoko Takahashi, Yohei Miyagi

Source: Frontiers in Pharmacology, Vol 15 (2024)

Subject Terms: ovarian clear cell carcinoma, clear cell renal cell carcinoma, lipid droplet, fatty acid oxidation, lipophagy, poly ADP-ribose polymerase inhibition, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1437161/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/b473f0520a4d472e860a87596ab8d9ae

Increased RUNX3 expression mediates tumor‐promoting ability of human breast cancer‐associated fibroblasts

Authors: Yu Koyama, Hiroya Okazaki, Yang Shi, Yoshihiro Mezawa, Zixu Wang, Mizuki Sakimoto, Akane Ishizuka, Yasuhiko Ito, Takumi Koyama, Yataro Daigo, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Keisuke Sugahara, Okio Hino, Liying Yang, Reo Maruyama, Akira Katakura, Takehiro Yasukawa, Akira Orimo

Source: Cancer Medicine, Vol 12, Iss 17, Pp 18062-18077 (2023)

Subject Terms: breast cancer, CAFs, cancer‐associated fibroblasts, RUNX3, tumor microenvironment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/96ae5b868f724f33af3c3e73ed1001ff

Prognostic Significance of Plasma Neutrophil Extracellular Trap Levels in Patients with Non-Small Cell Lung Cancer Treated with Immune Checkpoint Inhibitors

Authors: Shun Horaguchi, Yoshiro Nakahara, Yuka Igarashi, Taku Kouro, Feifei Wei, Kenta Murotani, Seiichi Udagawa, Naoko Higashijima, Norikazu Matsuo, Shuji Murakami, Terufumi Kato, Tetsuro Kondo, Huihui Xiang, Rika Kasajima, Hidetomo Himuro, Kayoko Tsuji, Yasunobu Mano, Mitsuru Komahashi, Yohei Miyagi, Haruhiro Saito, Koichi Azuma, Shuichiro Uehara, Tetsuro Sasada

Source: Biomedicines, Vol 12, Iss 8, p 1831 (2024)

Subject Terms: neutrophil extracellular trap (NET), immune checkpoint inhibitor, anti-PD-1 antibody, anti-PD-L1 antibody, non-small cell lung cancer (NSCLC), Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/12/8/1831; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/4b39897048e4485b88664befbd1be51d

