An unconventional VH1-2 antibody tolerates escape mutations and shows an antigenic hotspot on SARS-CoV-2 spike

Authors: Liu, Banghui, Niu, Xuefeng, Deng, Yijun, Zhang, Zhaoyong, Wang, Yanqun, Gao, Xijie, Liang, Huan, Li, Zimu, Wang, Qian, Cheng, Yuanyi, Chen, Qiuluan, Huang, Shuangshuang, Pan, Yingxian, Su, Mengzhen, Lin, Xiancheng, Niu, Chuanying, Chen, Yinglin, Yang, Wenyi, Zhang, Yudi, Yan, Qihong, He, Jun, Zhao, Jincun, Chen, Ling, Xiong, Xiaoli

Source: In Cell Reports 25 June 2024 43(6)

Identification of a broad sarbecovirus neutralizing antibody targeting a conserved epitope on the receptor-binding domain

Authors: Wang, Yanqun, Zhang, Zhaoyong, Yang, Minnan, Xiong, Xinyi, Yan, Qihong, Cao, Lei, Wei, Peilan, Zhang, Yuting, Zhang, Lu, Lv, Kexin, Chen, Jiantao, Liu, Xuesong, Zhao, Xiaochu, Xiao, Juxue, Zhang, Shengnan, Zhu, Airu, Gan, Mian, Zhang, Jingjun, Cai, Ruoxi, Zhuo, Jianfen, Zhang, Yanjun, Rao, Haiyue, Qu, Bin, Zhang, Yuanyuan, Chen, Lei, Dai, Jun, Cheng, Linling, Hu, Qingtao, Chen, Yaoqing, Lv, Huibin, So, Ray T.Y., Peiris, Malik, Zhao, Jingxian, Liu, Xiaoqing, Mok, Chris Ka Pun, Wang, Xiangxi, Zhao, Jincun

Source: In Cell Reports 23 January 2024 43(1)

Pharmacological suppression of glycogen synthase kinase-3 reactivates HIV-1 from latency via activating Wnt/β-catenin/TCF1 axis in CD4+ T cells

Authors: Wen, Jing, Li, Xin, Zhao, Qing-Xia, Yang, Xiao-Fan, Wu, Meng-Li, Yan, Qihong, Chang, Junbiao, Wang, Haikun, Jin, Xia, Su, Xiao, Deng, Kai, Chen, Ling, Wang, Jian-Hua

Source: Emerging microbes & infections. 11(1):392-406

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194666513.0x000001&indx=1&recIds=ETOCvdc_100194666513.0x000001

Shared IGHV1-69-encoded neutralizing antibodies contribute to the emergence of L452R substitution in SARS-CoV-2 variants

Authors: Yan, Qihong, Hou, Ruitian, Huang, Xiaohan, Zhang, Yanjun, He, Ping, Zhang, Yudi, Liu, Banghui, Wang, Qian, Rao, Haiyue, Chen, Xianying, Zhao, Xinwei, Niu, Xuefeng, Zhao, Jincun, Xiong, Xiaoli, Chen, Ling

Source: Emerging microbes & infections. 11(1):2749-2761

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194692384.0x000001&indx=1&recIds=ETOCvdc_100194692384.0x000001

An allelic atlas of immunoglobulin heavy chain variable regions reveals antibody binding epitope preference resilient to SARS-CoV-2 mutation escape.

Authors: Deng, Weiqi, Niu, Xuefeng, He, Ping, Yan, Qihong, Liang, Huan, Wang, Yongping, Ning, Lishan, Lin, Zihan, Zhang, Yudi, Zhao, Xinwei, Feng, Liqiang, Qu, Linbing, Chen, Ling

Source: Frontiers in Immunology; 2025, p1-15, 15p

Subject Terms: IMMUNOGLOBULIN heavy chains, IMMUNE complexes, AMINO acid residues, HUMORAL immunity, POPULATION genetics

Robust mucosal SARS-CoV-2-specific T cells effectively combat COVID-19 and establish polyfunctional resident memory in patient lungs

Authors: Zhu, Airu, Chen, Zhao, Yan, Qihong, Jiang, Mei, Liu, Xuesong, Li, Zhengtu, Li, Na, Tang, Chunli, Jian, Wenhua, He, Jiangping, Chen, Lan, Cheng, Jinling, Chen, Canjie, Tang, Tian, Xu, Zhiwei, Hu, Qingtao, Li, Fang, Wang, Yanqun, Sun, Jing, Zhuang, Zhen, Wen, Liyan, Zhuo, Jianfen, Liu, Donglan, Zhang, Yanjun, Huang, Xiaofang, Li, Suxiang, Zeng, Qiuhui, Chen, Fangli, Zhou, Liang, Liu, Dongdong, Zhong, Changhao, Chen, Yu, Li, Shiyue, Liang, Kangli, Zhong, Na, Zhang, Xinmei, Chen, Jiekai, Chen, Xiaobo, Xu, Yonghao, Zhong, Nanshan, Zhao, Jingxian, Zhao, Jincun

