Establishment and characterization of a novel breast implant-associated anaplastic large cell lymphoma cell line and PDX model (BIA-XR1) with a unique KRAS mutation

Authors: Xagoraris, Ioanna, Stathopoulou, Konstantina, Aulerio, Roberta D', He, Minghui, Ketscher, Anett, Jatta, Kenbugul, de Flon, Felix Haglund, Barbany, Gisela, Rosenquist, Richard, Westerberg, Lisa S., Rassidakis, George Z.

Source: In Current Research in Translational Medicine July-September 2023 71(3)

MDMX/MDM4 is highly expressed and contributes to cell growth and survival in anaplastic large cell lymphoma

Authors: Sinatkas, Vaios, Stathopoulou, Konstantina, Xagoraris, Ioanna, Ye, Jingjing, Vyrla, Dimitra, Atsaves, Vasilios, Leventaki, Vasiliki, Medeiros, L. Jeffrey, Rassidakis, George Z., Drakos, Elias

Source: Leukemia & lymphoma. 62(7):1563-1573

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123446964.0x000001&indx=1&recIds=ETOCvdc_100123446964.0x000001

Expression of the novel tumour suppressor sterile alpha motif and HD domain‐containing protein 1 is an independent adverse prognostic factor in classical Hodgkin lymphoma

Authors: Xagoraris, Ioanna, Vassilakopoulos, Theodoros P., Drakos, Elias, Angelopoulou, Maria K., Panitsas, Fotios, Herold, Nikolas, Medeiros, L. Jeffrey, Giakoumis, Xanthoula, Pangalis, Gerassimos A., Rassidakis, George Z.

Source: British journal of haematology. 193(3):488-496

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100120376298.0x000001&indx=1&recIds=ETOCvdc_100120376298.0x000001

Trametinib and Dabrafenib in histiocytic sarcoma transdifferentiated from chronic lymphocytic leukemia with a K-RAS and a unique BRAF mutation

Authors: Rassidakis, George Z., Stromberg, Olga, Xagoraris, Ioanna, Jatta, Kenbugul, Sonnevi, Kristina

Source: Annals of hematology. 99(3):649-651

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164295804.0x000001&indx=1&recIds=ETOCvdc_100164295804.0x000001

Intestinal stroma guides monocyte differentiation to macrophages through GM-CSF.

Authors: Kvedaraite, Egle, Lourda, Magda, Mouratidou, Natalia, Düking, Tim, Padhi, Avinash, Moll, Kirsten, Czarnewski, Paulo, Sinha, Indranil, Xagoraris, Ioanna, Kokkinou, Efthymia, Damdimopoulos, Anastasios, Weigel, Whitney, Hartwig, Olga, Santos, Telma E., Soini, Tea, Van Acker, Aline, Rahkonen, Nelly, Flodström Tullberg, Malin, Ringqvist, Emma, Buggert, Marcus

Source: Nature Communications; 2/27/2024, Vol. 15 Issue 1, p1-16, 16p

Subject Terms: MONOCYTES, INFLAMMATORY bowel diseases, GRANULOCYTE-macrophage colony-stimulating factor, MACROPHAGES, INTESTINES, STROMAL cells, HOMEOSTASIS

Modulation of the CGAS-Sting Anti-Tumor Immune Response Pathway in an NF-KB-Dependent or -Independent Manner As a Potential Therapeutic Target in Classical Hodgkin Lymphoma (cHL)

Authors: Xagoraris, Ioanna, Stathopoulou, Konstantina ^*, Xyderou, Persa ^*, Palma, Marzia ^*, Drakos, Elias ^*, Vassilakopoulos, Theodoros P. ^*, Rassidakis, George Z. ^*

Source: In Blood 15 November 2022 140 Supplement 1:3579-3580

Mutations of the Novel Tumor Suppressor Gene SAMHD1 Are Frequent and Correlate with Decreased Protein Expression in Peripheral T-Cell Lymphomas (PTCL)

Authors: Kokaraki, Georgia, Xagoraris, Ioanna, Farrajota Neves Da Silva, Pedro, Sutton, Lesley Ann, Maia Falcão, Raul, Estefano Santana de Souza, Jorge, Österborg, Anders, Wirta, Valtteri, Rosenquist Brandell, Richard, Rassidakis, Georgios Z.

