Targeting Piezo1 channel to alleviate intervertebral disc degeneration

Authors: Li, Feiyun ^{a, 1}, Chen, Mingjue ^{a, 1}, Zhang, Mengrui ^{b, 1}, Chen, Sheng ^c, Qu, Minghao ^{d, e}, He, Shuangshuang ^a, Wang, Lin ^{d, e}, Wu, Xiaohao ^{f, g, ⁎}, Xiao, Guozhi ^{a, ⁎⁎}

Source: In Journal of Orthopaedic Translation March 2025 51:145-158

Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis

Authors: Huang, Changyuan ^{a, b, 1}, Zeng, Bin ^{c, d, 1}, Zhou, Bo ^b, Chen, Guanming ^b, Zhang, Qi ^b, Hou, Wenhong ^{b, e}, Xiao, Guozhi ^f, Duan, Li ^{c, ∗∗}, Hong, Ni ^{b, ∗∗∗}, Jin, Wenfei ^{g, ∗, 2}

Source: In Genes & Diseases March 2025 12(2)

Structure–activity relationship of synthesized glucans from Ganoderma lucidum with in vitro hypoglycemic activity

Authors: Yang, Liu ^{a, 1}, Huang, Jia ^{a, d, 1}, Huang, Ni ^{a, c, 1}, Qin, Shihui ^a, Chen, Zhiyuan ^a, Xiao, Guozhi ^a, Shao, Huiyan ^{a, ⁎}, Zi, Chengting ^{b, ⁎}, Hu, Jiang-Miao ^{a, ⁎}

Source: In International Journal of Biological Macromolecules February 2025 288

Development of novel osteoarthritis therapy by targeting AMPK-β-catenin-Runx2 signaling

Authors: Zeng, Daofu, Umar, Muhammad, Zhu, Zhenglin, Pan, Haobo, Lu, William W., Xiao, Guozhi, Chen, Yan, Tong, Liping, Chen, Di

Source: In Genes & Diseases January 2025 12(1)

Piezo1 activation accelerates osteoarthritis progression and the targeted therapy effect of artemisinin

Authors: Gan, Donghao, Tao, Chu, Jin, Xiaowan, Wu, Xiaohao, Yan, Qinnan, Zhong, Yiming, Jia, Qingyun, Wu, Lisheng, Huo, Shaochuan, Qin, Lei, Xiao, Guozhi

Source: In Journal of Advanced Research August 2024 62:105-117

Disruption of cyclin D1 degradation leads to the development of mantle cell lymphoma

Authors: Lu, Ke, Zhang, Ming, Qin, Hongyu, Shen, Siyu, Song, Haiqing, Jiang, Hua, Zhang, Chunxiang, Xiao, Guozhi, Tong, Liping, Jiang, Qing, Chen, Di

Source: In Acta Pharmaceutica Sinica B July 2024 14(7):2977-2991

Bone transport induces the release of factors with multi-tissue regenerative potential for diabetic wound healing in rats and patients

Authors: Xie, Jing, Liu, Xuhua, Wu, Biaoliang, Chen, Bochong, Song, Qiancheng, Guan, Yuan, Gong, Yuanxun, Yang, Chengliang, Lin, Jinbo, Huang, Mingfeng, Tan, Xinyu, Lai, Ruijun, Lin, Xiaozhen, Zhang, Sheng, Xie, Xiaoling, Chen, Xiaoli, Zhang, Chunyuan, Yang, Mei, Nong, Huijiao, Zhao, Xiaoyang, Xia, Laixin, Zhou, Weijie, Xiao, Guozhi, Jiang, Qing, Zou, Weiguo, Chen, Di, Lu, Di, Liu, Jia, Bai, Xiaochun

Source: In Cell Reports Medicine 18 June 2024 5(6)

An integrated multi-omics analysis reveals osteokines involved in global regulation

Authors: Liang, Wenquan, Wei, Tiantian, Hu, Le, Chen, Meijun, Tong, Liping, Zhou, Wu, Duan, Xingwei, Zhao, Xiaoyang, Zhou, Weijie, Jiang, Qing, Xiao, Guozhi, Zou, Weiguo, Chen, Di, Zou, Zhipeng, Bai, Xiaochun

Source: In Cell Metabolism 7 May 2024 36(5):1144-1163

Pip5k1c expression in osteocytes regulates bone remodeling in mice

Authors: Lin, Sixiong, Tao, Chu, Yan, Qinnan, Gao, Huanqing, Qin, Lei, Zhong, Yiming, Yao, Qing, Zhang, Peijun, Yang, Jiaming, Zou, Xuenong, Xiao, Guozhi

