Nuclear translocation of metabolic enzyme PKM2 participates in high glucose-promoted HCC metastasis by strengthening immunosuppressive environment

Authors: Jiali Qian, Chuxin Huang, Mimi Wang, Ying Liu, Yingying Zhao, Miao Li, Xi Zhang, Xiangyu Gao, Yawen Zhang, Yi Wang, Jinya Huang, Jiajun Li, Qiwen Zhou, Rui Liu, Xuanchun Wang, Jiefeng Cui, Yehong Yang

Source: Redox Biology, Vol 71, Iss , Pp 103103- (2024)

Subject Terms: Diabetes mellitus, Hepatocellular carcinoma, Pyruvate kinase M2, Thioredoxin, Chemerin, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S221323172400079X; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/dd7690893a4940ccbc57103cb042a6de

Secreted EMC10 is upregulated in human obesity and its neutralizing antibody prevents diet-induced obesity in mice

Authors: Xuanchun Wang, Yanliang Li, Guifen Qiang, Kaihua Wang, Jiarong Dai, Maximilian McCann, Marcos D. Munoz, Victoria Gil, Yifei Yu, Shengxian Li, Zhihong Yang, Shanshan Xu, Jose Cordoba-Chacon, Dario F. De Jesus, Bei Sun, Kuangyang Chen, Yahao Wang, Xiaoxia Liu, Qing Miao, Linuo Zhou, Renming Hu, Qiang Ding, Rohit N. Kulkarni, Daming Gao, Matthias Blüher, Chong Wee Liew

Source: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/5b0502f9dec14a5fa157af171c82f84a

PS-341 alleviates chronic low-grade inflammation and improves insulin sensitivity through the inhibition of TM4 (UBAC2) degradation

Authors: Lili Chen, Kuanping Ye, Xiaocheng Feng, Lianxi Li, Qin Li, Ying Huang, Xuanchun Wang, Rumei Li, Cheng Hu, Zhen Yang, Bin Lu, Yehong Yang, Jie Wen, Zhaoyun Zhang, Min He, Qinghua Wang, Wenbai Zhou, Yintao Li, Naijia Liu, Jinya Huang, Qiwei Shen, Qiyuan Yao, Renming Hu

Source: Nutrition & Metabolism, Vol 18, Iss 1, Pp 1-10 (2021)

Subject Terms: PS-341, UBAC2, Obesity, Metabolic inflammation, Insulin resistance, Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627

File Description: electronic resource

Relation: https://doaj.org/toc/1743-7075

Access URL: https://doaj.org/article/686aea3c30884153b82af19006dcbbe2

Circulating heat shock protein 27 as a novel marker of subclinical atherosclerosis in type 2 diabetes: a cross-sectional community-based study

Authors: Xinru Wang, Jie Shi, Bin Lu, Weiwei Zhang, Yehong Yang, Jie Wen, Renming Hu, Zhen Yang, Xuanchun Wang

Source: BMC Cardiovascular Disorders, Vol 20, Iss 1, Pp 1-8 (2020)

Subject Terms: HSP27, Carotid intima–media thickness, Subclinical atherosclerosis, Type 2 diabetes, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12872-020-01456-7; https://doaj.org/toc/1471-2261

Access URL: https://doaj.org/article/f0f23c7acea24bf6be5bea5bdeeb8f09

Association of Circulating Cathepsin S and Cardiovascular Disease Among Patients With Type 2 Diabetes: A Cross-Sectional Community-Based Study

Authors: Yu Jing, Jie Shi, Bin Lu, Weiwei Zhang, Yehong Yang, Jie Wen, Renming Hu, Zhen Yang, Xuanchun Wang

Source: Frontiers in Endocrinology, Vol 12 (2021)

Subject Terms: cathepsin S, cardiovascular disease, type 2 diabetes, adipokine, diagnostic biomarker, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2021.615913/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/b53b567e12014f53b9d2883798554d10

