Spatial analyses revealed S100P + TFF1 + tumor cells in spread through air spaces samples correlated with undesirable therapy response in non-small cell lung cancer.

Authors: Fan, Guangyu¹ (AUTHOR), Xie, Tongji¹ (AUTHOR), Yang, Mengwei¹ (AUTHOR), Li, Lin² (AUTHOR), Tang, Le¹ (AUTHOR), Han, Xiaohong³ (AUTHOR) hanxiaohong@pumch.cn, Shi, Yuankai¹ (AUTHOR) syuankai@cicams.ac.cn

Source: Journal of Translational Medicine. 10/9/2024, Vol. 22 Issue 1, p1-18. 18p.

Subject Terms: *NON-small-cell lung carcinoma, *PREOPERATIVE risk factors, *BIOMARKERS, *AIR sampling, *LUNG cancer

High-Throughput Antigen Microarray Identifies Longitudinal Prognostic Autoantibody for Chemoimmunotherapy in Advanced Non-Small Cell Lung Cancer

Authors: Dai, Liyuan, Tan, Qiaoyun, Li, Lin, Lou, Ning, Zheng, Cuiling, Yang, Jianliang, Huang, Liling, Wang, Shasha, Luo, Rongrong, Fan, Guangyu, Xie, Tongji, Yao, Jiarui, Zhang, Zhishang, Tang, Le, Shi, Yuankai, Han, Xiaohong

Source: In Molecular & Cellular Proteomics May 2024 23(5)

An immunosuppressive subtype of senescent tumor cells predicted worse immunotherapy response in lung adenocarcinoma

Authors: Fan, Guangyu ^{1, 5}, Xie, Tongji ^{1, 5}, Tan, Qiaoyun ^{2, 5}, Lou, Ning ³, Wang, Shasha ³, Han, Xiaohong ^{4, ∗}, Shi, Yuankai ^{1, 6, ∗∗}

Source: In iScience 20 October 2023 26(10)

YAP1 protein expression has variant prognostic significance in small cell lung cancer (SCLC) stratified by histological subtypes

Authors: Wang, Xin, Guo, Yiying, Liu, Li, Wei, Jiacong, Zhang, Jinyao, Xie, Tongji, Dong, Jiyan, Li, Junling, Xing, Puyuan, Yang, Lin

Source: In Lung Cancer October 2021 160:166-174

A cohort-based multi-omics identifies nuclear translocation of eIF5B /PD-L1/CD44 complex as the target to overcome Osimertinib resistance of ARID1A-deficient lung adenocarcinoma.

Authors: Sun, Dantong, Hou, Helei, Feng, Feiyue, Wu, Weizheng, Tan, Jingyu, Xie, Tongji, Liu, Jiayu, Wang, Jinsong, Qian, Haili, Li, Junling, Xing, Puyuan

Source: Experimental Hematology & Oncology; 1/7/2025, Vol. 14 Issue 1, p1-19, 19p

Subject Terms: APOPTOSIS, CYTOLOGY, OSIMERTINIB, LIFE sciences, PROGRAMMED death-ligand 1

Artificial neural network systems to predict the response to sintilimab in squamous-cell non-small-cell lung cancer based on data of ORIENT-3 study.

Authors: Xie, Tongji¹ (AUTHOR), Fan, Guangyu¹ (AUTHOR), Tang, Le¹ (AUTHOR), Xing, Puyuan¹ (AUTHOR) xingpuyuan@cicams.ac.cn, Shi, Yuankai¹ (AUTHOR) syuankai@cicams.ac.cn

Source: Cancer Immunology, Immunotherapy. Jan2025, Vol. 74 Issue 1, p1-14. 14p.

Multi-omics analysis and response prediction of PD-1 monoclonal antibody containing regimens in patients with relapsed/refractory diffuse large B-cell lymphoma.

Authors: Chen, Xinrui, Qin, Yan, Xue, Xuemin, Xie, Zucheng, Xie, Tongji, Huang, Liling, Zhu, Haohua, Gao, Lina, Li, Jiangtao, Yang, Jianliang, Gui, Lin, Yang, Sheng, Chen, Haizhu, Feng, Xiaoli, Shi, Yuankai

Source: Cancer Immunology, Immunotherapy; Dec2024, Vol. 73 Issue 12, p1-13, 13p

Subject Terms: ARTIFICIAL neural networks, DIFFUSE large B-cell lymphomas, TUMOR-infiltrating immune cells, PROGRAMMED cell death 1 receptors, SALVAGE therapy

DKK1+ tumor cells inhibited the infiltration of CCL19+ fibroblasts and plasma cells contributing to worse immunotherapy response in hepatocellular carcinoma.

