Addition of TLR9 agonist immunotherapy to radiation improves systemic antitumor activity

Authors: Younes, Ahmed I., Barsoumian, Hampartsoum B., Sezen, Duygu, Verma, Vivek, Patel, Roshal, Wasley, Mark, Hu, Yun, Dunn, Joe D., He, Kewen, Chen, Dawei, Menon, Hari, Masrorpour, Fatemeh, Gu, Meidi, Yang, Liangpeng, Puebla-Osorio, Nahum, Cortez, Maria Angelica, Welsh, James W.

Source: In Translational Oncology February 2021 14(2)

Radiation Therapy Enhanced by NBTXR3 Nanoparticles Overcomes Anti-PD1 Resistance and Evokes Abscopal Effects

Authors: Hu, Yun, Paris, Sébastien, Barsoumian, Hampartsoum, Abana, Chike O., He, Kewen, Wasley, Mark, Younes, Ahmed I., Masrorpour, Fatemeh, Chen, Dawei, Yang, Liangpeng, Dunn, Joe Dan, Zhang, Jie, Gandhi, Saumil, Nguyen, Quynh-Nhu, Cortez, Maria Angelica, Welsh, James

Source: International journal of radiation oncology, biology, physics. 111(3):647-657

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100141217961.0x000001&indx=1&recIds=ETOCvdc_100141217961.0x000001

Targeting DNA damage response in head and neck cancers through abrogation of cell cycle checkpoints

Authors: Molkentine, Jessica M., Molkentine, David P., Bridges, Kathleen A., Xie, Tongxin, Yang, Liangpeng, Sheth, Aakash, Heffernan, Timothy P., Clump, David A., Faust, Alma Z., Ferris, Robert L., Myers, Jeffrey N., Frederick, Mitchell J., Mason, Kathryn A., Meyn, Raymond E., Pickering, Curtis R., Skinner, Heath D.

Source: International journal of radiation biology. 97(8):1121-1128

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123802748.0x000001&indx=1&recIds=ETOCvdc_100123802748.0x000001

Combining a nanoparticle-mediated immunoradiotherapy with dual blockade of LAG3 and TIGIT improves the treatment efficacy in anti-PD1 resistant lung cancer.

Authors: Hu, Yun, Paris, Sébastien, Bertolet, Genevieve, Barsoumian, Hampartsoum B., He, Kewen, Sezen, Duygu, Chen, Dawei, Wasley, Mark, SILVA, Jordan DA, Mitchell, Joylise A., Voss, Tiffany A., Masrorpour, Fatemeh, Leyton, Claudia Kettlun, Yang, Liangpeng, Leuschner, Carola, Puebla-Osorio, Nahum, Gandhi, Saumil, Nguyen, Quynh-Nhu, Cortez, Maria Angelica, Welsh, James W.

Source: Journal of Nanobiotechnology; 9/19/2022, Vol. 20 Issue 1, p1-19, 19p

Subject Terms: TREATMENT effectiveness, PROGRAMMED cell death 1 receptors, LUNG cancer, IMMUNE checkpoint proteins, CANCER prognosis, CANCER cells

A radioenhancing nanoparticle mediated immunoradiation improves survival and generates long-term antitumor immune memory in an anti-PD1-resistant murine lung cancer model.

Authors: Hu, Yun, Paris, Sébastien, Barsoumian, Hampartsoum, Abana, Chike O., He, Kewen, Sezen, Duygu, Wasley, Mark, Masrorpour, Fatemeh, Chen, Dawei, Yang, Liangpeng, Dunn, Joe D., Gandhi, Saumil, Nguyen, Quynh-Nhu, Cortez, Maria Angelica, Welsh, James W.

Source: Journal of Nanobiotechnology; 12/11/2021, Vol. 19 Issue 1, p1-14, 14p

Subject Terms: IMMUNOLOGIC memory, SECONDARY primary cancer, LUNG cancer, SURVIVAL rate, LABORATORY mice, LUNGS, LEG, CYTOTOXIC T cells

Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function.

