An Improved Drugs Screening System Reveals that Baicalein Ameliorates the Aβ/AMPA/NMDA-Induced Depolarization of Neurons.

Authors: Tian-Syuan Lin, Han-Jung Tsai, Chih-Han Lee, Yan-Qing Song, Rih-Sheng Huang, Hsiu-Mei Hsieh-Li, Yenshou Lin, Mei-Chih Liang, Lin, Tian-Syuan, Tsai, Han-Jung, Lee, Chih-Han, Song, Yan-Qing, Huang, Rih-Sheng, Hsieh-Li, Hsiu-Mei, Lin, Yenshou, Liang, Mei-Chih

Source: Journal of Alzheimer's Disease; 2017, Vol. 56 Issue 3, p959-976, 18p, 6 Color Photographs, 1 Chart, 2 Graphs

Subject Terms: ALZHEIMER'S disease research, AMYLOID beta-protein, TAU proteins, GLUTAMATE receptors, MEMANTINE, ANIMAL experimentation, ANIMALS, BIOLOGICAL transport, CELL culture, CELL receptors, CEREBRAL cortex, DRUGS, DRUG design, CLINICAL drug trials, EPITHELIAL cells, HERBAL medicine, MICE, NEURONS, NEUROTRANSMITTERS, PEPTIDES, TRANSFERASES, PLANT extracts, NEUROPROTECTIVE agents, FLAVANONES, PHARMACODYNAMICS, PHYSIOLOGY

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Chemical Constituents Analysis and Antidiabetic Activity Validation of Four Fern Species from Taiwan.

Authors: Chen-Yu Chen, Fu-Yu Chiu, Yenshou Lin, Wei-Jan Huang, Po-Shiuan Hsieh, Feng-Lin Hsu

Source: International Journal of Molecular Sciences; 2015, Vol. 16 Issue 2, following p2497-2516, 23p, 1 Color Photograph, 2 Diagrams, 3 Charts, 5 Graphs

Subject Terms: CERATOPTERIS thalictroides, PTERIDIUM, HYPOGLYCEMIC agents, ADENOSINE monophosphate, PROTEIN kinase regulation, OXYGEN in the body, GLUCOPYRANOSIDE, BLOOD sugar

Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor1.

Authors: Joseph Avruch, Xiaomeng Long, Yenshou Lin, Sara Ortiz-vega, Joseph Rapley, Angela Papageorgiou, Noriko Oshiro, Ushio Kikkawa

Source: Biochemical Society Transactions; 2009, Vol. 37 Issue 1, p223-226, 4p

Subject Terms: ENZYME activation, SERINE proteinases, GUANOSINE triphosphate, CELLULAR signal transduction, PROTEIN binding, PROTEIN kinases, CARRIER proteins, PHOSPHORYLATION

The Rheb Switch 2 Segment Is Critical for Signaling to Target of Rapamycin Complex 1.

Authors: Xiaomeng Long¹, Yenshou Lin¹, Ortiz-Vega, Sara¹, Busch, Susann¹, Avruch, Joseph¹ avruch@molbio.mgh.harvard.edu.

Source: Journal of Biological Chemistry. 6/22/2007, Vol. 282 Issue 25, p18542-18551. 10p.

Subject Terms: *GUANOSINE triphosphatase, *RAPAMYCIN, *ALANINE, *PHOSPHORYLATION, *PEPTIDES

Recent advances in the regulation of the TOR pathway by insulin and nutrients.

Authors: Joseph Avruch, Yenshou Lin, Xiaomeng Long, Sid Murthy, Sara Ortiz-Vega

Source: Current Opinion in Clinical Nutrition & Metabolic Care; Jan2005, Vol. 8 Issue 1, p67-72, 6p

Alterations of nPKC distribution, but normal Akt/PKB activation in denervated rat soleus muscle.

Authors: Yenshou Lin, Brady, Matthew J., Wolanske, Kristen, Holbert, Richard, Ruderman, Neil B., Yaney, Gordon C.

Source: American Journal of Physiology: Endocrinology & Metabolism. Aug2002, Vol. 46 Issue 2, pE318. 8p. 8 Graphs.

Subject Terms: *PROTEIN kinase C, *GLYCOGEN synthesis, *MUSCLES, *RAT physiology

Inhibition of insulin signaling and glycogen synthesis by phorbol dibutyrate in rat skeletal muscle.

Authors: Yenshou Lin, Itani, Samar I., Kurowski, Theodore G., Dean, David J., Zhijun Lou, Yaney, Gordon C., Ruderman, Neil B.

Source: American Journal of Physiology. Jul2001 Part 1 of 2, Vol. 281 Issue 1, pE8. 8p. 4 Diagrams, 1 Chart, 18 Graphs.

Subject Terms: *PHORBOL esters, *GLUCOSE, *MUSCULOSKELETAL system, *PROTEIN-tyrosine kinases, *METABOLISM

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Rheb Binding to Mammalian Target of Rapamycin (mTOR) Is Regulated by Amino Acid Sufficiency.

Authors: Xiaomeng Long¹, Ortiz-Vega, Sara¹, Yenshou Lin¹, Avruch, Joseph¹ avruch@molbio.mgh.harvard.edu

Source: Journal of Biological Chemistry. 6/24/2005, Vol. 280 Issue 25, p23433-23436. 4p. 4 Diagrams.

Subject Terms: *RAPAMYCIN, *IMMUNOSUPPRESSIVE agents, *MACROLIDE antibiotics, *AMINO acids, *ORGANIC acids, *LEUCINE