Authors: Fan, Guangyu, Gao, Ruyun, Xie, Tongji, Li, Lin, Tang, Le, Han, Xiaohong, Shi, Yuankai

Source: Cell Death & Disease; Nov2024, Vol. 15 Issue 11, p1-15, 15p

Mechanism exploration and model construction for small cell transformation in EGFR-mutant lung adenocarcinomas.

Authors: Li, Yan, Xie, Tongji, Wang, Shouzheng, Yang, Lin, Hao, Xuezhi, Wang, Yan, Hu, Xingsheng, Wang, Lin, Li, Junling, Ying, Jianming, Xing, Puyuan

Source: Signal Transduction & Targeted Therapy; 10/2/2024, Vol. 9 Issue 1, p1-13, 13p

The co‐location of CD14+APOE+ cells and MMP7+ tumour cells contributed to worse immunotherapy response in non‐small cell lung cancer.

Authors: Fan, Guangyu¹ (AUTHOR), Xie, Tongji¹ (AUTHOR), Tang, Le¹ (AUTHOR), Li, Lin² (AUTHOR), Han, Xiaohong³ (AUTHOR) hanxiaohong@pumch.cn, Shi, Yuankai¹ (AUTHOR) syuankai@cicams.ac.cn

Source: Clinical & Translational Medicine. Sep2024, Vol. 14 Issue 9, p1-21. 21p.

Subject Terms: *MACROPHAGE migration inhibitory factor, *MYELOID cells, *LUNG cancer, *TRANSCRIPTOMES, *TERTIARY structure

Mutational variant allele frequency profile as a biomarker of response to immune checkpoint blockade in non-small cell lung Cancer.

Authors: Gao, Ruyun, Lou, Ning, Li, Lin, Xie, Tongji, Xing, Puyuan, Tang, Le, Yao, Jiarui, Han, Xiaohong, Shi, Yuankai

Source: Journal of Translational Medicine; 6/18/2024, Vol. 22 Issue 1, p1-15, 15p

Subject Terms: NON-small-cell lung carcinoma, IMMUNE checkpoint proteins, GENE frequency, DNA repair, BIOMARKERS

Single-cell and spatial transcriptomics reveal a high glycolysis B cell and tumor-associated macrophages cluster correlated with poor prognosis and exhausted immune microenvironment in diffuse large B-cell lymphoma.

Authors: Dai, Liyuan, Fan, Guangyu, Xie, Tongji, Li, Lin, Tang, Le, Chen, Haizhu, Shi, Yuankai, Han, Xiaohong

Source: Biomarker Research; 6/5/2024, Vol. 12 Issue 1, p1-25, 25p

Identification of novel prognostic autoantibodies in diffuse large B‐cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone via a high‐throughput antigen microarray.

Authors: Dai, Liyuan, Chen, Haizhu, Tan, Qiaoyun, Wang, Yanrong, Li, Lin, Lou, Ning, Fan, Guangyu, Xie, Tongji, Luo, Rongrong, Wang, Shasha, Zhou, Yu, Zhong, Qiaofeng, Yao, Jiarui, Zhang, Zhishang, Tang, Le, Shi, Yuankai, Han, Xiaohong

Source: Cancer (0008543X); Apr2024, Vol. 130 Issue 8, p1257-1269, 13p

Subject Terms: DIFFUSE large B-cell lymphomas, RITUXIMAB, PROGNOSIS, AUTOANTIBODIES, VINCRISTINE, DISEASE risk factors

Single-cell and spatial analyses revealed the co-location of cancer stem cells and SPP1+ macrophage in hypoxic region that determines the poor prognosis in hepatocellular carcinoma.

Authors: Fan, Guangyu, Xie, Tongji, Li, Lin, Tang, Le, Han, Xiaohong, Shi, Yuankai

Source: NPJ Precision Oncology; 3/23/2024, Vol. 8 Issue 1, p1-16, 16p

Subject Terms: CANCER stem cells, CANCER prognosis, LIVER regeneration, STEM cells, MACROPHAGES, CEREBRAL anoxia-ischemia, HEPATIC veno-occlusive disease

Low TP53 variant allele frequency as a biomarker for anti‐programmed death (ligand) 1 monotherapy in lung adenocarcinoma.