Source: Nature Immunology; March 2025, Vol. 26 Issue: 3 p459-472, 14p

Germline IGHV3-53-encoded RBD-targeting neutralizing antibodies are commonly present in the antibody repertoires of COVID-19 patients

Authors: Yan, Qihong, He, Ping, Huang, Xiaohan, Luo, Kun, Zhang, Yudi, Yi, Haisu, Wang, Qian, Li, Feng, Hou, Ruitian, Fan, Xiaodi, Li, Pingchao, Liu, Xinglong, Liang, Huan, Deng, Yijun, Chen, Zhaoming, Chen, Yunfei, Mo, Xiaoneng, Feng, Liqiang, Xiong, Xiaoli, Li, Song, Han, Jian, Qu, Linbing, Niu, Xuefeng, Chen, Ling

Source: Emerging microbes & infections. 10(1):1097-1111

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140633315.0x000001&indx=1&recIds=ETOCvdc_100140633315.0x000001

Longitudinal Peripheral Blood Transcriptional Analysis Reveals Molecular Signatures of Disease Progression in COVID-19 Patients

Authors: Yan, Qihong, Li, Pingchao, Ye, Xianmiao, Huang, Xiaohan, Feng, Bo, Ji, Tianxing, Chen, Zhilong, Li, Feng, Zhang, Yudi, Luo, Kun

Source: Journal of immunology. 206(9):2146-2159

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN626447307&indx=1&recIds=ETOCRN626447307

Defining the features and structure of neutralizing antibody targeting the silent face of the SARS‐CoV‐2 spike N‐terminal domain.

Authors: Zhang, Zhaoyong, Zhang, Yuanyuan, Zhang, Yuting, Cheng, Linling, Zhang, Lu, Yan, Qihong, Liu, Xuesong, Chen, Jiantao, Dai, Jun, Guo, Yingying, Wei, Peilan, Xiong, Xinyi, Xiao, Juxue, Zhu, Airu, Zhuo, Jianfen, Cai, Ruoxi, Zhang, Jingjun, Rao, Haiyue, Qu, Bin, Zhang, Shengnan

Source: MedComm; Dec2024, Vol. 5 Issue 12, p1-16, 16p

Subject Terms: SARS-CoV-2, VIRAL mutation, BINDING site assay, STERIC hindrance, GLYCANS, IMMUNOGLOBULINS

Chloroquine inhibits endosomal viral RNA release and autophagy-dependent viral replication and effectively prevents maternal to fetal transmission of Zika virus

Authors: Zhang, Shengnan, Yi, Changhua, Li, Chufang, Zhang, Fan, Peng, Jiaojiao, Wang, Qian, Liu, Xinglong, Ye, Xianmiao, Li, Pingchao, Wu, Min, Yan, Qihong, Guo, Wenjing, Niu, Xuefeng, Feng, Liqiang, Pan, Weiqi, Chen, Ling, Qu, Linbing

Source: In Antiviral Research September 2019 169

Longitudinal analysis of the antibody repertoire of a Zika virus-infected patient revealed dynamic changes in antibody response

Authors: Niu, Xuefeng, Yan, Qihong, Yao, Zhipeng, Zhang, Fan, Qu, Linbing, Wang, Chunlin, Wang, Chengrui, Lei, Hui, Chen, Chaoming, Liang, Renshan, Luo, Jia, Wang, Qian, Zhao, Lingzhai, Zhang, Yudi, Luo, Kun, Wang, Longyu, Wu, Hongkai, Liu, Tingting, Li, Pingchao, Zheng, Zhiqiang, Tan, Yee Joo, Feng, Liqiang, Zhang, Zhenhai, Han, Jian, Zhang, Fuchun, Chen, Ling

Source: Emerging microbes & infections. 9(1):111-123

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100117718240.0x000001&indx=1&recIds=ETOCvdc_100117718240.0x000001

Convalescent patient-derived monoclonal antibodies targeting different epitopes of E protein confer protection against Zika virus in a neonatal mouse model

Authors: Niu, Xuefeng, Zhao, Lingzhai, Qu, Linbing, Yao, Zhipeng, Zhang, Fan, Yan, Qihong, Zhang, Shengnan, Liang, Renshan, Chen, Peihai, Luo, Jia, Xu, Wei, Lv, Huibin, Liu, Xinglong, Lei, Hui, Yi, Changhua, Li, Pingchao, Wang, Qian, Wang, Yang, Yu, Lei, Zhang, Xiaoyan, Bryan, L. Aubrey, Davidson, Edgar, Doranz, j. Benjamin, Feng, Liqiang, Pan, Weiqi, Zhang, Fuchun, Chen, Ling

Source: Emerging microbes & infections. 8(1):749-759

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100094548112.0x000001&indx=1&recIds=ETOCvdc_100094548112.0x000001

A Class of Shark‐Derived Single‐Domain Antibodies can Broadly Neutralize SARS‐Related Coronaviruses and the Structural Basis of Neutralization and Omicron Escape

