Targeting DKK3 to remodel tumor immune microenvironment and enhance cancer immunotherapy

Authors: Kai Shi, Yan Zhao, Hao Ye, Xiaoming Zhu, Zhenghai Chen

Source: BMC Cancer, Vol 25, Iss 1, Pp 1-12 (2025)

Subject Terms: DKK3, Tumor immune microenvironment, T cell, PD-1 Blockade, Cancer immunotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/a308b7cdebd54ff8856bf1f21fec4b92

Molecular insights into the α6β4 nicotinic acetylcholine receptor function and ligand recognition

Authors: Jiawei Su, Zhuoya Yu, Zhengji Yin, Zixuan Zhang, Jun Zhao, Yufei Meng, Renjie Li, Yiwei Gao, Hongwei Zhang, Rilei Yu, Yan Zhao

Source: Nature Communications, Vol 16, Iss 1, Pp 1-10 (2025)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/e941b733755649e3ad22c9706f8cbe4d

c-Ski is a novel repressor of NF-κB through interaction with p65 and HDAC1 in U937 cells

Authors: Yan Peng, Ren-Ping Xiong, Bo Wang, Xing Chen, Ya-Lie Ning, Yan Zhao, Nan Yang, Jing Zhang, Chang-Hong Li, Yuan-Guo Zhou, Ping Li

Source: Cell Communication and Signaling, Vol 23, Iss 1, Pp 1-17 (2025)

Subject Terms: c-Ski, NF-κB, Inflammation, p65, HDAC1, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/73d4159a650041638150d63ce6f12713

Pharmacokinetics modulation in solid tumors through thrombin-embedded nanomedicine

Authors: Sheng Lin, Liuwei Zhang, Hongyan Cui, Yue Wang, Yang Zheng, Jianhua Hu, Mingzhu Li, Wentao Wang, Shijia Zhang, Kehui Zhou, Qixian Chen, Xiabin Lan, Yan Zhao

Source: Journal of Nanobiotechnology, Vol 23, Iss 1, Pp 1-15 (2025)

Subject Terms: Solid tumor, Nanomedicine, Targeted drug delivery, Prodrug nanomedicine, Tumor microenvironment-responsive, Synergistic anticancer therapy, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5

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Relation: https://doaj.org/toc/1477-3155

Access URL: https://doaj.org/article/4771a7e8b62f4dd393f7b94ed6cc6f87

Clinical application of polar body-based preimplantation genetic testing for maternal mutations in women with a limited number of oocytes

Authors: Jia Chen, Xingwu Wu, Qiang Xu, Tao Ding, Ge Chen, Houyang Chen, Yongyi Zou, Jialyu Huang, Ziyu Zhang, Lifeng Tian, Yan Zhao, Ranhui Duan, Zengming Li, Qiongfang Wu, Yanqiu Liu

Source: Orphanet Journal of Rare Diseases, Vol 20, Iss 1, Pp 1-13 (2025)

Subject Terms: Preimplantation genetic testing, PGT, Monogenic disease, Polar body, A limited number of oocytes, Single nucleotide polymorphism, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1172

Access URL: https://doaj.org/article/6cbc0c4210be44c5973b3b7c007f9ca9

Efficacy and Safety of 611 in Chinese Adults with Moderate-to-Severe Atopic Dermatitis: Results from a Phase II Trial

Authors: Yan Zhao, Litao Zhang, Liming Wu, Xinsuo Duan, Chao Ji, Rong Xiao, Mingkai Ji, Lunfei Liu, Bin Yang, Guohong Hu, Yanyan Feng, Jianjian Zhu, Jianguo Li, Yangfeng Ding, Haomin Huang, Qinghong Zhou, Yuyu Xu, Jianzhong Zhang

Source: Dermatology and Therapy, Vol 15, Iss 4, Pp 857-867 (2025)

Subject Terms: Atopic dermatitis, Chinese patients, 611, Interleukin-4 receptor alpha, Eczema area, Severity index, Dermatology, RL1-803

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Relation: https://doaj.org/toc/2193-8210; https://doaj.org/toc/2190-9172

Access URL: https://doaj.org/article/cd4a7d5931a4473f94c48667b4ba12f5

Global trend and disparity in the burden of thyroid cancer attributable to high body-mass index from 1990 to 2021 and projection to 2049: a systematic analysis based on the Global Burden of Disease Study 2021

Authors: Ye-xin Chen, Han-zhang Hong, Zi-heng Gao, Yu-xin Hu, Ling-zi Yao, Jiang-teng Liu, Yan Zhao, Gai-weng Cui, Dan-dan Mao, Jin-xi Zhao

