Development of a high-affinity anti-bovine PD-1 rabbit–bovine chimeric antibody using an efficient selection and large production system

Authors: Tomohiro Okagawa, Satoru Konnai, Shinya Goto, Yamato Sajiki, Otgontuya Ganbaatar, Kei Watari, Hayato Nakamura, Cai-Xia Wang, Taro Tachibana, Yukinari Kato, Yayoi Kameda, Junko Kohara, Nobuhiro Terasaki, Manabu Kubota, Akira Takeda, Hirofumi Takahashi, Yasuhiko Suzuki, Naoya Maekawa, Shiro Murata, Kazuhiko Ohashi

Source: Veterinary Research, Vol 54, Iss 1, Pp 1-14 (2023)

Subject Terms: Monoclonal antibodies, programmed death-1, cattle, antibody production, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://doaj.org/toc/1297-9716

Access URL: https://doaj.org/article/d1e0e81c1ed349c095a5bc6af2dd26e6

Exploration of serum biomarkers in dogs with malignant melanoma receiving anti-PD-L1 therapy and potential of COX-2 inhibition for combination therapy

Authors: Naoya Maekawa, Satoru Konnai, Yumie Asano, Yamato Sajiki, Tatsuya Deguchi, Tomohiro Okagawa, Kei Watari, Hiroto Takeuchi, Satoshi Takagi, Kenji Hosoya, Sangho Kim, Hiroshi Ohta, Yukinari Kato, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/9195edeb9fe7415f92cb3f8d09b03d7b

mTOR regulates T cell exhaustion and PD-1–targeted immunotherapy response during chronic viral infection

Authors: Satomi Ando, Charles M. Perkins, Yamato Sajiki, Chase Chastain, Rajesh M. Valanparambil, Andreas Wieland, William H. Hudson, Masao Hashimoto, Suresh S. Ramalingam, Gordon J. Freeman, Rafi Ahmed, Koichi Araki

Source: The Journal of Clinical Investigation, Vol 133, Iss 2 (2023)

Subject Terms: Immunology, Infectious disease, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/dfaca50a88f74b02a4c1d34e9ba0a73c

Tick saliva-induced programmed death-1 and PD-ligand 1 and its related host immunosuppression

Authors: Yamato Sajiki, Satoru Konnai, Yoshinori Ikenaka, Kevin Christian Montecillo Gulay, Atsushi Kobayashi, Luís Fernando Parizi, Benvindo Capela João, Kei Watari, Sotaro Fujisawa, Tomohiro Okagawa, Naoya Maekawa, Carlos Logullo, Itabajara da Silva Vaz, Shiro Murata, Kazuhiko Ohashi

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/638fdda85f414409bc159c27d999af7e

Estradiol-induced immune suppression via prostaglandin E2 during parturition in bovine leukemia virus-infected cattle

Authors: Yamato Sajiki, Satoru Konnai, Tomohiro Okagawa, Naoya Maekawa, Shinya Goto, Junko Kohara, Atsushi Nitanai, Hirofumi Takahashi, Kentaro Kubota, Hiroshi Takeda, Shiro Murata, Kazuhiko Ohashi

Source: PLoS ONE, Vol 17, Iss 3 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906636/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/1fc529d9dc554e37891e8707f6dd9ce1

Enhancement of Vaccine-Induced T-Cell Responses by PD-L1 Blockade in Calves

Authors: Tomohiro Okagawa, Satoru Konnai, Hayato Nakamura, Otgontuya Ganbaatar, Yamato Sajiki, Kei Watari, Haruka Noda, Mitsuru Honma, Yukinari Kato, Yasuhiko Suzuki, Naoya Maekawa, Shiro Murata, Kazuhiko Ohashi

Source: Vaccines, Vol 11, Iss 3, p 559 (2023)

Subject Terms: PD-L1, PD-1, T cell, live attenuated vaccine, immunotherapy, cattle, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/11/3/559; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/9b1ef7c06a6e4dc39be8f67a5c02b2b4

