Crosstalk between CD64+MHCII+ macrophages and CD4+ T cells drives joint pathology during chikungunya

Authors: Fok-Moon Lum, Yi-Hao Chan, Teck-Hui Teo, Etienne Becht, Siti Naqiah Amrun, Karen WW Teng, Siddesh V Hartimath, Nicholas KW Yeo, Wearn-Xin Yee, Nicholas Ang, Anthony M Torres-Ruesta, Siew-Wai Fong, Julian L Goggi, Evan W Newell, Laurent Renia, Guillaume Carissimo, Lisa FP Ng

Source: EMBO Molecular Medicine, Vol 16, Iss 3, Pp 641-663 (2024)

Subject Terms: Chikungunya, Immune Crosstalk, Immunopathogenesis, GM-CSF, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/c0fe0f20a551413cb93e952b39752db9

Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose

Authors: Laurent Renia, Yun Shan Goh, Angeline Rouers, Nina Le Bert, Wan Ni Chia, Jean-Marc Chavatte, Siew‐Wai Fong, Zi Wei Chang, Nicole Ziyi Zhuo, Matthew Zirui Tay, Yi-Hao Chan, Chee Wah Tan, Nicholas Kim‐Wah Yeo, Siti Naqiah Amrun, Yuling Huang, Joel Xu En Wong, Pei Xiang Hor, Chiew Yee Loh, Bei Wang, Eve Zi Xian Ngoh, Siti Nazihah Mohd Salleh, Guillaume Carissimo, Samanzer Dowla, Alicia Jieling Lim, Jinyan Zhang, Joey Ming Er Lim, Cheng-I. Wang, Ying Ding, Surinder Pada, Louisa Jin Sun, Jyoti Somani, Eng Sing Lee, Desmond Luan Seng Ong, SCOPE Cohort Study Group, Yee‐Sin Leo, Paul A. MacAry, Raymond Tzer Pin Lin, Lin-Fa Wang, Ee Chee Ren, David C. Lye, Antonio Bertoletti, Barnaby Edward Young, Lisa F. P. Ng

Source: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f557f150209f4990850aaa97c4f0f4e6

Decreased memory B cell frequencies in COVID‐19 delta variant vaccine breakthrough infection

Authors: Matthew Zirui Tay, Angeline Rouers, Siew‐Wai Fong, Yun Shan Goh, Yi‐Hao Chan, Zi Wei Chang, Weili Xu, Chee Wah Tan, Wan Ni Chia, Anthony Torres‐Ruesta, Siti Naqiah Amrun, Yuling Huang, Pei Xiang Hor, Chiew Yee Loh, Nicholas Kim‐Wah Yeo, Bei Wang, Eve Zi Xian Ngoh, Siti Nazihah Mohd Salleh, Jean‐Marc Chavatte, Alicia Jieling Lim, Sebastian Maurer‐Stroh, Lin‐Fa Wang, Raymond Valentine Tzer Pin Lin, Cheng‐I Wang, Seow‐Yen Tan, Barnaby Edward Young, Yee‐Sin Leo, David C Lye, Laurent Renia, Lisa FP Ng

Source: EMBO Molecular Medicine, Vol 14, Iss 3, Pp 1-11 (2022)

Subject Terms: correlate of risk, COVID‐19, delta, memory B cells, vaccine breakthrough, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/34cfbff82720458e9823ad77b78c0e87

Asymptomatic COVID‐19: disease tolerance with efficient anti‐viral immunity against SARS‐CoV‐2

Authors: Yi‐Hao Chan, Siew‐Wai Fong, Chek‐Meng Poh, Guillaume Carissimo, Nicholas Kim‐Wah Yeo, Siti Naqiah Amrun, Yun Shan Goh, Jackwee Lim, Weili Xu, Rhonda Sin‐Ling Chee, Anthony Torres‐Ruesta, Cheryl Yi‐Pin Lee, Matthew Zirui Tay, Zi Wei Chang, Wen‐Hsin Lee, Bei Wang, Seow‐Yen Tan, Shirin Kalimuddin, Barnaby Edward Young, Yee‐Sin Leo, Cheng‐I Wang, Bernett Lee, Olaf Rötzschke, David Chien Lye, Laurent Renia, Lisa F P Ng

Source: EMBO Molecular Medicine, Vol 13, Iss 6, Pp 1-15 (2021)