Authors: Feng, Bo, Chen, Zhilong, Sun, Jing, Xu, Tingting, Wang, Qian, Yi, Haisu, Niu, Xuefeng, Zhu, Jiabin, Fan, Mengzhu, Hou, Ruitian, Shao, Ying, Huang, Sihui, Li, Cuiyun, Hu, Peiyu, Zheng, Pingqian, He, Ping, Luo, Jia, Yan, Qihong, Xiong, Xiaoli, Liu, Jinsong, Zhao, Jincun, Chen, Ling

Source: Small methods. 6(7)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100156110851.0x000001&indx=1&recIds=ETOCvdc_100156110851.0x000001

Incorporation of NS1 and prM/M are important to confer effective protection of adenovirus-vectored Zika virus vaccine carrying E protein

Authors: Liu, Xinglong, Qu, Linbing, Ye, Xianmiao, Yi, Changhua, Zheng, Xuehua, Hao, Mingli, Su, Wan, Yao, Zhipeng, Chen, Peihai, Zhang, Shengnan, Feng, Yupeng, Wang, Qian, Yan, Qihong, Li, Pingchao, Li, Heying, Li, Feng, Pan, Weiqi, Niu, Xuefeng, Xu, Ruian, Feng, Liqiang, Chen, Ling

Source: Npj vaccines. 3:1-8

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100175390968.0x000001&indx=1&recIds=ETOCvdc_100175390968.0x000001

Mosaic RBD Nanoparticles Elicit Protective Immunity Against Multiple Human Coronaviruses in Animal Models.

Authors: Zhang, Yanjun¹, Sun, Jing¹, Zheng, Jian², Li, Suxiang¹, Rao, Haiyue¹, Dai, Jun³, Zhang, Zhaoyong¹, Wang, Yanqun¹, Liu, Donglan¹, Chen, Zhao¹, Ran, Wei¹, Zhu, Airu¹, Li, Fang¹, Yan, Qihong¹, Wang, Yiliang¹, Yu, Kuai¹, Zhang, Shengnan¹, Wang, Dong¹, Tang, Yanhong¹, Liu, Banghui⁴

Source: Advanced Science; 3/6/2024, Vol. 11 Issue 9, p1-13, 13p

Antibody dynamics for heterologous boosters with aerosolized Ad5-nCoV following inactivated COVID-19 vaccines.

Authors: Chen, Canjie, Tang, Tian, Chen, Zhao, Chen, Lan, Cheng, Jinling, Li, Fang, Sun, Jing, Zhao, Jingxian, Wang, Yanqun, Yan, Qihong, Zhao, Jincun, Zhu, Airu

Source: Human Vaccines & Immunotherapeutics; 2024, Vol. 20 Issue 1, p1-8, 8p

Pharmacological suppression of glycogen synthase kinase-3 reactivates HIV-1 from latency via activating Wnt/β-catenin/TCF1 axis in CD4⁺ T cells.

Authors: Wen, Jing, Li, Xin, Zhao, Qing-Xia, Yang, Xiao-Fan, Wu, Meng-Li, Yan, Qihong, Chang, Junbiao, Wang, Haikun, Jin, Xia, Su, Xiao, Deng, Kai, Chen, Ling, Wang, Jian-Hua

Source: Emerging Microbes & Infections; Dec2022, Vol. 11 Issue 1, p392-406, 15p

Low Innate Immunity and Lagged Adaptive Immune Response in the Re-Tested Viral RNA Positivity of a COVID-19 Patient.

Authors: Lai, Changchun, Liu, Xinglong, Yan, Qihong, Lv, Hualiang, Zhou, Lei, Hu, Longbo, Cai, Yong, Wang, Guoqiang, Chen, Yufeng, Chai, Renjie, Liu, Zhenwei, Xu, Yuhua, Huang, Wendong, Xiao, Fei, Hu, Linhui, Li, Yaocai, Huang, Jianhong, Zhou, Qiang, Li, Luqian, Peng, Tao

Source: Frontiers in Immunology; 7/1/2021, Vol. 12, p1-12, 12p

Subject Terms: COVID-19, NATURAL immunity, IMMUNE response, RNA, SARS-CoV-2

Longitudinal Analysis of T and B Cell Receptor Repertoire Transcripts Reveal Dynamic Immune Response in COVID-19 Patients.

Authors: Niu, Xuefeng, Li, Song, Li, Pingchao, Pan, Wenjing, Wang, Qian, Feng, Ying, Mo, Xiaoneng, Yan, Qihong, Ye, Xianmiao, Luo, Jia, Qu, Linbing, Weber, Daniel, Byrne-Steele, Miranda L., Wang, Zhe, Yu, Fengjia, Li, Fang, Myers, Richard M., Lotze, Michael T., Zhong, Nanshan, Han, Jian

Source: Frontiers in Immunology; 9/30/2020, Vol. 11, pN.PAG-N.PAG, 9p

Subject Terms: B cell receptors, T cell receptors, COVID-19, IMMUNE response, VIRUS diseases

UniBind: a novel artificial intelligence-based prediction model for SARS-CoV-2 infectivity and variant evolution.

Authors: Yan, Qihong, Zhao, Jincun

Source: Signal Transduction & Targeted Therapy; 12/19/2023, Vol. 8 Issue 1, p1-2, 2p