Authors: Wang, Shouzheng^1,2 (AUTHOR), Xie, Tongji¹ (AUTHOR), Li, Yan³ (AUTHOR), Guo, Lei³ (AUTHOR), Ying, Jianming³ (AUTHOR), Wang, Yan¹ (AUTHOR), Hao, Xuezhi¹ (AUTHOR), Wang, Xingyuan¹ (AUTHOR), Li, Junling¹ (AUTHOR) lijunling@cicams.ac.cn, Xing, Puyuan¹ (AUTHOR) xingpuyuan@cicams.ac.cn

Source: Cancer (0008543X). 12/15/2023, Vol. 129 Issue 24, p3873-3883. 11p.

Subject Terms: *GENE frequency, *BIOMARKERS, *GENE expression, *LUNGS, *ADENOCARCINOMA

Identification of an antigen-presenting cells/T/NK cells-related gene signature to predict prognosis and CTSL to predict immunotherapeutic response for lung adenocarcinoma: an integrated analysis of bulk and single-cell RNA sequencing.

Authors: Huang, Liling, Lou, Ning, Xie, Tongji, Tang, Le, Han, Xiaohong, Shi, Yuankai

Source: Cancer Immunology, Immunotherapy; Oct2023, Vol. 72 Issue 10, p3259-3277, 19p

Subject Terms: RNA sequencing, MEDICAL sciences, IMMUNE checkpoint inhibitors, DISEASE risk factors, KILLER cells, PROGRAMMED cell death 1 receptors

Integrative analyses of bulk and single-cell RNA-seq identified cancer-associated fibroblasts-related signature as a prognostic factor for immunotherapy in NSCLC.

Authors: Wang, Shasha, Fan, Guangyu, Li, Lin, He, Yajun, Lou, Ning, Xie, Tongji, Dai, Liyuan, Gao, Ruyun, Yang, Mengwei, Shi, Yuankai, Han, Xiaohong

Source: Cancer Immunology, Immunotherapy; Jul2023, Vol. 72 Issue 7, p2423-2442, 20p

Subject Terms: TRANSFORMING growth factors-beta, PROGNOSIS, NON-small-cell lung carcinoma, RNA sequencing, IMMUNE checkpoint proteins

Incidence, survival comparison, and novel prognostic evaluation approaches for stage iii-iv pulmonary large cell neuroendocrine carcinoma and small cell lung cancer.

Authors: Huang, Liling, Feng, Yu, Xie, Tongji, Zhu, Haohua, Tang, Le, Shi, Yuankai

Source: BMC Cancer; 4/5/2023, Vol. 23 Issue 1, p1-17, 17p

Subject Terms: SMALL cell lung cancer, SMALL cell carcinoma, MEDICAL sciences, NEUROENDOCRINE tumors, PROGNOSIS, MERKEL cell carcinoma

Multiomics analysis revealed the mechanisms related to the enhancement of proliferation, metastasis and EGFR-TKI resistance in EGFR-mutant LUAD with ARID1A deficiency.

Authors: Sun, Dantong, Feng, Feiyue, Teng, Fei, Xie, Tongji, Wang, Jinsong, Xing, Puyuan, Qian, Haili, Li, Junling

Source: Cell Communication & Signaling; 3/3/2023, Vol. 21 Issue 1, p1-16, 16p

Subject Terms: MULTIOMICS, KINASE inhibitors, ONCOGENIC proteins, CELL division, CELL cycle

Integrated molecular characterization of esophageal basaloid squamous cell carcinoma: a subtype with distinct RNA expression pattern and immune characteristics, but no specific genetic mutations.

Authors: Li, Yan, Liu, Linxiu, Pan, Yi, Fang, Fang, Xie, Tongji, Cheng, Na, Guo, Changyuan, Xue, Xuemin, Zeng, Hua, Xue, Liyan

Source: Journal of Pathology; Feb2023, Vol. 259 Issue 2, p136-148, 13p

Subject Terms: GENE expression, SQUAMOUS cell carcinoma, GENETIC mutation, ESOPHAGEAL cancer, HEAD & neck cancer, NEOADJUVANT chemotherapy, EPITHELIAL-mesenchymal transition, DNA mismatch repair, DEGLUTITION