Source: In Blood 23 November 2021 138 Supplement 1:3515-3515

The NPM-ALK Oncogenic Kinase Suppresses CGAS-Sting-Associated Anti-Tumor Immune Responses through STAT3 Activation in Anaplastic Large Cell Lymphoma (ALCL)

Authors: Xagoraris, Ioanna, Kokaraki, Georgia, Plastira, Christina, Stathopoulou, Konstantina, Leventaki, Vasiliki, Drakos, Elias, Medeiros, Jeffrey, Österborg, Anders, Rassidakis, George Z.

Source: In Blood 23 November 2021 138 Supplement 1:1338-1338

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Sting Is Commonly and Differentially Expressed in T- and Nk-Cell but Not B-Cell Non-Hodgkin Lymphomas.

Authors: Xagoraris, Ioanna¹ (AUTHOR) ioanna.xagoraris@ki.se, Farrajota Neves da Silva, Pedro¹ (AUTHOR) pedro.farrajota.neves.da.silva@ki.se, Kokaraki, Georgia¹ (AUTHOR) georgia.kokaraki@ki.se, Stathopoulou, Konstantina¹ (AUTHOR) konstantina.stathopoulou@ki.se, Wahlin, Björn² (AUTHOR) bjorn.wahlin@ki.se, Österborg, Anders¹ (AUTHOR) anders.osterborg@ki.se, Herold, Nikolas³ (AUTHOR) nikolas.herold@ki.se, Ng, Siok-Bian⁴ (AUTHOR) patnsb@nus.edu.sg, Medeiros, L. Jeffrey⁵ (AUTHOR) ljmedeiros@mdanderson.org, Drakos, Elias⁶ (AUTHOR) hdrakos@hotmail.com, Sander, Birgitta⁷ (AUTHOR) birgitta.sander@ki.se, Rassidakis, George Z.^1,5 (AUTHOR) georgios.rassidakis@ki.se

Source: Cancers. Mar2022, Vol. 14 Issue 5, p1186. 1p.

Subject Terms: *BIOPSY, *IMMUNOHISTOCHEMISTRY, *MYCOSIS fungoides, *WESTERN immunoblotting, *KILLER cells, *MESSENGER RNA, *DESCRIPTIVE statistics, *T cells, *LYMPHOMAS, *TUMOR markers, *CELL lines

SAMHD1 Is Variably Expressed in Mantle Cell Lymphoma and Correlated to SOX11 but Not to Survival

Authors: Wasik, Agata Magdalena ^*, Marin, Elin ^*, Merrien, Magali ^*, de Matos Rodrigues, Joana ^*, Lord, Martin ^*, Xagoraris, Ioanna ^*, Christensson, Birger ^*, Rassidakis, George ^*, Jerkeman, Mats, Ek, Sara ^*, Sander, Birgitta

Source: In Blood 29 November 2018 132 Supplement 1:4136-4136

The Novel Tumor Suppressor SAMHD1 Is Differentially Expressed and Partly Regulated By MYC in Peripheral T-Cell Lymphomas (PTCL)

Authors: Farrajota Neves Da Silva, Pedro ^*, Tsesmetzis, Nikolaos ^*, Xagoraris, Ioanna ^*, Wasik, Agata Magdalena ^*, Kokaraki, Georgia ^*, Tzoras, Evangelos ^*, Österborg, Anders, Sander, Birgitta, Herold, Nikolas ^*, Rassidakis, George ^*

Source: In Blood 29 November 2018 132 Supplement 1:4130-4130

MAPKAP1 (Sin1), a Key Component of the MTORC2 Complex, Confers Resistance to Sorafenib and Correlates with Adverse Clinical Outcomes in Acute Myeloid Leukemia

Authors: Khoury, Joseph David, Xagoraris, Ioanna ^*, Tsesmetzis, Nikolaos ^*, Myrberg, Ida Hed Hed ^*, Olsen, Thale Kristin ^*, Ng, Siok Bian ^*, Chng, Wee-Joo, Yan, Benedict ^*, Ng, Chin Hin ^*, Andreeff, Michael, Medeiros, L. Jeffrey, Kantarjian, Hagop M., Nikolas, Herold ^*, Grander, Dan ^*, Rassidakis, George ^*

