Viral Live‐Attenuated Vaccines (LAVs): Past and Future Directions

Authors: Yan‐Dong Tang, Yuming Li, Xue‐Hui Cai, Xin Yin

Source: Advanced Science, Vol 12, Iss 3, Pp n/a-n/a (2025)

Subject Terms: adaptation, attenuation, evolution, live attenuated vaccines (LAVs), pathogenicity, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/41f789388a744ba7a865e17c29bdfef6

Lipid A-modified Escherichia coli can produce porcine parvovirus virus-like particles with high immunogenicity and minimal endotoxin activity

Authors: Xuegang Shen, Yong-Bo Yang, Yanfei Gao, Shujie Wang, Haiwei Wang, Mingxia Sun, Fandan Meng, Yan-Dong Tang, Yabin Tu, Qingke Kong, Tong-Qing An, Xue-Hui Cai

Source: Microbial Cell Factories, Vol 23, Iss 1, Pp 1-13 (2024)

Subject Terms: Porcine parvovirus, Virus-like particle, Minimal endotoxin activity, Escherichia coli, Lipid A, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2859

Access URL: https://doaj.org/article/76b5aab8e71349bea27177c50301c830

Generation of an infectious cDNA clone for NADC30-like PRRSV

Authors: Yang-Yang Qiao, Hai-Ming Wang, Hui Lu, Yong-Juan Wang, Wei Zhang, Hao Gu, Xue-Hui Cai, Qin-Se Xu, Zhang-Yan Chen, Yan-Dong Tang

Source: Frontiers in Veterinary Science, Vol 11 (2024)

Subject Terms: NADC30-like, infectious cDNA clone, PRRSV, NADC30, PRRSV-2, Veterinary medicine, SF600-1100

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Relation: https://www.frontiersin.org/articles/10.3389/fvets.2024.1468981/full; https://doaj.org/toc/2297-1769

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Minor envelope proteins from GP2a to GP4 contribute to the spread pattern and yield of type 2 PRRSV in MARC-145 cells

Authors: Yuan-Zhe Bai, Yue Sun, Yong-Gang Liu, Hong-Liang Zhang, Tong-Qing An, Qian Wang, Zhi-Jun Tian, Xinyuan Qiao, Xue-Hui Cai, Yan-Dong Tang

Source: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)

Subject Terms: spread pattern, PRRSV, cell-to-cell, cell-free, yield, Microbiology, QR1-502

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Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2024.1376725/full; https://doaj.org/toc/2235-2988

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A novel viral vaccine platform based on engineered transfer RNA

Authors: Tong-Yun Wang, Fan-Dan Meng, Guo-Ju Sang, Hong-Liang Zhang, Zhi-Jun Tian, Hao Zheng, Xue-Hui Cai, Yan-Dong Tang

Source: Emerging Microbes and Infections, Vol 12, Iss 1 (2023)

Subject Terms: Engineered transfer RNA, PTC virus, vaccine, switch, Pseudorabies virus, novel vaccine, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/eb72437023af48d4b654c3f4d8195a47

Protective efficacy of a candidate live attenuated vaccine derived from the SD-R strain of lineage 1 porcine reproductive and respiratory syndrome virus against a lethal challenge with HP-PRRSV HuN4 in piglets

Authors: Hongliang Zhang, Chao Li, Hu Xu, Bangjun Gong, Wansheng Li, Zhenyang Guo, Lirun Xiang, Qi Sun, Jing Zhao, Jinmei Peng, Qian Wang, Guohui Zhou, Yan-Dong Tang, Tongqing An, Xue-Hui Cai, Zhi-Jun Tian

Source: Microbiology Spectrum, Vol 11, Iss 6 (2023)

Subject Terms: lineage 1, attenuated vaccine, SD-R, HP-PRRSV HuN4, cross-protection efficacy, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/f9888485612147bdb3c4826d40d4d30d

Genomic characteristics of a novel emerging PRRSV branch in sublineage 8.7 in China

Authors: Wansheng Li, Chao Li, Zhenyang Guo, Hu Xu, Bangjun Gong, Qi Sun, Jing Zhao, Lirun Xiang, Chaoliang Leng, Jinmei Peng, Guohui Zhou, Yandong Tang, Huairan Liu, Tongqing An, Xue-Hui Cai, Zhi-Jun Tian, Qian Wang, Hongliang Zhang

Source: Frontiers in Microbiology, Vol 14 (2023)