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Authors: Jianxin Shi, Kouya Shiraishi, Jiyeon Choi, Keitaro Matsuo, Tzu-Yu Chen, Juncheng Dai, Rayjean J. Hung, Kexin Chen, Xiao-Ou Shu, Young Tae Kim, Maria Teresa Landi, Dongxin Lin, Wei Zheng, Zhihua Yin, Baosen Zhou, Bao Song, Jiucun Wang, Wei Jie Seow, Lei Song, I-Shou Chang, Wei Hu, Li-Hsin Chien, Qiuyin Cai, Yun-Chul Hong, Hee Nam Kim, Yi-Long Wu, Maria Pik Wong, Brian Douglas Richardson, Karen M. Funderburk, Shilan Li, Tongwu Zhang, Charles Breeze, Zhaoming Wang, Batel Blechter, Bryan A. Bassig, Jin Hee Kim, Demetrius Albanes, Jason Y. Y. Wong, Min-Ho Shin, Lap Ping Chung, Yang Yang, She-Juan An, Hong Zheng, Yasushi Yatabe, Xu-Chao Zhang, Young-Chul Kim, Neil E. Caporaso, Jiang Chang, James Chung Man Ho, Michiaki Kubo, Yataro Daigo, Minsun Song, Yukihide Momozawa, Yoichiro Kamatani, Masashi Kobayashi, Kenichi Okubo, Takayuki Honda, Dean H. Hosgood, Hideo Kunitoh, Harsh Patel, Shun-ichi Watanabe, Yohei Miyagi, Haruhiko Nakayama, Shingo Matsumoto, Hidehito Horinouchi, Masahiro Tsuboi, Ryuji Hamamoto, Koichi Goto, Yuichiro Ohe, Atsushi Takahashi, Akiteru Goto, Yoshihiro Minamiya, Megumi Hara, Yuichiro Nishida, Kenji Takeuchi, Kenji Wakai, Koichi Matsuda, Yoshinori Murakami, Kimihiro Shimizu, Hiroyuki Suzuki, Motonobu Saito, Yoichi Ohtaki, Kazumi Tanaka, Tangchun Wu, Fusheng Wei, Hongji Dai, Mitchell J. Machiela, Jian Su, Yeul Hong Kim, In-Jae Oh, Victor Ho Fun Lee, Gee-Chen Chang, Ying-Huang Tsai, Kuan-Yu Chen, Ming-Shyan Huang, Wu-Chou Su, Yuh-Min Chen, Adeline Seow, Jae Yong Park, Sun-Seog Kweon, Kun-Chieh Chen, Yu-Tang Gao, Biyun Qian, Chen Wu, Daru Lu, Jianjun Liu, Ann G. Schwartz, Richard Houlston, Margaret R. Spitz, Ivan P. Gorlov, Xifeng Wu, Ping Yang, Stephen Lam, Adonina Tardon, Chu Chen, Stig E. Bojesen, Mattias Johansson, Angela Risch, Heike Bickeböller, Bu-Tian Ji, H-Erich Wichmann, David C. Christiani, Gadi Rennert, Susanne Arnold, Paul Brennan, James McKay, John K. Field, Sanjay S. Shete, Loic Le Marchand, Geoffrey Liu, Angeline Andrew, Lambertus A. Kiemeney, Shan Zienolddiny-Narui, Kjell Grankvist, Mikael Johansson, Angela Cox, Fiona Taylor, Jian-Min Yuan, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Hyo-Sung Jeon, Shih Sheng Jiang, Jae Sook Sung, Chung-Hsing Chen, Chin-Fu Hsiao, Yoo Jin Jung, Huan Guo, Zhibin Hu, Laurie Burdett, Meredith Yeager, Amy Hutchinson, Belynda Hicks, Jia Liu, Bin Zhu, Sonja I. Berndt, Wei Wu, Junwen Wang, Yuqing Li, Jin Eun Choi, Kyong Hwa Park, Sook Whan Sung, Li Liu, Chang Hyun Kang, Wen-Chang Wang, Jun Xu, Peng Guan, Wen Tan, Chong-Jen Yu, Gong Yang, Alan Dart Loon Sihoe, Ying Chen, Yi Young Choi, Jun Suk Kim, Ho-Il Yoon, In Kyu Park, Ping Xu, Qincheng He, Chih-Liang Wang, Hsiao-Han Hung, Roel C. H. Vermeulen, Iona Cheng, Junjie Wu, Wei-Yen Lim, Fang-Yu Tsai, John K. C. Chan, Jihua Li, Hongyan Chen, Hsien-Chih Lin, Li Jin, Jie Liu, Norie Sawada, Taiki Yamaji, Kathleen Wyatt, Shengchao A. Li, Hongxia Ma, Meng Zhu, Zhehai Wang, Sensen Cheng, Xuelian Li, Yangwu Ren, Ann Chao, Motoki Iwasaki, Junjie Zhu, Gening Jiang, Ke Fei, Guoping Wu, Chih-Yi Chen, Chien-Jen Chen, Pan-Chyr Yang, Jinming Yu, Victoria L. Stevens, Joseph F. Fraumeni, Nilanjan Chatterjee, Olga Y. Gorlova, Chao Agnes Hsiung, Christopher I. Amos, Hongbing Shen, Stephen J. Chanock, Nathaniel Rothman, Takashi Kohno, Qing Lan

Source: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/91497ad90e1e4c55a94f6aaf69b16ba4

ASPSCR1::TFE3 orchestrates the angiogenic program of alveolar soft part sarcoma

Authors: Miwa Tanaka, Surachada Chuaychob, Mizuki Homme, Yukari Yamazaki, Ruyin Lyu, Kyoko Yamashita, Keisuke Ae, Seiichi Matsumoto, Kohei Kumegawa, Reo Maruyama, Wei Qu, Yohei Miyagi, Ryuji Yokokawa, Takuro Nakamura

Source: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f50b7143e44a43cdb1e1c9081c28b300

Histological markers, sickle-shaped blood vessels, myxoid area, and infiltrating growth pattern help stratify the prognosis of patients with myxofibrosarcoma/undifferentiated sarcoma

