A Mass Spectrometry-Based Strategy for Mapping Modification Sites for the Ubiquitin-Like Modifier NEDD8

Authors: Oliveira, Caio A. B., Isaakova, Ekaterina, Beli, Petra, Xirodimas, Dimitris P.

Source: Methods in molecular biology. 2602:137-150

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Mixed in chains: NEDD8 polymers in the Protein Quality Control system

Authors: Meszka, Igor, Polanowska, Jolanta, Xirodimas, Dimitris P.

Source: In Seminars in Cell and Developmental Biology December 2022 132:27-37

A nuclear protein quality control system for elimination of nucleolus-related inclusions.

Authors: Brunello, Lorène, Polanowska, Jolanta, Le Tareau, Léo, Maghames, Chantal, Georget, Virginie, Guette, Charlotte, Chaoui, Karima, Balor, Stéphanie, O'Donohue, Marie-Françoise, Bousquet, Marie-Pierre, Gleizes, Pierre-Emmanuel, Xirodimas, Dimitris P

Source: EMBO Journal; Feb2025, Vol. 44 Issue 3, p801-823, 23p

Subject Terms: NUCLEAR proteins, LIFE sciences, PROTEASOMES, QUALITY control, CYTOLOGY

Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis

Authors: Serrano-Maciá, Marina, Simón, Jorge, González-Rellan, Maria J., Azkargorta, Mikel, Goikoetxea-Usandizaga, Naroa, Lopitz-Otsoa, Fernando, De Urturi, Diego Saenz, Rodríguez-Agudo, Rubén, Lachiondo-Ortega, Sofia, Mercado-Gomez, Maria, Gutiérrez de Juan, Virginia, Bizkarguenaga, Maider, Fernández-Ramos, David, Buque, Xabier, Baselli, Guido A., Valenti, Luca V.C., Iruzubieta, Paula, Crespo, Javier, Villa, Erica, Banales, Jesus M., Avila, Matias A., Marin, Jose J.G., Aspichueta, Patricia, Sutherland, James, Barrio, Rosa, Mayor, Ugo, Elortza, Félix, Xirodimas, Dimitris P., Nogueiras, Rubén, Delgado, Teresa C., Martínez-Chantar, María Luz

Source: In Molecular Metabolism November 2021 53

An Anti-Invasive Role for Mdmx through the RhoA GTPase under the Control of the NEDD8 Pathway.

Authors: Bou Malhab, Lara J., Schmidt, Susanne, Fagotto-Kaufmann, Christine, Pion, Emmanuelle, Gadea, Gilles, Roux, Pierre, Fagotto, Francois, Debant, Anne, Xirodimas, Dimitris P.

Source: Cells (2073-4409); Oct2024, Vol. 13 Issue 19, p1625, 24p

Subject Terms: CELL morphology, CELL migration, CELL motility, CELL membranes, GUANOSINE triphosphatase, GASTRULATION

Antibody RING-Mediated Destruction of Endogenous Proteins

Authors: Ibrahim, Adel F.M., Shen, Linnan, Tatham, Michael H., Dickerson, David, Prescott, Alan R., Abidi, Naima, Xirodimas, Dimitris P., Hay, Ronald T.

Source: In Molecular Cell 2 July 2020 79(1):155-166

Deneddylation of ribosomal proteins promotes synergy between MLN4924 and chemotherapy to elicit complete therapeutic responses

Authors: Aubry, Arthur, Pearson, Joel D., Charish, Jason, Yu, Tao, Sivak, Jeremy M., Xirodimas, Dimitris P., Avet-Loiseau, Hervé, Corre, Jill, Monnier, Philippe P., Bremner, Rod

Source: Cell reports. 42(8)

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The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity

Authors: Bailly, Aymeric P., Perrin, Aurelien, Serrano-Macia, Marina, Maghames, Chantal, Leidecker, Orsolya, Trauchessec, Helene, Martinez-Chantar, M.L., Gartner, Anton, Xirodimas, Dimitris P.

Source: In Cell Reports 1 October 2019 29(1):212-224

Interplay between SUMOylation and NEDDylation regulates RPL11 localization and function

Authors: El Motiam, Ahmed, Vidal, Santiago, De La Cruz-Herrera, Carlos F., Da Silva-Álvarez, Sabela, Baz-Martínez, Maite, Seoane, Rocío, Vidal, Anxo, Rodríguez, Manuel S., Xirodimas, Dimitris P., Carvalho, Ana Sofia, Beck, Hans Christian, Matthiesen, Rune, Collado, Manuel, Rivas, Carmen

Source: FASEB journal. 33(1):643-651

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103326663.0x000001&indx=1&recIds=ETOCvdc_100103326663.0x000001

Deneddylation of ribosomal proteins promotes synergy between MLN4924 and chemotherapy to elicit complete therapeutic responses

Authors: Aubry, Arthur, Pearson, Joel D., Charish, Jason, Yu, Tao, Sivak, Jeremy M., Xirodimas, Dimitris P., Avet-Loiseau, Hervé, Corre, Jill, Monnier, Philippe P., Bremner, Rod

Source: In Cell Reports 27 February 2024 43(2)

Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylation

Authors: Lobato-Gil, Sofia, Heidelberger, Jan B., Maghames, Chantal, Bailly, Aymeric, Brunello, Lorene, Rodriguez, Manuel S., Beli, Petra, Xirodimas, Dimitris P.