Source: In Blood 8 December 2017 130 Supplement 1:3964-3964

Low-Level SAMHD1 Expression in Acute Myeloid Leukemia Blasts Correlates with Favorable Outcome in Patients with Diploid Cytogenetics Treated with Cytarabine-Based Chemotherapy Regimens

Authors: Rassidakis, George ^*, Nikolas, Herold ^*, Myrberg, Ida Hed Hed ^*, Tsesmetzis, Nikolaos ^*, Grander, Dan ^*, Kantarjian, Hagop M., Medeiros, L. Jeffrey, Xagoraris, Ioanna ^*, Khoury, Joseph David

Source: In Blood 8 December 2017 130 Supplement 1:3928-3928

Downregulation of the Tumor Suppressor SAMHD1 in Classical Hodgkin Lymphoma

Authors: Xagoraris, Ioanna ^*, Vassilakopoulos, Theodoros ^*, Herold, Nikolas ^*, Tsesmetzis, Nikolaos ^*, Drakos, Elias ^*, Khoury, Joseph David, Rassidakis, George ^*

Source: In Blood 8 December 2017 130 Supplement 1:1480-1480

P052: Targeting CSN5/JAB1 oncogene in classical Hodgkin Lymphoma (cHL)

Authors: Xagoraris, Ioanna, Stathopoulou, Konstantina, Renken, Stefanie, Lundqvist, Andreas, Claret, Francois Xavier, Drakos, Elias, Rassidakis, Georgios Z.

Source: HemaSphere; 2022 Supplement, Vol. 6, p23-24, 2p

P032: Circulating immune biomarkers in classical Hodgkin lymphoma in relation to tumor burden and response to treatment.

Authors: Mulder, Tom A., Andersson, Maria L., Peña‐Pérez, Lucia, Heimersson, Kia, Xagoraris, Ioanna, Wahlin, Björn E., Månsson, Robert, Hansson, Lotta, Rassidakis, Georgios Z., Palma, Marzia

Source: HemaSphere; 2022 Supplement, Vol. 6, p15-16, 2p

Immune Biomarkers in the Peripheral Blood and Tumor Microenvironment of Classical Hodgkin Lymphoma Patients in Relation to Tumor Burden and Response to Treatment.

Authors: Mulder, Tom A., Andersson, Maria L., Peña-Pérez, Lucía, Heimersson, Kia, Xagoraris, Ioanna, Wahlin, Björn E., Månsson, Robert, Hansson, Lotta, Rassidakis, Georgios, Palma, Marzia

Source: HemaSphere; Nov2022, Vol. 6 Issue 11, pe794-e794, 1p

P114: Very late relapses in patients with Hodgkin Lymphoma occuring ≥5 years after initial treament with chemotherapy ± radiotherapy: Treatment strategies and prognostic factors for the outcome.

Authors: Vassilakopoulos, Theodoros P., Liaskas, Athanasios, Rizzuto, Giuliana, Symeonidis, Argyrios, Palma, Marzia, Angelopoulou, Maria K., Giatra, Chara, Kondopidou, Flora, Dimou, Maria, Musseti, Alberto, Xagoraris, Ioanna, Siakantaris, Marina, Verigou, Evgenia, Panitsas, Fotios, Asimakopoulos, John, Arapaki, Maria, Chatzidimitriou, Chrysovalantou, Belia, Marina, Sachanas, Sotirios, Korkolopoulou, Penelope

Source: HemaSphere; 2022 Supplement, Vol. 6, p53-53, 1p

P053: The cGAS‐STING anti‐tumor immune response pathway as a potential therapeutic target in classical Hodgkin Lymphoma (cHL)

Authors: Xagoraris, Ioanna, Stathopoulou, Konstantina, Xyderou, Persa, Palma, Marzia, Drakos, Elias, Vassilakopoulos, Theodoros P., Rassidakis, Georgios Z.

Source: HemaSphere; 2022 Supplement, Vol. 6, p24-24, 1p