Combinatorial immunotherapy with anti-ROR1 CAR NK cells and an IL-21 secreting oncolytic virus against neuroblastoma

Authors: Yaya Chu, Meijuan Tian, Uksha Saini, Jessica Ayala-Cuesta, Kayleigh Klose, Alyssa S. Mendelowitz, Keira Foley, Mehmet F. Ozkaynak, Wen Luo, Timothy P. Cripe, Dean A. Lee, Kevin A. Cassady, Mitchell S. Cairo

Source: Molecular Therapy: Oncology, Vol 33, Iss 1, Pp 200927- (2025)

Subject Terms: neuroblastoma, chimeric antigen receptor, CAR, ROR1, natural killer cells, oncolytic herpes simplex virus, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2950329924001693; https://doaj.org/toc/2950-3299

Access URL: https://doaj.org/article/890724d086f648c186b0f186148081c8

Safety and Efficacy of Inactivated SARS-CoV-2 Vaccine in Patients with Rheumatic Diseases and Serum Antibody Changes Post-Omicron Variant Infection

Authors: Xiaowei Zhang, Yifei Li, Chunqing Dai, Yaya Chu, Chaoqi Luan, Guihong Wang

Source: Rheumatology and Therapy, Vol 11, Iss 1, Pp 191-200 (2024)

Subject Terms: Rheumatic diseases, Musculoskeletal diseases, SARS-CoV-2 vaccine, Serum antibodies, Adverse events, Omicron variant, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/2198-6576; https://doaj.org/toc/2198-6584

Access URL: https://doaj.org/article/ec1ebe374f58418e95f35249c83af3c2

Efficiently targeting neuroblastoma with the combination of anti-ROR1 CAR NK cells and N-803 in vitro and in vivo in NB xenografts

Authors: Yaya Chu, Gaurav Nayyar, Meijuan Tian, Dean A. Lee, Mehmet F. Ozkaynak, Jessica Ayala-Cuesta, Kayleigh Klose, Keira Foley, Alyssa S. Mendelowitz, Wen Luo, Yanling Liao, Janet Ayello, Gregory K. Behbehani, Stanley Riddell, Timothy P. Cripe, Mitchell S. Cairo

Source: Molecular Therapy: Oncology, Vol 32, Iss 2, Pp 200820- (2024)

Subject Terms: MT: Regular Issue, neuroblastoma, chimerical antigen receptor, ROR1, expanded natural killer cells, targeted immunotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2950329924000626; https://doaj.org/toc/2950-3299

Access URL: https://doaj.org/article/2644140197174223981934890cc1a2e8

Inflammation-mediated fibroblast activation and immune dysregulation in collagen VII-deficient skin

Authors: Morgan Anderson-Crannage, Alex M. Ascensión, Olga Ibanez-Solé, Hongwen Zhu, Edo Schaefer, Darcy Ottomanelli, Bruno Hochberg, Jian Pan, Wen Luo, Meijuan Tian, Yaya Chu, Mitchell S. Cairo, Ander Izeta, Yanling Liao

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: epidermolysis bullosa, inflammation, immune suppression, dermal microenvironment, fibroblast activation, interleukin-1, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1211505/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/34e1d4686234451eb208aeefa7d3b96f

Donor chimerism and immune reconstitution following haploidentical transplantation in sickle cell disease

Authors: Yaya Chu, Julie-An Talano, Lee Ann Baxter-Lowe, James W. Verbsky, Erin Morris, Harshini Mahanti, Janet Ayello, Carolyn Keever-Taylor, Bryon Johnson, Rona S. Weinberg, Qiuhu Shi, Theodore B. Moore, Sandra Fabricatore, Brenda Grossman, Carmella van de Ven, Shalini Shenoy, Mitchell S. Cairo

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: sickle cell disease, donor chimerism, immune reconstitution, HLA antibodies, CD34 enrichment, donor grafts, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1055497/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/b0d0c172bee649e4b8a967bf44eea504

Combinatorial immunotherapy of N-803 (IL-15 superagonist) and dinutuximab with ex vivo expanded natural killer cells significantly enhances in vitro cytotoxicity against GD2+ pediatric solid tumors and in vivo survival of xenografted immunodeficient NSG mice

Authors: Patrick Soon-Shiong, Dean A. Lee, Yaya Chu, Gaurav Nayyar, Jeffrey T Safrit, Susiyan Jiang, Jeremy M. Rosenblum, Mitchell S. Cairo

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/9/7/e002267.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/88879cd3923d4e4d9638289ac32ef8a0

Novel cytokine–antibody fusion protein, N-820, to enhance the functions of ex vivo expanded natural killer cells against Burkitt lymphoma

Authors: John Lee, Dean Lee, Patrick Soon-Shiong, Yaya Chu, Gaurav Nayyar, Nang Kham Su, Jeremy M Rosenblum, Jeffrey T Safrit, Matthew Barth, Mitchell S Cairo

