Safety and activity of varlilumab, a novel and first-in-class agonist anti-CD27 antibody, for hematologic malignancies

Authors: Ansell, Stephen M., Flinn, Ian, Taylor, Matthew H., Sikic, Branimir I., Brody, Joshua, Nemunaitis, John, Feldman, Andrew, Hawthorne, Thomas R., Rawls, Tracey, Keler, Tibor, Yellin, Michael J.

Source: In Blood Advances 12 May 2020 4(9):1917-1926

Flt3 ligand augments immune responses to anti-DEC-205-NY-ESO-1 vaccine through expansion of dendritic cell subsets

Authors: Bhardwaj, Nina, Friedlander, Philip A., Pavlick, Anna C., Ernstoff, Marc S., Gastman, Brian R., Hanks, Brent A., Curti, Brendan D., Albertini, Mark R., Luke, Jason J., Blazquez, Ana B., Balan, Sreekumar, Bedognetti, Davide, Beechem, Joseph M., Crocker, Andrea S., D'Amico, Leonard, Danaher, Patrick, Davis, Thomas A., Hawthorne, Thomas, Hess, Bruce W., Keler, Tibor, Lundgren, Lisa, Morishima, Chihiro, Ramchurren, Nirasha, Rinchai, Darawan, Salazar, Andres M., Salim, Bob A., Sharon, Elad, Vitale, Laura A., Wang, Ena, Warren, Sarah, Yellin, Michael J., Disis, Mary L., Cheever, Martin A., Fling, Steven P.

Source: Nature cancer. 1(12):1204-1217

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194251465.0x000001&indx=1&recIds=ETOCvdc_100194251465.0x000001

A Phase I Trial of Atezolizumab and Varlilumab in Combination With Radiation in Patients With Metastatic NSCLC

Authors: Malhotra, Jyoti, Lin, Yong, Patel, Malini, Yellin, Michael J., Zachariah, Emmanuel, Krier, Curtis, Saxena, Ankit, Jabbour, Salma K.

Source: In JTO Clinical and Research Reports August 2024 5(8)

Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial

Authors: Butowski, Nicholas, Campian, Jian, Recht, Lawrence, Lim, Michael, Ashby, Lynn, Drappatz, Jan, Hirte, Hal, Iwamoto, Fabio, Mechtler, Laszlo, Goldlust, Samuel, Becker, Kevin, Barnett, Gene, Nicholas, Garth, Desjardins, Annick, Benkers, Tara, Wagle, Naveed, Groves, Morris, Kesari, Santosh, Horvath, Zsolt, Merrell, Ryan, Curry, Richard, O'Rourke, James, Schuster, David, Wong, Mark, Mrugala, Maciej, Jensen, Randy, Trusheim, John, Lesser, Glenn, Belanger, Karl, Sloan, Andrew, Purow, Benjamin, Fink, Karen, Raizer, Jeffrey, Schulder, Michael, Nair, Suresh, Peak, Scott, Perry, James, Brandes, Alba, Weller, Michael, Mohile, Nimish, Landolfi, Joseph, Olson, Jon, Finocchiaro, Gaetano, Jennens, Ross, DeSouza, Paul, Robinson, Bridget, Crittenden, Marka, Shih, Kent, Flowers, Alexandra, Ong, Shirley, Connelly, Jennifer, Hadjipanayis, Costas, Giglio, Pierre, Mott, Frank, Mathieu, David, Lessard, Nathalie, Sepulveda, Sanchez Juan, Lövey, József, Wheeler, Helen, Inglis, Po-Ling, Hardie, Claire, Bota, Daniela, Lesniak, Maciej, Portnow, Jana, Frankel, Bruce, Junck, Larry, Thompson, Reid, Berk, Lawrence, McGhie, John, Macdonald, David, Saran, Frank, Soffietti, Riccardo, Blumenthal, Deborah, André de, Sá Barreto Costa Marcos, Nowak, Anna, Singhal, Nimit, Hottinger, Andreas, Schmid, Andrea, Srkalovic, Gordan, Baskin, David, Fadul, Camilo, Nabors, Louis, LaRocca, Renato, Villano, John, Paleologos, Nina, Kavan, Petr, Pitz, Marshall, Thiessen, Brian, Idbaih, Ahmed, Frenel, Jean Sébastien, Domont, Julien, Grauer, Oliver, Hau, Peter, Marosi, Christine, Sroubek, Jan, Hovey, Elizabeth, Sridhar, P.S., Cher, Lawrence, Dunbar, Erin, Coyle, Thomas, Raymond, Jane, Barton, Kevin, Guarino, Michael, Raval, Sumul, Stea, Baldassarre, Dietrich, Jorge, Hopkins, Kirsten, Erridge, Sara, Steinbach, Joachim-Peter, Pineda, Losada Estela, Balana, Quintero Carmen, Sonia del, Barco Berron, Wenczl, Miklós, Molnár, Katalin, Hideghéty, Katalin, Lossos, Alexander, Myra van, Linde, Levy, Ana, Harrup, Rosemary, Patterson, William, Lwin, Zarnie, Sathornsumetee, Sith, Lee, E-Jian, Ho, Jih-Tsun, Emmons, Steven, Duic, J. Paul, Shao, Spencer, Ashamalla, Hani, Weaver, Michael, Lutzky, Jose, Avgeropoulos, Nicholas, Hanna, Wahid, Nadipuram, Mukund, Cecchi, Gary, O'Donnell, Robert, Pannullo, Susan, Carney, Jennifer, Hamilton, Mark, MacNeil, Mary, Beaney, Ronald, Fabbro, Michel, Schnell, Oliver, Fietkau, Rainer, Stockhammer, Guenther, Malinova, Bela, Odrazka, Karel, Sames, Martin, Miguel Gil, Gil, Razis, Evangelia, Lavrenkov, Konstantin, Castro, Guillermo, Ramirez, Francisco, Baldotto, Clarissa, Viola, Fabiana, Malheiros, Suzana, Lickliter, Jason, Gauden, Stanislaw, Dechaphunkul, Arunee, Thaipisuttikul, Iyavut, Thotathil, Ziad, Ma, Hsin-I, Cheng, Wen-Yu, Chang, Chin-Hong, Salas, Fernando, Dietrich, Pierre-Yves, Mamot, Christoph, Nayak, Lakshmi, Nag, Shona, Tran, David D, Recht, Lawrence D, Goldlust, Samuel A, O'Rourke, Donald M, Hamilton, Mark G, Wick, Wolfgang, Green, Jennifer, He, Yi, Turner, Christopher D, Yellin, Michael J, Keler, Tibor, Davis, Thomas A, Stupp, Roger, Sampson, John H