Source: Cell reports. 34(3)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135787025.0x000001&indx=1&recIds=ETOCvdc_100135787025.0x000001

Quantitative FLIM-FRET Microscopy to Monitor Nanoscale Chromatin Compaction In Vivo Reveals Structural Roles of Condensin Complexes

Authors: Llères, David, Bailly, Aymeric P., Perrin, Aurélien, Norman, David G., Xirodimas, Dimitris P., Feil, Robert

Source: Cell reports. 18(7):1791-1803

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100042377911.0x000001&indx=1&recIds=ETOCvdc_100042377911.0x000001

Pediatric liver cancer: Hepatoblastoma and Neddylation post-translational modification

Authors: Zapata-Pavas, Leidy Estefanía, Serrano-Macia, Marina, Merlos Rodrigo, Miguel Angel, Felix, Patricia Peña-San, Gil-Pitarch, Claudia, Goikoetxea, Naroa, Michalkova, Hana, Heger, Zbynek, del Rio, Alvaro, Domingo-Sàbat, Montserrat, Royo, Laura, Barrenechea-Barrenechea, Jon Ander, Mercado-Gómez, Maria, Lachiondo-Ortega, Sofia, Delgado, Teresa Cardoso, Xirodimas, Dimitris, Marin, Jose, Fernandez-Barrena, Maite G, Avila, Matías A, Armengol, Carolina, Martínez-Chantar, María Luz

Source: Journal of hepatology. 78(S1):S546-S546

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195504948.0x000001&indx=1&recIds=ETOCvdc_100195504948.0x000001

Characterization of MRFAP1 Turnover and Interactions Downstream of the NEDD8 Pathway

Authors: Larance, Mark ^‡, Kirkwood, Kathryn J. ^‡, Xirodimas, Dimitris P. ^{‡, §}, Lundberg, Emma ^¶, Uhlen, Mathias ^¶, Lamond, Angus I. ^{‡, ‖}

Source: In Molecular & Cellular Proteomics March 2012 11(3)

Spatio-temporal modelling of the Hes1 and p53-Mdm2 intracellular signalling pathways

Authors: Sturrock, Marc, Terry, Alan J., Xirodimas, Dimitris P., Thompson, Alastair M., Chaplain, Mark A.J.

Source: In Journal of Theoretical Biology 2011 273(1):15-31

FRI-466-YI Implications and therapeutic potential of neddylation for pediatric liver cancer: hepatoblastoma

Authors: Zapata-Pavas, Leidy Estefanía, Serrano-Macía, Marina, Rodrigo, Miguel Angel Merlos, Peña-Sanfelix, Patricia, Gil-Pitarch, Claudia, Goikoetxea-Usandizaga, Naroa, Michalkova, Hana, Heger, Zbynek, del Río-Álvarez, Alvaro, Royo, Laura, Rejano-Gordillo, Claudia M., Barrenechea-Barrenechea, Jon Ander, Mercado-Gómez, Maria, Lachiondo-Ortega, Sofia, Delgado, Teresa C., Xirodimas, Dimitris, Marin, Jose J.G., Fernandez-Barrena, Maite G., Avila, Matías A., Armengol, Carolina, Martínez-Chantar, María Luz

Source: In Journal of Hepatology June 2024 80 Supplement 1:S417-S417

The ubiquitin E1 enzyme Ube1 mediates NEDD8 activation under diverse stress conditions

Authors: Leidecker, Orsolya, Matic, Ivan, Mahata, Bidesh, Pion, Emmanuelle, Xirodimas, Dimitris P.

Source: Cell cycle. 11(6):1142-1150

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The p53 isoforms are differentially modified by Mdm2

Authors: Camus, Suzanne, Menéndez, Sergio, Fernandes, Kenneth, Kua, Nelly, Liu, Geng, Xirodimas, Dimitris P., Lane, David P., Bourdon, Jean-Christophe

Source: Cell cycle. 11(8):1646-1655

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Perturbation of 60 S Ribosomal Biogenesis Results in Ribosomal Protein L5- and L11-dependent p53 Activation

Authors: Sun, Xiao-Xin, Wang, Yue-Gang, Xirodimas, Dimitris P., Dai, Mu-Shui

Source: In Journal of Biological Chemistry 13 August 2010 285(33):25812-25821

NEDD8 specific protease 1 (NEDP1) as a tumor suppressor in hepatocellular carcinoma

Authors: Serrano-Macia, Marina, Bailly, Aymeric, Perrin, Aurelien, Chantal, Maghames, Leidecker, Orsolya, Trauchessec, Helene, Goikoetxea, Naroa, Agudo, Rubén Rodríguez, Lachiondo-Ortega, Sofia, Gartner, Anton, Delgado, Teresa Cardoso, Xirodimas, Dimitris, Martińez-Chantar, Mariá Luz

Source: Journal of hepatology. 73(S1):S644-S645

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100120837241.0x000001&indx=1&recIds=ETOCvdc_100120837241.0x000001