Authors: Kota Washimi, Rika Kasajima, Eigo Shimizu, Shinya Sato, Yoichiro Okubo, Emi Yoshioka, Hiroto Narimatsu, Toru Hiruma, Kotoe Katayama, Rui Yamaguchi, Kiyoshi Yamaguchi, Yoichi Furukawa, Satoru Miyano, Seiya Imoto, Tomoyuki Yokose, Yohei Miyagi

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/f8c48a501cdd40eab902075a4f8a951f

Incorporation of human iPSC-derived stromal cells creates a pancreatic cancer organoid with heterogeneous cancer-associated fibroblasts

Authors: Kenta Takeuchi, Shunsuke Tabe, Kenta Takahashi, Kenji Aoshima, Megumi Matsuo, Yasuharu Ueno, Yoichi Furukawa, Kiyoshi Yamaguchi, Masayuki Ohtsuka, Soichiro Morinaga, Yohei Miyagi, Tomoyuki Yamaguchi, Naoki Tanimizu, Hideki Taniguchi

Source: Cell Reports, Vol 42, Iss 11, Pp 113420- (2023)

Subject Terms: CP: Cancer, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723014328; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/60c92d8cab9240c1b5e205b61ce0efa4

Non-CpG sites preference in G:C > A:T transition of TP53 in gastric cancer of Eastern Europe (Poland, Romania and Hungary) compared to East Asian countries (China and Japan)

Authors: Hiroko Natsume, Kinga Szczepaniak, Hidetaka Yamada, Yuji Iwashita, Marta Gędek, Jelena Šuto, Keiko Ishino, Rika Kasajima, Tomonari Matsuda, Felix Manirakiza, Augustin Nzitakera, Yijia Wu, Nong Xiao, Qiong He, Wenwen Guo, Zhenming Cai, Tsutomu Ohta, Tıberiu Szekely, Zoltan Kadar, Akiko Sekiyama, Takashi Oshima, Takaki Yoshikawa, Akira Tsuburaya, Nobuhito Kurono, Yaping Wang, Yohei Miyagi, Simona Gurzu, Haruhiko Sugimura

Source: Genes and Environment, Vol 45, Iss 1, Pp 1-13 (2023)

Subject Terms: Gastric cancer, TP53, Molecular epidemiology, Mutation spectrum, Mutation signature, Gene-environmental interaction, Ecology, QH540-549.5, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1880-7062

Access URL: https://doaj.org/article/cbf4ee58a8bd45a5ab90f396841a9a36

Differential diagnosis of uterine adenosarcoma: identification of JAZF1-BCORL1 rearrangement by comprehensive cancer genomic profiling

Authors: Chie Hasegawa, Kota Washimi, Yukihiko Hiroshima, Rika Kasajima, Keiji Kikuchi, Tsuguto Notomi, Hisamori Kato, Toru Hiruma, Shinya Sato, Yoichiro Okubo, Emi Yoshioka, Kyoko Ono, Yohei Miyagi, Tomoyuki Yokose

Source: Diagnostic Pathology, Vol 18, Iss 1, Pp 1-7 (2023)

Subject Terms: Uterine adenosarcoma, Comprehensive genomic profiling, JAZF1-BCORL1, Pathology, RB1-214

File Description: electronic resource

Relation: https://doaj.org/toc/1746-1596

Access URL: https://doaj.org/article/2fee853fce144e138814f5c09bf4e4d1

Arginase-1 inhibition reduces migration ability and metastatic colonization of colon cancer cells

Authors: Xiangdong Wang, Huihui Xiang, Yujiro Toyoshima, Weidong Shen, Shunsuke Shichi, Hiroki Nakamoto, Saori Kimura, Ko Sugiyama, Shigenori Homma, Yohei Miyagi, Akinobu Taketomi, Hidemitsu Kitamura

Source: Cancer & Metabolism, Vol 11, Iss 1, Pp 1-14 (2023)

Subject Terms: Arginase 1, Arginine, Metastatic colonization, Malignancy, Colorectal cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2049-3002

Access URL: https://doaj.org/article/c661565bb42845f1a856b18d34b1bd51

A practical spatial analysis method for elucidating the biological mechanisms of cancers with abdominal dissemination in vivo

Authors: Yukihide Ota, Shinya Sato, Mitsuyo Yoshihara, Yoshiyasu Nakamura, Etsuko Miyagi, Yohei Miyagi

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/ed8a24b4b9b042b392b57c6b3c35a495