Resting heart rate and impaired glucose regulation in middle-aged and elderly Chinese people: a cross-sectional analysis

Authors: Zhen Yang, Weiwei Zhang, Lingfei Zhu, Ning Lin, Yixin Niu, Xiaoyong Li, Shuai Lu, Hongmei Zhang, Xuanchun Wang, Jie Wen, Guang Ning, Li Qin, Qing Su

Source: BMC Cardiovascular Disorders, Vol 17, Iss 1, Pp 1-7 (2017)

Subject Terms: Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12872-017-0675-2; https://doaj.org/toc/1471-2261

Access URL: https://doaj.org/article/d3b2d986a2db4f9c9a4d6c6cd0ae03de

Spironolactone Protects against Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Rats

Authors: Wenjuan Liu, Wei Gong, Min He, Yemei Liu, Yeping Yang, Meng Wang, Meng Wu, Shizhe Guo, Yifei Yu, Xuanchun Wang, Fei Sun, Yiming Li, Linuo Zhou, Shengmei Qin, Zhaoyun Zhang

Source: Journal of Diabetes Research, Vol 2018 (2018)

Subject Terms: Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://doaj.org/toc/2314-6745; https://doaj.org/toc/2314-6753

Access URL: https://doaj.org/article/dbe5ae7315d642538bcc6e0032e07974

Analysis of gene expression profiling in meningioma: deregulated signaling pathways associated with meningioma and EGFL6 overexpression in benign meningioma tissue and serum.

Authors: Xuanchun Wang, Ye Gong, Daijun Wang, Qing Xie, Mingzhe Zheng, Yu Zhou, Qin Li, Zhen Yang, Hailiang Tang, Yiming Li, Renming Hu, Xiancheng Chen, Ying Mao

Source: PLoS ONE, Vol 7, Iss 12, p e52707 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3532066?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/4822c6392d4a4f0c88b305165acf5ecd

Metabolic effects of fluoxetine in adults with type 2 diabetes mellitus: a meta-analysis of randomized placebo-controlled trials.

Authors: Zi Ye, Lili Chen, Zhen Yang, Qin Li, Ying Huang, Min He, Shuo Zhang, Zhaoyun Zhang, Xuanchun Wang, Weiwei Zhao, Ji Hu, Chao Liu, Shen Qu, Renming Hu

Source: PLoS ONE, Vol 6, Iss 7, p e21551 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3145630?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/070f446e9d7c4dcc8e6862b720f928d5

Serum scEMC10 Levels are Negatively Associated With Resting Metabolic Rate and age in Humans.

Authors: Kuangyang Chen, Jiarong Dai, Nora Klöting, Xinyi Cao, Shuoshuo Jin, Lijiao Chen, Yahao Wang, Shan Liu, Yao Hu, Lin Jiang, Chong Wee Liew, Blüher, Matthias, Xuanchun Wang

Source: Journal of Clinical Endocrinology & Metabolism; Oct2023, Vol. 108 Issue 10, pe1074-e1081, 8p

Subject Terms: ENDOPLASMIC reticulum, GENE expression, BODY mass index

The transcriptional coregulator CITED2 suppresses expression of IRS-2 and impairs insulin signaling in endothelial cells.

Authors: Kunkemoeller, Britta, Kuangyang Chen, Lockhart, Sam M., Xuanchun Wang, Rask-Madsen, Christian

Source: American Journal of Physiology: Endocrinology & Metabolism; Aug2021, Vol. 321 Issue 2, pE252-E259, 8p

Subject Terms: INSULIN receptors, ENDOTHELIAL cells, INSULIN sensitivity, INSULIN resistance, PHOSPHATIDYLINOSITOL 3-kinases, INSULIN, NITRIC-oxide synthases

Regulation of Macrophage Apoptosis and Atherosclerosis by Lipid-Induced PKCδ Isoform Activation.

