Proapoptotic activity of JNK-sensitive BH3-only proteins underpins ovarian cancer response to replication checkpoint inhibitors

Authors: Annapoorna Venkatachalam, Cristina Correia, Kevin L. Peterson, Xianon Hou, Paula A. Schneider, Annabella R. Strathman, Karen S. Flatten, Chance C. Sine, Emily A. Balczewski, Cordelia D. McGehee, Melissa C. Larson, Laura N. Duffield, X. Wei Meng, Nicole D. Vincelette, Husheng Ding, Ann L. Oberg, Fergus J. Couch, Elizabeth M. Swisher, Hu Li, S. John Weroha, Scott H. Kaufmann

Source: Molecular Cancer, Vol 23, Iss 1, Pp 1-16 (2024)

Subject Terms: High grade serous ovarian cancer, Apoptosis, CHK1 inhibitor, ATR inhibitor, WEE1 inhibitor, BH3 proteins, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

Access URL: https://doaj.org/article/10416db1db3e4dd388e15b58bcaf44a8

Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells

Authors: Barbara Schroeder, Travis Vander Steen, Ingrid Espinoza, Chandra M. Kurapaty Venkatapoorna, Zeng Hu, Fernando Martín Silva, Kevin Regan, Elisabet Cuyàs, X. Wei Meng, Sara Verdura, Aina Arbusà, Paula A. Schneider, Karen S. Flatten, George Kemble, Joan Montero, Scott H. Kaufmann, Javier A. Menendez, Ruth Lupu

Source: Cell Death and Disease, Vol 12, Iss 11, Pp 1-10 (2021)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/aa72c25e3f5c4af1a2822139760db5bf

Mitochondrial apoptosis and BH3 mimetics [version 1; referees: 3 approved]

Authors: Haiming Dai, X. Wei Meng, Scott H. Kaufmann

Source: F1000Research, Vol 5 (2016)

Subject Terms: Cancer Therapeutics, Cell Signaling, Cellular Death & Stress Responses, Immunopharmacology & Hematologic Pharmacology, Leukemia & Proliferative Disorders of Hematic Cells, Membranes & Sorting, Pediatric Hematology, Pediatric Oncology, Medicine, Science

File Description: electronic resource

Relation: https://f1000research.com/articles/5-2804/v1; https://doaj.org/toc/2046-1402

Access URL: https://doaj.org/article/82afa4c14b1641aba5f3ca3068b3ba7b

Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells

Authors: Husheng Ding, Jennifer S. McDonald, Seongseok Yun, Paula A. Schneider, Kevin L. Peterson, Karen S. Flatten, David A. Loegering, Ann L. Oberg, Shaun M. Riska, Shengbing Huang, Frank A. Sinicrope, Alex A. Adjei, Judith E. Karp, X. Wei Meng, Scott H. Kaufmann

Source: Haematologica, Vol 99, Iss 1 (2014)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/6906; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/c8ce24c260924fff83b4f73d3d068613

Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation.

Authors: Sainski, Amy M.^1,2, Dai, Haiming³, Natesampillai, Sekar², Yuan-Ping Pang¹, Bren, Gary D.², Cummins, Nathan W.², Correia, Cristina³, X. Wei Meng^1,3, Tarara, James E.⁴, Ramirez-Alvarado, Marina⁴, Katzmann, David J.⁴, Ochsenbauer, Christina⁵, Kappes, John C.⁵, Kaufmann, Scott H.^1,3, Kaufmann.Scott@Mayo.edu, Badley, Andrew D.^2,6, Badley.Andrew@Mayo.edu

Source: Journal of Cell Biology; 9/29/2014, Vol. 206 Issue 7, p867-876, 10p

Poly(ADP-ribose) Polymerase Inhibitors Sensitize Cancer Cells to Death Receptor-mediated Apoptosis by Enhancing Death Receptor Expression.

Authors: X. Wei Meng^1,2 Meng.Xue@Mayo.edu, Koh, Brian D.¹, Jin-San Zhang¹, Flatten, Karen S.¹, Schneider, Paula A.¹, Billadeau, Daniel D.¹, Hess, Allan D.³, Smith, B. Douglas³, Karp, Judith E.³, Kaufmann, Scott H.^1,2 Kaufmann.scott@mayo.edu

Source: Journal of Biological Chemistry. 7/25/2014, Vol. 289 Issue 30, p20543-20558. 16p.

Subject Terms: *TUMOR necrosis factors, *APOPTOSIS, *MONOCLONAL antibodies, *CELL death, *ANTINEOPLASTIC agents, *CHROMATIN, *TRANSCRIPTION factors

Context-dependent Bcl-2/Bak Interactions Regulate Lymphoid Cell Apoptosis.

Authors: Haiming Dai¹, X. Wei Meng^1,2, Sun-Hee Lee², Schneider, Paula A.¹, Kaufmann, Scott H.^1,2 Kaufmann.scott@mayo.edu

Source: Journal of Biological Chemistry. 7/3/2009, Vol. 284 Issue 27, p18311-18322. 12p. 5 Graphs.

Subject Terms: *CYTOCHROME c, *MITOCHONDRIA, *HOMOLOGY (Biology), *APOPTOSIS, *AMINO acids, *MITOCHONDRIAL membranes

Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells.

Authors: Haiming Dai^1,2,3, dai.haiming@mayo.edu, Husheng Ding¹, X. Wei Meng^1,2, Peterson, Kevin L.¹, Schneider, Paula A.¹, Karp, Judith E.⁴, Kaufmann, Scott H.^1,2, kaufmann.scott@mayo.edu

Source: Genes & Development; Oct2015, Vol. 29 Issue 20, p3-3, 1p

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization.

Authors: Haiming Dai¹, Smith, Alyson², X. Wei Meng¹, Schneider, Paula A.¹, Yuan-Ping Pang², Kaufmann, Scott H.^1,2 Kaufmann.scott@mayo.edu

Source: Journal of Cell Biology. 7/11/2011, Vol. 194 Issue 1, p39-48. 10p.

Subject Terms: *CYTOCHROMES, *MITOCHONDRIA, *PROTEINS, *PROTEIN-protein interactions, *CELL death

CXCR4 Chemokine Receptor Signaling Induces Apoptosis in Acute Myeloid Leukemia Cells via Regulation of the Bcl-2 Family Members Bcl-XL, Noxa, and Bak.

Authors: Kremer, Kimberly N.¹, Peterson, Kevin L.², Schneider, Paula A.², X. Wei Meng², Haiming Dai², Hess, Allan D.³, Smith, B. Douglas³, Rodriguez-Ramirez, Christie¹, Karp, Judith E.³, Kaufmann, Scott H.^2,4, Hedin, Karen E.¹ hedin.karen@mayo.edu

Source: Journal of Biological Chemistry. 8/9/2013, Vol. 288 Issue 32, p22899-22914. 18p.

Subject Terms: *CHEMOKINE receptors, *APOPTOSIS, *ACUTE myeloid leukemia, *BCL-2 genes, *BCL genes