The Suppression of Th1 Response by Inducing TGF-β1 From Regulatory T Cells in Bovine Mycoplasmosis

Authors: Yamato Sajiki, Satoru Konnai, Shinya Goto, Tomohiro Okagawa, Kosuke Ohira, Honami Shimakura, Naoya Maekawa, Satoshi Gondaira, Hidetoshi Higuchi, Motoshi Tajima, Yuki Hirano, Junko Kohara, Shiro Murata, Kazuhiko Ohashi

Source: Frontiers in Veterinary Science, Vol 7 (2020)

Subject Terms: TGF-β1, Mycoplasma bovis, regulatory T cell, immunosuppression, cattle, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fvets.2020.609443/full; https://doaj.org/toc/2297-1769

Access URL: https://doaj.org/article/322f6ea3de6c4d969d146127ca9fc2e9

Upregulation of PD-L1 Expression by Prostaglandin E2 and the Enhancement of IFN-γ by Anti-PD-L1 Antibody Combined With a COX-2 Inhibitor in Mycoplasma bovis Infection

Authors: Shinya Goto, Satoru Konnai, Yuki Hirano, Junko Kohara, Tomohiro Okagawa, Naoya Maekawa, Yamato Sajiki, Kei Watari, Erina Minato, Atsuhi Kobayashi, Satoshi Gondaira, Hidetoshi Higuchi, Masateru Koiwa, Motoshi Tajima, Eiji Taguchi, Ryoko Uemura, Shinji Yamada, Mika K. Kaneko, Yukinari Kato, Keiichi Yamamoto, Mikihiro Toda, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi

Source: Frontiers in Veterinary Science, Vol 7 (2020)

Subject Terms: immunoinhibitory molecules, PD-1, PD-L1, T-cell exhaustion, prostaglandin E2, immune dysfunction, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fvets.2020.00012/full; https://doaj.org/toc/2297-1769

Access URL: https://doaj.org/article/a6e71fa9104e4360be6bba148bb70726

In vitro and in vivo antivirus activity of an anti-programmed death-ligand 1 (PD-L1) rat-bovine chimeric antibody against bovine leukemia virus infection.

Authors: Asami Nishimori, Satoru Konnai, Tomohiro Okagawa, Naoya Maekawa, Ryoyo Ikebuchi, Shinya Goto, Yamato Sajiki, Yasuhiko Suzuki, Junko Kohara, Satoshi Ogasawara, Yukinari Kato, Shiro Murata, Kazuhiko Ohashi

Source: PLoS ONE, Vol 12, Iss 4, p e0174916 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5405919?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/014030c4e1884130b43fa0bb10f61216

Enhancement of interleukin-2 production by bovine peripheral blood mononuclear cells treated with the combination of antiprogrammed death-ligand 1 and cytotoxic T lymphocyte antigen 4 chimeric monoclonal antibodies.

Authors: Kei WATARI, Satoru KONNAI, Tomohiro OKAGAWA, Naoya MAEKAWA, Yamato SAJIKI, Yukinari KATO, Yasuhiko SUZUKI, Shiro MURATA, Kazuhiko OHASHI

Source: Journal of Veterinary Medical Science; 2022, Vol. 84 Issue 1, p6-15, 10p

Subject Terms: CYTOTOXIC T cells, MONONUCLEAR leukocytes, MONOCLONAL antibodies, T cells, PROGRAMMED death-ligand 1, PROGRAMMED cell death 1 receptors, INTERLEUKIN-2, ANTIGENS

The enhancement of Th1 immune response by anti-PD-L1 antibody in cattle infected with Mycobacterium avium subsp. paratuberculosis.

Authors: Yamato SAJIKI, Satoru KONNAI, Reiko NAGATA, Satoko KAWAJI, Hayato NAKAMURA, Sotaro FUJISAWA, Tomohiro OKAGAWA, Naoya MAEKAWA, Yukinari KATO, Yasuhiko SUZUKI, Shiro MURATA, Yasuyuki MORI, Kazuhiko OHASHI

Source: Journal of Veterinary Medical Science; 2021, Vol. 83 Issue 2, p162-166, 5p

Subject Terms: MYCOBACTERIUM avium paratuberculosis, PARATUBERCULOSIS, IMMUNE response, ANTIBODY formation, CATTLE

Clinical efficacy of the combined treatment of anti-PD-L1 rat-bovine chimeric antibody with a COX-2 inhibitor in calves infected with Mycoplasma bovis.