Subject Terms: asymptomatic, COVID‐19, disease tolerance, SARS‐CoV‐2, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/3b73e26cedcc4068b8a198daa09cbea2

Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19

Authors: Guillaume Carissimo, Weili Xu, Immanuel Kwok, Mohammad Yazid Abdad, Yi-Hao Chan, Siew-Wai Fong, Kia Joo Puan, Cheryl Yi-Pin Lee, Nicholas Kim-Wah Yeo, Siti Naqiah Amrun, Rhonda Sin-Ling Chee, Wilson How, Stephrene Chan, Bingwen Eugene Fan, Anand Kumar Andiappan, Bernett Lee, Olaf Rötzschke, Barnaby Edward Young, Yee-Sin Leo, David Chien Lye, Laurent Renia, Lai Guan Ng, Anis Larbi, Lisa FP Ng

Source: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/d967340f6639442885027de8b53a2e43

Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals

Authors: Jackwee Lim, Kia Joo Puan, Liang Wei Wang, Karen Wei Weng Teng, Chiew Yee Loh, Kim Peng Tan, Guillaume Carissimo, Yi-Hao Chan, Chek Meng Poh, Cheryl Yi-Pin Lee, Siew-Wai Fong, Nicholas Kim-Wah Yeo, Rhonda Sin-Ling Chee, Siti Naqiah Amrun, Zi Wei Chang, Matthew Zirui Tay, Anthony Torres-Ruesta, Norman Leo Fernandez, Wilson How, Anand Kumar Andiappan, Wendy Lee, Kaibo Duan, Seow-Yen Tan, Gabriel Yan, Shirin Kalimuddin, David Chien Lye, Yee-Sin Leo, Sean W. X. Ong, Barnaby E. Young, Laurent Renia, Lisa F. P. Ng, Bernett Lee, Olaf Rötzschke

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: COVID-19, cytokine profile, severity, SARS – CoV – 2, inflammation, active infection, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.710217/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/09415a4209cb486cbf1d519aa8d7c6ff

Resistance of SARS-CoV-2 Delta variant to neutralization by BNT162b2-elicited antibodies in Asians

Authors: Bei Wang, Yun Shan Goh, Siew-Wai Fong, Barnaby Edward Young, Eve Zi Xian Ngoh, Jean-Marc Chavatte, Siti Nazihah Mohd Salleh, Nicholas Kim-Wah Yeo, Siti Naqiah Amrun, Pei Xiang Hor, Chiew Yee Loh, Chia Yin Lee, Yi-Hao Chan, Zi Wei Chang, Matthew Zirui Tay, Angeline Rouers, Anthony Torres-Ruesta, Guillaume Carissimo, Mun Kuen Soh, Raphael Tze Chuen Lee, Yani Xu, Surinder Pada, Raymond Tzer Pin Lin, Yee-Sin Leo, David C. Lye, Sebastian Maurer-Stroh, Lisa F.P. Ng, Laurent Renia, Cheng-I Wang

Source: The Lancet Regional Health. Western Pacific, Vol 15, Iss , Pp 100276- (2021)

Subject Terms: Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666606521001851; https://doaj.org/toc/2666-6065

Access URL: https://doaj.org/article/c5c88876218f4ec49b1ea4b858d583d9

Differential Cytokine Responses in Hospitalized COVID-19 Patients Limit Efficacy of Remdesivir

Authors: Yi-Hao Chan, Barnaby E. Young, Siew-Wai Fong, Ying Ding, Yun Shan Goh, Rhonda Sin-Ling Chee, Seow-Yen Tan, Shirin Kalimuddin, Paul A. Tambyah, Yee-Sin Leo, Lisa F. P. Ng, David Chien Lye, Laurent Renia

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: COVID-19, remdesivir (GS-5734), T-cells, tissue repair, disease progression, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.680188/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/8a02a39764fe485fb57a9944f6c13c6a

Association of SARS-CoV-2 clades with clinical, inflammatory and virologic outcomes: An observational study