Source: BMC Public Health, Vol 25, Iss 1, Pp 1-13 (2025)

Subject Terms: Thyroid cancer, High body-mass index, Global Burden of Disease Study 2021, Deaths, Disability-adjusted life years, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2458

Access URL: https://doaj.org/article/02479753137a4124a4e29379aa8fda93

Whole-genome resequencing data reveal the genetic diversity of local chickens in southern Zhejiang and surrounding areas in China

Authors: Yawen Zhang, Bo Zhang, Ziwei Li, Fengxiang Hou, Yan Zhao, Junjie Jin, Bin Song, Wenjie Gu

Source: Czech Journal of Animal Science, Vol 70, Iss 3, Pp 113-120 (2025)

Subject Terms: breeding, chinese native chicken breeds, population structure, single nucleotide polymorphism, Animal culture, SF1-1100

File Description: electronic resource

Relation: https://cjas.agriculturejournals.cz/artkey/cjs-202503-0004_whole-genome-resequencing-data-reveal-the-genetic-diversity-of-local-chickens-in-southern-zhejiang-and-surround.php; https://doaj.org/toc/1212-1819; https://doaj.org/toc/1805-9309

Access URL: https://doaj.org/article/d5cb4f9a1e504c2f829a2381c087127b

Structural characterization reveals substrate recognition by the taurine transporter TauT

Authors: Hao Xu, Qinru Bai, Han Wang, Jun Zhao, Aiping Guo, Renjie Li, Qihao Chen, Yiqing Wei, Na Li, Zhuo Huang, Yan Zhao

Source: Cell Discovery, Vol 11, Iss 1, Pp 1-4 (2025)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2056-5968

Access URL: https://doaj.org/article/a492a5e10ff34a009e22ee47c193bb09

Early prediction of microvascular obstruction prior to percutaneous coronary intervention

Authors: Ziyu Zhou, Qing Chen, Zeqing Zhang, Tingting Wang, Yan Zhao, Wensu Chen, Zhuoqi Zhang, Shuyan Li, Boming Song

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-13 (2025)

Subject Terms: Percutaneous coronary intervention, Acute myocardial infarction, Microvascular obstruction, Machine learning, Logistic regression, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/9d24521058eb4366a68bd706168cc697

Modulation of the human GlyT1 by clinical drugs and cholesterol

Authors: Na Li, Yiqing Wei, Renjie Li, Yufei Meng, Jun Zhao, Qinru Bai, Gang Wang, Yan Zhao

Source: Nature Communications, Vol 16, Iss 1, Pp 1-11 (2025)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/52c23ac618ef4f95b01d8c14378ec42f

Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinflammation in a food-borne polystyrene microplastic exposed mouse model

Authors: Chong Liu, Yan Zhao, Wei Zhang, Ji-Ji Dao, Qian Li, Jia Huang, Zhen-Feng Li, Yu-Ke Ma, Chen-Meng Qiao, Chun Cui, Shuang-Xi Chen, Li Yu, Yan-Qin Shen, Wei-Jiang Zhao

Source: Journal of Neuroinflammation, Vol 22, Iss 1, Pp 1-20 (2025)

Subject Terms: PS-MPs, Neuronal damage, Neuroinflammation, ErbB4 receptor, Small molecule, Mitochondrial damage, Neurology. Diseases of the nervous system, RC346-429

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Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/c1c2206263fa403590ffceedfa63847d

Biomechanical analysis of clear aligners for mandibular anterior teeth intrusion and its clinical application in the design of new aligner attachment

Authors: Shengzhao Xiao, Caiqi Cheng, Haochen Li, Lin Li, Canao Shen, Qiping Feng, Yan Zhao, Yufeng Duan, Lunguo Xia, Fengting Chu, Bing Fang

Source: Progress in Orthodontics, Vol 26, Iss 1, Pp 1-17 (2025)

Subject Terms: Clear aligner, Anterior teeth intrusion, Finite element analysis, Dentistry, RK1-715

File Description: electronic resource

Relation: https://doaj.org/toc/2196-1042

Access URL: https://doaj.org/article/96bc9fe8502b42c48a92c32d72a99c3e

Nano-confined controllable crystallization in supramolecular polymeric membranes for ultra-selective desalination

Authors: Gang Lu, Hubao A, Yuanyuan Zhao, Yan Zhao, Hengyue Xu, Wentao Shang, Xi Chen, Jiawei Sun, Huacheng Zhang, Jun Wu, Bing Dai, Bart Van der Bruggen, Raf Dewil, Alicia Kyoungjin An, Shuang Zheng

