Lessons Learned from Early Implementation and Scale-up of Stool-Based Xpert Testing to Diagnose Tuberculosis in Children

Authors: Eveline Klinkenberg, Petra de Haas, Charles Manyonge, Joanita Namutebi, Bibiche Mujangi, Hebert Mutunzi, Amri Kingalu, Nkiru Nwokoye, Kuzani Mbendera, Yohannes D. Babo, Gulmira Kalmambetova, Gunta Dravniece, Winnie Mwanza, Ahmed Bedru, Degu D. Jerene, Lisa V. Adams, Andwele Mwansasu, Charlotte Colvin

Source: Emerging Infectious Diseases, Vol 31, Iss 3, Pp 1-9 (2025)

Subject Terms: tuberculosis, Xpert MTB/RIF Ultra, NTP, stool, fecal testing, children, Medicine, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://wwwnc.cdc.gov/eid/article/31/3/24-1580_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059

Access URL: https://doaj.org/article/9bc22ee7a4dd4fdf9d51a8c5705f413d

Efficacy of Xpert MTB/RIF assay in detecting Mycobacterium tuberculosis in samples with different results by smear and culture in a coastal city with high incidence of tuberculosis

Authors: Gang Feng, Hongyu Jiang, Ying Chen

Source: BMC Infectious Diseases, Vol 25, Iss 1, Pp 1-14 (2025)

Subject Terms: Tuberculosis, Drug resistance, Xpert MTB/RIF, Diagnosis, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2334

Access URL: https://doaj.org/article/d03758a410ba48f495854d5d66a9ebc2

A Lumbar Drug-Resistant Tuberculosis: A Case Report and Review of Literature

Authors: Li T, Liu S

Source: Infection and Drug Resistance, Vol Volume 17, Pp 5867-5873 (2024)

Subject Terms: multi-drug resistant tuberculosis (mdr-tb), anti-tuberculosis treatment(att), metagenomic next-generation sequencing (mngs), xpert mtb/rif, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://www.dovepress.com/a-lumbar-drug-resistant-tuberculosis-a-case-report-and-review-of-liter-peer-reviewed-fulltext-article-IDR; https://doaj.org/toc/1178-6973

Access URL: https://doaj.org/article/15196eb13de84bd1919d5fe3f05fb7e3

Stool Xpert® MTB/RIF Ultra for TB diagnosis in children: experience from a national scale-up programme

Authors: S. Kabir, S. Choudhury, T. Rahman, S.M.M. Rahman, M.K.M. Uddin, A. Nashra, A. Hossain, S. Naher, K.M.S. Towhid, L. Shahrin, S. Ahmed, P. Daru, J. Hoffmann, S. Banu

Source: IJTLD Open, Vol 1, Iss 10, Pp 437-442 (2024)

Subject Terms: tuberculosis, xpert mtb/rif ultra, non-invasive, high tb burden country, diagnosis, bangladesh, paediatric tb, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000010/art00003; https://doaj.org/toc/3005-7590

Access URL: https://doaj.org/article/938219c014ce450d861b15de4dc67932

Unveiling the role of cartridge-based nucleic acid amplification test in extrapulmonary tuberculosis diagnosis: insights from a cross-sectional study

Authors: Anil Sontakke, Rajasi Bundale, Sagar Kolte, Nidhi Girdhar, Hrishikesh Gaikwad, Harshal Ital

Source: Monaldi Archives for Chest Disease (2025)

Subject Terms: Composite reference standard, Xpert MTB/RIF, lymph node TB, TB pleural effusion, abdominal TB, bone and joint TB, Medicine

File Description: electronic resource

Relation: https://www.monaldi-archives.org/macd/article/view/3238; https://doaj.org/toc/1122-0643; https://doaj.org/toc/2532-5264

Access URL: https://doaj.org/article/e7782e0ff6ae4dc7a649acc5d075d6b1

A multicountry evaluation of the Xpert MTB/RIF assay for the diagnosis of intrathoracic tuberculosis in children using alternative specimens (nasopharyngeal aspirate and stool): A prospective cohort study conducted in Madagascar, Ivory Coast and Cameroon (TB KIDS project)

