Human Pharmacokinetic Profiling and Comparative Analysis of Mangiferin and Its Monosodium Derivative from Mangifera indica Extracts Using UHPLC-MS/MS with 1 H NMR and MALDI-TOF Confirmation.

Authors: Fuentes-Rios, David^1,2 (AUTHOR) dfuentes@nektium.com, Sanchez-Rodriguez, Alvaro¹ (AUTHOR) asanchez@nektium.com, Lopez-Rios, Laura¹ (AUTHOR) llopez@nektium.com, Garcia-Gonzalez, Eduardo³ (AUTHOR) eduardo.garcia124@alu.ulpgc.es, Martinez-Canton, Miriam³ (AUTHOR) miriammartinezcanton@gmail.com, Galvan-Alvarez, Victor³ (AUTHOR) victor_galvan@hotmail.es, Gallego-Selles, Angel³ (AUTHOR) angelgallegoselles@hotmail.com, Martin-Rincon, Marcos³ (AUTHOR) marcos.martinrincon@gmail.com, Calbet, Jose A. L.³ (AUTHOR) lopezcalbet@gmail.com, Vega-Morales, Tanausu^1,4 (AUTHOR) tvega@nektium.com

Source: Molecules. Feb2025, Vol. 30 Issue 3, p461. 19p.

Subject Terms: *LIQUID chromatography-mass spectrometry, *XANTHONE, *BIOAVAILABILITY, *PHARMACOKINETICS, *ETHICS committees, *MANGIFERIN

Forced Degradation Studies of Mangiferin and Gallic Acid by High Performance Thin Layer Chromatography.

Authors: HAGE, AJAY G.¹, JADHAV, ARUNA P.¹ aruna.jadhav@bvcop.in

Source: Indian Journal of Pharmaceutical Sciences. Sep/Oct2024, Vol. 86 Issue 5, p1900-1903. 4p.

Subject Terms: *ALKALINE hydrolysis, *XANTHONE, *MANGIFERIN, *PHENOLIC acids, *ALKALIES, *GALLIC acid, *THIN layer chromatography

The evaluation of stability and bioactivity of xanthone nanoemulsion.

Authors: Hiranchansook, Mattawan¹ (AUTHOR), Trongsiriwat, Nisalak¹ (AUTHOR), Simasatitkul, Lida¹ (AUTHOR), Pranee, Siriporn² (AUTHOR), Seeyangnok, Samitthichai¹ (AUTHOR) samitthichai.s@sci.kmutnb.ac.th

Source: Journal of Dispersion Science & Technology. 2024, Vol. 45 Issue 9, p1746-1754. 9p.

Subject Terms: *XANTHONE, *VEGETABLE oils, *ANTI-infective agents, *MANGOSTEEN, *ANTIOXIDANTS, *PETROLEUM

Xanthone Derivatives and Their Potential Usage in the Treatment of Telangiectasia and Rosacea.

Authors: Brezdeń, Katarzyna^1,2, katarzyna.brezden@uj.edu.pl, Waszkielewicz, Anna M.¹, anna.waszkielewicz@uj.edu.pl

Source: Applied Sciences (2076-3417); May2024, Vol. 14 Issue 10, p4037, 14p

Evaluation of Antitumor Activity of Xanthones Conjugated with Amino Acids.

Authors: Barbosa, Flávia¹ (AUTHOR) a24728@alunos.cespu.pt, Araújo, Joana² (AUTHOR) m.araujo.joana@gmail.com, Gonçalves, Virgínia M. F.^1,3 (AUTHOR) virginia.goncalves@cespu.pt, Palmeira, Andreia^2,4 (AUTHOR) apalmeira@ff.up.pt, Cunha, Andrea¹ (AUTHOR) andrea.cunha@iucs.cespu.pt, Silva, Patrícia M. A.^1,3 (AUTHOR) patricia.silva@cespu.pt, Fernandes, Carla^2,4 (AUTHOR) cfernandes@ff.up.pt, Pinto, Madalena^2,4 (AUTHOR) madalenakijjoa@gmail.com, Bousbaa, Hassan¹ (AUTHOR) hassan.bousbaa@iucs.cespu.pt, Queirós, Odília¹ (AUTHOR) odilia.queiros@iucs.cespu.pt, Tiritan, Maria Elizabeth^1,2,3,4 (AUTHOR) beth@ff.up.pt

Source: International Journal of Molecular Sciences. Feb2024, Vol. 25 Issue 4, p2121. 19p.