Authors: Shinya Goto, Satoru Konnai, Yuki Hirano, Junko Kohara, Tomohiro Okagawa, Naoya Maekawa, Yamato Sajiki, Kei Watari, Erina Minato, Atsuhi Kobayashi, Satoshi Gondaira, Hidetoshi Higuchi, Masateru Koiwa, Motoshi Tajima, Eiji Taguchi, Masaru Ishida, Ryoko Uemura, Shinji Yamada, Mika K. Kaneko, Yukinari Kato

Source: Japanese Journal of Veterinary Research; 2020, Vol. 68 Issue 2, p77-90, 14p

Prostaglandin E2-Induced Immune Exhaustion and Enhancement of Antiviral Effects by Anti-PD-L1 Antibody Combined with COX-2 Inhibitor in Bovine Leukemia Virus Infection.

Authors: Yamato Sajiki¹, Satoru Konnai^1,2 konnai@vetmed.hokudai.ac.jp, Tomohiro Okagawa², Asami Nishimori¹, Naoya Maekawa², Shinya Goto¹, Kei Watari¹, Minato, Erina³, Atsushi Kobayashi³, Junko Kohara⁴, Shinji Yamada⁵, Mika K. Kaneko⁵, Yukinari Kato⁵, Hirofumi Takahashi⁶, Nobuhiro Terasaki⁶, Akira Takeda⁶, Keiichi Yamamoto^2,7, Mikihiro Toda^2,8, Yasuhiko Suzuki^2,9,10, Shiro Murata^1,2

Source: Journal of Immunology. 9/1/2019, Vol. 203 Issue 5, p1313-1324. 12p.

Subject Terms: *BOVINE leukemia virus, *VIRUS diseases, *PROSTAGLANDINS, *BACTERIAL diseases

Geographic Terms: JAPAN

Intrauterine infection with bovine leukemia virus in pregnant dam with high viral load.

Authors: Yamato SAJIKI, Satoru KONNAI, Asami NISHIMORI, Tomohiro OKAGAWA, Naoya MAEKAWA, Shinya GOTO, Masashi NAGANO, Junko KOHARA, Nana KITANO, Toshihiko TAKAHASHI, Motoshi TAJIMA, Hirohisa MEKATA, Yoichiro HORII, Shiro MURATA, Kazuhiko OHASHI

Source: Journal of Veterinary Medical Science; Dec2017, Vol. 79 Issue 12, p2036-2039, 4p, 1 Chart, 1 Graph

Subject Terms: BOVINE leukosis, LIVESTOCK diseases, BOVINE leukemia virus, CATTLE infections, INSECT bites & stings, CESAREAN section, NUCLEOTIDE sequence, INFECTIOUS disease transmission

Combined Immune Checkpoint Blockade Enhances Antiviral Immunity against Bovine Leukemia Virus.

Authors: Hayato Nakamura¹, Satoru Konnai^1,2,3 konnai@vetmed.hokudai.ac.jp, Tomohiro Okagawa², Naoya Maekawa², Yamato Sajiki¹, Kei Watari¹, Kana Kamitani⁴, Maya Saito⁴, Yukinari Kato^5,6, Yasuhiko Suzuki^2,3,7, Shiro Murata^1,2, Kazuhiko Ohashia^1,2

Source: Journal of Virology. Jan2023, Vol. 97 Issue 1, p1-16. 16p.

Subject Terms: *BOVINE leukemia virus, *IMMUNE checkpoint proteins, *BOVINE viral diarrhea, *MONONUCLEAR leukocytes, *CATTLE herding, *HEPATITIS A virus cellular receptors, *BLOCKADE

Geographic Terms: JAPAN