Authors: Rindra Vatosoa Randremanana, Mathurin Tejiokem, Niaina Rakotosamimanana, Valérie Donkeng Donfack, Verlaine Bolyse Mbouchong, Mirella Randrianarisoa, Aina Harimanana, Jean Voisin Taguebue, Suzie Tetang Ndiang, Valère Itchy, Annick Robinson, Lovaniaina Ravelomanana, Mbola Rakotomahefa, Dina Ranoharison, Man-Koumba Soumahoro, Brigitte Gicquel, Raymond N'Guessan, Sara Eyangoh, Voahangy Rasolofo, Emery Flavien Akpafi, Marius Irie Bi Irie, Anabelle Bai-Orsot, Jaudel Francis Yuya Septoh, Serge Abogo, Mamy Serge Raherison, Andrianantenaina Rakotoson, Vaomalala Raharimanga, Patrice Piola, Paulo Ranaivomanana, Jean-Marc Collard, Gabrielle Prisca Emmylou Andrianah, Turibio Razafindranaivo, Reziky Tiandraza Mangahasimbola, Kathleen Victoir

Source: International Journal of Infectious Diseases, Vol 151, Iss , Pp 107366- (2025)

Subject Terms: Tuberculosis, Children, Diagnosis, Xpert MTB/RIF, Nasopharyngeal aspirate, Stools, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1201971224004417; https://doaj.org/toc/1201-9712

Access URL: https://doaj.org/article/9a0de289fdde45a58c90286dacb63699

Sputum availability and quality in country-level TB prevalence surveys

Authors: P. Papadopoulou, M. Gaeddert, A. Gupta-Wright, C.M. Denkinger, F.M. Marx

Source: IJTLD Open, Vol 1, Iss 11, Pp 528-530 (2024)

Subject Terms: tuberculosis, people living with hiv, xpert mtb/rif, national-level tb surveys, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000011/art00010; https://doaj.org/toc/3005-7590

Access URL: https://doaj.org/article/c00bd233f5e54da797be2d0fcc4b5c60

TB burden and diagnostic challenges at Sandaun Provincial Hospital in West Sepik Province of PNG, 2016–2021

Authors: S. Bita, T. Kelebi, A. Holmes, S. Vaccher, S.S. Majumdar, J. Greig

Source: Public Health Action, Vol 14, Iss 3, Pp 91-96 (2024)

Subject Terms: tuberculosis diagnosis, bacteriological confirmation, xpert mtb/rif assay, Other systems of medicine, RZ201-999

File Description: electronic resource

Relation: https://www.ingentaconnect.com/contentone/iuatld/pha/2024/00000014/00000003/art00003; https://doaj.org/toc/2220-8372

Access URL: https://doaj.org/article/bb4636cfc42048599767c7744929cdc2

Diagnostic value of the Xpert MTB/RIF assay combined with endobronchial ultrasonography with a guide sheath for peripheral nodular pulmonary tuberculosis

Authors: Lihong Zhou, Yan Yong, Xiaoqin Ran, Hao Li, Qin Hu

Source: BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-8 (2024)

Subject Terms: Peripheral nodular pulmonary tuberculosis, Xpert MTB/RIF, Endobronchial ultrasound with guide sheath, Mycobacterium tuberculosis infection, Pulmonary tuberculosis, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2334

Access URL: https://doaj.org/article/d0fd4128885c4168b9b4aca0667efade

Subtracting the background by reducing cell-free DNA’s confounding effects on Mycobacterium tuberculosis quantitation and the sputum microbiome

Authors: Charissa C. Naidoo, Rouxjeane Venter, Francesc Codony, Gemma Agustí, Natasha Kitchin, Selisha Naidoo, Hilary Monaco, Hridesh Mishra, Yonghua Li, Jose C. Clemente, Robin M. Warren, Leopoldo N. Segal, Grant Theron