Subject Terms: *XANTHONE, *ANTINEOPLASTIC agents, *AMINO acids, *CELL lines, *TREATMENT failure, *CANCER cells

Antibacterial Potential of Symmetrical Twin-Drug 3,6-Diaminoxanthones.

Authors: Resende, Diana I. S. P.^1,2 (AUTHOR), Durães, Fernando^1,2 (AUTHOR), Zubarioglu, Sidika¹ (AUTHOR), Freitas-Silva, Joana^2,3 (AUTHOR), Szemerédi, Nikoletta⁴ (AUTHOR), Pinto, Madalena^1,2 (AUTHOR), Pinto, Eugénia^2,5 (AUTHOR) epinto@ff.up.pt, Martins da Costa, Paulo^2,3 (AUTHOR), Spengler, Gabriella⁴ (AUTHOR), Sousa, Emília^1,2 (AUTHOR) epinto@ff.up.pt

Source: Pharmaceuticals (14248247). Feb2024, Vol. 17 Issue 2, p209. 18p.

Subject Terms: *XANTHONE, *METHICILLIN-resistant staphylococcus aureus, *PATHOGENIC bacteria, *GENTIAN violet, *DRUG resistance in bacteria, *STAPHYLOCOCCUS aureus, *ENTEROCOCCUS faecalis, *SECONDARY amines

Company/Entity: NATIONAL Institutes of Health (U.S.)

Anti-Inflammatory Properties of Oxygenated Isocoumarins and Xanthone from Thai Mangrove-Associated Endophytic Fungus Setosphaeria rostrata.

Authors: Koopklang, Kedkarn¹ (AUTHOR) sujittra_wu@hotmail.com, Choodej, Siwattra² (AUTHOR), Hantanong, Sujitra¹ (AUTHOR), Intayot, Ratchadaree³ (AUTHOR), Jungsuttiwong, Siriporn³ (AUTHOR), Insumran, Yuwadee⁴ (AUTHOR), Ngamrojanavanich, Nattaya⁵ (AUTHOR), Pudhom, Khanitha⁵ (AUTHOR) khanitha.p@chula.ac.th

Source: Molecules. Feb2024, Vol. 29 Issue 3, p603. 11p.

Subject Terms: *XANTHONE, *ENDOPHYTIC fungi, *ISOCOUMARINS, *CIRCULAR dichroism, *ANTI-inflammatory agents, *CYCLOOXYGENASE 2

Identification, characterization and quantification of xanthones from Fridericia formosa leaves extract with antiviral activity.

Authors: Vaz, Luana Beatriz Araújo¹ (AUTHOR), Amparo, Tatiane Roquete¹ (AUTHOR), Reis, Adriana Cotta Cardoso¹ (AUTHOR), de Mello Silva, Breno² (AUTHOR), de Brito Magalhães, Cíntia Lopes² (AUTHOR), Kohlhoff, Markus³ (AUTHOR), Brandão, Geraldo Célio¹ (AUTHOR) celiobrandao@ufop.edu.br

Source: Scientific Reports. 1/26/2024, Vol. 14 Issue 1, p1-12. 12p.

Subject Terms: *XANTHONE, *HIGH performance liquid chromatography, *CHROMATOGRAPHIC analysis

Geographic Terms: BRAZIL

The Synthesis and Characterization of a Delivery System Based on Polymersomes and a Xanthone with Inhibitory Activity in Glioblastoma.

Authors: Alves, Ana^1,2,3 (AUTHOR), Silva, Ana Margarida⁴ (AUTHOR), Nunes, Claúdia⁵ (AUTHOR), Cravo, Sara^2,6 (AUTHOR), Reis, Salette⁵ (AUTHOR), Pinto, Madalena^2,6 (AUTHOR), Sousa, Emília^2,6 (AUTHOR), Rodrigues, Francisca⁴ (AUTHOR), Ferreira, Domingos^1,3 (AUTHOR), Costa, Paulo C.^1,3 (AUTHOR) pccosta@ff.up.pt, Correia-da-Silva, Marta^2,6 (AUTHOR) pccosta@ff.up.pt

Source: Life (2075-1729). Jan2024, Vol. 14 Issue 1, p132. 17p.

Subject Terms: *XANTHONE, *POLYMERSOMES, *GLIOBLASTOMA multiforme, *BRAIN tumors, *ETHYLENE glycol, *CYTOTOXINS, *POLYCAPROLACTONE

Robust Sandwich‐Structured Thermally Activated Delayed Fluorescence Molecules Utilizing 11,12‐Dihydroindolo[2,3‐a]carbazole as Bridge.