Subject Terms: PRRSV, new branch, sublineage 8.7, 1 + 8 + 1, genomic characteristics, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2023.1186322/full; https://doaj.org/toc/1664-302X

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Characterization of Two Immunodominant Antigenic Peptides in NSP2 of PRRSV-2 and Generation of a Marker PRRSV Strain Based on the Peptides

Authors: Dong-Yan Li, Xing-Yang Cui, Xin-Yi Huang, Yue Hu, Xiao-Xiao Tian, Tao Wang, Yong-Bo Yang, Qian Wang, Zhi-Jun Tian, Xue-Hui Cai, Tong-Qing An

Source: Frontiers in Veterinary Science, Vol 9 (2022)

Subject Terms: porcine reproductive and respiratory syndrome virus, differentiating infected from vaccinated animals vaccine, non-structural protein 2, peptides, enzyme-linked immunosorbent assay, Veterinary medicine, SF600-1100

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Relation: https://www.frontiersin.org/articles/10.3389/fvets.2022.902822/full; https://doaj.org/toc/2297-1769

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CRISPR-Cas13d Exhibits Robust Antiviral Activity Against Seneca Valley Virus

Authors: Yu-Yuan Zhang, Ming-Xia Sun, Yuexiao Lian, Tong-Yun Wang, Mei-Yu Jia, Chaoliang Leng, Meng Chen, Yuan-Zhe Bai, Fandan Meng, Xue-Hui Cai, Yan-Dong Tang

Source: Frontiers in Microbiology, Vol 13 (2022)

Subject Terms: CRISPR-Cas13d, CasRx, SVV, antiviral, virus, Microbiology, QR1-502

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Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2022.835040/full; https://doaj.org/toc/1664-302X

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New Characterization of Multi-Drug Resistance of Streptococcus suis and Biofilm Formation from Swine in Heilongjiang Province of China

Authors: Chun-Liu Dong, Rui-Xiang Che, Tong Wu, Qian-Wei Qu, Mo Chen, Si-Di Zheng, Xue-Hui Cai, Gang Wang, Yan-Hua Li

Source: Antibiotics, Vol 12, Iss 1, p 132 (2023)

Subject Terms: Streptococcus suis, serotype, multi-drug resistance, biofilm, drug resistance gene, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2079-6382/12/1/132; https://doaj.org/toc/2079-6382

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Self-assembly into virus–like particles of the recombinant capsid protein of porcine circovirus type 3 and its application on antibodies detection

Authors: Yu Wang, Gang Wang, Wei-Tong Duan, Ming-Xia Sun, Meng-Hang Wang, Shang-Hui Wang, Xue-Hui Cai, Ya-bin Tu

Source: AMB Express, Vol 10, Iss 1, Pp 1-10 (2020)

Subject Terms: PCV3, VLPs, Diagnostic, Swine, ELISA, Biotechnology, TP248.13-248.65, Microbiology, QR1-502

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Relation: https://doaj.org/toc/2191-0855

Access URL: https://doaj.org/article/99bb79b9258c4ba3b1870f92940072b3

Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus

Authors: Tong-Yun Wang, Ming-Xia Sun, Hong-Liang Zhang, Gang Wang, Guoqing Zhan, Zhi-Jun Tian, Xue-Hui Cai, Chenhe Su, Yan-Dong Tang

Source: Frontiers in Microbiology, Vol 12 (2021)

Subject Terms: antiviral innate immunity, PRRSV, PRRs, interferon, JAK-STAT, immune evasion, Microbiology, QR1-502

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Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2021.693799/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/94fe87d70906493183d19a97574c5aa0

The Nsp12-coding region of type 2 PRRSV is required for viral subgenomic mRNA synthesis

Authors: Tong-Yun Wang, Qiong-Qiong Fang, Feng Cong, Yong-Gang Liu, Hai-Ming Wang, Hong-Liang Zhang, Zhi-Jun Tian, Yan-Dong Tang, Xue-Hui Cai

Source: Emerging Microbes and Infections, Vol 8, Iss 1, Pp 1501-1510 (2019)

Subject Terms: PRRSV, Nsp12, dimer, subgenomic mRNA, RNA synthesis, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

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Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/c4446db1224f42208f81598a7ec88a2f

Annexin A2 binds to vimentin and contributes to porcine reproductive and respiratory syndrome virus multiplication