Source: Nature Communications, Vol 16, Iss 1, Pp 1-11 (2025)

Subject Terms: Science

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Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/dd73446418334a9cb6901b586c4dbe8a

tRF-5028c disrupts trophoblast function in recurrent spontaneous abortion by inhibiting CRKL-mediated Rap1 signaling pathway

Authors: Jialyu Huang, Jiawei Wang, Shuang Wang, Xiangpeng Xiong, Ruiyin Jiang, Chaoyi Xiong, Lu Wang, Lingling Huang, Yan Zhao, Zheng Fang, Xiaoyan Ai, Jiaying Lin

Source: Cellular & Molecular Biology Letters, Vol 30, Iss 1, Pp 1-19 (2025)

Subject Terms: Recurrent spontaneous abortion, Trophoblast, tRF-5028c, CRKL, Rap1, Cytology, QH573-671

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Relation: https://doaj.org/toc/1689-1392

Access URL: https://doaj.org/article/8241af7b50704292953172a7ba6c2e19

High-resolution shallow structures of the Red River fault zone in the southeastern Tibetan Plateau of China revealed by multiple seismic dense linear arrays

Authors: HongYu Ni, JunLun Li, Bao Deng, JinYu Zhang, YuanChao Lu, Yan Zhao, JianYe Chen, Peng Su

Source: Earth and Planetary Physics, Vol 9, Iss 2, Pp 195-211 (2025)

Subject Terms: red river fault zone, shallow fault structure, seismic dense array, ambient noise tomography, extended range phase shift method., Science, Geophysics. Cosmic physics, QC801-809, Environmental sciences, GE1-350

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Relation: https://doaj.org/toc/2096-3955

Access URL: https://doaj.org/article/6bee8e97547440f19575e74e6829b946

Assessing the declining trend in soil erodibility across China: A comparison of conventional and digital K-factor maps

Authors: Zhiyuan Tian, Yan Zhao, Longxi Cao, Yuan Zhao, Yin Liang

Source: International Soil and Water Conservation Research, Vol 13, Iss 1, Pp 15-26 (2025)

Subject Terms: Soil erosion, Random forest, Environmental variables, Soil survey database, Spatiotemporal variation, Engineering (General). Civil engineering (General), TA1-2040

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Relation: http://www.sciencedirect.com/science/article/pii/S2095633924000297; https://doaj.org/toc/2095-6339

Access URL: https://doaj.org/article/9b93125bd04c4bf084416e532e3fe11b

Research on blasting damage to tunnel surrounding rock based on acoustic full waveform signal analysis

Authors: Lijie Ge, Jiaxing Tao, Yan Zhao, Zhuang Zhang, Shuai Li, Ying Shi

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-17 (2025)

Subject Terms: Acoustic full waveform signal, Gini coefficient, Fractal theory, Time-frequency analysis, Energy spectrum, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/4ba52b237d74401581966d25b5632ee0

Effects of SARS-CoV-2 infection during IVF treatment on embryo morphokinetics and pregnancy outcomes after fresh transfer: a prospective cohort study

Authors: Jialyu Huang, Yuxin Liu, Leizhen Xia, Haisheng Wu, Houyang Chen, Zhihui Huang, Yajie Liao, Xinxia Wan, Hong Chen, Yan Zhao, Frauke von Versen-Höynck, Xingwu Wu

Source: Reproductive Biology and Endocrinology, Vol 23, Iss 1, Pp 1-9 (2025)

Subject Terms: COVID-19, SARS-CoV-2, In vitro fertilization, Embryo morphokinetics, Pregnancy, Gynecology and obstetrics, RG1-991, Reproduction, QH471-489

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Relation: https://doaj.org/toc/1477-7827

Access URL: https://doaj.org/article/068415e92ba9400e897bb4ea50aa2c67

Effect of 24-hour heart rate fluctuations on mortality in patients with acute myocardial infarction: based on the MIMIC III database

Authors: Guihong Zhang, Xiaohe Liu, Yan Zhao, Dan Li, Bo Wu

Source: BMC Cardiovascular Disorders, Vol 25, Iss 1, Pp 1-13 (2025)

Subject Terms: Heart rate fluctuation, Acute myocardial infarction, Intensive care unit, Retrospective cohort study, Mortality, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2261

Access URL: https://doaj.org/article/389cdc0ec0b94023b5692f132beba74e