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Subject Terms: PEMAX, Propidium monoazide, DNaseI, Mycobacterium tuberculosis, Xpert MTB/RIF, Sputum microbiome, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/74ec4169bc7344518d316f9672c00713

Comparison of Nucleotide MALDI-TOF MS with Xpert MTB/RIF for Rifampicin Susceptibility Identification and Associated Risk Factors of Rifampicin Resistance Among Drug Resistant Mycobacterium tuberculosis

Authors: Song S, Xu H, Cao J, Wu G, Sun H, Dai X, Li X, Chen M, Zhang M, Yan Y, Tong J, Wang Z

Source: Infection and Drug Resistance, Vol Volume 17, Pp 4223-4236 (2024)

Subject Terms: mtb, rifampicin, nucleotide maldi-tof ms, xpert mtb/rif, comparison, risk factors, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://www.dovepress.com/comparison-of-nucleotide-maldi-tof-ms-with-xpert-mtbrif-for-rifampicin-peer-reviewed-fulltext-article-IDR; https://doaj.org/toc/1178-6973

Access URL: https://doaj.org/article/f2775110358f45b3a7d92150f57855e4

Skin Rash with Acute Respiratory Distress Syndrome in Chronic Miliary Tuberculosis: The Role of HRCT Thorax and Bronchoscopy as Diagnostic Tools

Authors: Priyanka Malhotra, Mahesh Unni, Abhishek Vairagade, Patil Shital

Source: The Journal of Association of Chest Physicians, Vol 12, Iss 3, Pp 120-123 (2024)

Subject Terms: miliary tuberculosis, ards, erythematous macules, afb, gene xpert mtb/rif, bronchoscopy, hrct thorax, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://journals.lww.com/ascp/fulltext/2024/12030/skin_rash_with_acute_respiratory_distress_syndrome.5.aspx; https://doaj.org/toc/2320-9089

Access URL: https://doaj.org/article/e248a019c13d4e63b68f52fcce45d8a8

PneumoniaCheck, a novel aerosol collection device, permits capture of airborne Mycobacterium tuberculosis and characterisation of the cough aeromicrobiome in people with tuberculosis

Authors: Tinaye L. Chiyaka, Georgina R. Nyawo, Charissa C. Naidoo, Suventha Moodley, Jose C. Clemente, Stephanus T. Malherbe, Robin M. Warren, David N. Ku, Leopoldo N. Segal, Grant Theron

Source: Annals of Clinical Microbiology and Antimicrobials, Vol 23, Iss 1, Pp 1-8 (2024)

Subject Terms: PneumoniaCheck, Tuberculosis, Microbiota, Aerosols, Xpert MTB/RIF Ultra, Therapeutics. Pharmacology, RM1-950, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/1476-0711

Access URL: https://doaj.org/article/955ee3b6f2b74408a29aa176f64b7d47

Evaluation of targeted sequencing for pathogen identification in bone and joint infections: a cohort study from China

Authors: Qiang Zhang, Yonghua Ding, Quanzhong Ren, Feng Zhang, Guoqiang Lyu, Tongxin Lu, Zhen Song, Qing Wang, Yongxiang Cheng, Jing Wang, Hongcang Gu

Source: Annals of Clinical Microbiology and Antimicrobials, Vol 23, Iss 1, Pp 1-10 (2024)

Subject Terms: Diagnosis, Infection, Targeted nanopore sequencing, Bone and joint, Tuberculosis, Xpert MTB/RIF, Therapeutics. Pharmacology, RM1-950, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/1476-0711

Access URL: https://doaj.org/article/155dbd0c7d3d4cd596686d41b011c7ce

Diagnostic efficacy of endobronchial ultrasound-guided transbronchoscopic lung biopsy for identifying tuberculous nodules

Authors: Xingwu Zou, Hanmin Xu, Qin Hu, Qi Qi, Xiaoqing Ma, Qingshan Cai, Yanling Zhu

Source: BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-11 (2024)

Subject Terms: Pulmonary tuberculosis, Endobronchial ultrasound-guided transbronchoscopic lung biopsy, Next-generation sequencing technology, Xpert MTB/RIF, Diagnostic efficacy, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2334

