Machine learning and biological validation identify sphingolipids as potential mediators of paclitaxel-induced neuropathy in cancer patients

Authors: Jörn Lötsch, Khayal Gasimli, Sebastian Malkusch, Lisa Hahnefeld, Carlo Angioni, Yannick Schreiber, Sandra Trautmann, Saskia Wedel, Dominique Thomas, Nerea Ferreiros Bouzas, Christian H Brandts, Benjamin Schnappauf, Christine Solbach, Gerd Geisslinger, Marco Sisignano

Source: eLife, Vol 13 (2024)

Subject Terms: paclitaxel, neuropathy, sphingolipids, CIPN, TRPV1, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/91941; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/2f70ecc6b60c49e0aa4c7ee6c353f55a

SAFit2 ameliorates paclitaxel-induced neuropathic pain by reducing spinal gliosis and elevating pro-resolving lipid mediators

Authors: Saskia Wedel, Lisa Hahnefeld, Yannick Schreiber, Christian Namendorf, Tim Heymann, Manfred Uhr, Mathias V. Schmidt, Natasja de Bruin, Felix Hausch, Dominique Thomas, Gerd Geisslinger, Marco Sisignano

Source: Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-21 (2023)

Subject Terms: SAFit2, FKBP51, Neuropathic pain, Chemotherapy, Oxylipins, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/7393b95fee1a48c09212292b2adeaadf

Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells

Authors: Tamara Rothenburger, Dominique Thomas, Yannick Schreiber, Paul R. Wratil, Tamara Pflantz, Kirsten Knecht, Katie Digianantonio, Joshua Temple, Constanze Schneider, Hanna-Mari Baldauf, Katie-May McLaughlin, Florian Rothweiler, Berna Bilen, Samira Farmand, Denisa Bojkova, Rui Costa, Nerea Ferreirós, Gerd Geisslinger, Thomas Oellerich, Yong Xiong, Oliver T. Keppler, Mark N. Wass, Martin Michaelis, Jindrich Cinatl

Source: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-19 (2021)

Subject Terms: Leukemia, Acute myeloid leukemia, Acute lymphoblastic leukemia, CNDAC, Sapacitabine, SAMHD1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/d96327060ccf4b409f6c8453b5c904c2

Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation by enhancing CX3CL1 expression

Authors: Peter Rappl, Silvia Rösser, Patrick Maul, Rebekka Bauer, Arnaud Huard, Yannick Schreiber, Dominique Thomas, Gerd Geisslinger, Per-Johan Jakobsson, Andreas Weigert, Bernhard Brüne, Tobias Schmid

Source: Cell Death and Disease, Vol 12, Iss 2, Pp 1-10 (2021)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/82e45cbb0c5e4c0696246dff61defdd3

The Roles of Long-Term Hyperhomocysteinemia and Micronutrient Supplementation in the AppNL–G–F Model of Alzheimer’s Disease

Authors: Hendrik Nieraad, Natasja de Bruin, Olga Arne, Martine C. J. Hofmann, Nina Pannwitz, Eduard Resch, Sonja Luckhardt, Ann-Kathrin Schneider, Sandra Trautmann, Yannick Schreiber, Robert Gurke, Michael J. Parnham, Uwe Till, Gerd Geisslinger

Source: Frontiers in Aging Neuroscience, Vol 14 (2022)

Subject Terms: hyperhomocysteinemia, vitamin B deficiency, Alzheimer’s disease, amyloid betapeptides, memory and learning tests, proteomics, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnagi.2022.876826/full; https://doaj.org/toc/1663-4365

Access URL: https://doaj.org/article/5aafda3fb0b74237ad0cd5b0b0337cc4

Mitofusin 2 Deficiency Causes Pro-Inflammatory Effects in Human Primary Macrophages

Authors: Vera Khodzhaeva, Yannick Schreiber, Gerd Geisslinger, Ralf P. Brandes, Bernhard Brüne, Dmitry Namgaladze

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: macrophages, mitochondria, zymosan, inflammation, mitochondrial dynamics, endoplasmic reticulum, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.723683/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/b46e44135c894a1d84fafbff01de9537

In Vitro Safety, Off-Target and Bioavailability Profile of the Antiviral Compound Silvestrol

Authors: Susanne Schiffmann, Sandra Gunne, Thomas Ulshöfer, Marina Henke, Luise A. Roser, Ann-Kathrin Schneider, Jindrich Cinatl, Dominique Thomas, Yannick Schreiber, Pia Viktoria Wagner, Arnold Grünweller, Michael J. Parnham

Source: Pharmaceuticals, Vol 15, Iss 9, p 1086 (2022)

Subject Terms: silvestrol, rocaglates, antiviral, RNA helicase eIF4A, safety profile, micronuclei assay, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/15/9/1086; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/b619ea0c7826480faf8049ba991d8de3

Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells

Authors: Juliane Hitzel, Eunjee Lee, Yi Zhang, Sofia Iris Bibli, Xiaogang Li, Sven Zukunft, Beatrice Pflüger, Jiong Hu, Christoph Schürmann, Andrea Estefania Vasconez, James A. Oo, Adelheid Kratzer, Sandeep Kumar, Flávia Rezende, Ivana Josipovic, Dominique Thomas, Hector Giral, Yannick Schreiber, Gerd Geisslinger, Christian Fork, Xia Yang, Fragiska Sigala, Casey E. Romanoski, Jens Kroll, Hanjoong Jo, Ulf Landmesser, Aldons J. Lusis, Dmitry Namgaladze, Ingrid Fleming, Matthias S. Leisegang, Jun Zhu, Ralf P. Brandes

