A study on supercooling processes of leaf lettuces produced in plant factory

Authors: Thinh, Nguyen Quang, Iwamura, Koji, Shrestha, Rajesh, Fukumoto, Seisuke, Takematsu, Ryo, Yamaguchi, Jun-ichi, Kimura, Kazunuki, Tanimizu, Yoshitaka, Sugimura, Nobuhiro

Source: 2016 International Symposium on Flexible Automation (ISFA) Flexible Automation (ISFA), International Symposium on. :77-80 Aug, 2016

Relation: 2016 International Symposium on Flexible Automation (ISFA)

Preclinical Metabolism and Disposition of TP0473292, a Novel Oral Prodrug of the Potent Metabotropic Glutamate 2/3 Receptor Antagonist TP0178894 for the Treatment of Depression

Authors: Inatani, Shoko ^*, Ochi, Motoki, Kinoshita, Kohnosuke, Yamaguchi, Jun-ichi, Endo, Hiromi

Source: In Drug Metabolism and Disposition May 2023 51(5):572-582

Elucidation of clearance mechanism of TP0463518, a novel hypoxia-inducible factor prolyl hydroxylase inhibitor: does a species difference in excretion routes exist between humans and animals?

Authors: Takano, Hiroki, Mizuno-Yasuhira, Akiko, Yamaguchi, Jun-ichi, Endo, Hiromi

Source: Xenobiotica. 52(7):729-741

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167359115.0x000001&indx=1&recIds=ETOCvdc_100167359115.0x000001

Bottom-up physiologically based pharmacokinetic modelling for predicting the human pharmacokinetic profiles of the ester prodrug MGS0274 and its active metabolite MGS0008, a metabotropic glutamate 2/3 receptor agonist

Authors: Ochi, Motoki, Kinoshita, Kohnosuke, Yamaguchi, Jun-ichi, Endo, Hiromi

Source: Xenobiotica. 52(2):119-128

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100147898716.0x000001&indx=1&recIds=ETOCvdc_100147898716.0x000001

Downregulation of CYP1A2, CYP2B6, and CYP3A4 in Human Hepatocytes by Prolyl Hydroxylase Domain 2 Inhibitors via Hypoxia-Inducible Factor-α Stabilization

Authors: Takano, Hiroki ^*, Yamaguchi, Jun-ichi, Kato, Sota, Hamada, Makoto, Tada, Mika, Endo, Hiromi

Source: In Drug Metabolism and Disposition January 2021 49(1):20-30

Guaiazulene derivative 1, 2, 3, 4‐tetrahydroazuleno[1, 2‐b] tropone reduces the production of ATP by inhibiting electron transfer complex II

Authors: Kasami, Chieko, Yamaguchi, Jun‐ichi, Inoue, Hideki

Source: FEBS open bio. 11(11):2921-2932

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100134824760.0x000001&indx=1&recIds=ETOCvdc_100134824760.0x000001

Discovery of MGS0274, an ester prodrug of a metabotropic glutamate receptor 2/3 agonist with improved oral bioavailability

Authors: Urabe, Hiroki, Miyakoshi, Naoki, Ohtake, Norikazu, Nozoe, Akiko, Ochi, Motoki, Fukasawa, Misako, Kinoshita, Kohnosuke, Yamaguchi, Jun-ichi, Marumo, Toshiyuki, Hikichi, Hirohiko, Chaki, Shigeyuki, Hashihayata, Takashi

Source: In European Journal of Medicinal Chemistry 1 October 2020 203

Chiral LC-MS/MS method for the simultaneous determination of (R, S)-ketamine, (R, S)-norketamine, and (2R, 6R;2S, 6S)-hydroxynorketamine in mouse plasma and brain

Authors: Toki, Hidetoh, Yamaguchi, Jun-ichi, Mizuno-Yasuhira, Akiko, Endo, Hiromi

Source: Journal of pharmaceutical and biomedical analysis. 224

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178441578.0x000001&indx=1&recIds=ETOCvdc_100178441578.0x000001

Now is the time for (2R,6R)-hydroxynorketamine to be viewed independently from its parent drug

Authors: Chaki, Shigeyuki, Yamaguchi, Jun-ichi

Source: In Pharmacology, Biochemistry and Behavior December 2018 175:24-26

AMPA Receptor Activation–Independent Antidepressant Actions of Ketamine Metabolite (S)-Norketamine

Authors: Yang, Chun, Kobayashi, Shizuka, Nakao, Kazuhito, Dong, Chao, Han, Mei, Qu, Youge, Ren, Qian, Zhang, Ji-chun, Ma, Min, Toki, Hidetoh, Yamaguchi, Jun-ichi, Chaki, Shigeyuki, Shirayama, Yukihiko, Nakazawa, Kazu, Manabe, Toshiya, Hashimoto, Kenji