Source: In The Lancet Oncology October 2017 18(10):1373-1385

Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial

Authors: Weller, Michael, Butowski, Nicholas, Tran, David D, Recht, Lawrence D, Lim, Michael, Hirte, Hal, Ashby, Lynn, Mechtler, Laszlo, Goldlust, Samuel A, Iwamoto, Fabio, Drappatz, Jan, O'Rourke, Donald M, Wong, Mark, Hamilton, Mark G, Finocchiaro, Gaetano, Perry, James, Wick, Wolfgang, Green, Jennifer, He, Yi, Turner, Christopher D, Yellin, Michael J, Keler, Tibor, Davis, Thomas A, Stupp, Roger, Sampson, John H

Source: Lancet oncology. 18(10):1373-1385

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Therapeutic applications of T-BAM (CD40L) technology to treat diseases involving smooth muscle cells

Method for inhibiting inflammation with an antibody that binds the 5C8 protein

Murine monoclonal antibody (5c8) recognizes T-B cell activating molecule (T-BAM) (CD40 LIGAND) on the surface of T-lymphocytes, compositions containing same and methods of use

Therapeutic applications for the anti-T-BAM (CD40-1) monoclonal antibody 5C8

5c8 Antigen

Nucleic acid molecule encoding heavy or light chain of an antibody which specifically recognizes a protein specifically recognized by monoclonal antibody 5c8 (anti-CD40 ligand)

Human T cell leukemia cell line designated D1.1

Methods to inhibit humoral immune responses, immunoglobulin production and B cell activation with 5c8-specific antibodies

Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same

Go, no-go decision making for phase 3 clinical trials: ACT IV revisited – Authors' reply

Authors: Weller, Michael, Butowski, Nicholas, Tran, David D, Recht, Lawrence D, Lim, Michael, Hirte, Hal, Ashby, Lynn, Mechtler, Laszlo, Goldlust, Samuel A, Iwamoto, Fabio, Drappatz, Jan, O'Rourke, Donald M, Wong, Mark, Hamilton, Mark G, Finocchiaro, Gaetano, Perry, James, Wick, Wolfgang, Green, Jennifer, He, Yi, Turner, Christopher D, Yellin, Michael J, Keler, Tibor, Davis, Thomas A, Stupp, Roger, Sampson, John H

Source: Lancet oncology. 18(12):e709-e710

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100053421770.0x000001&indx=1&recIds=ETOCvdc_100053421770.0x000001

CD154 (CD40L) Induces Human Endothelial Cell Chemokine Production and Migration of Leukocyte Subsets

Authors: Thienel, Ulrich, Loike, John, Yellin, Michael J.

Source: In Cellular Immunology 15 December 1999 198(2):87-95

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