Authors: Kumar, Manish, Molkentine, David, Molkentine, Jessica, Bridges, Kathleen, Xie, Tongxin, Yang, Liangpeng, Hefner, Andrew, Gao, Meng, Bahri, Reshub, Dhawan, Annika, Frederick, Mitchell J., Seth, Sahil, Abdelhakiem, Mohamed, Beadle, Beth M., Johnson, Faye, Wang, Jing, Shen, Li, Heffernan, Timothy, Sheth, Aakash, Ferris, Robert L.

Source: Nature Communications; 11/3/2021, Vol. 12 Issue 1, p1-16, 16p

Subject Terms: HISTONE acetyltransferase, RECOMBINANT DNA, SQUAMOUS cell carcinoma, ACETYLTRANSFERASES, DNA damage

NF-κB Hyper-Activation by HTLV-1 Tax Induces Cellular Senescence, but Can Be Alleviated by the Viral Anti-Sense Protein HBZ.

Authors: Zhi, Huijun, Yang, Liangpeng, Kuo, Yu-Liang, Ho, Yik-Khuan, Shih, Hsiu-Ming, Giam, Chou-Zen

Source: PLoS Pathogens. Apr2011, Vol. 7 Issue 4, p1-12. 12p.

Subject Terms: *NF-kappa B, *VIRAL proteins, *T cells, *CD4 antigen, *LYMPHOMAS, *GENETIC transcription, *MESSENGER RNA

(OA30) In Vivo Screening Identifies ESR1 as a Clinically Relevant Target for Radiosensitization In HNSCC

Authors: Sheth, Aakash, Molkentine, David, Bridges, Second Author, Kathleen, Yang, Liangpeng, Xie, Tongxin, Fredrick, Mitchell, Myers, Jeffrey, Meyn, Raymond, Pickering, Curtis, Skinner, Heath

Source: International journal of radiation oncology, biology, physics. 101(S):e13-e13

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100141013472.0x000001&indx=1&recIds=ETOCvdc_100141013472.0x000001

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Evaluating Response to Metformin/Cisplatin Combination in Cancer Cells via Metabolic Measurement and Clonogenic Survival.

Authors: Woo, Sang Hyeok, Sandulache, Vlad C., Yang, Liangpeng, Skinner, Heath D.

Source: Cancer Cell Signaling: Methods & Protocols; 2014, p11-18, 8p

Use of Biguanides to Improve Response to Chemotherapy.

Authors: Sandulache, Vlad C., Yang, Liangpeng, Skinner, Heath D.

Source: Cancer Cell Signaling: Methods & Protocols; 2014, p3-9, 7p

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High Plus Low Dose Radiation Strategy in Combination with TIGIT and PD1 Blockade to Promote Systemic Antitumor Responses.

Authors: Barsoumian, Hampartsoum B., Sezen, Duygu, Menon, Hari, Younes, Ahmed I., Hu, Yun, He, Kewen, Puebla-Osorio, Nahum, Wasley, Mark, Hsu, Ethan, Patel, Roshal R., Yang, Liangpeng, Cortez, Maria A., Welsh, James W.

Source: Cancers; Jan2022, Vol. 14 Issue 1, p221, 1p

Subject Terms: LUNG cancer treatment, ADENOCARCINOMA, BIOLOGICAL models, IMMUNE checkpoint inhibitors, ANIMAL experimentation, RADIOTHERAPY, COMBINED modality therapy, CELL lines, IMMUNOTHERAPY, MICE, THERAPEUTICS

Molecular cloning of the cDNA of mouse mitochondrial NADP-dependent isocitrate dehydrogenase and the expression of the gene during lymphocyte activation.

Authors: Yang, Liangpeng, Luo, Hongyu, Vinay, Patrick, Wu, Jiangping

Source: Journal of Cellular Biochemistry; Mar1996, Vol. 60 Issue 3, p400-410, 11p

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