Authors: Lan, Xia¹, Zeng, Jiajie¹, Chen, Jinke¹, Yang, Tao¹, Dong, Xiaobin¹, Tang, Ben Zhong², Zhao, Zujin¹, mszjzhao@scut.edu.cn

Source: Angewandte Chemie International Edition; Jan2025, Vol. 64 Issue 1, p1-7, 7p

C–Glucosyl Xanthone derivative Mangiferin downregulates the JNK3 mediated caspase activation in Almal induced neurotoxicity in differentiated SHSY-5Y neuroblastoma cells.

Authors: PK, Nafila¹ (AUTHOR), Rajan, Ravi Kumar² (AUTHOR), Nanchappan, Vanitha³ (AUTHOR), Karuppaiah, Arjunan⁴ (AUTHOR), Chandrasekaran, Jaikanth⁵ (AUTHOR), Jayaraman, Saravanan⁶ (AUTHOR), Gunasekaran, Venkatesh³ (AUTHOR) gvenkatpharma@gmail.com

Source: Toxicology Mechanisms & Methods. 2023, Vol. 33 Issue 9, p707-718. 12p.

Subject Terms: *MANGIFERIN, *XANTHONE, *CASPASES, *ENZYME activation, *NEUROTOXICOLOGY

Xanthones as potential α‐glucosidase non‐competition inhibitors: Synthesis, inhibitory activities, and in silico studies.

Authors: Wang, Lili^1,2 (AUTHOR), Ai, Chenyang¹ (AUTHOR), Jin, Chaoqun¹ (AUTHOR), Mou, Jiajia¹ (AUTHOR) moujiajia66@163.com, Deng, Yanru^1,2 (AUTHOR) dyanru@sina.com

Source: Chemical Biology & Drug Design. Sep2023, Vol. 102 Issue 3, p547-556. 10p.

Subject Terms: *XANTHONE, *ALPHA-glucosidases, *AMINO acid residues, *TYPE 2 diabetes, *AMINO compounds, *HYDROGEN bonding

Xanthones with Potential Anti-Inflammatory and Anti-HIV Effects from the Stems and Leaves of Cratoxylum cochinchinense.

Authors: Zhang, Yong¹ (AUTHOR), Guo, Jia-Ming¹ (AUTHOR), Zhang, Ming-Ming¹ (AUTHOR), Wang, Ran¹ (AUTHOR), Liang, Chai-Huan¹ (AUTHOR), Zhao, Yi-Meng¹ (AUTHOR), Deng, Ya-Yuan¹ (AUTHOR), Liu, Yan-Ping^1,2,3,4 (AUTHOR) liuyanpinghs@163.com, Fu, Yan-Hui^1,2,3,4 (AUTHOR) liuyanpinghs@163.com

Source: Molecules. Aug2023, Vol. 28 Issue 16, p6050. 11p.

Subject Terms: *XANTHONE, *ANTI-HIV agents, *HIV, *CHEMICAL structure, *ANTI-inflammatory agents, *LIPOPOLYSACCHARIDES, *NITRIC oxide, *MACROPHAGES

Xanthone synthetic derivatives with high anticandidal activity and positive mycostatic selectivity index values.

Authors: Rząd, Kamila¹ (AUTHOR), Ioannidi, Rachel² (AUTHOR), Marakos, Panagiotis² (AUTHOR), Pouli, Nicole² (AUTHOR), Olszewski, Mateusz¹ (AUTHOR), Kostakis, Ioannis K.² (AUTHOR), Gabriel, Iwona¹ (AUTHOR) iwona.gabriel@pg.edu.pl

Source: Scientific Reports. 7/23/2023, Vol. 13 Issue 1, p1-13. 13p.

Subject Terms: *XANTHONE, *ATP-binding cassette transporters, *DNA topoisomerase II, *ANTIFUNGAL agents, *MEMBRANE proteins, *MYCOSES

1,2-Dihydroxy- 9H -Xanthen-9-One, a Multifunctional Nature-Inspired Active Ingredient.