Source: Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4401176dc9754aceb3a9a13dbd4a3e34

The Role of PGE2 in Alveolar Epithelial and Lung Microvascular Endothelial Crosstalk

Authors: Thomas Bärnthaler, Jovana Maric, Wolfgang Platzer, Viktoria Konya, Anna Theiler, Carina Hasenöhrl, Benjamin Gottschalk, Sandra Trautmann, Yannick Schreiber, Wolfgang F. Graier, Rudolf Schicho, Gunther Marsche, Andrea Olschewski, Dominique Thomas, Rufina Schuligoi, Akos Heinemann

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/5954ae3d0f3245918a8d9c82f4b24f8b

Sphingolipid and Endocannabinoid Profiles in Adult Attention Deficit Hyperactivity Disorder

Authors: Nathalie Brunkhorst-Kanaan, Sandra Trautmann, Yannick Schreiber, Dominique Thomas, Sarah Kittel-Schneider, Robert Gurke, Gerd Geisslinger, Andreas Reif, Irmgard Tegeder

Source: Biomedicines, Vol 9, Iss 9, p 1173 (2021)

Subject Terms: attention deficit hyperactivity disorder, endocannabinoids, ceramides, bipolar disorder, major depression, tandem mass spectrometry, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/9/9/1173; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/3347387d05d044cb907faff9e33e58e1

Epigenetic control of microsomal prostaglandin E synthase-1 by HDAC-mediated recruitment of p300

Authors: Christian Fork, Andrea E. Vasconez, Patrick Janetzko, Carlo Angioni, Yannick Schreiber, Nerea Ferreirós, Gerd Geisslinger, Matthias S. Leisegang, Dieter Steinhilber, Ralf P. Brandes

Source: Journal of Lipid Research, Vol 58, Iss 2, Pp 386-392 (2017)

Subject Terms: epigenetics, prostaglandins, prostaglandin E2, vascular biology, smooth muscle cells, histone deacetylase, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S002222752031419X; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/9bf37fdf2b6e410a8cb48d901a0dbe37

Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis.

Authors: Alexander Queck, Dominique Thomas, Christian Jansen, Yannick Schreiber, Sabrina Rüschenbaum, Michael Praktiknjo, Katharina Maria Schwarzkopf, Marcus Maximilian Mücke, Robert Schierwagen, Frank Erhard Uschner, Carsten Meyer, Joan Clària, Stefan Zeuzem, Gerd Geisslinger, Jonel Trebicka, Christian Markus Lange

Source: PLoS ONE, Vol 14, Iss 10, p e0222840 (2019)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/d522e264dc63433d807dcfdd0d4ee556

Beta adrenoceptor blockade ameliorates impaired glucose tolerance and alterations of the cerebral ceramide metabolism in an experimental model of ischemic stroke

Authors: Sebastian Luger, Annette Schwebler, Rajkumar Vutukuri, Nerea Ferreiros Bouzas, Sandra Labocha, Yannick Schreiber, Robert Brunkhorst, Helmuth Steinmetz, Josef Pfeilschifter, Waltraud Pfeilschifter

Source: Therapeutic Advances in Neurological Disorders, Vol 11 (2018)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1756-2864

Access URL: https://doaj.org/article/95ad1416b8f548539b5a84dda46762ab

Activated Platelets Induce an Anti-Inflammatory Response of Monocytes/Macrophages through Cross-Regulation of PGE2 and Cytokines

Authors: Bona Linke, Yannick Schreiber, Bettina Picard-Willems, Patrick Slattery, Rolf M. Nüsing, Sebastian Harder, Gerd Geisslinger, Klaus Scholich

Source: Mediators of Inflammation, Vol 2017 (2017)

Subject Terms: Pathology, RB1-214

File Description: electronic resource

Relation: https://doaj.org/toc/0962-9351; https://doaj.org/toc/1466-1861

Access URL: https://doaj.org/article/1f8495722a3c4c3a94bc72fd7164db46

Interferon-beta increases plasma ceramides of specific chain length in multiple sclerosis patients, unlike fingolimod or natalizumab

Authors: Florian Ottenlinger, Christoph Alexander Mayer, Nerea Ferreirós, Yannick Schreiber, Anja Schwiebs, Katrin Schmidt, Hanns Ackermann, Josef Pfeilschifter, Heinfried H. Radeke

Source: Frontiers in Pharmacology, Vol 7 (2016)

Subject Terms: Ceramides, Interferon-beta, Multiple Sclerosis, Sphingolipids, fingolimod, natalizumab, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00412/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/51d06afcf4e646f083e2801d1cfe9fba

Synthesis of lipid mediators during UVB-induced inflammatory hyperalgesia in rats and mice.

Authors: Marco Sisignano, Carlo Angioni, Nerea Ferreiros, Claus-Dieter Schuh, Jing Suo, Yannick Schreiber, John M Dawes, Ana Antunes-Martins, David L H Bennett, Stephen B McMahon, Gerd Geisslinger, Klaus Scholich

Source: PLoS ONE, Vol 8, Iss 12, p e81228 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3857181?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/2c28a62bcbf44ae09164ca0d469730c6

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