Authors: Barnaby E Young, Wycliffe E Wei, Siew-Wai Fong, Tze-Minn Mak, Danielle E Anderson, Yi-Hao Chan, Rachael Pung, Cheryl SY Heng, Li Wei Ang, Adrian Kang Eng Zheng, Bernett Lee, Shirin Kalimuddin, Surinder Pada, Paul A Tambyah, Purnima Parthasarathy, Seow Yen Tan, Louisa Sun, Gavin JD Smith, Raymond Tzer Pin Lin, Yee-Sin Leo, Laurent Renia, Lin-Fa Wang, Lisa FP Ng, Sebastian Maurer-Stroh, David Chien Lye, Vernon J Lee

Source: EBioMedicine, Vol 66, Iss , Pp 103319- (2021)

Subject Terms: COVID-19, SARS-CoV-2, Clade, D614G, Severity, Transmission, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396421001122; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/57251a51906e4eea898c0b3503c062e7

Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation

Authors: Florence WJ Chioh, Siew-Wai Fong, Barnaby E Young, Kan-Xing Wu, Anthony Siau, Shuba Krishnan, Yi-Hao Chan, Guillaume Carissimo, Louis LY Teo, Fei Gao, Ru San Tan, Liang Zhong, Angela S Koh, Seow-Yen Tan, Paul A Tambyah, Laurent Renia, Lisa FP Ng, David C Lye, Christine Cheung

Source: eLife, Vol 10 (2021)

Subject Terms: COVID-19, circulating endothelial cells, cytokines, endothelial activation, immune effector cells, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/64909; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/811181762de644d299a5ece0f37ee81c

Linear B-cell epitopes in the spike and nucleocapsid proteins as markers of SARS-CoV-2 exposure and disease severity

Authors: Siti Naqiah Amrun, Cheryl Yi-Pin Lee, Bernett Lee, Siew-Wai Fong, Barnaby Edward Young, Rhonda Sin-Ling Chee, Nicholas Kim-Wah Yeo, Anthony Torres-Ruesta, Guillaume Carissimo, Chek Meng Poh, Zi Wei Chang, Matthew Zirui Tay, Yi-Hao Chan, Mark I-Cheng Chen, Jenny Guek-Hong Low, Paul A. Tambyah, Shirin Kalimuddin, Surinder Pada, Seow-Yen Tan, Louisa Jin Sun, Yee-Sin Leo, David C. Lye, Laurent Renia, Lisa F.P. Ng

Source: EBioMedicine, Vol 58, Iss , Pp 102911- (2020)

Subject Terms: Epitopes, SARS-CoV-2, COVID-19, Patients, Biomarkers, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396420302863; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/3fef66fffc014648a71bf06e74b83944

Mutating chikungunya virus non‐structural protein produces potent live‐attenuated vaccine candidate

Authors: Yi‐Hao Chan, Teck‐Hui Teo, Age Utt, Jeslin JL Tan, Siti Naqiah Amrun, Farhana Abu Bakar, Wearn‐Xin Yee, Etienne Becht, Cheryl Yi‐Pin Lee, Bernett Lee, Ravisankar Rajarethinam, Evan Newell, Andres Merits, Guillaume Carissimo, Fok‐Moon Lum, Lisa FP Ng

Source: EMBO Molecular Medicine, Vol 11, Iss 6, Pp 1-17 (2019)

Subject Terms: chikungunya, live‐attenuated vaccine, mutation, neutralizing antibody, non‐structural protein, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/7a62dbf737b044d2be9223a7852aa699

Longitudinal [18F]FB-IL-2 PET Imaging to Assess the Immunopathogenicity of O'nyong-nyong Virus Infection

Authors: Yi-Hao Chan, Teck-Hui Teo, Anthony Torres-Ruesta, Siddesh V. Hartimath, Rhonda Sin-Ling Chee, Shivashankar Khanapur, Fui Fong Yong, Boominathan Ramasamy, Peter Cheng, Ravisankar Rajarethinam, Edward G. Robins, Julian L. Goggi, Fok-Moon Lum, Guillaume Carissimo, Laurent Rénia, Lisa F. P. Ng

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: O'nyong-nyong virus, alphavirus, immunopathogenesis, CD4+ T cells, drug repositioning, PET imaging, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2020.00894/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/934e388fe2504d76ab72f450dfa1a577

Plasmodium co-infection protects against chikungunya virus-induced pathologies

Authors: Teck-Hui Teo, Fok-Moon Lum, Khairunnisa Ghaffar, Yi-Hao Chan, Siti Naqiah Amrun, Jeslin J. L. Tan, Cheryl Y. P. Lee, Tze-Kwang Chua, Guillaume Carissimo, Wendy W. L. Lee, Carla Claser, Ravisankar Rajarethinam, Laurent Rénia, Lisa F. P. Ng