Source: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/8/2/e001238.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/752d96bf91744f83a32d2522239e2b10

Immunophenotypic, cytotoxic, proteomic and genomic characterization of human cord blood vs. peripheral blood CD56 NK cells

Authors: Evan Shereck, Nancy S Day, Aradhana Awasthi, Janet Ayello, Yaya Chu, Catherine McGuinn, Carmella van de Ven, Megan S Lim, Mitchell S Cairo

Source: Innate Immunity, Vol 25 (2019)

Subject Terms: Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/1753-4259; https://doaj.org/toc/1753-4267

Access URL: https://doaj.org/article/3d10d650b9dc4ac7b329c1b175b030a6

Overcoming Resistance to Natural Killer Cell Based Immunotherapies for Solid Tumors

Authors: Gaurav Nayyar, Yaya Chu, Mitchell S. Cairo

Source: Frontiers in Oncology, Vol 9 (2019)

Subject Terms: natural killer cell, chimeric antigen receptor, immunotherapy, solid tumor, cytokines, tumor microenvironment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fonc.2019.00051/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/b1b6f40144ad44c1bc4283004279ae18

Ibrutinib significantly inhibited Bruton’s tyrosine kinase (BTK) phosphorylation,in-vitro proliferation and enhanced overall survival in a preclinical Burkitt lymphoma (BL) model

Authors: Yaya Chu, Sanghoon Lee, Tishi Shah, Changhong Yin, Matthew Barth, Rodney R. Miles, Janet Ayello, Erin Morris, Lauren Harrison, Carmella Van de Ven, Paul Galardy, Stanton C. Goldman, Megan S. Lim, Michelle Hermiston, Linda M. McAllister-Lucas, Lisa Giulino-Roth, Sherrie L. Perkins, Mitchell S. Cairo

Source: OncoImmunology, Vol 8, Iss 1 (2019)

Subject Terms: ibrutinib, bruton’s tyrosine kinase, burkitt lymphoma, xenografted nsg mice, cell proliferation, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/2466fcc030424707a6dd1a4e9329ef32

Romidepsin alone or in combination with anti-CD20 chimeric antigen receptor expanded natural killer cells targeting Burkitt lymphoma in vitro and in immunodeficient mice

Authors: Yaya Chu, Ashlin Yahr, Brian Huang, Janet Ayello, Matthew Barth, Mitchell S. Cairo

Source: OncoImmunology, Vol 6, Iss 9 (2017)

Subject Terms: anti-cd20 chimeric antigen receptor, expanded natural killer cells, rituximab sensitive and resistant burkitt lymphoma, romidepsin, targeted immunotherapy, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/3d97c21bef2d4a73ada97bf6a5104891

Inflammation-mediated fibroblast activation and immune dysregulation in collagen VII-deficient skin.

Authors: Anderson-Crannage, Morgan, Ascensión, Alex M., Ibanez-Solé, Olga, Hongwen Zhu, Schaefer, Edo, Ottomanelli, Darcy, Hochberg, Bruno, Jian Pan, Wen Luo, Tian, Meijuan, Yaya Chu, Cairo, Mitchell S., Izeta, Ander, Yanling Liao

Source: Frontiers in Immunology; 2023, p1-20, 20p

Subject Terms: FIBROBLASTS, CELL populations, EPIDERMOLYSIS bullosa, LANGERHANS cells, SQUAMOUS cell carcinoma, GENE expression, LANGERHANS-cell histiocytosis

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Upregulation of NKG2D ligands in acute lymphoblastic leukemia and non-Hodgkin lymphoma cells by romidepsin and enhanced in vitro and in vivo natural killer cell cytotoxicity.

Authors: SATWANI, PRAKASH¹ ps2087@columbia.edu, BAVISHI, SEJAL¹, SAHA, ANIKET¹, ZHAO, FRANCES¹, AYELLO, JANET², VAN DE VEN, CARMELLA², YAYA CHU², CAIRO, MITCHELL S.^2,3,4,5,6

Source: Cytotherapy (Elsevier Inc.). Oct2014, Vol. 16 Issue 10, p1431-1440. 10p.

Subject Terms: *LIGANDS (Biochemistry), *LYMPHOBLASTIC leukemia, *HODGKIN'S disease, *KILLER cells, *CELL-mediated cytotoxicity, *FLOW cytometry

Two Steps in Maf1-dependent Repression of Transcription by RNA Polymerase III.

Authors: Desai, Neelam¹, Jaehoon Lee¹, Upadhya, Rajendra¹, Yaya Chu¹, Moir, Robyn D.¹, Willis, Tan M.¹ willis@aecom.yu.edu

Source: Journal of Biological Chemistry. 2/25/2005, Vol. 280 Issue 8, p6455-6462. 8p. 1 Graph.

Subject Terms: *SACCHAROMYCES cerevisiae, *GENETIC transcription, *CELLULAR signal transduction, *PHYSIOLOGICAL control systems, *RNA polymerases, *NUCLEIC acids