Source: In Journal of Orthopaedic Translation March 2024 45:36-47

Kindlin-2 maintains liver homeostasis by regulating GSTP1–OPN-mediated oxidative stress and inflammation in mice

Authors: Zhong, Yiming, Zhou, Liang, Wang, Hui, Lin, Sixiong, Liu, Tiemin, Kong, Xingxing, Xiao, Guozhi, Gao, Huanqing

Source: In Journal of Biological Chemistry February 2024 300(2)

Osteocyte β3 integrin promotes bone mass accrual and force-induced bone formation in mice

Authors: Qin, Lei, Chen, Zecai, Yang, Dazhi, He, Tailin, Xu, Zhen, Zhang, Peijun, Chen, Di, Yi, Weihong, Xiao, Guozhi

Source: Journal of orthopaedic translation. 40:58-71

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193657215.0x000001&indx=1&recIds=ETOCvdc_100193657215.0x000001

MiR-204 ameliorates osteoarthritis pain by inhibiting SP1-LRP1 signaling and blocking neuro-cartilage interaction

Authors: Lu, Ke, Wang, Qingyun, Hao, Liuzhi, Wei, Guizheng, Wang, Tingyu, Lu, William W., Xiao, Guozhi, Tong, Liping, Zhao, Xiaoli, Chen, Di

Source: Bioactive materials. 26:425-436

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191504450.0x000001&indx=1&recIds=ETOCvdc_100191504450.0x000001

Highly Stereoselective Assembly of 1, 2-cis-Arap Linkages

Authors: Li, Penghua, Fan, Hanyingzi, Tan, Qiang, Xiao, Guozhi

Source: Organic letters. 25(16):2788-2792

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632530997&indx=1&recIds=ETOCRN632530997

Roles of focal adhesion proteins in skeleton and diseases

Authors: Chen, Sheng, He, Tailin, Zhong, Yiming, Chen, Mingjue, Yao, Qing, Chen, Di, Shao, Zengwu, Xiao, Guozhi

Source: Acta pharmaceutica sinica B. 13(3):998-1013

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185223096.0x000001&indx=1&recIds=ETOCvdc_100185223096.0x000001

AMPK activator decelerates osteoarthritis development by inhibition of β-catenin signaling in chondrocytes

Authors: Zhu, Zhenglin, Huang, Yanran, Li, Jun, Yi, Dan, Liao, Junyi, Xiao, Jun, Xiao, Guozhi, Tong, Liping, Huang, Wei, Di, Chen

Source: Journal of orthopaedic translation. 38:158-166

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183320722.0x000001&indx=1&recIds=ETOCvdc_100183320722.0x000001

Total Synthesis of Starfish Cyclic Steroid Glycosides. Part 2, Model Synthesis via Intramolecular Etherification

Authors: Chen, Youxi, Xiao, Guozhi, Zhu, Dapeng, Yu, Biao

Source: Chinese journal of chemistry. 41(8):897-902

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100179398946.0x000001&indx=1&recIds=ETOCvdc_100179398946.0x000001

Recent chemical synthesis of plant polysaccharides

Authors: Wang, Xiufang, Xiao, Guozhi

Source: In Current Opinion in Chemical Biology December 2023 77

Comparison of Kindlin-2 deficiency-stimulated osteoarthritis-like lesions induced by Prg4CreERT2 versus AggrecanCreERT2 transgene in mice

Authors: Yao, Qing, Gong, Weiyuan, Wu, Xiaohao, Gan, Donghao, Tao, Chu, Lin, Sixiong, Qu, Minghao, Ouyang, Zhongtian, Chen, Mingjue, Hu, Xinjia, Xiao, Guozhi

Source: In Journal of Orthopaedic Translation July 2023 41:12-19

TREM2 acts as a receptor for IL-34 to suppress acute myeloid leukemia in mice

Authors: Xie, Xiaoling, Zhang, Wuju, Xiao, Min, Wei, Tiantian, Qiu, Yingqi, Qiu, Jingyang, Wang, Hao, Qiu, Zeyou, Zhang, Sheng, Pan, Yating, Mao, Linlin, Li, Yuhua, Guo, Bin, Yang, Wanwen, Hu, Yuxing, Hu, Shujie, Gong, Yan, Yang, Jun, Xiao, Guozhi, Zhang, Yue, Bai, Xiaochun

Source: In Blood 29 June 2023 141(26):3184-3198

Regulated cell death in musculoskeletal development, homeostasis, and diseases

Authors: Chen, Sheng, Yang, Wenbo, Chen, Mingjue, Liu, Sheng, Shao, Zengwu, Xiao, Guozhi

Source: In Fundamental Research August 2023