Access URL: https://doaj.org/article/80be51b142a64f44af0638a3e2036e03

Enhanced diagnosis of pulmonary tuberculosis through nucleotide MALDI-TOF MS analysis of BALF: a retrospective clinical study

Authors: Ling Jiang, Junqiu Xin, Lijun Liang, Mingqiang Xia, Jiyao Li, Jingfeng Tong, Chengchen Huang, Tongxin Li

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

Subject Terms: Bronchoalveolar lavage fluid, Nucleotide MALDI-TOF MS, Xpert MTB/RIF, Pulmonary tuberculosis, Diagnosis, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/f575f63e6f7447c29c6c83b4f58a128a

Role of Gene Xpert MTB/RIF assay for detecting tuberculous spondylitis in specimens obtained by CT-guided aspiration/biopsy and spectrum of imaging findings in spinal tuberculosis

Authors: Misra, Richa ^{a, ∗}, Singh, Anil Kumar ^b, Neyaz, Zafar ^b, Singh, Vivek Kumar ^b, Paliwal, Vimal K. ^c, Mishra, Prabhakar ^d

Source: In Indian Journal of Tuberculosis January 2025 72(1):61-68

Intensive reprocessing of reusable bronchoscopes can reduce the false positive rate of Xpert MTB/RIF caused by nucleic acid residue

Authors: Xingxing Jin, Qianfang Hu, Yishi Li, Xia Zhang, Wan Tao, Houyu Zhong, Qinghai Zhao

Source: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, Vol 37, Iss , Pp 100476- (2024)

Subject Terms: Nucleic acid residue, Reusable bronchoscope, Intensive reprocessing procedure, Standard reprocessing procedure, Xpert MTB/RIF, Diseases of the respiratory system, RC705-779, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405579424000639; https://doaj.org/toc/2405-5794

Access URL: https://doaj.org/article/8f8633f64b11415f87f2f894d2d8bfd7

Pattern of Mutations in Rifampicin Resistance (rpoB) Gene and Analysis of Rifampicin Indeterminate Result in Tuberculosis Detected by Xpert MTB/RIF Assay in Kalaburagi, India

Authors: M. Ravish Kumar, Praveen Kumar Doddamani, Lavanya S. Peter, Prashant Parandekar, Shrinivas Reddy

Source: Journal of Pure and Applied Microbiology, Vol 18, Iss 2, Pp 1290-1296 (2024)

Subject Terms: xpert mtb/rif, rpob mutation, rifampicin indeterminate, Microbiology, QR1-502

File Description: electronic resource

Relation: https://microbiologyjournal.org/pattern-of-mutations-in-rifampicin-resistance-rpob-gene-and-analysis-of-rifampicin-indeterminate-result-in-tuberculosis-detected-by-xpert-mtb-rif-assay-in-kalaburagi-india/; https://doaj.org/toc/0973-7510; https://doaj.org/toc/2581-690X

Access URL: https://doaj.org/article/371f83e8b84344d4893e5ca58da39bcd

Impact of Xpert MTB/RIF implementation in tuberculosis case detection and control in Brazil: a nationwide intervention time-series analysis (2011–2022)Research in context

Authors: Klauss Villalva-Serra, Beatriz Barreto-Duarte, João P. Miguez-Pinto, Artur T.L. Queiroz, Moreno M. Rodrigues, Peter F. Rebeiro, Gustavo Amorim, Marcelo Cordeiro-Santos, Timothy R. Sterling, Mariana Araújo-Pereira, Bruno B. Andrade

Source: The Lancet Regional Health. Americas, Vol 36, Iss , Pp 100804- (2024)

Subject Terms: Xpert MTB/RIF, Intervention time-series, Drug-resistant tuberculosis, Laboratory diagnostics, Public health measures, Brazil, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2667193X24001315; https://doaj.org/toc/2667-193X

Access URL: https://doaj.org/article/058b4ca68b1c4b0db71aaa0478a44cd4