Source: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/b8b01aeb3e824b2697f9b75b4b313838

Role of T Cells in Chikungunya Virus Infection and Utilizing Their Potential in Anti-Viral Immunity

Authors: Chek Meng Poh, Yi-Hao Chan, Lisa F. P. Ng

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: chikungunya, T cells, immunopathology, vaccination, resident-memory T cells, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2020.00287/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/cf02253ff56b4bf7b87ba9d897e787e8

Associations of viral ribonucleic acid (RNA) shedding patterns with clinical illness and immune responses in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) infection

Authors: Pei Hua Lee, Woo Chiao Tay, Stephanie Sutjipto, Siew‐Wai Fong, Sean Wei Xiang Ong, Wycliff Enli Wei, Yi‐Hao Chan, Li Min Ling, Barnaby E Young, Matthias Paul HS Toh, Laurent Renia, Lisa FP Ng, Yee‐Sin Leo, David C Lye, Tau Hong Lee

Source: Clinical & Translational Immunology, Vol 9, Iss 7, Pp n/a-n/a (2020)

Subject Terms: COVID‐19, cytokines, immune responses, SARS‐CoV‐2, viral RNA shedding, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/2050-0068

Access URL: https://doaj.org/article/61bd508c080c4454baf08593c0788452

Safety and potential efficacy of cyclooxygenase‐2 inhibitors in coronavirus disease 2019

Authors: Sean Wei Xiang Ong, Wilnard Yeong Tze Tan, Yi‐Hao Chan, Siew‐Wai Fong, Laurent Renia, Lisa FP Ng, Yee‐Sin Leo, David Chien Lye, Barnaby Edward Young

Source: Clinical & Translational Immunology, Vol 9, Iss 7, Pp n/a-n/a (2020)

Subject Terms: COVID‐19, COX‐2 inhibitors, interleukin‐6, SARS‐CoV‐2, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/2050-0068

Access URL: https://doaj.org/article/cedb365425694b718ac292a581f03a8b

VCP/p97 Is a Proviral Host Factor for Replication of Chikungunya Virus and Other Alphaviruses

Authors: Guillaume Carissimo, Yi-Hao Chan, Age Utt, Tze-Kwang Chua, Farhana Abu Bakar, Andres Merits, Lisa F. P. Ng

Source: Frontiers in Microbiology, Vol 10 (2019)

Subject Terms: VCP, VCP/p97, alphavirus, chikungunya, host factor, proviral factor, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fmicb.2019.02236/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/3cab8fd991b8431fa21c26cac92bc987

Immunological observations and transcriptomic analysis of trimester‐specific full‐term placentas from three Zika virus‐infected women

Authors: Fok‐Moon Lum, Vipin Narang, Susan Hue, Jie Chen, Naomi McGovern, Ravisankar Rajarethinam, Jeslin JL Tan, Siti Naqiah Amrun, Yi‐Hao Chan, Cheryl YP Lee, Tze‐Kwang Chua, Wearn‐Xin Yee, Nicholas KW Yeo, Thiam‐Chye Tan, Xuan Liu, Sam Haldenby, Yee‐sin Leo, Florent Ginhoux, Jerry KY Chan, Julian Hiscox, Chia‐Yin Chong, Lisa FP Ng

Source: Clinical & Translational Immunology, Vol 8, Iss 11, Pp n/a-n/a (2019)

Subject Terms: histology, infection, placenta, RNA‐seq, transcriptomics, Zika virus, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/2050-0068

Access URL: https://doaj.org/article/b9299c4408624788967d7be0cf6b1dd0

Limitations of Current in Vivo Mouse Models for the Study of Chikungunya Virus Pathogenesis

Authors: Yi-Hao Chan, Fok-Moon Lum, Lisa Fong Poh Ng

Source: Medical Sciences, Vol 3, Iss 3, Pp 64-77 (2015)

Subject Terms: alphavirus, chikungunya, mouse models, pathogenesis, immunity, Medicine

File Description: electronic resource

Relation: http://www.mdpi.com/2076-3271/3/3/64; https://doaj.org/toc/2076-3271

Access URL: https://doaj.org/article/e0bdeb50a441447e9b68b4fb47943ec8