Authors: Qian Li, Kyoungmin Park, Yu Xia, Motonobu Matsumoto, Weier Qi, Jialin Fu, Hisashi Yokomizo, Khamaisi, Mogher, Xuanchun Wang, Rask-Madsen, Christian, King, George L.

Source: Circulation Research; 10/27/2017, Vol. 121 Issue 10, p1153-1167, 15p

KLF4 is a tumor suppressor in anaplastic meningioma stem-like cells and human meningiomas.

Authors: Hailiang Tang, Hongda Zhu, Xuanchun Wang, Lingyang Hua, Jingrun Li, Qing Xie, Xiancheng Chen, Tao Zhang, Ye Gong

Source: Journal of Molecular Cell Biology; Aug2017, Vol. 9 Issue 4, p315-324, 10p

Association of plasma osteoprotegerin levels with the severity of lower extremity arterial disease in patients with type 2 diabetes.

Authors: Yixin Niu, Weiwei Zhang, Zhen Yang, Xiaoyong Li, Jie Wen, Suijun Wang, Hongmei Zhang, Xuanchun Wang, Houguang Zhou, Wenjun Fang, Li Qin, Qing Su

Source: BMC Cardiovascular Disorders; Aug2015, Vol. 15 Issue 1, p1-6, 6p, 3 Charts, 1 Graph

Subject Terms: OSTEOPROTEGERIN, INPATIENT care, PATIENTS' rights, ALLOXAN diabetes, GLYCOSYLATED hemoglobin

CD133-Positive Cells Might Be Responsible for Efficient Proliferation of Human Meningioma Cells.

Authors: Hailiang Tang, Ye Gong, Ying Mao, Qing Xie, Mingzhe Zheng, Daijun Wang, Hongda Zhu, Xuanchun Wang, Hong Chen, Xiancheng Chen, Liangfu Zhou

Source: International Journal of Molecular Sciences; May2012, Vol. 13 Issue 5, p6424-6439, 16p, 5 Color Photographs, 1 Chart, 5 Graphs

Subject Terms: MENINGIOMA, CANCER cell proliferation, NEURONS, LABORATORY rats, NEURAL stem cells, GENE expression

Genetic variation in the GCKR gene is associated with non-alcoholic fatty liver disease in Chinese people.

Authors: Zhen Yang, Jie Wen, Xiaoming Tao, Bin Lu, Yanping Du, Mei Wang, Xuanchun Wang, Weiwei Zhang, Wei Gong, Charlotte Ling, Songhua Wu, Renming Hu

Source: Molecular Biology Reports; Feb2011, Vol. 38 Issue 2, p1145-1150, 6p

Stable knockdown of TPPP3 by RNA interference in Lewis lung carcinoma cell inhibits tumor growth and metastasis.

Authors: Wenbai Zhou, Jiada Li, Xuanchun Wang, Renming Hu

Source: Molecular & Cellular Biochemistry; Oct2010, Vol. 343 Issue 1/2, p231-238, 8p, 5 Graphs

Insulin resistance in Chinese patients with type 2 diabetes is associated with C-reactive protein independent of abdominal obesity.

Authors: Bin Lu, Yehong Yang, Zhihong Yang, Xiaocheng Feng, Xuanchun Wang, Zhaoyun Zhang, Renming Hu

Source: Cardiovascular Diabetology; 2010, Vol. 9, p92-97, 6p

Subject Terms: INSULIN resistance, TYPE 2 diabetes, C-reactive protein, OBESITY, BODY mass index

Molecular cloning of a novel secreted peptide, INM02, and regulation of its expression by glucose.

Authors: Xuanchun Wang¹

Source: Journal of Endocrinology. Sep2009, Vol. 202 Issue 3, p355-364. 10p.

Subject Terms: *MOLECULAR cloning, *PEPTIDES, *GENETIC regulation, *GLUCOSE, *MESSENGER RNA, *AMINO acids, *GENETIC code, *ISLANDS of Langerhans, *ENZYME-linked immunosorbent assay

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