Source: In Biological Psychiatry 15 October 2018 84(8):591-600

Imaging Mass Microscopy of Kidneys from Azithromycin-Treated Rats with Phospholipidosis

Authors: Sakurai, Takanobu, Kamio, Kyohei, Sasaki, Kazuhiko, Nishimoto, Tomohiro, Yamaguchi, Jun-ichi, Sasaki, Minoru, Tsutsumi, Shunsuke

Source: In The American Journal of Pathology September 2018 188(9):1993-2003

Antidepressant Potential of (R)-Ketamine in Rodent Models: Comparison with (S)-Ketamine

Authors: Fukumoto, Kenichi, Toki, Hidetoh, Iijima, Michihiko, Hashihayata, Takashi, Yamaguchi, Jun-ichi, Hashimoto, Kenji, Chaki, Shigeyuki ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics April 2017 361(1):9-16

A rapid and sensitive chiral LC–MS/MS method for the determination of ketamine and norketamine in mouse plasma, brain and cerebrospinal fluid applicable to the stereoselective pharmacokinetic study of ketamine

Authors: Toki, Hidetoh, Ichikawa, Takuya, Mizuno-Yasuhira, Akiko, Yamaguchi, Jun-ichi

Source: Journal of pharmaceutical and biomedical analysis. 148:288-297

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100060997113.0x000001&indx=1&recIds=ETOCvdc_100060997113.0x000001

Heat release rate of wooden cribs with water application for fire suppression

Authors: Noaki, Masaki, Delichatsios, Michael A., Yamaguchi, Jun-ichi, Ohmiya, Yoshifumi

Source: Fire safety journal. 95:170-179

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100055395283.0x000001&indx=1&recIds=ETOCvdc_100055395283.0x000001

Lack of deuterium isotope effects in the antidepressant effects of (R)-ketamine in a chronic social defeat stress model

Authors: Zhang, Kai, Toki, Hidetoh, Fujita, Yuko, Ma, Min, Chang, Lijia, Qu, Youge, Harada, Shingo, Nemoto, Tetsuhiro, Mizuno-Yasuhira, Akiko, Yamaguchi, Jun-ichi, Chaki, Shigeyuki, Hashimoto, Kenji

Source: Psychopharmacology. 235(11):3177-3185

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125601712.0x000001&indx=1&recIds=ETOCvdc_100125601712.0x000001

(2R, 6R)-Hydroxynorketamine is not essential for the antidepressant actions of (R)-ketamine in mice

Authors: Yamaguchi, Jun-ichi, Toki, Hidetoh, Qu, Youge, Yang, Chun, Koike, Hiroyuki, Hashimoto, Kenji, Mizuno-Yasuhira, Akiko, Chaki, Shigeyuki

Source: Neuropsychopharmacology. 43(9):1900-1907

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129224866.0x000001&indx=1&recIds=ETOCvdc_100129224866.0x000001

Conjugate addition of an ynone containing azulene with a tertiary amine

Authors: Yamaguchi, Jun-ichi, Sugiyama, Sayuri

Source: In Tetrahedron Letters 12 October 2016 57(41):4514-4518

Halogenating agent-promoted transformation of enaminones into α,α-dihaloketones (halo = Cl, Br)

Authors: Yamaguchi, Jun-ichi, Akagi, Yuka, Koike, Ryo, Katou, Kounosuke, Katakura, Tomoya, Hanase, Tomoya, Homma, Tatsuya

Source: In Tetrahedron Letters 31 January 2024 135

Preclinical metabolism and the disposition of vornorexant/TS‐142, a novel dual orexin 1/2 receptor antagonist for the treatment of insomnia.

Authors: Konno, Yoshihiro, Kamigaso, Shunsuke, Toki, Hidetoh, Terasaka, Shuichi, Hikichi, Hirohiko, Endo, Hiromi, Yamaguchi, Jun‐Ichi, Mizuno‐Yasuhira, Akiko

Source: Pharmacology Research & Perspectives; Apr2024, Vol. 12 Issue 2, p1-14, 14p

Subject Terms: ENDOTHELIN receptors, ORAL drug administration, DRUG efficacy, HYPNOTICS, INSOMNIA, METABOLISM, CEREBROSPINAL fluid

Impact of Humidity on In Vitro Human Skin Permeation Experiments for Predicting In Vivo Permeability

Authors: Ishida, Masahiro ^*, Takeuchi, Hiroyuki, Endo, Hiromi, Yamaguchi, Jun-Ichi

Source: In Journal of Pharmaceutical Sciences December 2015 104(12):4223-4231