Authors: Xiao-Bo Chang, Yong-Qian Yang, Jia-Cong Gao, Kuan Zhao, Jin-Chao Guo, Chao Ye, Cheng-Gang Jiang, Zhi-Jun Tian, Xue-Hui Cai, Guang-Zhi Tong, Tong-Qing An

Source: Veterinary Research, Vol 49, Iss 1, Pp 1-12 (2018)

Subject Terms: Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13567-018-0571-5; https://doaj.org/toc/1297-9716

Access URL: https://doaj.org/article/3de704adfbc7413da7569644e262bfe5

Generation of Premature Termination Codon (PTC)-Harboring Pseudorabies Virus (PRV) via Genetic Code Expansion Technology

Authors: Tong-Yun Wang, Guo-Ju Sang, Qian Wang, Chao-Liang Leng, Zhi-Jun Tian, Jin-Mei Peng, Shu-Jie Wang, Ming-Xia Sun, Fan-Dan Meng, Hao Zheng, Xue-Hui Cai, Yan-Dong Tang

Source: Viruses, Vol 14, Iss 3, p 572 (2022)

Subject Terms: premature termination codon, pseudorabies virus, genetic code expansion, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/14/3/572; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/e543ee52c45b4592af612a4cd2b8259b

Comparison of Pathogenicity-Related Genes in the Current Pseudorabies Virus Outbreak in China

Authors: Yan-Dong Tang, Ji-Ting Liu, Tong-Yun Wang, Ming-Xia Sun, Zhi-Jun Tian, Xue-Hui Cai

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/422b0939b2094770be86c52bedf828fc

Pseudorabies Virus UL24 Abrogates Tumor Necrosis Factor Alpha-Induced NF-κB Activation by Degrading P65

Authors: Tong-Yun Wang, Yue-Lin Yang, Cong Feng, Ming-Xia Sun, Jin-Mei Peng, Zhi-Jun Tian, Yan-Dong Tang, Xue-Hui Cai

Source: Viruses, Vol 12, Iss 1, p 51 (2020)

Subject Terms: tnf-α, nf-κb, pseudorabies virus, ul24, p65, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/12/1/51; https://doaj.org/toc/1999-4915

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Attenuation of Virulent Porcine Reproductive and Respiratory Syndrome Virus Strain CH-1a and Genetic Variation of ORF5 Gene

Authors: Xue-hui CAI, Guo-jun WU, Yong-gang LIU, Guang-qing LIU, Wen-da SHI, Shu-jie WANG, Ping MA, Cheng-jun LI, Wen-yu HAN

Source: Journal of Integrative Agriculture, Vol 11, Iss 12, Pp 2035-2042 (2012)

Subject Terms: attenuation, porcine reproductive and respiratory syndrome virus, genetic variation, ORF5 gene, Agriculture (General), S1-972

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Relation: http://www.sciencedirect.com/science/article/pii/S2095311912604614; https://doaj.org/toc/2095-3119

Access URL: https://doaj.org/article/6a6a03a953904696b5b560499043b2fd

Correction to: Annexin A2 binds to vimentin and contributes to porcine reproductive and respiratory syndrome virus multiplication

Authors: Xiao‑Bo Chang, Yong‑Qian Yang, Jia‑Cong Gao, Kuan Zhao, Jin‑Chao Guo, Chao Ye, Cheng‑Gang Jiang, Zhi‑Jun Tian, Xue‑Hui Cai, Guang‑Zhi Tong, Tong‑Qing An

Source: Veterinary Research, Vol 49, Iss 1, Pp 1-1 (2018)

Subject Terms: Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13567-018-0595-x; https://doaj.org/toc/1297-9716

Access URL: https://doaj.org/article/bf8a303e5f7d4880b1f1d71e2251d401

Recombinant Pseudorabies Virus (PRV) Expressing Firefly Luciferase Effectively Screened for CRISPR/Cas9 Single Guide RNAs and Antiviral Compounds

Authors: Yan-Dong Tang, Ji-Ting Liu, Qiong-Qiong Fang, Tong-Yun Wang, Ming-Xia Sun, Tong-Qing An, Zhi-Jun Tian, Xue-Hui Cai

Source: Viruses, Vol 8, Iss 4, p 90 (2016)

Subject Terms: pseudorabies virus, firefly luciferase, CRISPR/Cas9, chloroquine, Cyclosporine A, Microbiology, QR1-502

File Description: electronic resource

Relation: http://www.mdpi.com/1999-4915/8/4/90; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/7e37d177e4a54284b473a09cff9ddf8b