Antisense oligonucleotide-mediated disruption of HTT caspase-6 cleavage site ameliorates the phenotype of YAC128 Huntington disease mice

Authors: Elsa C. Kuijper, Maurice Overzier, Ernst Suidgeest, Oleh Dzyubachyk, Cécile Maguin, Jean-Baptiste Pérot, Julien Flament, Yavuz Ariyurek, Hailiang Mei, Ronald A.M. Buijsen, Louise van der Weerd, Willeke van Roon-Mom

Source: Neurobiology of Disease, Vol 190, Iss , Pp 106368- (2024)

Subject Terms: Huntington disease, YAC128 mice, Antisense oligonucleotides, Caspase-6, RNA splicing, RNA sequence analysis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996123003844; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/0b4874be3df4497fb539494749184266

Mitochondrial and redox modifications in early stages of Huntington's disease

Authors: Carla Lopes, I. Luísa Ferreira, Carina Maranga, Margarida Beatriz, Sandra I. Mota, José Sereno, João Castelhano, Antero Abrunhosa, Francisco Oliveira, Maura De Rosa, Michael Hayden, Mário N. Laço, Cristina Januário, Miguel Castelo Branco, A. Cristina Rego

Source: Redox Biology, Vol 56, Iss , Pp 102424- (2022)

Subject Terms: 64Cu]-ATSM PET, Human skin fibroblasts, YAC128 mice, Reactive oxygen species, Mitochondrial bioenergetics, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231722001963; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/41a596c6e228444184c1c9a70b5c8a8a

Temporal Characterization of Behavioral and Hippocampal Dysfunction in the YAC128 Mouse Model of Huntington’s Disease

Authors: Cristine de Paula Nascimento-Castro, Elisa C. Winkelmann-Duarte, Gianni Mancini, Priscilla Gomes Welter, Evelini Plácido, Marcelo Farina, Joana Gil-Mohapel, Ana Lúcia S. Rodrigues, Andreza Fabro de Bem, Patricia S. Brocardo

Source: Biomedicines, Vol 10, Iss 6, p 1433 (2022)

Subject Terms: Huntington’s disease, hippocampus, YAC128 mice, electron microscopy, neurodegeneration, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/10/6/1433; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/f76cc44072f5426a9693e92fe72a028b

The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease

Authors: Daniel Ryskamp, Jun Wu, Michal Geva, Rebecca Kusko, Iris Grossman, Michael Hayden, Ilya Bezprozvanny

Source: Neurobiology of Disease, Vol 97, Iss , Pp 46-59 (2017)

Subject Terms: Huntington disease, Pridopidine, 3-PPP, Sigma-1 receptor, Medium spiny neurons, YAC128 mice, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996116302479; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/9663a4e2c25e4386a5bcd97f7b718930

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