Characterisation of digital therapeutic clinical trials: a systematic review with natural language processing

Authors: Miao, Brenda Y ^*, Sushil, Madhumita, Xu, Ava, Wang, Michelle, Arneson, Douglas, Berkley, Ellen, Subash, Meera, Vashisht, Rohit, Rudrapatna, Vivek, Butte, Atul J

Source: In The Lancet Digital Health March 2024 6(3):e222-e229

Pyrazinamide Safety, Efficacy, and Dosing for Treating Drug-Susceptible Pulmonary Tuberculosis: A Phase 3, Randomized Controlled Clinical Trial.

Authors: Xu, Ava Y., Velásquez, Gustavo E., Zhang, Nan, Chang, Vincent K., Phillips, Patrick P. J., Nahid, Payam, Dorman, Susan E., Kurbatova, Ekaterina V., Whitworth, William C., Sizemore, Erin, Bryant, Kia, Carr, Wendy, Brown, Nicole E., Engle, Melissa L., Nhung, Nguyen Viet, Nsubuga, Pheona, Diacon, Andreas, Dooley, Kelly E., Chaisson, Richard E., Swindells, Susan

Source: American Journal of Respiratory & Critical Care Medicine; 12/1/2024, Vol. 210 Issue 11, p1358-1369, 12p

Subject Terms: CLINICAL trials, TUBERCULOSIS, PYRAZINAMIDE, LOGISTIC regression analysis, BODY weight

Pharmacokinetic-Pharmacodynamic Evidence From a Phase 3 Trial to Support Flat-Dosing of Rifampicin for Tuberculosis.

Authors: Ngo, Huy X¹, Xu, Ava Y^1,2, Velásquez, Gustavo E^3,4, Zhang, Nan¹, Chang, Vincent K¹, Kurbatova, Ekaterina V⁵, Whitworth, William C⁵, Sizemore, Erin⁵, Bryant, Kia⁵, Carr, Wendy⁵, Weiner, Marc⁶, Dooley, Kelly E⁷, Engle, Melissa⁶, Dorman, Susan E⁸, Nahid, Payam³, Swindells, Susan⁹, Chaisson, Richard E¹⁰, Nsubuga, Pheona¹¹, Lourens, Madeleine¹², Dawson, Rodney¹³

Source: Clinical Infectious Diseases. 6/15/2024, Vol. 78 Issue 6, p1680-1689. 10p.

Subject Terms: *DRUG therapy for tuberculosis, *CHAOS theory, *PATIENT safety, *DRUG side effects, *RESEARCH funding, *BODY weight, *LOGISTIC regression analysis, *DOSE-effect relationship in pharmacology, *DRUG efficacy, *SIMULATED patients, *RIFAMPIN, *PROPORTIONAL hazards models, *PHARMACODYNAMICS

siRNA Therapeutics for the Therapy of COVID-19 and Other Coronaviruses.

Authors: Sajid, Muhammad Imran, Moazzam, Muhammad, Cho, Yeseom, Kato, Shun, Xu, Ava, Way, J. J., Lohan, Sandeep, Tiwari, Rakesh K.

Source: Molecular Pharmaceutics; 6/7/2021, Vol. 18 Issue 6, p2105-2121, 17p