Authors: Jesus, Ana^1,2, anaaimjesus@gmail.com, Vieira, Sara F.^3,4, saravieira2409@gmail.com, Brites, Gonçalo^5,6, g.sousabrites3@gmail.commylenecarrascal87@gmail.com, Carrascal, Mylène^6,7, Ferreira, Helena^3,4, helenaferreira@i3bs.uminho.pt, Neves, Nuno M.^3,4, nuno@i3bs.uminho.pt, Cidade, Honorina^8,9,10, hcidade@ff.up.pt, Pinto, Madalena^8,9, madalena@ff.up.pt, Sousa, Emília^8,9, esousa@ff.up.pt, Almeida, Isabel F.^1,2, esousa@ff.up.pt, Cruz, Maria T.^5,6, trosete@ff.uc.pt

Source: Cosmetics (2079-9284); Dec2024, Vol. 11 Issue 6, p215, 11p

Synthesis and Anti-Inflammatory Evaluation of a Library of Chiral Derivatives of Xanthones Conjugated with Proteinogenic Amino Acids.

Authors: Vieira, Sara F.^1,2 (AUTHOR) sara.vieira@i3bs.uminho.pt, Araújo, Joana³ (AUTHOR) m.araujo@gmail.com, Gonçalves, Virgínia M. F.^4,5 (AUTHOR) virginia.goncalves@cespu.pt, Fernandes, Carla^3,6 (AUTHOR) cfernandes@ff.up.pt, Pinto, Madalena^3,6 (AUTHOR) madalenakijjoa@gmail.com, Ferreira, Helena^1,2 (AUTHOR) helenaferreira@i3bs.uminho.pt, Neves, Nuno M.^1,2 (AUTHOR), Tiritan, Maria Elizabeth^3,4,5,6 (AUTHOR) helenaferreira@i3bs.uminho.pt

Source: International Journal of Molecular Sciences. Jun2023, Vol. 24 Issue 12, p10357. 36p.

Subject Terms: *XANTHONE, *AMINO acids, *AMINO acid derivatives, *ENANTIOMERIC purity, *PHARMACEUTICAL chemistry, *ANTI-inflammatory agents

Xanthone Derivatives in the Fight against Glioblastoma and Other Cancers.

Authors: Mazur, Gabriela¹, Pańczyk-Straszak, Katarzyna¹, Waszkielewicz, Anna Maria¹, anna.waszkielewicz@uj.edu.pl

Source: Applied Sciences (2076-3417); Mar2023, Vol. 13 Issue 5, p2897, 21p

Quantification of Xanthone and Anthocyanin in Mangosteen Peel by UPLC-MS/MS and Preparation of Nanoemulsions for Studying Their Inhibition Effects on Liver Cancer Cells.

Authors: Li, Rui¹ (AUTHOR), Inbaraj, Baskaran Stephen¹ (AUTHOR), Chen, Bing-Huei¹ (AUTHOR) 002622@mail.fju.edu.tw

Source: International Journal of Molecular Sciences. Feb2023, Vol. 24 Issue 4, p3934. 29p.

Subject Terms: *XANTHONE, *ANTHOCYANINS, *LIVER cells, *LIVER cancer, *CANCER cells, *MANGOSTEEN, *SOY oil

Key insights into secondary metabolites from various Chaetomium species.

Authors: Dwibedi, Vagish¹, Rath, Santosh Kumar², skrath1985@gmail.com, Jain, Sahil³, Martínez-Argueta, Nayeli^4,5, Prakash, Ranjana⁶, Saxena, Sanjai⁷, Rios-Solis, Leonardo^4,5, leo.rios@ncl.ac.uk

Source: Applied Microbiology & Biotechnology; Feb2023, Vol. 107 Issue 4, p1077-1093, 17p

Xanthones from Gentianella acuta (Michx.) Hulten Ameliorate Colorectal Carcinoma via the PI3K/Akt/mTOR Signaling Pathway.

Authors: Lu, Meng-Qi¹ (AUTHOR), Ruan, Jing-Ya¹ (AUTHOR), Li, Hui-Min¹ (AUTHOR), Yang, Ding-Shan¹ (AUTHOR), Liu, Yan-Xia² (AUTHOR), Hao, Mi-Mi² (AUTHOR), Yu, Hai-Yang¹ (AUTHOR), Zhang, Yi^1,2 (AUTHOR) zhwwxzh@tjutcm.edu.cn, Wang, Tao^1,2 (AUTHOR) zhwwxzh@tjutcm.edu.cn

Source: International Journal of Molecular Sciences. Feb2023, Vol. 24 Issue 3, p2279. 23p.

Subject Terms: *COLORECTAL cancer, *XANTHONE, *CELLULAR signal transduction, *ULCERATIVE colitis, *WESTERN immunoblotting, *TREATMENT effectiveness, *MOLECULAR docking